Advances in Virus Research最新文献_第9页

Virus Assembly and Exit Pathways 病毒组装和退出途径

2区医学

Advances in Virus Research Pub Date : 2020-01-01 DOI: 10.1016/s0065-3527(20)x0004-2

引用次数: 0

Potyviral coat protein and genomic RNA: A striking partnership leading virion assembly and more. 波病毒外壳蛋白和基因组RNA:引领病毒粒子组装和更多的惊人伙伴关系。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-09-18 DOI: 10.1016/bs.aivir.2020.09.001

Sandra Martínez-Turiño, Juan Antonio García

{"title":"Potyviral coat protein and genomic RNA: A striking partnership leading virion assembly and more.","authors":"Sandra Martínez-Turiño, Juan Antonio García","doi":"10.1016/bs.aivir.2020.09.001","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.09.001","url":null,"abstract":"Potyvirus genus clusters a significant and expanding number of widely distributed plant viruses, responsible for large losses impacting most crops of economic interest. The potyviral genome is a single-stranded, linear, positive-sense RNA of around 10kb that is encapsidated in flexuous rod-shaped filaments, mostly made up of a helically arranged coat protein (CP). Beyond its structural role of protecting the viral genome, the potyviral CP is a multitasking protein intervening in practically all steps of the virus life cycle. In particular, interactions between the CP and the viral RNA must be tightly controlled to allow the correct assignment of the RNA to each of its functions through the infection process. This review attempts to bring together the most relevant available information regarding the architecture and modus operandi of potyviral CP and virus particles, highlighting significant discoveries, but also substantial gaps in the existing knowledge on mechanisms orchestrating virion assembly and disassembly. Biotechnological applications based on potyvirus nanoparticles is another important topic addressed here.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"108 ","pages":"165-211"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25593411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Structural and cellular biology of adeno-associated virus attachment and entry. 腺相关病毒附着和侵入的结构和细胞生物学。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-02-13 DOI: 10.1016/bs.aivir.2020.01.002

James Zengel, Jan E Carette

{"title":"Structural and cellular biology of adeno-associated virus attachment and entry.","authors":"James Zengel, Jan E Carette","doi":"10.1016/bs.aivir.2020.01.002","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.01.002","url":null,"abstract":"Adeno-associated virus (AAV) is a nonenveloped, ssDNA virus in the parvovirus family, which has become one of the leading candidate vectors for human gene therapy. AAV has been studied extensively to identify host cellular factors involved in infection, as well as to identify capsid variants that confer clinically favorable transduction profiles ex vivo and in vivo. Recent advances in technology have allowed for direct genetic approaches to be used to more comprehensively characterize host factors required for AAV infection and allowed for identification of a critical multi-serotype receptor, adeno-associated virus receptor (AAVR). In this chapter, we will discuss the interactions of AAV with its glycan and proteinaceous receptors and describe the host and viral components involved in AAV entry, which requires cellular attachment, endocytosis, trafficking to the trans-Golgi network and nuclear import. AAV serves as a paradigm for entry of nonenveloped viruses. Furthermore, we will discuss the potential of utilizing our increased understanding of virus-host interactions during AAV entry to develop better AAV-based therapeutics, with a focus on host factors and capsid interactions involved in in vivo tropism.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"106 ","pages":"39-84"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37866012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Preface. 前言。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 DOI: 10.1016/S0065-3527(20)30034-8

John P Carr, Marilyn J Roossinck

引用次数: 0

Influenza A virus uncoating. 甲型流感病毒脱落。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-02-13 DOI: 10.1016/bs.aivir.2020.01.001

Yohei Yamauchi

{"title":"Influenza A virus uncoating.","authors":"Yohei Yamauchi","doi":"10.1016/bs.aivir.2020.01.001","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.01.001","url":null,"abstract":"Influenza A virus (IAV) is an enveloped virus of the Orthomyxoviridae with a negative-sense single-stranded RNA genome. During virus cell entry, viral and cellular cues are delivered in a stepwise manner within two distinct cellular compartments-the endosomes and the cytosol. Endosome maturation primes the viral core for uncoating by cytosolic host proteins and host-mediated virus disaggregation is essential for genome import and replication in the nucleus. Recent evidence shows that two well-known cellular proteins-histone deacetylase 6 (HDAC6) and karyopherin-β2 (kapβ2)-uncoat influenza virus. HDAC6 is 1 of 11 HDACs and an X-linked, cytosolic lysine deacetylase. Under normal cellular conditions HDAC6 is the tubulin deacetylase. Under proteasomal stress HDAC6 binds unanchored ubiquitin, dynein and myosin II to sequester misfolded protein aggregates for autophagy. Kapβ2 is a member of the importin β family that transports RNA-binding proteins into the nucleus by binding to disordered nuclear localization signals (NLSs) known as PY-NLS. Kapβ2 is emerging as a universal uncoating factor for IAV and human immunodeficiency virus type 1 (HIV-1). Kapβ2 can also reverse liquid-liquid phase separation (LLPS) of RNA-binding proteins by promoting their disaggregation. Thus, it is becoming evident that key players in the management of cellular condensates and membraneless organelles are potent virus uncoating factors. This emerging concept reveals implications in viral pathogenesis, as well as, the promise for cell-targeted therapeutic strategies to block universal virus uncoating pathways hijacked by enveloped RNA viruses.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"106 ","pages":"1-38"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37866088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Viral and subviral derived small RNAs as pathogenic determinants in plants and insects. 病毒和亚病毒衍生的小rna作为植物和昆虫的致病决定因素。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-05-27 DOI: 10.1016/bs.aivir.2020.04.001

Paola Leonetti, Pascal Miesen, Ronald P van Rij, Vitantonio Pantaleo

{"title":"Viral and subviral derived small RNAs as pathogenic determinants in plants and insects.","authors":"Paola Leonetti, Pascal Miesen, Ronald P van Rij, Vitantonio Pantaleo","doi":"10.1016/bs.aivir.2020.04.001","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.04.001","url":null,"abstract":"The phenotypic manifestations of disease induced by viruses and subviral infectious entities are the result of complex molecular interactions between host and viral factors. The viral determinants of the diseased phenotype have traditionally been sought at the level of structural or non-structural proteins. However, the discovery of RNA silencing mechanisms has led to speculations that determinants of the diseased phenotype are caused by viral nucleic acid sequences in addition to proteins. RNA silencing is a gene regulation mechanism conserved within eukaryotic kingdoms (with the exception of some yeast species), and in plants and insects it also functions as an antiviral mechanism. Non-coding RNAs of viral origin, ranging in size from 21 to 24 nucleotides (viral small interfering RNAs, vsiRNAs) accumulate in virus-infected tissues and organs, in some cases to comparable levels as the entire complement of host-encoded small interfering RNAs. Upon incorporation into RNA-induced silencing complexes, vsiRNAs can mediate cleavage or induce translational inhibition of nucleic acid targets in a sequence-specific manner. This review focuses on recent findings that suggest an increased complexity of small RNA-based interactions between virus and host. We mainly address plant viruses, but where applicable discuss insect viruses as well. Prominence is given to studies that have indisputably demonstrated that vsiRNAs determine diseased phenotype by either carrying sequence determinants or, indirectly, by altering host-gene regulatory pathways. Results from these studies suggest biotechnological applications, which are also discussed.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"107 ","pages":"1-36"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38192136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Update on immunopathology of bornavirus infections in humans and animals. 人类和动物感染博纳病毒的免疫病理学最新进展。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-06-30 DOI: 10.1016/bs.aivir.2020.06.004

Daniel Nobach, Jana Müller, Dennis Tappe, Christiane Herden

引用次数: 8

Immunopathology of Zika virus infection. 寨卡病毒感染的免疫病理学。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-07-07 DOI: 10.1016/bs.aivir.2020.06.007

Derek J Platt, Jonathan J Miner

引用次数: 0

Viral cell-to-cell spread: Conventional and non-conventional ways. 病毒细胞间传播:常规和非常规方式。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-09-29 DOI: 10.1016/bs.aivir.2020.09.002

Nicolas Cifuentes-Munoz, Farah El Najjar, Rebecca Ellis Dutch

{"title":"Viral cell-to-cell spread: Conventional and non-conventional ways.","authors":"Nicolas Cifuentes-Munoz, Farah El Najjar, Rebecca Ellis Dutch","doi":"10.1016/bs.aivir.2020.09.002","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.09.002","url":null,"abstract":"A critical step in the life cycle of a virus is spread to a new target cell, which generally involves the release of new viral particles from the infected cell which can then initiate infection in the next target cell. While cell-free viral particles released into the extracellular environment are necessary for long distance spread, there are disadvantages to this mechanism. These include the presence of immune system components, the low success rate of infection by single particles, and the relative fragility of viral particles in the environment. Several mechanisms of direct cell-to-cell spread have been reported for animal viruses which would avoid the issues associated with cell-free particles. A number of viruses can utilize several different mechanisms of direct cell-to-cell spread, but our understanding of the differential usage by these pathogens is modest. Although the mechanisms of cell-to-cell spread differ among viruses, there is a common exploitation of key pathways and components of the cellular cytoskeleton. Remarkably, some of the viral mechanisms of cell-to-cell spread are surprisingly similar to those used by bacteria. Here we summarize the current knowledge of the conventional and non-conventional mechanisms of viral spread, the common methods used to detect viral spread, and the impact that these mechanisms can have on viral pathogenesis.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"108 ","pages":"85-125"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25587085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Quasi-enveloped hepatitis virus assembly and release. 准包膜肝炎病毒的组装和释放。

2区医学

Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-09-28 DOI: 10.1016/bs.aivir.2020.08.004

Zongdi Feng

引用次数: 6