Advances in Virus Research最新文献_第6页

Proteomics approaches for the identification of protease substrates during virus infection. 鉴定病毒感染过程中蛋白酶底物的蛋白质组学方法。

2区医学

Advances in Virus Research Pub Date : 2021-01-01 Epub Date: 2021-04-20 DOI: 10.1016/bs.aivir.2021.03.003

Xavier Martiáñez-Vendrell, Marjolein Kikkert

{"title":"Proteomics approaches for the identification of protease substrates during virus infection.","authors":"Xavier Martiáñez-Vendrell, Marjolein Kikkert","doi":"10.1016/bs.aivir.2021.03.003","DOIUrl":"https://doi.org/10.1016/bs.aivir.2021.03.003","url":null,"abstract":"Proteases precisely and irreversibly catalyze the hydrolysis of peptide bonds, regulating the fate, localization, and activity of many proteins. Consequently, proteolytic activity plays an important role in fundamental cellular processes such as differentiation and migration, immunological and inflammatory reactions, apoptosis and survival. During virus infection, host proteases are involved in several processes, from cell entry to initiation, progression and resolution of inflammation. On the other hand, many viruses encode their own highly specific proteases, responsible for the proteolytic processing of viral proteins, but, at the same time, to cleave host proteins to corrupt antiviral host responses and adjust protein activity to favor viral replication. Traditionally, protease substrate identification has been addressed by means of hypothesis-driven approaches, but recent advances in proteomics have made a toolkit available to uncover the extensive repertoire of host proteins cleaved during infection, either by viral or host proteases. Here, we review the currently available proteomics-based methods that can and have contributed to the systematic and unbiased identification of new protease substrates in the context of virus-host interactions. The role of specific proteases during the course of virus infections will also be highlighted.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"109 ","pages":"135-161"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2021.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38938844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Post-translational modification control of viral DNA sensors and innate immune signaling. 病毒 DNA 传感器和先天性免疫信号的翻译后修饰控制。

2区医学

Advances in Virus Research Pub Date : 2021-01-01 Epub Date: 2021-04-16 DOI: 10.1016/bs.aivir.2021.03.001

Bokai Song, Dawei Liu, Todd M Greco, Ileana M Cristea

{"title":"Post-translational modification control of viral DNA sensors and innate immune signaling.","authors":"Bokai Song, Dawei Liu, Todd M Greco, Ileana M Cristea","doi":"10.1016/bs.aivir.2021.03.001","DOIUrl":"10.1016/bs.aivir.2021.03.001","url":null,"abstract":"The vertebrate innate immune system confers host cells with mechanisms to protect against both evolutionarily ancient pathogens and newly emerging pathogenic strains. Innate immunity relies on the host cell's ability to distinguish between self and pathogen-derived molecules. To achieve this, the innate immune system uses germline encoded receptors called pattern recognition receptors (PRRs), which recognize various molecular signatures, including nucleic acids, proteins, lipids, glycans and glycolipids. Among these molecules, the recognition of pathogenic, mislocalized, or damaged DNA by cellular protein receptors, commonly called DNA sensors, represents a major surveillance pathway for initiating immune signaling. The ability of cells to temporally regulate DNA sensor activation and subsequent signal termination is critical for effective immune signaling. These same mechanisms are also co-opted by pathogens to promote their replication. Therefore, there is significant interest in understanding DNA sensor regulatory networks during microbial infections and autoimmune disease. One emerging aspect of DNA sensor regulation is through post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, ADP-ribosylation, SUMOylation, methylation, deamidation, glutamylation. In this chapter, we discuss how PTMs have been shown to positively or negatively impact DNA sensor functions via diverse mechanisms, including direct regulation of enzymatic activity, protein-protein and protein-DNA interactions, protein translocations and protein turnover. In addition, we highlight the ability of virus-induced PTMs to promote immune evasion. We also discuss the recent evidence linking PTMs on DNA sensors with human diseases and more broadly, highlight promising directions for future research on PTM-mediated regulation of DNA sensor-dependent immune signaling.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"109 ","pages":"163-199"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489191/pdf/nihms-1715593.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38938848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 in animals: From potential hosts to animal models. 动物中的 SARS-CoV-2：从潜在宿主到动物模型

2区医学

Advances in Virus Research Pub Date : 2021-01-01 Epub Date: 2021-04-07 DOI: 10.1016/bs.aivir.2021.03.004

Anna Michelitsch, Kerstin Wernike, Lorenz Ulrich, Thomas C Mettenleiter, Martin Beer

{"title":"SARS-CoV-2 in animals: From potential hosts to animal models.","authors":"Anna Michelitsch, Kerstin Wernike, Lorenz Ulrich, Thomas C Mettenleiter, Martin Beer","doi":"10.1016/bs.aivir.2021.03.004","DOIUrl":"10.1016/bs.aivir.2021.03.004","url":null,"abstract":"Within only one year after the first detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), nearly 100 million infections were reported in the human population globally, with more than two million fatal cases. While SARS-CoV-2 most likely originated from a natural wildlife reservoir, neither the immediate viral precursor nor the reservoir or intermediate hosts have been identified conclusively. Due to its zoonotic origin, SARS-CoV-2 may also be relevant to animals. Thus, to evaluate the host range of the virus and to assess the risk to act as potential animal reservoir, a large number of different animal species were experimentally infected with SARS-CoV-2 or monitored in the field in the last months. In this review, we provide an update on studies describing permissive and resistant animal species. Using a scoring system based on viral genome detection subsequent to SARS-CoV-2 inoculation, seroconversion, the development of clinical signs and transmission to conspecifics or humans, the susceptibility of diverse animal species was classified on a semi-quantitative scale. While major livestock species such as pigs, cattle and poultry are mostly resistant, companion animals appear moderately susceptible, while several model animal species used in research, including several Cricetidae species and non-human primates, are highly susceptible to SARS-CoV-2 infection. By natural infections, it became obvious that American minks (Neovison vison) in fur farms, e.g., in the Netherlands and Denmark are highly susceptible resulting in local epidemics in these animals.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"110 ","pages":"59-102"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10707708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions 蛋白质组学方法揭示病毒-脊椎动物宿主相互作用

2区医学

Advances in Virus Research Pub Date : 2021-01-01 DOI: 10.1016/s0065-3527(21)x0002-4

引用次数: 0

Elucidation of host-virus surfaceome interactions using spatial proteotyping. 利用空间蛋白分型阐明宿主-病毒表面体相互作用。

2区医学

Advances in Virus Research Pub Date : 2021-01-01 Epub Date: 2021-04-12 DOI: 10.1016/bs.aivir.2021.03.002

Fabian Wendt, Emanuela S Milani, Bernd Wollscheid

引用次数: 4

Applications of mass spectrometry imaging in virus research. 质谱成像在病毒研究中的应用。

2区医学

Advances in Virus Research Pub Date : 2021-01-01 Epub Date: 2020-11-09 DOI: 10.1016/bs.aivir.2020.10.002

Luca D Bertzbach, Benedikt B Kaufer, Axel Karger

{"title":"Applications of mass spectrometry imaging in virus research.","authors":"Luca D Bertzbach, Benedikt B Kaufer, Axel Karger","doi":"10.1016/bs.aivir.2020.10.002","DOIUrl":"https://doi.org/10.1016/bs.aivir.2020.10.002","url":null,"abstract":"Mass spectrometry imaging (MSI) is a label-free molecular imaging technique allowing an untargeted detection of a broad range of biomolecules and xenobiotics. MSI enables imaging of the spatial distribution of proteins, peptides, lipids and metabolites from a wide range of samples. To date, this technique is commonly applied to tissue sections in cancer diagnostics and biomarker development, but also molecular histology in general. Advances in the methodology and bioinformatics improved the resolution of MS images below the single cell level and increased the flexibility of the workflow. However, MSI-based research in virology is just starting to gain momentum and its full potential has not been exploited yet. In this review, we discuss the main applications of MSI in virology. We review important aspects of matrix-assisted laser desorption/ionization (MALDI) MSI, the most widely used MSI technique in virology. In addition, we summarize relevant literature on MSI studies that aim to unravel virus-host interactions and virus pathogenesis, to elucidate antiviral drug kinetics and to improve current viral disease diagnostics. Collectively, these studies strongly improve our general understanding of virus-induced changes in the proteome, metabolome and metabolite distribution in host tissues of humans, animals and plants upon infection. Furthermore, latest MSI research provided important insights into the drug distribution and distribution kinetics, especially in antiretroviral research. Finally, MSI-based investigations of oncogenic viruses greatly increased our knowledge on tumor mass signatures and facilitated the identification of cancer biomarkers.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"109 ","pages":"31-62"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2020.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38938845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

A great ape perspective on the origins and evolution of human viruses. 从类人猿的角度看人类病毒的起源和进化。

2区医学

Advances in Virus Research Pub Date : 2021-01-01 Epub Date: 2021-07-08 DOI: 10.1016/bs.aivir.2021.06.001

Sébastien Calvignac-Spencer, Ariane Düx, Jan F Gogarten, Fabian H Leendertz, Livia V Patrono

引用次数: 7

Advancing phage therapy through the lens of virus host-breadth and emergence potential. 从病毒宿主宽度和出现潜力的角度推进噬菌体治疗。

2区医学

Advances in Virus Research Pub Date : 2021-01-01 Epub Date: 2021-09-02 DOI: 10.1016/bs.aivir.2021.07.004

Lisa M Bono, Stephanie Mao, Rachel E Done, Kenichi W Okamoto, Benjamin K Chan, Paul E Turner

{"title":"Advancing phage therapy through the lens of virus host-breadth and emergence potential.","authors":"Lisa M Bono, Stephanie Mao, Rachel E Done, Kenichi W Okamoto, Benjamin K Chan, Paul E Turner","doi":"10.1016/bs.aivir.2021.07.004","DOIUrl":"https://doi.org/10.1016/bs.aivir.2021.07.004","url":null,"abstract":"Phages are viruses that specifically infect bacteria, and their biodiversity contributes to historical and current development of phage therapy to treat myriad bacterial infections. Phage therapy holds promise as an alternative to failing chemical antibiotics, but there are benefits and costs of this technology. Here, we review the rich history of phage therapy, highlighting reasons (often political) why it was widely rejected by Western medicine until recently. One longstanding idea involves mixing different phages together in cocktails, to increase the probability of killing target pathogenic bacteria without pre-screening for phage susceptibility. By challenging 30 lytic phages to infect 14 strains of the bacteria Pseudomonas aeruginosa, we showed that some phages were \"generalists\" with broad host-ranges, emphasizing that extreme host-specificity of phages was not necessarily a liability. Using a \"greedy algorithm\" analysis, we identified the best cocktail mixture of phages to achieve broad bacteria killing. Additionally, we review how virus host-range can evolve and connect lessons learned from virus emergence-including contributions of elevated virus mutation rates in promoting emergence and virus evolutionary transitions from specialized to generalized host-use-as cautionary tales for avoiding risk of \"off-target\" phage emergence on commensal bacteria in microbiomes. Throughout, we highlight how fundamental understanding of virus ecology and evolution is vital for developing phage therapy; heeding these principles should help in designing therapeutic strategies that do not recapitulate consequences of virus selection to emerge on novel hosts.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":" ","pages":"63-110"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39532041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A holistic perspective on herpes simplex virus (HSV) ecology and evolution. 单纯疱疹病毒(HSV)生态学和进化的整体观点。

2区医学

Advances in Virus Research Pub Date : 2021-01-01 Epub Date: 2021-06-26 DOI: 10.1016/bs.aivir.2021.05.001

Molly M Rathbun, Moriah L Szpara

{"title":"A holistic perspective on herpes simplex virus (HSV) ecology and evolution.","authors":"Molly M Rathbun, Moriah L Szpara","doi":"10.1016/bs.aivir.2021.05.001","DOIUrl":"https://doi.org/10.1016/bs.aivir.2021.05.001","url":null,"abstract":"Herpes simplex viruses (HSV) cause chronic infection in humans that are characterized by periodic episodes of mucosal shedding and ulcerative disease. HSV causes millions of infections world-wide, with lifelong bouts of viral reactivation from latency in neuronal ganglia. Infected individuals experience different levels of disease severity and frequency of reactivation. There are two distantly related HSV species, with HSV-1 infections historically found most often in the oral niche and HSV-2 infections in the genital niche. Over the last two decades, HSV-1 has emerged as the leading cause of first-episode genital herpes in multiple countries. While HSV-1 has the highest level of genetic diversity among human alpha-herpesviruses, it is not yet known how quickly the HSV-1 viral population in a human host adapts over time, or if there are population bottlenecks associated with viral reactivation and/or transmission. It is also unknown how the ecological environments in which HSV infections occur influence their evolutionary trajectory, or that of co-occurring viruses and microbes. In this review, we explore how HSV accrues genetic diversity within each new infection, and yet maintains its ability to successfully infect most of the human population. A holistic examination of the ecological context of natural human infections can expand our awareness of how HSV adapts as it moves within and between human hosts, and reveal the complexity of these lifelong human-virus interactions. These insights may in turn suggest new areas of exploration for other chronic pathogens that successfully evolve and persist among their hosts.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":" ","pages":"27-57"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aivir.2021.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39288392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Parainfluenza virus entry at the onset of infection. 副流感病毒在感染开始时进入。

2区医学

Advances in Virus Research Pub Date : 2021-01-01 DOI: 10.1016/bs.aivir.2021.07.001

Tara C Marcink, Matteo Porotto, Anne Moscona

{"title":"Parainfluenza virus entry at the onset of infection.","authors":"Tara C Marcink, Matteo Porotto, Anne Moscona","doi":"10.1016/bs.aivir.2021.07.001","DOIUrl":"https://doi.org/10.1016/bs.aivir.2021.07.001","url":null,"abstract":"Parainfluenza viruses, members of the enveloped, negative-sense, single stranded RNA Paramyxoviridae family, impact global child health as the cause of significant lower respiratory tract infections. Parainfluenza viruses enter cells by fusing directly at the cell surface membrane. How this fusion occurs via the coordinated efforts of the two molecules that comprise the viral surface fusion complex, and how these efforts may be blocked, are the subjects of this chapter. The receptor binding protein of parainfluenza forms a complex with the fusion protein of the virus, remaining stably associated until a receptor is reached. At that point, the receptor binding protein actively triggers the fusion protein to undergo a series of transitions that ultimately lead to membrane fusion and viral entry. In recent years it has become possible to examine this remarkable process on the surface of viral particles and to begin to understand the steps in the transition of this molecular machine, using a structural biology approach. Understanding the steps in entry leads to several possible strategies to prevent fusion and inhibit infection.","PeriodicalId":50977,"journal":{"name":"Advances in Virus Research","volume":"111 ","pages":"1-29"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270304/pdf/nihms-1903208.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9633911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1