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Advances in Virus Research最新文献

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Preface. 前言。
2区 医学
Advances in Virus Research Pub Date : 2021-01-01 DOI: 10.1016/S0065-3527(21)00014-2
Gisa Gerold
{"title":"Preface.","authors":"Gisa Gerold","doi":"10.1016/S0065-3527(21)00014-2","DOIUrl":"https://doi.org/10.1016/S0065-3527(21)00014-2","url":null,"abstract":"","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"109 ","pages":"xi-xiv"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0065-3527(21)00014-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38938847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alphavirus RNA replication in vertebrate cells. 脊椎动物细胞中的甲病毒RNA复制。
2区 医学
Advances in Virus Research Pub Date : 2021-01-01 Epub Date: 2021-08-06 DOI: 10.1016/bs.aivir.2021.07.003
Tero Ahola, Gerald McInerney, Andres Merits
{"title":"Alphavirus RNA replication in vertebrate cells.","authors":"Tero Ahola,&nbsp;Gerald McInerney,&nbsp;Andres Merits","doi":"10.1016/bs.aivir.2021.07.003","DOIUrl":"https://doi.org/10.1016/bs.aivir.2021.07.003","url":null,"abstract":"<p><p>Alphaviruses are positive-strand RNA viruses, typically transmitted by mosquitoes between vertebrate hosts. They encode four essential replication proteins, the non-structural proteins nsP1-4, which possess the enzymatic activities of RNA capping, RNA helicase, site-specific protease, ADP-ribosyl removal and RNA polymerase. Alphaviruses have been key models in the study of membrane-associated RNA replication, which is a conserved feature among the positive-strand RNA viruses of animals and plants. We review new structural and functional information on the nsPs and their interaction with host proteins and membranes, as well as with viral RNA sequences. The dodecameric ring structure of nsP1 is likely to be one of the evolutionary innovations that facilitated the success of the progenitors of current positive-strand RNA viruses.</p>","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":" ","pages":"111-156"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39529222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Virus systems biology: Proteomics profiling of dynamic protein networks during infection. 病毒系统生物学:感染过程中动态蛋白质网络的蛋白质组学分析。
2区 医学
Advances in Virus Research Pub Date : 2021-01-01 Epub Date: 2021-01-04 DOI: 10.1016/bs.aivir.2020.12.001
Kevin Klann, Georg Tascher, Christian Münch
{"title":"Virus systems biology: Proteomics profiling of dynamic protein networks during infection.","authors":"Kevin Klann,&nbsp;Georg Tascher,&nbsp;Christian Münch","doi":"10.1016/bs.aivir.2020.12.001","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.12.001","url":null,"abstract":"<p><p>The host cell proteome undergoes a variety of dynamic changes during viral infection, elicited by the virus itself or host cell defense mechanisms. Studying these changes on a global scale by integrating functional and physical interactions within protein networks during infection is an important tool to understand pathology. Indeed, proteomics studies dissecting protein signaling cascades and interaction networks upon infection showed how global information can significantly improve understanding of disease mechanisms of diverse viral infections. Here, we summarize and give examples of different experimental designs, proteomics approaches and bioinformatics analyses that allow profiling proteome changes and host-pathogen interactions to gain a molecular systems view of viral infection.</p>","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"109 ","pages":"1-29"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38938917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Proximity labeling approaches to study protein complexes during virus infection. 接近标记方法研究病毒感染过程中的蛋白质复合物。
2区 医学
Advances in Virus Research Pub Date : 2021-01-01 Epub Date: 2021-04-16 DOI: 10.1016/bs.aivir.2021.02.001
Francisco José Zapatero-Belinchón, Belén Carriquí-Madroñal, Gisa Gerold
{"title":"Proximity labeling approaches to study protein complexes during virus infection.","authors":"Francisco José Zapatero-Belinchón,&nbsp;Belén Carriquí-Madroñal,&nbsp;Gisa Gerold","doi":"10.1016/bs.aivir.2021.02.001","DOIUrl":"https://doi.org/10.1016/bs.aivir.2021.02.001","url":null,"abstract":"<p><p>Cellular compartmentalization of proteins and protein complex formation allow cells to tightly control biological processes. Therefore, understanding the subcellular localization and interactions of a specific protein is crucial to uncover its biological function. The advent of proximity labeling (PL) has reshaped cellular proteomics in infection biology. PL utilizes a genetically modified enzyme that generates a \"labeling cloud\" by covalently labeling proteins in close proximity to the enzyme. Fusion of a PL enzyme to a specific antibody or a \"bait\" protein of interest in combination with affinity enrichment mass spectrometry (AE-MS) enables the isolation and identification of the cellular proximity proteome, or proxisome. This powerful methodology has been paramount for the mapping of membrane or membraneless organelles as well as for the understanding of hard-to-purify protein complexes, such as those of transmembrane proteins. Unsurprisingly, more and more infection biology research groups have recognized the potential of PL for the identification of host-pathogen interactions. In this chapter, we introduce the enzymes commonly used for PL labeling as well as recent promising advancements and summarize the major achievements in organelle mapping and nucleic acid PL. Moreover, we comprehensively describe the research on host-pathogen interactions using PL, giving special attention to studies in the field of virology.</p>","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"109 ","pages":"63-104"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2021.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38938846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Molecular archeology of human viruses. 人类病毒的分子考古学。
2区 医学
Advances in Virus Research Pub Date : 2021-01-01 Epub Date: 2021-08-11 DOI: 10.1016/bs.aivir.2021.07.002
Sébastien Calvignac-Spencer, Ariane Düx, Jan F Gogarten, Livia V Patrono
{"title":"Molecular archeology of human viruses.","authors":"Sébastien Calvignac-Spencer,&nbsp;Ariane Düx,&nbsp;Jan F Gogarten,&nbsp;Livia V Patrono","doi":"10.1016/bs.aivir.2021.07.002","DOIUrl":"https://doi.org/10.1016/bs.aivir.2021.07.002","url":null,"abstract":"<p><p>The evolution of human-virus associations is usually reconstructed from contemporary patterns of genomic diversity. An intriguing, though still rarely implemented, alternative is to search for the genetic material of viruses in archeological and medical archive specimens to document evolution as it happened. In this chapter, we present lessons from ancient DNA research and incorporate insights from virology to explore the potential range of applications and likely limitations of archeovirological approaches. We also highlight the numerous questions archeovirology will hopefully allow us to tackle in the near future, and the main expected roadblocks to these avenues of research.</p>","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":" ","pages":"31-61"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39529223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Copyright 版权
2区 医学
Advances in Virus Research Pub Date : 2021-01-01 DOI: 10.1016/s0065-3527(21)00027-0
{"title":"Copyright","authors":"","doi":"10.1016/s0065-3527(21)00027-0","DOIUrl":"https://doi.org/10.1016/s0065-3527(21)00027-0","url":null,"abstract":"","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s0065-3527(21)00027-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55768518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bluetongue virus assembly and exit pathways. 蓝舌病病毒的聚集和退出途径。
2区 医学
Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-09-16 DOI: 10.1016/bs.aivir.2020.08.002
Polly Roy
{"title":"Bluetongue virus assembly and exit pathways.","authors":"Polly Roy","doi":"10.1016/bs.aivir.2020.08.002","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.08.002","url":null,"abstract":"<p><p>Bluetongue virus (BTV) is an insect-vectored emerging pathogen of wild ruminants and livestock in many parts of the world. The virion particle is a complex structure of consecutive layers of protein surrounding a genome of 10 double-stranded (ds) RNA segments. BTV has been studied extensively as a model system for large, nonenveloped dsRNA viruses. A combination of recombinant proteins and particles together with reverse genetics, high-resolution structural analysis by X-ray crystallography and cryo-electron microscopy techniques have been utilized to provide an order for the assembly of the capsid shell and the protein sequestration required for it. Further, a reconstituted in vitro assembly system and RNA-RNA interaction assay, have defined the individual steps required for the assembly and packaging of the 10-segmented RNA genome. In addition, various microscopic techniques have been utilized to illuminate the stages of virus maturation and its egress via multiple pathways. These findings have not only given an overall understanding of BTV assembly and morphogenesis but also indicated that similar assembly and egress pathways are likely to be used by related viruses and provided an informed starting point for intervention or prevention.</p>","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"108 ","pages":"249-273"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25587080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Geminivirus structure and assembly. 双子星病毒的结构和组装。
2区 医学
Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-10-06 DOI: 10.1016/bs.aivir.2020.09.005
Antonette Bennett, Mavis Agbandje-McKenna
{"title":"Geminivirus structure and assembly.","authors":"Antonette Bennett,&nbsp;Mavis Agbandje-McKenna","doi":"10.1016/bs.aivir.2020.09.005","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.09.005","url":null,"abstract":"<p><p>The geminivirus capsid architecture is unique and built from twinned pseudo T=1 icosahedrons with 110 copies of the coat protein (CP). The CP is multifunctional. It performs various functions during the infection of a wide range of agriculturally important plant hosts. The CP multimerizes via pentameric intermediates during assembly and encapsulates the ssDNA genome to generate the unique capsid morphology. The virus capsid protects and transports the genome in the insect vector and plant host enroute to the plant nucleus for replication and the production of progeny. This review further explores CP:CP and CP:DNA interactions, and the environmental conditions that govern the assembly of the geminivirus capsid. This analysis was facilitated by new data available for the family, including three-dimensional structures and molecular biology data for several members. In addition, current and promising new control strategies of plant crop infection, which can lead to starvation for subsistence farmers, are discussed.</p>","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"108 ","pages":"1-32"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.09.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25593409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
One hundred years of (influenza) immunopathology. 一百年的(流感)免疫病理学。
2区 医学
Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-06-25 DOI: 10.1016/bs.aivir.2020.06.005
David F Boyd, Taylor L Wilson, Paul G Thomas
{"title":"One hundred years of (influenza) immunopathology.","authors":"David F Boyd,&nbsp;Taylor L Wilson,&nbsp;Paul G Thomas","doi":"10.1016/bs.aivir.2020.06.005","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.06.005","url":null,"abstract":"<p><p>It has been over 100 years since the 1918 influenza pandemic, one of the most infamous examples of viral immunopathology. Since that time, there has been an inevitable repetition of influenza pandemics every few decades and yearly influenza seasons, which have a significant impact on human health. Recently, noteworthy progress has been made in defining the cellular and molecular mechanisms underlying pathology induced by an exuberant host response to influenza virus infection. Infection with influenza viruses is associated with a wide spectrum of disease, from mild symptoms to severe complications including respiratory failure, and the severity of influenza disease is driven by a complex interplay of viral and host factors. This chapter will discuss mechanisms of infection severity using concepts of disease resistance and tolerance as a framework for understanding the balance between viral clearance and immunopathology. We review mechanistic studies in animal models of infection and correlational studies in humans that have begun to define these factors and discuss promising host therapeutic targets to improve outcomes from severe influenza disease.</p>","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"107 ","pages":"247-284"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.06.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38191540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Current capsid assembly models of icosahedral nucleocytoviricota viruses. 二十面体核病毒衣壳组装模型。
2区 医学
Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-10-05 DOI: 10.1016/bs.aivir.2020.09.006
Yuejiao Xian, Chuan Xiao
{"title":"Current capsid assembly models of icosahedral nucleocytoviricota viruses.","authors":"Yuejiao Xian,&nbsp;Chuan Xiao","doi":"10.1016/bs.aivir.2020.09.006","DOIUrl":"10.1016/bs.aivir.2020.09.006","url":null,"abstract":"<p><p>Nucleocytoviricota viruses (NCVs) belong to a newly established phylum originally grouped as Nucleocytoplasmic large DNA viruses. NCVs are unique because of their large and complicated genomes that contain cellular genes with homologs from all kingdoms of life, raising intensive debates on their evolutional origins. Many NCVs pack their genomes inside massive icosahedral capsids assembled from thousands of proteins. Studying the assembly mechanism of such capsids has been challenging until breakthroughs from structural studies. Subsequently, several models of the capsid assembly were proposed, which provided some interesting insights on this elaborate process. In this review, we discuss three of the most recent assembly models as well as supporting experimental observations. Furthermore, we propose a new model that combines research developments from multiple sources. Investigation of the assembly process of these vast NCV capsids will facilitate future deciphering of the molecular mechanisms driving the formation of similar supramolecular complexes.</p>","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"108 ","pages":"275-313"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.09.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25587082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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