Ashish J. Mathew , Alan L. Zhou , Mikkel Østergaard , Sahil Koppikar
{"title":"Imaging in the diagnosis and management of peripheral psoriatic arthritis: Update and recent advances","authors":"Ashish J. Mathew , Alan L. Zhou , Mikkel Østergaard , Sahil Koppikar","doi":"10.1016/j.berh.2025.102061","DOIUrl":"10.1016/j.berh.2025.102061","url":null,"abstract":"<div><div><span><span>Psoriatic arthritis is an immune-mediated </span>inflammatory disease characterized by inflammatory and structural changes in multiple clinical domains, including peripheral and axial arthritis, </span>enthesitis<span><span>, and dactylitis<span>. Early diagnosis and initiation of targeted therapies in patients with PsA lead to a better </span></span>quality of life<span><span>. Conventional radiography<span> continues to be the most frequently used imaging modality in routine care, given its easy accessibility and low cost. Advanced imaging techniques, such as ultrasound and magnetic resonance imaging, with their ability to assess both inflammatory and structural pathologies simultaneously, have facilitated a better understanding of disease pathogenesis, early diagnosis leading to early initiation of therapy, sensitive outcome measurement in </span></span>clinical trials, and close monitoring of the disease process, enabling practical switching of therapies. Novel imaging techniques still seeking broad applicability have demonstrated encouraging results but require further testing before clinical use. This review focuses on the progress in imaging techniques for peripheral psoriatic disease.</span></span></div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 3","pages":"Article 102061"},"PeriodicalIF":4.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to “Arthritis related to parasitic infections” [Best Practice Res Clinic Rheumatol 39 (2025) 102062]","authors":"Shaheed Ahmed , Jasmin Raja","doi":"10.1016/j.berh.2025.102086","DOIUrl":"10.1016/j.berh.2025.102086","url":null,"abstract":"","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 3","pages":"Article 102086"},"PeriodicalIF":4.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Berit D. Nielsen , Luca Seitz , Wolfgang A. Schmidt
{"title":"Update in imaging for large vessel vasculitis","authors":"Berit D. Nielsen , Luca Seitz , Wolfgang A. Schmidt","doi":"10.1016/j.berh.2025.102060","DOIUrl":"10.1016/j.berh.2025.102060","url":null,"abstract":"<div><div>Diagnostic imaging is recommended to confirm suspected giant cell arteritis (GCA) or Takayasu arteritis (TAK), and may, in the follow-up of these patients, be used to assess vascular damage. Ultrasound, magnetic resonance imaging (MRI) and 18F-Fluorodeoxyglucose (<sup>18</sup>F-FDG) positron emission tomography (PET)/computed tomography (CT) can all visualise inflammation in vascular regions affected. Ultrasound and MRI are recommended first line diagnostic test in GCA and TAK, respectively, but local expertise, availability and potential differential diagnoses are important prerequisites for the choice of imaging modality. Ultrasound, MR- and CT-angiography may also be used to assess morphologic changes. Further research is necessary on the role of imaging for monitoring disease activity and guide treatment decisions. Advantages and limitations apply to all modalities separately. This review will discuss the pros and cons, the application and pitfalls of each of these imaging modalities in the diagnosis and management of GCA and TAK.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 3","pages":"Article 102060"},"PeriodicalIF":4.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel therapies - IMID Co-morbidities.","authors":"Tsz On Lam, Ho So, Lai-Shan Tam","doi":"10.1016/j.berh.2025.102089","DOIUrl":"https://doi.org/10.1016/j.berh.2025.102089","url":null,"abstract":"<p><p>Cardiovascular diseases (CVD) and metabolic syndrome are common in patients with immune-mediated inflammatory diseases (IMID). These conditions exhibit significant interactions, between diseases and in relation to treatments, highlighting the need for rheumatologists to take an active role in their management. It is now known that inflammation mediated by adipokines is important in the pathogenesis of obesity and cardiovascular-kidney-metabolic (CKM) syndrome. Novel therapeutics developed for metabolic comorbidities have demonstrated pleiotropic benefit across a range of diseases. Some of them even possess anti-inflammatory and immuno-modulatory effects, serving as adjuncts to the management of IMID. On the other hand, anti-inflammatory drugs have been rigorously tested for their efficacy in CVD and colchicine has become the first anti-inflammatory drug approved for this purpose. This paper will focus on the novel therapeutics and new purposes of conventional drugs in the management of CVD and metabolic syndrome, with additional discussion of their relevance in IMID.</p>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":" ","pages":"102089"},"PeriodicalIF":4.8,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristina Pelkas, Kyle B Franke, Fabien B Vincent, Maureen Rischmueller
{"title":"Novel therapies in Sjögren's disease: A systematic review of the literature.","authors":"Cristina Pelkas, Kyle B Franke, Fabien B Vincent, Maureen Rischmueller","doi":"10.1016/j.berh.2025.102084","DOIUrl":"https://doi.org/10.1016/j.berh.2025.102084","url":null,"abstract":"<p><p>Sjögren's disease (SjD) is a chronic systemic autoimmune disorder that primarily involves lymphocytic infiltration of exocrine glands, with frequent extra-glandular manifestations. Historically, treatment options for SjD have been limited to alleviating symptoms, rather than treating the underlying cause or preventing disease progression. Furthermore, past clinical trials of therapies such as rituximab failed to demonstrate improvement in symptoms or disease activity. Recently, novel therapeutic strategies targeting underlying disease pathogenesis - including transcription factors, circulating RNA, and B and T cell activity - herald a paradigm shift. Given the complexities of diagnosis, clinical assessment and treatment in SjD, improved clinical trial design with enhanced patient stratification, greater inclusivity and better outcome measures are paramount in evaluating new therapeutics. This systematic review aims to provide a comprehensive overview of recent SjD therapeutic advances, assess trial inclusivity with respect to sex/gender and ethnicity, critically examine negative pivotal trials and highlight promising directions for future research.</p>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":" ","pages":"102084"},"PeriodicalIF":4.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Praveen Kumar Tirlangi , Anjely Sebastian , Mukhyaprana Prabhu M
{"title":"Tropical pyomyositis","authors":"Praveen Kumar Tirlangi , Anjely Sebastian , Mukhyaprana Prabhu M","doi":"10.1016/j.berh.2025.102041","DOIUrl":"10.1016/j.berh.2025.102041","url":null,"abstract":"<div><div>Tropical pyomyositis is a serious infectious disease characterised by the formation of abscesses in the skeletal muscles and is primarily caused by <em>Staphylococcus aureus</em>, with an increasing incidence in non-tropical regions. The disease primarily affects men and young adults, often following minor trauma, with an increasing incidence in immunocompromised individuals. Immunocompromised hosts are more likely to be affected by Gram-negative organisms, <em>Mycobacterium tuberculosis</em>, opportunistic infections such as fungal pathogens, non-tuberculous mycobacteria, and <em>Nocardia</em> species. Diagnosis is complicated by non-specific symptoms and the low yield of blood cultures, so imaging studies such as Magnetic Resonance Imaging (MRI) are required for accurate identification. Treatment focuses on controlling the source through drainage, tailored antibiotic therapy, and supportive care, especially in patients with complications such as multi-organ dysfunction. Given the complex clinical manifestations, heightened awareness and a collaborative approach to education and resource provision are critical to improving outcomes in patients with tropical pyomyositis.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 2","pages":"Article 102041"},"PeriodicalIF":4.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benoit Suzon , Aurore Abel , Emmanuelle Sylvestre , Andre Cabie , Arthur Felix , Fabienne Louis-Sidney
{"title":"Correspondence on “Epidemiology of rheumatic diseases in tropical populations” by Goyal & Santhanam","authors":"Benoit Suzon , Aurore Abel , Emmanuelle Sylvestre , Andre Cabie , Arthur Felix , Fabienne Louis-Sidney","doi":"10.1016/j.berh.2025.102073","DOIUrl":"10.1016/j.berh.2025.102073","url":null,"abstract":"","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 2","pages":"Article 102073"},"PeriodicalIF":4.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Access to rheumatologic care in tropical regions: Barriers and solutions","authors":"Keerthi Talari , Himanshu Pathak , Neeraj Jain , Vinod Ravindran","doi":"10.1016/j.berh.2025.102052","DOIUrl":"10.1016/j.berh.2025.102052","url":null,"abstract":"<div><div>Due to systemic, cultural, and economic barriers, tropical regions face unique challenges in delivering rheumatologic care. This review outlines key obstacles such as disjointed healthcare systems, shortage of trained manpower in rheumatology, limited diagnostic tools, treatment barriers, lack of multidisciplinary care and cultural barriers in tropical countries. These barriers lead to delays in diagnosis, disease progression, disability, and poor quality of life. This chapter discusses actionable solutions such as building healthcare infrastructure, healthcare policy changes, expanding rheumatology training programs, leveraging telemedicine, and fostering community-driven awareness initiatives with examples. By tackling these challenges directly, access to rheumatologic care can be improved, making it more widely available to people, regardless of their location within tropical countries.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 2","pages":"Article 102052"},"PeriodicalIF":4.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Arthritis related to parasitic infections","authors":"Shaheed Ahmed , Jasmin Raja","doi":"10.1016/j.berh.2025.102062","DOIUrl":"10.1016/j.berh.2025.102062","url":null,"abstract":"<div><div>Various parasitic infections can manifest with symptoms resembling inflammatory rheumatic diseases. Parasitic arthritis is uncommon, and the literature concerning rheumatic manifestations of specific parasitic infections tends to be limited to case reports. Despite its rarity, parasitic infections should always be included in the differential diagnosis of rheumatic presentations when there is a history of risk factors, particularly in patients from endemic regions and in atypical rheumatic presentations. Specific treatment of the parasitic infection often leads to significant improvement or resolution of symptoms. This account discusses various parasites that have been reported to be associated with arthritis and other related musculoskeletal manifestations.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 2","pages":"Article 102062"},"PeriodicalIF":4.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chikungunya and other viral arthritis","authors":"Arvind Chopra , Anuradha Venugopalan","doi":"10.1016/j.berh.2025.102068","DOIUrl":"10.1016/j.berh.2025.102068","url":null,"abstract":"<div><div>Several viruses cause acute and chronic arthritis. Millions of people suffered from Chikungunya(CHIK) during the recent epidemics/outbreaks in Asia, Africa and the Americas. Almost 20–40 % failed to recover completely and suffered from chronic pain and arthritis sequel. A wide spectrum of clinical phenotypic arthritis was described. Non-specific arthralgias(NSA) and soft tissue pains were predominant although inflammatory arthritis (mostly undifferentiated)(IA-U) was substantial. Specifically, rheumatoid arthritis(RA) and spondyloarthritis(SpA) like disorders were described. The frequency of biomarkers such as rheumatoid factor(RF) was low. Arthritis was mostly non-erosive in population studies. Abnormal immune mechanisms and persistent specific CHIK virus (CHIKV) IgM and IgG antibodies were shown. The etiopathogenetic evidence was divided between intense joint tissue inflammation due to prolonged virus persistence and abnormal autoimmune mechanisms. There was no specific therapy. The symptomatic management was often combined with an empirical use of disease modifying anti rheumatoid drugs and steroids. Substantial research is required to address knowledge gaps and unravel evidence-based medicine.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 2","pages":"Article 102068"},"PeriodicalIF":4.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}