Best Practice & Research in Clinical Rheumatology最新文献_第2页

Systemic involvement in rheumatic diseases 风湿病的系统性参与。

IF 7 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-09-01 Epub Date: 2026-07-30 DOI: 10.1016/j.berh.2026.102185

Rachel M. Wolfe MD, Kenneth S. O'Rourke MD

引用次数: 0

Managing comorbidities in psoriatic arthritis: A state-of-the-art approach to integrated care (2025) 管理银屑病关节炎的合并症：综合护理的最先进方法（2025）。

IF 7 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-09-01 Epub Date: 2026-09-02 DOI: 10.1016/j.berh.2026.102166

Stephanie Tancer, M. Elaine Husni

{"title":"Managing comorbidities in psoriatic arthritis: A state-of-the-art approach to integrated care (2025)","authors":"Stephanie Tancer, M. Elaine Husni","doi":"10.1016/j.berh.2026.102166","DOIUrl":"10.1016/j.berh.2026.102166","url":null,"abstract":"<div><div>Psoriatic arthritis (PsA) is a chronic immune mediated musculoskeletal condition that is associated with psoriasis. PsA is recognized not as an isolated articular disorder, but as a systemic inflammatory condition with interrelated involvement of the skin, joints, entheses, spine, and gut. The systemic nature of PsA extends beyond musculoskeletal and cutaneous involvement to include a broad spectrum of comorbid and related inflammatory conditions that contribute to disease burden, treatment complexity, and long-term outcomes. PsA is associated with significant comorbidities. This includes cardiovascular disease, obesity, diabetes, fatigue and sleep disorders, mental health disorders and end-organ complications involving the kidney, liver, and bone, as well as related immune-mediated conditions such as inflammatory bowel disease and uveitis. This chapter examines the comorbidity landscape in PsA and underscores its importance in guiding more integrated and effective care. There is particular emphasis on multi-disciplinary evaluation to guide management. We will also explore the updated guidelines for screening, diagnostics, and treatment recommendations in addition to updates in the digital age.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"40 3","pages":"Article 102166"},"PeriodicalIF":7.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The challenges in managing Psoriatic Arthritis in resource poor settings 在资源贫乏的环境中管理银屑病关节炎的挑战。

IF 7 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-09-01 Epub Date: 2026-02-24 DOI: 10.1016/j.berh.2026.102123

Jan René Nkeck, Adewale O. Adebajo, Ajesh B. Maharaj

{"title":"The challenges in managing Psoriatic Arthritis in resource poor settings","authors":"Jan René Nkeck, Adewale O. Adebajo, Ajesh B. Maharaj","doi":"10.1016/j.berh.2026.102123","DOIUrl":"10.1016/j.berh.2026.102123","url":null,"abstract":"<div><h3>Background</h3><div>Psoriatic arthritis (PsA) is a systemic autoimmune and auto-inflammatory disease associated with significant morbidity, increased mortality, and substantial socioeconomic burden globally. While therapeutic advances have improved outcomes, their implementation in resource-limited settings faces profound challenges.</div></div><div><h3>Methods</h3><div>This narrative review synthesises findings from relevant publications identified via PubMed, Medline, Google Scholar and Embase, focusing on the management of PsA in resource-limited settings.</div></div><div><h3>Results</h3><div>We identified four critical challenge domains. Epidemiological: a severe lack of robust population-based data on prevalence, incidence, and phenotype in resource-limited settings hinders public health planning. Diagnostic: significant delays occur due to a scarcity of specialists, limited access to diagnostic tools, and unclear patient pathways, leading to missed therapeutic opportunities and increased structural damage. Therapeutic: access to conventional and advanced biologic/targeted therapies is severely restricted by high costs, limited availability, and insufficient health coverage. This is compounded by a lack of adapted treatment guidelines and multidisciplinary care infrastructure. Research: minimal local research capacity, few clinical trials, and limited funding stifle innovation and context-specific solution development.</div></div><div><h3>Conclusion</h3><div>The effective management of PsA in resource-limited settings requires a multifaceted strategy. Key priorities include: strengthening health systems through clear care pathways; task-shifting and enhanced training for primary care providers; developing national registries and context-adapted guidelines; advocating for improved drug access and affordability; and fostering local research capacity. Addressing these challenges is essential to mitigate health inequities and improve outcomes for PsA patients in resource-limited settings.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"40 3","pages":"Article 102123"},"PeriodicalIF":7.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147286043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New age of Lupus Nephritis: Updates in guidelines, biomarkers, and therapies 狼疮性肾炎的新时代：指南、生物标志物和治疗方法的更新。

IF 7 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-09-01 Epub Date: 2026-05-06 DOI: 10.1016/j.berh.2026.102153

Malika Ibrahim, Emily He, Diana Tran, Divya Vundamati, Jennifer Grossman

引用次数: 0

Alopecia across the spectrum of rheumatic disease 横跨风湿病谱的脱发。

IF 7 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-09-01 Epub Date: 2026-05-26 DOI: 10.1016/j.berh.2026.102163

Lauren Burke, Kathleen Smith, Henry Contag, Kayla Felix Taylor

{"title":"Alopecia across the spectrum of rheumatic disease","authors":"Lauren Burke, Kathleen Smith, Henry Contag, Kayla Felix Taylor","doi":"10.1016/j.berh.2026.102163","DOIUrl":"10.1016/j.berh.2026.102163","url":null,"abstract":"<div><div>Hair loss is a common clinical concern with significant diagnostic and psychosocial implications, particularly in patients with rheumatologic disease. This review examines the association between rheumatologic conditions and alopecia, exploring underlying mechanisms, clinical presentations, and diagnostic considerations. Rheumatologic diseases may precipitate hair loss through a variety of immune, fibrotic, and vascular mechanisms. In addition, pharmacologic therapies commonly used to treat rheumatologic diseases, as well as coexisting autoimmune scalp disorders, can also contribute to alopecia. Recognition of shared mechanisms linking autoimmune disease and hair loss is essential for identification of systemic disease, adverse therapeutic effects, or distinct dermatologic conditions. For optimal diagnosis and management, a structured approach to hair loss should be taken by obtaining a targeted history, physical examination, and laboratory testing or biopsy. Increased awareness of the relationship between alopecia and rheumatologic disease enhances interdisciplinary collaboration, ultimately facilitating earlier diagnosis, more efficient treatment and, most importantly, better patient outcomes.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"40 3","pages":"Article 102163"},"PeriodicalIF":7.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac sarcoidosis: An algorithmic approach to diagnosis and treatment of the “Great Mimicker” 心脏结节病：“大模仿者”诊断和治疗的算法方法。

IF 7 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-09-01 Epub Date: 2026-05-12 DOI: 10.1016/j.berh.2026.102157

Irena Kuzma, Kristen R. Mathias, Jana Lovell, Nisha A. Gilotra

引用次数: 0

Cutaneous manifestations in myositis syndromes 肌炎综合征的皮肤表现。

IF 7 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-09-01 Epub Date: 2026-05-26 DOI: 10.1016/j.berh.2026.102162

Nathan C. Schedler, Omar Raheel, Jesus Alberto Cardenas de la Garza, John R. Edminister

引用次数: 0

Psoriatic arthritis-evolution of our understanding of the phenotype 银屑病关节炎-我们对表型的理解的演变。

IF 7 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-09-01 Epub Date: 2026-04-02 DOI: 10.1016/j.berh.2026.102136

Philip S. Helliwell, Dafna D. Gladman

引用次数: 0

Management of glucocorticoid-induced osteoporosis in rheumatic diseases 风湿性疾病中糖皮质激素所致骨质疏松症的处理。

IF 7 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-09-01 Epub Date: 2026-04-29 DOI: 10.1016/j.berh.2026.102151

Pritee Shrestha, Sowmya B. Popuri, Colton Hoffer, Anam Qureshi, Joshua Barzilay, Eunice Adu Dapaah, Laura D. Carbone

{"title":"Management of glucocorticoid-induced osteoporosis in rheumatic diseases","authors":"Pritee Shrestha, Sowmya B. Popuri, Colton Hoffer, Anam Qureshi, Joshua Barzilay, Eunice Adu Dapaah, Laura D. Carbone","doi":"10.1016/j.berh.2026.102151","DOIUrl":"10.1016/j.berh.2026.102151","url":null,"abstract":"<div><div>Glucocorticoid-induced osteoporosis (GIOP) and its attendant fractures are a major concern for patients with rheumatic diseases. This 2025 review highlights preventive and treatment strategies for GIOP. An overview of the epidemiology and pathogenesis of GIOP is discussed. Key questions considered are.</div><div>(1) What are the optimum risk factor assessment strategies to identify patients with GIOP at fracture risk, including the role of clinical risk factors, imaging modalities and fracture risk calculators?</div><div>(2). What are the preventive strategies for GIOP incorporating information on steroid-sparing agents for the treatment of rheumatic diseases, the role of calcium and vitamin D intake, and exercise ?</div><div>(3). What are treatment strategies for GIOP with a focus on clinical trial data for FDA-approved therapies that have been studied in patients with rheumatic diseases?</div><div>Clinical practice guidelines are discussed. Future directions for the prevention and treatment of GIOP in persons with rheumatic diseases are considered.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"40 3","pages":"Article 102151"},"PeriodicalIF":7.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pneumocystis prophylaxis in rheumatic disease 风湿病中肺囊虫的预防。

IF 7 2区医学

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-09-01 Epub Date: 2026-06-05 DOI: 10.1016/j.berh.2026.102164

Rachel M. Wolfe, Kevin L. Winthrop

引用次数: 0