One hundred years of (influenza) immunopathology.

2区 医学 Q1 Medicine
Advances in Virus Research Pub Date : 2020-01-01 Epub Date: 2020-06-25 DOI:10.1016/bs.aivir.2020.06.005
David F Boyd, Taylor L Wilson, Paul G Thomas
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引用次数: 3

Abstract

It has been over 100 years since the 1918 influenza pandemic, one of the most infamous examples of viral immunopathology. Since that time, there has been an inevitable repetition of influenza pandemics every few decades and yearly influenza seasons, which have a significant impact on human health. Recently, noteworthy progress has been made in defining the cellular and molecular mechanisms underlying pathology induced by an exuberant host response to influenza virus infection. Infection with influenza viruses is associated with a wide spectrum of disease, from mild symptoms to severe complications including respiratory failure, and the severity of influenza disease is driven by a complex interplay of viral and host factors. This chapter will discuss mechanisms of infection severity using concepts of disease resistance and tolerance as a framework for understanding the balance between viral clearance and immunopathology. We review mechanistic studies in animal models of infection and correlational studies in humans that have begun to define these factors and discuss promising host therapeutic targets to improve outcomes from severe influenza disease.

一百年的(流感)免疫病理学。
1918年流感大流行是病毒免疫病理学最臭名昭著的例子之一,距今已有100多年。从那时起,每隔几十年和每年的流感季节就不可避免地重复发生一次流感大流行,对人类健康产生重大影响。最近,在确定流感病毒感染引起的旺盛宿主反应的病理基础的细胞和分子机制方面取得了显著进展。流感病毒感染与多种疾病有关,从轻微症状到包括呼吸衰竭在内的严重并发症,流感疾病的严重程度是由病毒和宿主因素的复杂相互作用驱动的。本章将讨论感染严重程度的机制,使用疾病抗性和耐受性的概念作为理解病毒清除和免疫病理学之间平衡的框架。我们回顾了动物感染模型的机制研究和人类的相关研究,这些研究已经开始确定这些因素,并讨论了有希望的宿主治疗靶点,以改善严重流感疾病的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.10
自引率
0.00%
发文量
7
审稿时长
>12 weeks
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