{"title":"Les surcharges hépatiques en fer","authors":"Bruno Turlin, Pierre Allaume","doi":"10.1016/j.annpat.2024.09.007","DOIUrl":"10.1016/j.annpat.2024.09.007","url":null,"abstract":"<div><div>Le fer est indispensable au fonctionnement cellulaire et de l’organisme dans son ensemble. La coloration de Perls permet l’identification histopathologique de dépôts sidériques. En classant les sidéroses hépatiques en parenchymateuse, mésenchymateuse ou mixte, il est possible d’orienter la recherche étiologique. L’hémochromatose HFE1 est la sidérose la plus fréquente. Son diagnostic repose actuellement sur l’analyse génétique. Son expressivité étant variable et sa pénétrance incomplète, la mise en évidence d’une sidérose hépatique peut représenter un mode de découverte.</div></div><div><div>Iron is essential for functioning of cells and of the body as a whole. Perls staining allows the histopathological identification of iron deposits. By classifying hepatic siderosis as parenchymal, mesenchymal or mixed, it may guide the search for its etiology. HFE1 hemochromatosis is the most common siderosis. Its diagnosis is currently based on genetic analysis. Its expressivity being variable and its penetrance incomplete, the demonstration of hepatic siderosis may represent a mode of discovery.</div></div>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"44 6","pages":"Pages 461-469"},"PeriodicalIF":0.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Une curieuse lésion biphasique du sein","authors":"","doi":"10.1016/j.annpat.2023.12.011","DOIUrl":"10.1016/j.annpat.2023.12.011","url":null,"abstract":"<div><div>L’adénomyoépithéliome représente 0,5 % des tumeurs du sein de la femme ménopausée. Il est généralement de bon pronostic quand la tumeur est bénigne. En revanche, sa variante maligne est associée à un pronostic péjoratif avec un potentiel d’agressivité locale et métastatique marqué. Nous présentons le cas d’un adénomyoépithéliome malin, exposons la problématique de la classification OMS 2019 des adénomyoépithéliomes et proposons une classification en trois catégories : adénomyoépithéliome bénin, atypique et malin (in situ et invasif).</div></div><div><div>Adenomyoepithelioma represents 0.5% of breast tumors in postmenauposal women. Prognosis is good when the tumor is benign. However, its malignant variant is associated with a poor prognosis with local recurrences and metastatic potential. We present the case of a malignant adenomyoepithelioma, expose the 2019 WHO classification issues and propose a classification in three categories: benign, atypical and malignant adenomyoepitheliomas (in situ and invasive).</div></div>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"44 6","pages":"Pages 510-513"},"PeriodicalIF":0.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"L’amylose – point de vue du pathologiste","authors":"David Buob","doi":"10.1016/j.annpat.2024.09.014","DOIUrl":"10.1016/j.annpat.2024.09.014","url":null,"abstract":"<div><div>Malgré l’avènement du diagnostic scintigraphique de l’amylose à transthyrétine, le rôle des pathologistes demeure central pour le diagnostic et le typage, indispensable, des amyloses. Le diagnostic anatomopathologique et le typage des amyloses sont jalonnés de pièges qu’il convient de connaître, liés au rouge Congo (réalisation technique et interprétation) et aux difficultés de l’immunohistochimie. Le recours à des centres experts est recommandé pour les cas difficiles et lorsque le type de l’amylose ne peut être affirmé.</div></div><div><div>Despite the advent of scintigraphic diagnosis of transthyretin amyloidosis, the role of pathologists remains central for the diagnosis and typing of amyloidosis. The anatomo-pathological diagnosis and typing of amyloidosis are hindered by pitfalls that should be known, linked to the Congo red staining (technical implementation and interpretation) and the difficulties of immunohistochemistry. The use of expert centers is recommended for difficult cases and when the type cannot be confirmed.</div></div>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"44 6","pages":"Pages 414-422"},"PeriodicalIF":0.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aspects cliniques des amyloses systémiques en 2024","authors":"Sophie Georgin-Lavialle , Gilles Grateau","doi":"10.1016/j.annpat.2024.09.015","DOIUrl":"10.1016/j.annpat.2024.09.015","url":null,"abstract":"<div><div>Les trois variétés les plus fréquentes d’amyloses systémiques sont les amyloses à transthyrétine (ATTR), l’amylose immunoglobulinique (AL) et l’amylose inflammatoire (AA). Il existe deux formes d’amyloses à transthyrétine : la forme sauvage, la plus fréquente, « wild type » en anglais, représente environ 15 % des cardiopathies et la forme génétique, ou « mutée », qui est une maladie rare et se manifeste principalement par une neuropathie périphérique et une cardiopathie. Des avancées thérapeutiques majeures ont été réalisées dans les dernières années grâce à des molécules qui stabilisent la transthyrétine et/ou qui empêchent sa traduction en détruisant l’ARN messager. L’amylose immunoglobulinique (AL) est une maladie hématologique dont la gravité est due à la toxicité des chaînes légères d’immunoglobulines formant des dépôts amyloïdes toxiques pour les tissus, en particulier cardiaque et rénal. Les traitements de l’amylose immunoglobulinique sont de plus en plus efficaces, et ciblent le plasmocyte permettant une amélioration globale du pronostic, l’atteinte cardiaque étant l’atteinte la plus préoccupante. Les amyloses inflammatoires (AA) compliquent moins souvent les maladies inflammatoires chroniques en raison de l’efficacité des biothérapies anti-inflammatoires dans les rhumatismes inflammatoires, les maladies inflammatoires chroniques de l’intestin et les maladies auto-inflammatoires génétiques. Les causes de l’amylose inflammatoire sont maintenant plus diverses avec une augmentation des cas de cause indéterminée associés ou non à l’obésité.</div></div><div><div>The three most common varieties of systemic amyloidosis are transthyretin amyloidosis (ATTR), immunoglobulin amyloidosis (AL) and inflammatory amyloidosis (AA). There are two forms of transthyretin amyloidosis: the wild type, the most common, represents approximately 15% of heart diseases and the genetic, or “mutated” form, which is a rare disease and manifests mainly by peripheral neuropathy and heart disease. Major therapeutic advances have been made in recent years thanks to molecules that stabilize transthyretin and/or prevent its translation by destroying messenger RNA. Immunoglobulin amyloidosis (AL) is a hematological disease whose severity is due to the toxicity of immunoglobulin light chains forming amyloid deposits that are toxic to tissues, particularly the heart and kidneys. Treatments for immunoglobulin amyloidosis are increasingly effective, and target the plasma cell, leading to an overall improvement in the prognosis, with cardiac involvement being the most worrying condition. Inflammatory amyloidosis (AA) complicates chronic inflammatory diseases less often due to the effectiveness of anti-inflammatory biotherapies in inflammatory rheumatism, chronic inflammatory bowel diseases and genetic auto-inflammatory diseases. The causes of inflammatory amyloidosis are now more diverse with an increase in cases of unknown cause associated or not with obesity.</div></di","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"44 6","pages":"Pages 407-413"},"PeriodicalIF":0.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dépôts tissulaires non amyloïdes d’immunoglobuline monoclonale (hors atteinte rénale)","authors":"Magali Colombat","doi":"10.1016/j.annpat.2024.09.013","DOIUrl":"10.1016/j.annpat.2024.09.013","url":null,"abstract":"<div><div>Une immunoglobuline monoclonale peut se déposer dans des tissus variés sous d’autres formes que l’amylose. L’immunofluorescence est l’analyse clé pour l’identification d’une immunoglobuline monoclonale déposée dans les tissus. La maladie des dépôts de chaînes légères pulmonaire (LCDD pour <em>light chain deposition disease</em>) est un diagnostic à envisager devant une maladie pulmonaire kystique diffuse.</div></div><div><div>Monoclonal immunoglobulins can form deposits other than amyloidosis in various tissues. Immunofluorescence is the key analysis for the identification of monoclonal immunoglobulin deposits. Pulmonary light chain deposition disease is a diagnosis to be considered when dealing with diffuse cystic lung disease.</div></div>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"44 6","pages":"Pages 423-431"},"PeriodicalIF":0.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meriem Meddahi, Alexandre Denoyer, Fanny Pouillard, Kevin Didier, Camille Boulagnon-Rombi
{"title":"[Case report of a severe Mooren's ulcer].","authors":"Meriem Meddahi, Alexandre Denoyer, Fanny Pouillard, Kevin Didier, Camille Boulagnon-Rombi","doi":"10.1016/j.annpat.2024.08.004","DOIUrl":"https://doi.org/10.1016/j.annpat.2024.08.004","url":null,"abstract":"<p><p>Mooren's ulcer is a painless and idiopathic ulcer of the peripheral cornea related to autoimmunity against a corneal stromal antigen, calgranulin C. Corneal involvement is isolated. There are no specific histopathological features to differentiate Mooren's ulcer from pseudo-Mooren's, the latter being part of a systemic disease. Mooren ulcer is a diagnosis of elimination based on a complete etiological check-up. However, histopathological examination, when performed, could provide additional data to support the diagnosis. We report the case of a 78-year-old female patient who presented with Mooren's ulcer. The patient had complained of red eye and photophobia for two weeks. Initial visual acuity was \"counting fingers\". Clinical examination revealed a perforated perilimbic ulcer with an iris prolapse. Based on the peripheral ulcerative keratitis, with a negative etiological work-up and anatomopathological analysis of the cornea, the diagnosis of Mooren's ulcer was proposed. This rare case illustrates the need for a multidisciplinary approach involving ophthalmologists, pathologists, and internists, to reach a diagnosis and optimize the functional prognosis.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Justine Saucereau, Alicia Leymarie, Paul Petitgas, Antoine Bertolotti, Claire Chassagne, Laure Marie Dardaud
{"title":"[An exotic pseudotumour infection].","authors":"Justine Saucereau, Alicia Leymarie, Paul Petitgas, Antoine Bertolotti, Claire Chassagne, Laure Marie Dardaud","doi":"10.1016/j.annpat.2024.08.006","DOIUrl":"https://doi.org/10.1016/j.annpat.2024.08.006","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeanne Salesse, Matthieu Chicaud, Hamdi Braham, Sarah Taconet
{"title":"[Appendiceal goblet cell adenocarcinoma: Has the controversy come to an end?]","authors":"Jeanne Salesse, Matthieu Chicaud, Hamdi Braham, Sarah Taconet","doi":"10.1016/j.annpat.2024.08.008","DOIUrl":"https://doi.org/10.1016/j.annpat.2024.08.008","url":null,"abstract":"<p><p>In 2019, the 5th edition of the WHO classification of digestive tumours has retained the terminology \"goblet cell adenocarcinoma\" (GCA) to designate a tumour whose amphicrine nature owed it more than ten denominations since its initial description among which the most tenacious \"goblet cell carcinoid\" is no longer recommended today. This rare tumour represents 15-19% of appendicular tumours. Its incidence is rising. The positive diagnosis is based on morphological examination and mandatory identification of a low-grade component of glands comprising goblet cells stained by PAS and Alcian blue. The appendix must be entirely examined. Global tumour grade (low, intermediate, high) is based on the proportions of low-grade and high-grade components. This tumour's immunohistochemical profile is particular because of expression of CK20 and often CK7 as well as neuroendocrine markers. It is often an incidental finding on a surgical specimen, among individuals aged 50 or more years, presenting with a locally advanced stage with vascular and perineural invasion. Lymph node metastases are present in a third of cases. Non-specific mutations of ARID1A and genes of the Wnt pathway may be identified. GCA is not associated with microsatellite instability or Lynch syndrome. Its prognosis is intermediate. Surgery is the reference therapy based on the stage. The main differential diagnoses are colorectal adenocarcinoma NOS, mucinous adenocarcinoma and signet ring cell adenocarcinoma. Patients are referred to the RENAPE expert network.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Prognostic factors: Degree of subserosal invasion, tumor-serosal distance and subserosal elastic boundary invasion in colonic adenocarcinoma].","authors":"Arnaud Ronfaut, Christophe Attencourt, Jean-Rene Tesson, Charles Sabbagh, Jean-Marc Regimbeau, Denis Chatelain","doi":"10.1016/j.annpat.2024.08.001","DOIUrl":"https://doi.org/10.1016/j.annpat.2024.08.001","url":null,"abstract":"<p><p>The aim was to study the prognostic impact of tumor infiltration of the subserosa in colonic adenocarcinoma, by evaluating the degree of tumor infiltration in the subserosa (DISS), tumor-serosa distance (DTS), and invasion of the elastic boundary of the subserosa (ILE) after elastic fiber staining.</p><p><strong>Material and methods: </strong>All patients operated on for colonic adenocarcinoma classified as pT3 without lymph node or visceral metastasis operated on at the CHU d'Amiens between 2004 and 2017 were included. All slides were reviewed by 2 pathologists. Bivariate and subgroup analyses were performed according to the presence of a DISS≤5mm or>5mm, a DTS≤1mm or>1mm and the presence or absence of an ILE. These statistical analyses were then correlated with the 5-year survival.</p><p><strong>Results: </strong>One hundred and one patients were included in the study. We performed elastic fiber staining on an average of 2 tumor blocks per case and 39.6% of patients had invasion of the elastic boundary. However, bivariate and subgroup analyses showed no statistically significant association between DISS, DTS or ILE and 5-year survival.</p><p><strong>Conclusion: </strong>None of these three histopathological criteria proved to have prognostic value in our series, contrary to some results in the literature. However, as these data are subject to a number of confounding factors, we do not recommend that pathologists specify these different criteria in their reports.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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