Advances in Virus Research最新文献_第8页

Structure-guided paradigm shifts in flavivirus assembly and maturation mechanisms. 黄病毒组装和成熟机制中结构引导的范式转变。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-09-23 DOI: 10.1016/bs.aivir.2020.08.003

Conrrad M R Nicholls, Madhumati Sevvana, Richard J Kuhn

引用次数: 0

Implications of mixed viral infections on plant disease ecology and evolution. 混合病毒感染对植物病害生态学和进化的影响。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-03-13 DOI: 10.1016/bs.aivir.2020.02.001

Cristina Alcaide, M Pilar Rabadán, Manuel G Moreno-Pérez, Pedro Gómez

{"title":"Implications of mixed viral infections on plant disease ecology and evolution.","authors":"Cristina Alcaide, M Pilar Rabadán, Manuel G Moreno-Pérez, Pedro Gómez","doi":"10.1016/bs.aivir.2020.02.001","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.02.001","url":null,"abstract":"Mixed viral infections occur more commonly than would be expected by chance in nature. Virus-virus interactions may affect viral traits and leave a genetic signature in the population, and thus influence the prevalence and emergence of viral diseases. Understanding about how the interactions between viruses within a host shape the evolutionary dynamics of the viral populations is needed for viral disease prevention and management. Here, we first synthesize concepts implied in the occurrence of virus-virus interactions. Second, we consider the role of the within-host interactions of virus-virus and virus-other pathogenic microbes, on the composition and structure of viral populations. Third, we contemplate whether mixed viral infections can create opportunities for the generation and maintenance of viral genetic diversity. Fourth, we attempt to summarize the evolutionary response of viral populations to mixed infections to understand how they shape the spatio-temporal dynamics of viral populations at the individual plant and field scales. Finally, we anticipate the future research under the reconciliation of molecular epidemiology and evolutionary ecology, drawing attention to the need of adding more complexity to future research in order to gain a better understanding about the mechanisms operating in nature.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"106 ","pages":"145-169"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37866090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Copyright 版权

2区医学

Advances in Virus Research Pub Date : 2020-01-01 DOI: 10.1016/s0065-3527(20)30011-7

引用次数: 0

Series Page 系列页面

2区医学

Advances in Virus Research Pub Date : 2020-01-01 DOI: 10.1016/s0065-3527(20)30029-4

引用次数: 0

Immunopathology and immune homeostasis during viral infection in insects. 昆虫病毒感染过程中的免疫病理和免疫稳态。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-07-03 DOI: 10.1016/bs.aivir.2020.06.001

Andrea González-González, Marta L Wayne

引用次数: 4

Modulation of disease severity by plant positive-strand RNA viruses: The complex interplay of multifunctional viral proteins, subviral RNAs and virus-associated RNAs with plant signaling pathways and defense responses. 植物正链RNA病毒对疾病严重程度的调节:多功能病毒蛋白、亚病毒RNA和病毒相关RNA与植物信号通路和防御反应的复杂相互作用

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-05-21 DOI: 10.1016/bs.aivir.2020.04.003

Hélène Sanfaçon

{"title":"Modulation of disease severity by plant positive-strand RNA viruses: The complex interplay of multifunctional viral proteins, subviral RNAs and virus-associated RNAs with plant signaling pathways and defense responses.","authors":"Hélène Sanfaçon","doi":"10.1016/bs.aivir.2020.04.003","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.04.003","url":null,"abstract":"Plant viruses induce a range of symptoms of varying intensity, ranging from severe systemic necrosis to mild or asymptomatic infection. Several evolutionary constraints drive virus virulence, including the dependence of viruses on host factors to complete their infection cycle, the requirement to counteract or evade plant antiviral defense responses and the mode of virus transmission. Viruses have developed an array of strategies to modulate disease severity. Accumulating evidence has highlighted not only the multifunctional role that viral proteins play in disrupting or highjacking plant factors, hormone signaling pathways and intracellular organelles, but also the interaction networks between viral proteins, subviral RNAs and/or other viral-associated RNAs that regulate disease severity. This review focusses on positive-strand RNA viruses, which constitute the majority of characterized plant viruses. Using well-characterized viruses with different genome types as examples, recent advances are discussed as well as knowledge gaps and opportunities for further research.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"107 ","pages":"87-131"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.04.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38191543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Structure and assembly of double-stranded RNA mycoviruses. 双链RNA分枝病毒的结构与组装。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-09-16 DOI: 10.1016/bs.aivir.2020.08.001

Carlos P Mata, Javier M Rodríguez, Nobuhiro Suzuki, José R Castón

{"title":"Structure and assembly of double-stranded RNA mycoviruses.","authors":"Carlos P Mata, Javier M Rodríguez, Nobuhiro Suzuki, José R Castón","doi":"10.1016/bs.aivir.2020.08.001","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.08.001","url":null,"abstract":"Mycoviruses are a diverse group that includes ssRNA, dsRNA, and ssDNA viruses, with or without a protein capsid, as well as with a complex envelope. Most mycoviruses are transmitted by cytoplasmic interchange and are thought to lack an extracellular phase in their infection cycle. Structural analysis has focused on dsRNA mycoviruses, which usually package their genome in a 120-subunit T=1 icosahedral capsid, with a capsid protein (CP) dimer as the asymmetric unit. The atomic structure is available for four dsRNA mycovirus from different families: Saccharomyces cerevisiae virus L-A (ScV-L-A), Penicillium chrysogenum virus (PcV), Penicillium stoloniferum virus F (PsV-F), and Rosellinia necatrix quadrivirus 1 (RnQV1). Their capsids show structural variations of the same framework, with asymmetric or symmetric CP dimers respectively for ScV-L-A and PsV-F, dimers of similar domains of a single CP for PcV, or of two different proteins for RnQV1. The CP dimer is the building block, and assembly proceeds through dimers of dimers or pentamers of dimers, in which the genome is packed as ssRNA by interaction with CP and/or viral polymerase. These capsids remain structurally undisturbed throughout the viral cycle. The T=1 capsid participates in RNA synthesis, organizing the viral polymerase (1-2 copies) and a single loosely packaged genome segment. It also acts as a molecular sieve, to allow the passage of viral transcripts and nucleotides, but to prevent triggering of host defense mechanisms. Due to the close mycovirus-host relationship, CP evolved to allocate peptide insertions with enzyme activity, as reflected in a rough outer capsid surface.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"108 ","pages":"213-247"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25587079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Immunopathogenesis of alphaviruses. 甲病毒的免疫发病机制。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-07-08 DOI: 10.1016/bs.aivir.2020.06.002

Victoria K Baxter, Mark T Heise

{"title":"Immunopathogenesis of alphaviruses.","authors":"Victoria K Baxter, Mark T Heise","doi":"10.1016/bs.aivir.2020.06.002","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.06.002","url":null,"abstract":"Alphaviruses, members of the enveloped, positive-sense, single-stranded RNA Togaviridae family, represent a reemerging public health threat as mosquito vectors expand into new geographic territories. The Old World alphaviruses, which include chikungunya virus, Ross River virus, and Sindbis virus, tend to cause a clinical syndrome characterized by fever, rash, and arthritis, whereas the New World alphaviruses, which consist of Venezuelan equine encephalitis virus, eastern equine encephalitis virus, and western equine encephalitis virus, induce encephalomyelitis. Following recovery from the acute phase of infection, many patients are left with debilitating persistent joint and neurological complications that can last for years. Clues from human cases and studies using animal models strongly suggest that much of the disease and pathology induced by alphavirus infection, particularly atypical and chronic manifestations, is mediated by the immune system rather than directly by the virus. This review discusses the current understanding of the immunopathogenesis of the arthritogenic and neurotropic alphaviruses accumulated through both natural infection of humans and experimental infection of animals, particularly mice. As treatment following alphavirus infection is currently limited to supportive care, understanding the contribution of the immune system to the disease process is critical to developing safe and effective therapies.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"107 ","pages":"315-382"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38191548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Host protein chaperones, RNA helicases and the ubiquitin network highlight the arms race for resources between tombusviruses and their hosts. 宿主蛋白伴侣、RNA解旋酶和泛素网络凸显了tombusvirus与其宿主之间资源的军备竞赛。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-07-07 DOI: 10.1016/bs.aivir.2020.06.006

Peter D Nagy

{"title":"Host protein chaperones, RNA helicases and the ubiquitin network highlight the arms race for resources between tombusviruses and their hosts.","authors":"Peter D Nagy","doi":"10.1016/bs.aivir.2020.06.006","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.06.006","url":null,"abstract":"Positive-strand RNA viruses need to arrogate many cellular resources to support their replication and infection cycles. These viruses co-opt host factors, lipids and subcellular membranes and exploit cellular metabolites to built viral replication organelles in infected cells. However, the host cells have their defensive arsenal of factors to protect themselves from easy exploitation by viruses. In this review, the author discusses an emerging arms race for cellular resources between viruses and hosts, which occur during the early events of virus-host interactions. Recent findings with tomato bushy stunt virus and its hosts revealed that the need of the virus to exploit and co-opt given members of protein families provides an opportunity for the host to deploy additional members of the same or associated protein family to interfere with virus replication. Three examples with well-established heat shock protein 70 and RNA helicase protein families and the ubiquitin network will be described to illustrate this model on the early arms race for cellular resources between tombusviruses and their hosts. We predict that arms race for resources with additional cellular protein families will be discovered with tombusviruses. These advances will fortify research on interactions among other plant and animal viruses and their hosts.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"107 ","pages":"133-158"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.06.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38192137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

From foes to friends: Viral infections expand the limits of host phenotypic plasticity. 从敌人到朋友:病毒感染扩大了宿主表型可塑性的极限。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-01-27 DOI: 10.1016/bs.aivir.2020.01.003

Rubén González, Anamarija Butković, Santiago F Elena

{"title":"From foes to friends: Viral infections expand the limits of host phenotypic plasticity.","authors":"Rubén González, Anamarija Butković, Santiago F Elena","doi":"10.1016/bs.aivir.2020.01.003","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.01.003","url":null,"abstract":"Phenotypic plasticity enables organisms to survive in the face of unpredictable environmental stress. Intimately related to the notion of phenotypic plasticity is the concept of the reaction norm that places phenotypic plasticity in the context of a genotype-specific response to environmental gradients. Whether reaction norms themselves evolve and which factors might affect their shape has been the object of intense debates among evolutionary biologists along the years. Since their discovery, viruses have been considered as pathogens. However, new viromic techniques and a shift in conceptual paradigms are showing that viruses are mostly non-pathogenic ubiquitous entities. Recent studies have shown how viral infections can even be beneficial for their hosts. This may happen especially in the context of stressed hosts, where the virus infection can induce beneficial changes in the host's physiological homeostasis, hence changing the shape of the reaction norm. Despite the fact that underlying physiological mechanisms and evolutionary dynamics are still not well understood, such beneficial interactions are being discovered in a growing number of plant-virus systems. Here, we aim to review these disperse studies and place them into the context of phenotypic plasticity and the evolution of reaction norms. This is an emerging field that is posing many questions that still need to be properly answered. The answers would clearly interest virologists, plant pathologists and evolutionary biologists and likely they will suggest possible future biotechnological applications, including the development of crops with higher survival rates and yield under adverse environmental situations.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"106 ","pages":"85-121"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.01.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37866013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16