{"title":"What's new in osteoarthritis?","authors":"Graeme Jones","doi":"10.1016/j.berh.2025.102102","DOIUrl":null,"url":null,"abstract":"<p><p>Osteoarthritis is major and growing public health problem. Major advances have occurred in terms of understanding the pathogenesis of the disease primarily due to advances in imaging. Both systemic and local factors are involved. Some of these are modifiable making them attractive targets for therapy and the development of precision medicine in osteoarthritis. A growing number of these trials selecting subgroups of osteoarthritis with specific imaging features have been completed with mixed results. In many cases, the interventional studies have not replicated the results of the basic science and human observational studies and the majority of trials have been negative with a few notable exceptions. There is an urgent need for greater choice of therapies in this condition.</p>","PeriodicalId":50983,"journal":{"name":"Best Practice & Research in Clinical Rheumatology","volume":" ","pages":"102102"},"PeriodicalIF":4.8000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Best Practice & Research in Clinical Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.berh.2025.102102","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Osteoarthritis is major and growing public health problem. Major advances have occurred in terms of understanding the pathogenesis of the disease primarily due to advances in imaging. Both systemic and local factors are involved. Some of these are modifiable making them attractive targets for therapy and the development of precision medicine in osteoarthritis. A growing number of these trials selecting subgroups of osteoarthritis with specific imaging features have been completed with mixed results. In many cases, the interventional studies have not replicated the results of the basic science and human observational studies and the majority of trials have been negative with a few notable exceptions. There is an urgent need for greater choice of therapies in this condition.
期刊介绍：
Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions.
Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science.
The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update.
Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.
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