Annales De Pathologie最新文献

{"title":"[Breast adenomyoepithelioma: About a case and review of the literature].","authors":"Louis Vaquier, Magali Lacroix-Triki","doi":"10.1016/j.annpat.2025.02.014","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.02.014","url":null,"abstract":"<p><p>Adenomyoepithelioma (AME) is a rare primary breast tumor characterized by a mixed proliferation of epithelial and myoepithelial cells. This tumor can display heterogeneous, often nonspecific, imaging features. A definitive diagnosis of AME requires a biopsy with histopathological examination to guide therapeutic management. However, the rarity of this lesion, the type of sampling, and its polymorphic appearance can make diagnosis particularly challenging. Differential diagnoses are extensive, encompassing both benign and malignant lesions. We present herein the case of a 76-year-old female patient along with a review of the literature on breast AME.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Apocrine lesions of the breast].","authors":"Gaëtan MacGrogan","doi":"10.1016/j.annpat.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.03.001","url":null,"abstract":"<p><p>Apocrine breast lesions encompass a spectrum of histopathological abnormalities, ranging from benign apocrine metaplasia to invasive apocrine carcinomas. Their defining feature lies in cells with abundant eosinophilic cytoplasm and round nuclei with prominent nucleoli. These cells strongly express the androgen receptor while lacking estrogen receptor-alpha and progesterone receptor expression. Benign lesions, frequently associated with mammary cysts or papillomas, lack nuclear and architectural atypia. In contrast, atypical apocrine lesions exhibit significant nuclear and structural abnormalities, posing diagnostic challenges when distinguishing them from apocrine ductal or lobular carcinoma in situ. Diagnosis relies on the extent of atypia and the presence of tumor necrosis. Invasive apocrine carcinomas are rare, accounting for less than 1% of all breast cancers, and predominantly occur in postmenopausal women. Histologically, they are often grade 1 or 2 tumors. Approximately 50% exhibit HER2 amplification and overexpression. Immunohistochemically, they are characterized by positivity for FOXA1 and GATA3, and negativity for FOXC1 and SOX10, and variable expression of TRPS1. These carcinomas belong to the molecular apocrine carcinoma family, which includes HER2-enriched tumors driven by HER2 addiction and androgen receptor-positive luminal tumors, a subtype of triple-negative breast cancers. The latter are defined by androgen receptor pathway activation and are frequently associated with PI3K pathway alterations and cell cycle dysregulation, suggesting potential therapeutic targets.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Case #3. Pityriasis lichenoides].","authors":"Laurence Lamant","doi":"10.1016/j.annpat.2025.02.002","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.02.002","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pronostic de l’adénocarcinome prostatique de score de Gleason 7 (3 + 4) comportant un faible taux de grade 4 - Étude rétrospective de 104 cas","authors":"Guillaume Abitbol ,&nbsp;Thomas Forzini ,&nbsp;Philippe de Sousa ,&nbsp;Clémence Barthomeuf ,&nbsp;Quentin Doosterlinck ,&nbsp;Christophe Attencourt ,&nbsp;Emma Freyssinet ,&nbsp;Jean-René Tesson","doi":"10.1016/j.annpat.2025.01.002","DOIUrl":"10.1016/j.annpat.2025.01.002","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;L’objectif de cette étude était de comparer le pronostic de l’adénocarcinome prostatique de score de Gleason (GS) 7 (3&lt;!--&gt; &lt;!--&gt;+&lt;!--&gt; &lt;!--&gt;4) à faible taux de grade 4 à celui de l’adénocarcinome prostatique GS6 (3&lt;!--&gt; &lt;!--&gt;+&lt;!--&gt; &lt;!--&gt;3).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Matériel et méthodes&lt;/h3&gt;&lt;div&gt;Les patients porteurs d’un adénocarcinome prostatique GS6 ou GS7 et ayant bénéficié d’une prostatectomie entre 2014 et 2018 ont été sélectionnés. Les lames de biopsies prostatiques (BP) et des prostatectomies (PO) ont été relues par 2 pathologistes. Une analyse statistique a été réalisée afin d’évaluer la relation entre les caractéristiques cliniques, paracliniques et histologiques des patients sur biopsies et prostatectomies avec le risque de récidive.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Résultats&lt;/h3&gt;&lt;div&gt;Cent quatre patients ont été inclus. Vingt et un ont présenté une récidive (20,2 %). En analyse univariée, il a été observé une association entre le risque de récidive et le GS (&lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0,014 sur BP / &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0,006 sur PO), le pourcentage de grade 4 (&lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0,020/&lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0,002), notamment en appliquant des seuils de 5 % (&lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0,008/&lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0,018) et 10 % (&lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0,015/&lt;em&gt;p&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0,001), le stade tumoral pT (&lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0,045), la qualité de la résection chirurgicale R (&lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0,015) et la taille du foyer tumoral au contact des limites (&lt;em&gt;p&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0,001). En analyse multivariée, un pourcentage de grade 4 supérieur à 10 % était associé au risque de récidive sur BP et sur PO (respectivement OR 4,83 (IC95 1,38 ; 16,88) ; &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0,014 et OR 6,29 (IC95 1,96 ; 20,20) ; &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0,002), de même que la résection R1 (OR 3,65 (IC95 1,24 ; 10,76) ; &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0,019 et OR 4,06 (IC95 1,27 ; 13,03) ; &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0,018).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Notre étude suggère que les tumeurs GS7 (3&lt;!--&gt; &lt;!--&gt;+&lt;!--&gt; &lt;!--&gt;4) avec moins de 10 % de grade 4 ont un pronostic similaire aux tumeurs GS6 (3&lt;!--&gt; &lt;!--&gt;+&lt;!--&gt; &lt;!--&gt;3). Cela permettrait à certains patients GS7 (3&lt;!--&gt; &lt;!--&gt;+&lt;!--&gt; &lt;!--&gt;4) de bénéficier d’une prise en charge par surveillance active à la place d’un traitement plus agressif comme la chirurgie ou la radiothérapie.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;The aim of this study was to compare the prognosis of Gleason Score (GS) 7 (3&lt;!--&gt; &lt;!--&gt;+&lt;!--&gt; &lt;!--&gt;4) prostatic adenocarcinoma with a low percentage of grade 4 to that of GS6 (3&lt;!--&gt; &lt;!--&gt;+&lt;!--&gt; &lt;!--&gt;3) prostatic adenocarcinoma.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;All patients with GS6 or GS7 prostatic adenocarcinoma who underwent prostatectomy between 2014 and 2018 were selected. The prostate biopsy (PB) and prostatectomy resection specimen (RS) slides were reviewed by 2 pathologists. A statistic","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"45 2","pages":"Pages 163-175"},"PeriodicalIF":0.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revue de presse","authors":"Audrey Rousseau","doi":"10.1016/j.annpat.2025.01.015","DOIUrl":"10.1016/j.annpat.2025.01.015","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"45 2","pages":"Pages 106-107"},"PeriodicalIF":0.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrélations cytologie – histologie en pathologie urothéliale. Réponses au pré-test","authors":"Monique Courtade-Saidi ,&nbsp;Sophie Ferlicot ,&nbsp;Eva Comperat ,&nbsp;Jacqueline Fontugne","doi":"10.1016/j.annpat.2024.11.004","DOIUrl":"10.1016/j.annpat.2024.11.004","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"45 2","pages":"Page 119"},"PeriodicalIF":0.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facteurs pronostiques : degré d’invasion de la sous-séreuse, distance tumeur-séreuse et invasion de la limitante élastique de la sous-séreuse dans l’adénocarcinome colique","authors":"Arnaud Ronfaut ,&nbsp;Christophe Attencourt ,&nbsp;Jean-Rene Tesson ,&nbsp;Charles Sabbagh ,&nbsp;Jean-Marc Regimbeau ,&nbsp;Denis Chatelain","doi":"10.1016/j.annpat.2024.08.001","DOIUrl":"10.1016/j.annpat.2024.08.001","url":null,"abstract":"&lt;div&gt;&lt;div&gt;L’objectif était d’étudier l’impact pronostique de l’infiltration tumorale de la sous-séreuse dans l’adénocarcinome colique en évaluant le degré d’infiltration tumorale dans la sous-séreuse (DISS), la distance tumeur-séreuse (DTS), et l’invasion de la limitante élastique de la sous-séreuse (ILE) après coloration des fibres élastiques.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Matériel et méthodes&lt;/h3&gt;&lt;div&gt;Tous les patients opérés d’un adénocarcinome colique classé pT3 sans métastase ganglionnaire ou viscérale opérés au CHU d’Amiens entre 2004 et 2017 ont été inclus. Toutes les lames ont été relues par 2 pathologistes. Des analyses bivariées et en sous-groupes ont été réalisées en fonction de la présence d’un DISS&lt;!--&gt; &lt;!--&gt;≤&lt;!--&gt; &lt;!--&gt;5&lt;!--&gt; &lt;!--&gt;mm ou&lt;!--&gt; &lt;!--&gt;&gt;&lt;!--&gt; &lt;!--&gt;5&lt;!--&gt; &lt;!--&gt;mm, d’une DTS&lt;!--&gt; &lt;!--&gt;≤&lt;!--&gt; &lt;!--&gt;1&lt;!--&gt; &lt;!--&gt;mm ou&lt;!--&gt; &lt;!--&gt;&gt;&lt;!--&gt; &lt;!--&gt;1&lt;!--&gt; &lt;!--&gt;mm et de la présence ou non d’une ILE. Ces analyses statistiques ont ensuite été corrélées à la survie à 5 ans.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Résultats&lt;/h3&gt;&lt;div&gt;Cent un patients ont été inclus dans l’étude. Nous avons réalisé une coloration des fibres élastiques sur 2 blocs de tumeur par cas en moyenne et 39,6 % des patients avaient une invasion de la limitante élastique. Cependant, les analyses bivariées et en sous-groupe n’ont pas montré d’association statistiquement significative entre la DISS, DTS ou ILE et la survie à 5 ans.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Aucun de ces trois critères histopathologiques n’avait de valeur pronostique dans notre série contrairement à certains résultats de la littérature. Toutefois, ces données faisant l’objet d’un certain nombre de facteurs confondants, nous ne recommandons pas aux pathologistes de préciser ces différents critères dans leurs comptes rendus.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;The aim was to study the prognostic impact of tumor infiltration of the subserosa in colonic adenocarcinoma, by evaluating the degree of tumor infiltration in the subserosa (DISS), tumor-serosa distance (DTS), and invasion of the elastic boundary of the subserosa (ILE) after elastic fiber staining.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Material and methods&lt;/h3&gt;&lt;div&gt;All patients operated on for colonic adenocarcinoma classified as pT3 without lymph node or visceral metastasis operated on at the CHU d’Amiens between 2004 and 2017 were included. All slides were reviewed by 2 pathologists. Bivariate and subgroup analyses were performed according to the presence of a DISS&lt;!--&gt; &lt;!--&gt;≤&lt;!--&gt; &lt;!--&gt;5&lt;!--&gt; &lt;!--&gt;mm or&lt;!--&gt; &lt;!--&gt;&gt;&lt;!--&gt; &lt;!--&gt;5&lt;!--&gt; &lt;!--&gt;mm, a DTS&lt;!--&gt; &lt;!--&gt;≤&lt;!--&gt; &lt;!--&gt;1&lt;!--&gt; &lt;!--&gt;mm or&lt;!--&gt; &lt;!--&gt;&gt;&lt;!--&gt; &lt;!--&gt;1&lt;!--&gt; &lt;!--&gt;mm and the presence or absence of an ILE. These statistical analyses were then correlated with the 5-year survival.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;One hundred and one patients were included in the study. We performed elastic fiber staining on an average of 2 tumor blocks per case and 39.6% of patients had invasion of the elastic boundary. However, bivariate and subg","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"45 2","pages":"Pages 176-184"},"PeriodicalIF":0.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cas no 2 . cytologie urinaire réactionnelle dans un contexte de sonde JJ – cytologie négative pour un carcinome urothélial de haut grade selon le système de Paris 2022","authors":"Jacqueline Fontugne","doi":"10.1016/j.annpat.2024.12.003","DOIUrl":"10.1016/j.annpat.2024.12.003","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"45 2","pages":"Pages 125-129"},"PeriodicalIF":0.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cas no 8. Infiltration de la paroi vésicale par un adénocarcinome prostatique","authors":"Monique Courtade-Saïdi","doi":"10.1016/j.annpat.2025.02.005","DOIUrl":"10.1016/j.annpat.2025.02.005","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"45 2","pages":"Pages 147-150"},"PeriodicalIF":0.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cas no 1. Cytologie négative pour un carcinome urothélial de haut grade","authors":"Sophie Ferlicot","doi":"10.1016/j.annpat.2024.12.007","DOIUrl":"10.1016/j.annpat.2024.12.007","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"45 2","pages":"Pages 120-124"},"PeriodicalIF":0.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}