Acute rheumatic fever and Post-streptococcal reactive arthritis.

Acute rheumatic fever (ARF) and poststreptococcal reactive arthritis (PSRA) represent two distinct but related poststreptococcal conditions, both arising from an autoimmune response following Group A streptococcal (GAS) infection, typically pharyngitis. Although both illnesses have a shared trigger, their clinical presentations and long-term consequences differ markedly. ARF, a systemic inflammatory disorder, can impact several organs, particularly the heart, potentially resulting in chronic rheumatic heart disease with irreversible valve damage. The cornerstone of ARF treatment includes Streptococcus eradication therapy, symptom management, and secondary prophylaxis to prevent recurrence. In contrast, PSRA primarily presents as non-infectious, nonmigratory, persistent arthritis without carditis and generally resolves without lasting sequelae. Distinguishing PSRA from ARF is crucial for appropriate management and to avoid unnecessary long-term antibiotic prophylaxis. This review focuses on the key clinical features and diagnostic approaches for ARF and PSRA, along with an overview of their management strategies.