David A Kellner, Nicolette T Morris, Stephanie M Lee, Joshua F Baker, Philip Chu, Veena K Ranganath, Gurjit S Kaeley, Howard H Yang
{"title":"Clinical utility of ultrasound and MRI in rheumatoid arthritis: An expert review.","authors":"David A Kellner, Nicolette T Morris, Stephanie M Lee, Joshua F Baker, Philip Chu, Veena K Ranganath, Gurjit S Kaeley, Howard H Yang","doi":"10.1016/j.berh.2025.102072","DOIUrl":"https://doi.org/10.1016/j.berh.2025.102072","url":null,"abstract":"<p><p>Musculoskeletal ultrasound (MSUS) and magnetic resonance imaging (MRI) are advanced imaging techniques that are increasingly important in the diagnosis and management of rheumatoid arthritis (RA) and have significantly enhanced the rheumatologist's ability to assess RA disease activity and progression. This review serves as a five-year update to our previous publication on the contemporary role of imaging in RA, emphasizing the continued importance of MSUS and MRI in clinical practice and their expanding utility. The review examines the role of MSUS in diagnosing RA, differentiating RA from mimickers, scoring systems and quality control measures, novel longitudinal approaches to disease monitoring, and patient populations that may benefit most from MSUS. It also examines the role of MRI in diagnosing pre-clinical and early RA, disease activity monitoring, research and clinical trials, and development of alternative scoring approaches utilizing artificial intelligence. Finally, the role of MRI in RA diagnosis and management is summarized, and selected practice points offer key tips for integrating MSUS and MRI into clinical practice.</p>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":" ","pages":"102072"},"PeriodicalIF":4.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Best practice in rheumatology new developments in ultrasound and MRI imaging of pediatric rheumatic diseases.","authors":"Johannes Roth, Clara Malattia","doi":"10.1016/j.berh.2025.102069","DOIUrl":"https://doi.org/10.1016/j.berh.2025.102069","url":null,"abstract":"<p><p>The evidence base for ultrasound and MRI imaging in pediatric rheumatic diseases continues to grow, enabling the routine clinical use of the two techniques that complement each other. Ultrasound imaging has a superior spatial resolution, the ability to assess several joints at the same time without sedation and provides very detailed assessments of important structures like the entheses. MRI has advantages in the assessment of osteochondral damage and certain anatomic regions like the temporomandibular joint (TMJ) and the axial skeleton. Significant progress in the standardization of image acquisition and quantification of findings allows the utilisation of both techniques as an outcome measure. This will improve the standard of care in pediatric rheumatic diseases where objective measurements of disease activity are urgently needed. Finally, the integration of artificial intelligence (AI) represents a groundbreaking development in the field and potential applications will be discussed.</p>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":" ","pages":"102069"},"PeriodicalIF":4.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Federico Zaottini, Federico Pistoia, Riccardo Picasso, Marta Macciò, Giovanni Marcenaro, Marina Grandis, Luana Benedetti, Carlo Martinoli
{"title":"Imaging for inflammatory neuropathies.","authors":"Federico Zaottini, Federico Pistoia, Riccardo Picasso, Marta Macciò, Giovanni Marcenaro, Marina Grandis, Luana Benedetti, Carlo Martinoli","doi":"10.1016/j.berh.2025.102066","DOIUrl":"https://doi.org/10.1016/j.berh.2025.102066","url":null,"abstract":"<p><p>Inflammatory neuropathies comprise a heterogeneous group of conditions united by inflammation-mediated damage to peripheral nerves and their vasa nervorum. Although classification, diagnosis and management are largely based on clinical features, electrodiagnostic and laboratory examinations, imaging studies play an important supporting role. Ultrasound and MRI are the two modalities used for imaging peripheral nerves. The two techniques differ in the clinical context of application, the information provided and the diagnostic performance. This narrative review aims to provide guidance on when and how to use ultrasound or MRI in patients with inflammatory neuropathies, highlighting their respective strengths and pitfalls, and how to combine these imaging modalities to enhance their usefulness in the diagnostic-therapeutic management of these far from rare conditions.</p>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":" ","pages":"102066"},"PeriodicalIF":4.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Praveen Kumar Tirlangi , Anjely Sebastian , Mukhyaprana Prabhu M
{"title":"Tropical pyomyositis","authors":"Praveen Kumar Tirlangi , Anjely Sebastian , Mukhyaprana Prabhu M","doi":"10.1016/j.berh.2025.102041","DOIUrl":"10.1016/j.berh.2025.102041","url":null,"abstract":"<div><div>Tropical pyomyositis is a serious infectious disease characterised by the formation of abscesses in the skeletal muscles and is primarily caused by <em>Staphylococcus aureus</em>, with an increasing incidence in non-tropical regions. The disease primarily affects men and young adults, often following minor trauma, with an increasing incidence in immunocompromised individuals. Immunocompromised hosts are more likely to be affected by Gram-negative organisms, <em>Mycobacterium tuberculosis</em>, opportunistic infections such as fungal pathogens, non-tuberculous mycobacteria, and <em>Nocardia</em> species. Diagnosis is complicated by non-specific symptoms and the low yield of blood cultures, so imaging studies such as Magnetic Resonance Imaging (MRI) are required for accurate identification. Treatment focuses on controlling the source through drainage, tailored antibiotic therapy, and supportive care, especially in patients with complications such as multi-organ dysfunction. Given the complex clinical manifestations, heightened awareness and a collaborative approach to education and resource provision are critical to improving outcomes in patients with tropical pyomyositis.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 2","pages":"Article 102041"},"PeriodicalIF":4.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benoit Suzon , Aurore Abel , Emmanuelle Sylvestre , Andre Cabie , Arthur Felix , Fabienne Louis-Sidney
{"title":"Correspondence on “Epidemiology of rheumatic diseases in tropical populations” by Goyal & Santhanam","authors":"Benoit Suzon , Aurore Abel , Emmanuelle Sylvestre , Andre Cabie , Arthur Felix , Fabienne Louis-Sidney","doi":"10.1016/j.berh.2025.102073","DOIUrl":"10.1016/j.berh.2025.102073","url":null,"abstract":"","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 2","pages":"Article 102073"},"PeriodicalIF":4.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Access to rheumatologic care in tropical regions: Barriers and solutions","authors":"Keerthi Talari , Himanshu Pathak , Neeraj Jain , Vinod Ravindran","doi":"10.1016/j.berh.2025.102052","DOIUrl":"10.1016/j.berh.2025.102052","url":null,"abstract":"<div><div>Due to systemic, cultural, and economic barriers, tropical regions face unique challenges in delivering rheumatologic care. This review outlines key obstacles such as disjointed healthcare systems, shortage of trained manpower in rheumatology, limited diagnostic tools, treatment barriers, lack of multidisciplinary care and cultural barriers in tropical countries. These barriers lead to delays in diagnosis, disease progression, disability, and poor quality of life. This chapter discusses actionable solutions such as building healthcare infrastructure, healthcare policy changes, expanding rheumatology training programs, leveraging telemedicine, and fostering community-driven awareness initiatives with examples. By tackling these challenges directly, access to rheumatologic care can be improved, making it more widely available to people, regardless of their location within tropical countries.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 2","pages":"Article 102052"},"PeriodicalIF":4.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Arthritis related to parasitic infections","authors":"Shaheed Ahmed , Jasmin Raja","doi":"10.1016/j.berh.2025.102062","DOIUrl":"10.1016/j.berh.2025.102062","url":null,"abstract":"<div><div>Various parasitic infections can manifest with symptoms resembling inflammatory rheumatic diseases. Parasitic arthritis is uncommon, and the literature concerning rheumatic manifestations of specific parasitic infections tends to be limited to case reports. Despite its rarity, parasitic infections should always be included in the differential diagnosis of rheumatic presentations when there is a history of risk factors, particularly in patients from endemic regions and in atypical rheumatic presentations. Specific treatment of the parasitic infection often leads to significant improvement or resolution of symptoms. This account discusses various parasites that have been reported to be associated with arthritis and other related musculoskeletal manifestations.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 2","pages":"Article 102062"},"PeriodicalIF":4.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chikungunya and other viral arthritis","authors":"Arvind Chopra , Anuradha Venugopalan","doi":"10.1016/j.berh.2025.102068","DOIUrl":"10.1016/j.berh.2025.102068","url":null,"abstract":"<div><div>Several viruses cause acute and chronic arthritis. Millions of people suffered from Chikungunya(CHIK) during the recent epidemics/outbreaks in Asia, Africa and the Americas. Almost 20–40 % failed to recover completely and suffered from chronic pain and arthritis sequel. A wide spectrum of clinical phenotypic arthritis was described. Non-specific arthralgias(NSA) and soft tissue pains were predominant although inflammatory arthritis (mostly undifferentiated)(IA-U) was substantial. Specifically, rheumatoid arthritis(RA) and spondyloarthritis(SpA) like disorders were described. The frequency of biomarkers such as rheumatoid factor(RF) was low. Arthritis was mostly non-erosive in population studies. Abnormal immune mechanisms and persistent specific CHIK virus (CHIKV) IgM and IgG antibodies were shown. The etiopathogenetic evidence was divided between intense joint tissue inflammation due to prolonged virus persistence and abnormal autoimmune mechanisms. There was no specific therapy. The symptomatic management was often combined with an empirical use of disease modifying anti rheumatoid drugs and steroids. Substantial research is required to address knowledge gaps and unravel evidence-based medicine.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 2","pages":"Article 102068"},"PeriodicalIF":4.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RE: Response to Goyal & Santhanam best practice & research clinical rheumatology","authors":"Mohit Goyal , Sham Santhanam","doi":"10.1016/j.berh.2025.102074","DOIUrl":"10.1016/j.berh.2025.102074","url":null,"abstract":"","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 2","pages":"Article 102074"},"PeriodicalIF":4.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vitor Alves Cruz , Anna Carolina Faria Moreira Gomes Tavares , Andréa Monteiro de Araújo , Maria Stella Cochrane Feitosa , Joana Starling de Carvalho , Ciro Martins Gomes , Viviane Angelina de Souza , Licia Maria Henrique da Mota
{"title":"Musculoskeletal manifestations in leprosy","authors":"Vitor Alves Cruz , Anna Carolina Faria Moreira Gomes Tavares , Andréa Monteiro de Araújo , Maria Stella Cochrane Feitosa , Joana Starling de Carvalho , Ciro Martins Gomes , Viviane Angelina de Souza , Licia Maria Henrique da Mota","doi":"10.1016/j.berh.2025.102039","DOIUrl":"10.1016/j.berh.2025.102039","url":null,"abstract":"<div><div>Leprosy, a chronic infectious disease caused by <em>Mycobacterium leprae</em> and <em>Mycobacterium lepromatosis</em>, primarily targets the skin and peripheral nerves, frequently leading to dermatological, neurological, and musculoskeletal complications. This review highlights the spectrum of musculoskeletal manifestations in leprosy, including acute arthritis during Type 2 reactions, chronic arthritis mimicking autoimmune diseases like rheumatoid arthritis, and neuropathic arthropathy. These manifestations underscore the complex interplay of inflammatory and immune mechanisms. Acute arthritis often involves both small and large joints, while chronic forms may present diagnostic challenges due to their resemblance to other inflammatory arthritides. Clinical management centers on multidrug therapy (MDT) for infection control, complemented by immunosuppressive or anti-inflammatory agents for reactional episodes. Recent advancements, such as biologics and synthetic immunosuppressants, have demonstrated efficacy in refractory cases, offering new therapeutic avenues. Heightened clinician awareness is essential for timely diagnosis and integrated management, particularly in endemic regions, to mitigate long-term disabilities and improve patient outcomes.</div></div>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":"39 2","pages":"Article 102039"},"PeriodicalIF":4.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}