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Annales De Pathologie最新文献

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[A classic diagnostic trap of rectal mucinous adenocarcinoma]. [直肠粘液腺癌的典型诊断陷阱]。
IF 0.5 4区 医学
Annales De Pathologie Pub Date : 2025-07-23 DOI: 10.1016/j.annpat.2025.06.024
Jean-Michel Fayette, Chadi Abou Salha, Isabelle Beschet, Marilyn Augros, Sixte Thierry
{"title":"[A classic diagnostic trap of rectal mucinous adenocarcinoma].","authors":"Jean-Michel Fayette, Chadi Abou Salha, Isabelle Beschet, Marilyn Augros, Sixte Thierry","doi":"10.1016/j.annpat.2025.06.024","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.06.024","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Transitioning to digital pathology: Feedback from the eNovA-Path project of the 3 university hospitals of Nouvelle Aquitaine (Poitiers, Limoges and Bordeaux)]. [向数字病理学过渡：来自新阿基坦3所大学医院（普瓦捷、利莫日和波尔多）的eNovA-Path项目的反馈]。
IF 0.5 4区 医学
Annales De Pathologie Pub Date : 2025-07-22 DOI: 10.1016/j.annpat.2025.06.023
Bertrand Chauveau, Fanny Beltzung, Béatrice Vergier, Mathilde Duchesne, Anne Guyot, Fanny Sauvestre, Marie-Laure Jullie, Come Sesboue, Brigitte Le Bail, Stéphane Béteille, Alexandre Pavy, Naomi Yagalé Nditar, Aurélie Charissoux, Olivier Renaud
{"title":"[Transitioning to digital pathology: Feedback from the eNovA-Path project of the 3 university hospitals of Nouvelle Aquitaine (Poitiers, Limoges and Bordeaux)].","authors":"Bertrand Chauveau, Fanny Beltzung, Béatrice Vergier, Mathilde Duchesne, Anne Guyot, Fanny Sauvestre, Marie-Laure Jullie, Come Sesboue, Brigitte Le Bail, Stéphane Béteille, Alexandre Pavy, Naomi Yagalé Nditar, Aurélie Charissoux, Olivier Renaud","doi":"10.1016/j.annpat.2025.06.023","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.06.023","url":null,"abstract":"<p><p>In 2025, the adoption of digital pathology is no longer a revolution in our specialty. However, beyond the technical aspects, implementing such a project across a large region like Nouvelle Aquitaine, encompassing three university hospitals, soon to include seven regional hospital centers, and a regional cancer center, has been highly instructive. We would like to share our experience. The success of this project is multifactorial and relies on: (1) Structuring the initiative from the outset around three essential competencies: medical, informatics technology (IT)/biomedical, and administrative. The collaboration among the three university hospitals within a health cooperation group (GCS NovA), balanced governance, and a strong commitment to cooperation (formalized through a collaboration agreement) were key elements; (2) securing funding, with the Regional Health Agency covering 52% of the investment, supplemented by contributions from the university hospitals and research funding from sponsors in Bordeaux; (3) engaging all stakeholders, including technical pathology teams, IT managers, biomedical staff, hospital directors, and pathologists. This is fundamentally a human-centered project, requiring the enthusiasm and expertise of each participant, particularly the technical pathology team, to anticipate challenges and optimize the pre-analytical phase before digitization. After 8 to 16months of a \"big bang\" transition to digital pathology, without denying the questions raised by digitalization, the overall outcome has been highly positive in terms of medical practice, ease of teaching residents, inter-site collaboration, and even turnaround times for results.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The placenta: What should we know in 2024?] 胎盘：2024年我们应该知道些什么？]
IF 0.5 4区 医学
Annales De Pathologie Pub Date : 2025-07-11 DOI: 10.1016/j.annpat.2025.06.002
Sophie Patrier-Sallebert
{"title":"[The placenta: What should we know in 2024?]","authors":"Sophie Patrier-Sallebert","doi":"10.1016/j.annpat.2025.06.002","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.06.002","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Éditorial 社论
IF 0.5 4区 医学
Annales De Pathologie Pub Date : 2025-06-28 DOI: 10.1016/j.annpat.2025.06.022
Pr Audrey Rousseau
{"title":"Éditorial","authors":"Pr Audrey Rousseau","doi":"10.1016/j.annpat.2025.06.022","DOIUrl":"10.1016/j.annpat.2025.06.022","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"45 4","pages":"Page 283"},"PeriodicalIF":0.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cystic granulosa cell tumors and functional follicular cysts: Diagnostic challenges and differentiation criteria]. 囊性颗粒细胞瘤和功能性滤泡囊肿：诊断挑战和鉴别标准。
IF 0.5 4区 医学
Annales De Pathologie Pub Date : 2025-06-26 DOI: 10.1016/j.annpat.2025.04.013
Louis Vaquier, Catherine Genestie
{"title":"[Cystic granulosa cell tumors and functional follicular cysts: Diagnostic challenges and differentiation criteria].","authors":"Louis Vaquier, Catherine Genestie","doi":"10.1016/j.annpat.2025.04.013","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.04.013","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pathophysiology of cysts: An integrated genomic and biophysical approach]. [囊肿的病理生理学：整合基因组和生物物理方法]。
IF 0.5 4区 医学
Annales De Pathologie Pub Date : 2025-06-13 DOI: 10.1016/j.annpat.2025.05.003
Mohamed Amine Bani
{"title":"[Pathophysiology of cysts: An integrated genomic and biophysical approach].","authors":"Mohamed Amine Bani","doi":"10.1016/j.annpat.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.05.003","url":null,"abstract":"<p><p>Cysts, common and ubiquitous pathological anomalies, are defined as cavities lined by a distinct wall and filled with fluid or semi-solid material. They result from complex mechanisms involving genetic alterations, biophysical forces, and tissue microenvironment interactions. Recent advances in genomics have identified key mutations that disrupt cell polarity, intracellular signaling, and fluid dynamics. Concurrently, biophysical models elucidate the impact of mechanical and osmotic forces on cyst growth and rupture. Multiscale models, integrating these approaches, connect molecular mechanisms to tissue dynamics, providing powerful tools to unravel the complex interactions driving cyst formation. These advances offer promising perspectives in terms of diagnosis, through genetic and biophysical biomarkers and therapeutics. This article provides an integrative update on the genetic and biophysical mechanisms of cysts and explores their clinical applications within a multidisciplinary framework.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
En aparté : Entretien avec le Pr Mathilde Duchesne [旁白：对Mathilde Duchesne博士的采访]。
IF 0.5 4区 医学
Annales De Pathologie Pub Date : 2025-06-13 DOI: 10.1016/j.annpat.2025.05.002
Audrey Rousseau
{"title":"En aparté : Entretien avec le Pr Mathilde Duchesne","authors":"Audrey Rousseau","doi":"10.1016/j.annpat.2025.05.002","DOIUrl":"10.1016/j.annpat.2025.05.002","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"45 4","pages":"Pages 285-286"},"PeriodicalIF":0.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Un cas de lichen scléreux induit par pembrolizumab [派姆单抗诱导的硬化地衣]。
IF 0.5 4区 医学
Annales De Pathologie Pub Date : 2025-06-11 DOI: 10.1016/j.annpat.2025.04.008
Marianne Thérèse Signoret-Bravo , Fernando De la Barreda-Becerril , Marcela Saeb-Lima
{"title":"Un cas de lichen scléreux induit par pembrolizumab","authors":"Marianne Thérèse Signoret-Bravo ,&nbsp;Fernando De la Barreda-Becerril ,&nbsp;Marcela Saeb-Lima","doi":"10.1016/j.annpat.2025.04.008","DOIUrl":"10.1016/j.annpat.2025.04.008","url":null,"abstract":"<div><div>Le pembrolizumab, un anticorps monoclonal humanisé ciblant PD-1 (protéine de mort cellulaire programmée 1), est utilisé pour le traitement de divers cancers. Cependant, il est reconnu que celui-ci peut induire des événements indésirables liés au système immunitaire (irAE) ressemblant à des conditions auto-immunes ou inflammatoires. Nous présentons le cas d’une femme de 44 ans atteinte d’un cancer du poumon traitée par pembrolizumab et qui a développé un lichen scléreux (LS). Des cas de LS liés aux inhibiteurs de points de contrôle immunitaire (ICI) ont été documentés, principalement chez les femmes. Les corticostéroïdes topiques à forte puissance permettent d’obtenir des résultats favorables sans arrêt de l’immunothérapie. Détecter l'apparition de tumeurs malignes est essentiel, car les patients atteints de LS font face à un risque de carcinome épidermoïde.</div></div><div><div>Pembrolizumab, a humanized monoclonal antibody targeting PD-1 (programmed cell death protein 1), is employed for various cancers but can induce immune-related adverse events (irAEs) resembling autoimmune or inflammatory conditions. We present the case of a 44-year-old female with lung cancer treated with pembrolizumab who developed lichen sclerosus (LS). Cases of LS related to immune checkpoint inhibitors (ICIs) have been documented, primarily in women. High-potency topical steroids achieve favorable outcomes without immunotherapy discontinuation. Monitoring the development of malignancies is essential, as LS patients face a high-risk of developping squamous cell carcinoma.</div></div>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"45 4","pages":"Pages 349-352"},"PeriodicalIF":0.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RECAPitNETT : REgistre pour Caractériser l’Agressivité des PitNETs par l’analyse du Transcriptome [RECAPitNETT：使用转录组分析表征PitNETs侵袭性的注册表]。
IF 0.5 4区 医学
Annales De Pathologie Pub Date : 2025-05-28 DOI: 10.1016/j.annpat.2025.05.004
Chiara Villa , Guillaume Assié , Gérald Raverot
{"title":"RECAPitNETT : REgistre pour Caractériser l’Agressivité des PitNETs par l’analyse du Transcriptome","authors":"Chiara Villa ,&nbsp;Guillaume Assié ,&nbsp;Gérald Raverot","doi":"10.1016/j.annpat.2025.05.004","DOIUrl":"10.1016/j.annpat.2025.05.004","url":null,"abstract":"<div><div>Les tumeurs hypophysaires sont des tumeurs endocrines (PitNETs) qui représentent 15 % des tumeurs intracrâniennes. Bien que des progrès substantiels aient été réalisés dans la caractérisation anatomopathologique de ces tumeurs, les marqueurs pronostiques permettant d’appréhender leur évolution et les voies thérapeutiques associées au comportement iagressif , font toujours défaut. La prise en charge des PitNETs agressives ou métastatiques est discutée en Réunion Pluridisciplinaire Nationale HypoCARE ; toutefois les options thérapeutiques sont limitées, et en l’absence de marqueur prédictif de réponse, les approches thérapeutiques sont similaires pour tous. L’objectif de l’étude RECAPitNETT est de mettre à profit le réseau national de tumeurs rares en créant un registre de tumeurs hypophysaires (REDCap) et une banque de tumeurs qui bénéficiera d’une analyse moléculaire (transcriptome) qui, corrélée aux données cliniques et pathologiques recueillies, permettra d’identifier des facteurs pronostiques et théranostiques . Ce projet ambitieux est l’occasion d’améliorer la prise en charge des patients atteints de tumeurs endocrines hypophysaires agressives, et favorisera la recherche sur ce type de tumeur rare au niveau national.</div></div>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"45 4","pages":"Pages 287-289"},"PeriodicalIF":0.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Case report #4: Metaplastic carcinoma arising in microglandular adenosis]. [病例报告#4：微腺腺病引起的化生癌]。
IF 0.5 4区 医学
Annales De Pathologie Pub Date : 2025-05-28 DOI: 10.1016/j.annpat.2025.01.013
Aurélie Maran-Gonzalez
{"title":"[Case report #4: Metaplastic carcinoma arising in microglandular adenosis].","authors":"Aurélie Maran-Gonzalez","doi":"10.1016/j.annpat.2025.01.013","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.01.013","url":null,"abstract":"<p><p>This article reports the case of a mixed metaplastic carcinoma with heterologous mesenchymal chondroid and spindle cell differentiation, Elston and Ellis grade III, triple negative phenotype, developed on atypical microglandular adenosis. It describes the diagnoses of microglandular adenosis, atypical microglandular adenosis and their differential diagnoses and reviews the cases of carcinomas developed on microglandular adenosis reported in the literature with their molecular biology analyses.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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