Fungal arthritis

IF 4.5 2区医学 Q1 RHEUMATOLOGY

Best Practice & Research in Clinical Rheumatology Pub Date : 2025-05-01 DOI:10.1016/j.berh.2025.102058

Ying Xi Kong , Kok Ooi Kong

引用次数: 0

Abstract

Fungal arthritis is a rare infection with a global distribution that affects neonates, the elderly, and immunocompromised individuals, resulting in severe outcomes. It presents a challenge for healthcare professionals due to its rarity, lack of characteristic features, and difficulty isolating and identifying responsible organisms. Studies on their pathophysiology and treatment have been limited, and evidence-based treatment options are lacking. The pathogens infect through direct inoculation, extension from adjacent infective foci, or distant dissemination via the bloodstream. Typically, it manifests as either monoarthritis or oligoarthritis, with the knee joint being the most common target. Systemic disease is often absent, while pulmonary and cutaneous diseases are the most frequent extra-articular manifestations. Diagnosis frequently necessitates the direct visualisation of the organism in specimens and cultures of synovial fluid and membranes. A combination of medical (antifungal) and surgical treatments is often required.

查看原文本刊更多论文

真菌关节炎。

真菌性关节炎是一种罕见的感染与全球分布，影响新生儿，老年人和免疫功能低下的个体，导致严重的后果。由于其稀有性，缺乏特征，难以分离和识别负责任的生物体，因此对医疗保健专业人员提出了挑战。对其病理生理和治疗的研究有限，缺乏循证治疗方案。病原体通过直接接种、邻近感染灶的延伸或通过血液的远距离传播而感染。通常，它表现为单关节炎或寡关节炎，膝关节是最常见的目标。全身性疾病通常不存在，而肺部和皮肤疾病是最常见的关节外表现。诊断经常需要在标本和滑液和膜培养中直接观察生物体。通常需要药物（抗真菌）和手术治疗相结合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Best Practice & Research in Clinical Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

0.00%

发文量

审稿时长

27 days

期刊介绍： Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.