Annales De Pathologie最新文献

{"title":"[Upcoming changes to the 2027 WHO classification of lung tumors].","authors":"Sylvie Lantuejoul","doi":"10.1016/j.annpat.2026.09.006","DOIUrl":"https://doi.org/10.1016/j.annpat.2026.09.006","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Case #4: Bronchiolar adenoma].","authors":"Lara Chalabreysse","doi":"10.1016/j.annpat.2026.09.004","DOIUrl":"https://doi.org/10.1016/j.annpat.2026.09.004","url":null,"abstract":"<p><p>Bronchiolar adenoma/ciliated muconodular papillary tumour is a benign peripheral lung tumour. Histologically, it is characterized by a predominant papillary architecture and by a bilayered bronchiolar-type epithelium containing a continuous basal cell layer. This observation concerns a 72-year-old woman who underwent surgery for a bifocal adenocarcinoma. The peritumoral parenchyma contained BA/CMPT. The main differential diagnoses are discussed, including other benign or malignant lesions. The major criteria for diagnosis include location, architecture, cell population and immunohistochemistry profile on surgical specimens.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Imaging of pulmonary nodules: A diagnostic approach].","authors":"Antoine Khalil, Haythem Denguir, Valérie Gounant, Ibrahim Ghosn, Omar Lafi, Nisrine Chalhoub, Sarra Sahraoui, Nicolas Poté, Marie-Pierre Debray","doi":"10.1016/j.annpat.2026.09.008","DOIUrl":"https://doi.org/10.1016/j.annpat.2026.09.008","url":null,"abstract":"<p><p>The detection of pulmonary nodules has increased considerably with the widespread use of chest-computed tomography and the development of low-dose CT lung cancer screening. The pulmonary nodule represents a major diagnostic challenge, requiring rigorous evaluation in order to distinguish benign from malignant lesions while limiting unnecessary invasive investigations. Analysis relies on precise morphological characterization (density, size, margins), assessment of persistence and growth over time, and integration of the clinical context. The Fleischner Society guidelines and the protocols derived from organized screening programs now form the basis of standardized management. This article provides a detailed review of the radiological criteria, decision-making algorithms, and the role of transthoracic needle biopsy in the management of pulmonary nodules.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Case 3. Sclerosing pneumocytoma: A diagnostic pitfall mimicking pulmonary adenocarcinoma].","authors":"Myriam Kossaï","doi":"10.1016/j.annpat.2026.09.007","DOIUrl":"https://doi.org/10.1016/j.annpat.2026.09.007","url":null,"abstract":"<p><p>We report the case of a 72-year-old non-smoking woman with a 2.4cm parenchymal nodule in the left lower lobe discovered incidentally. Fine-needle aspiration cytology demonstrated an atypical papillary lesion with a CK7+/TTF1+ immunohistochemical profile and negativity for CK20, PS100 and synaptophysin, initially suggesting a primary pulmonary adenocarcinoma. A left lower lobectomy was performed. Pathological examination of the surgical specimen revealed a sclerosing pneumocytoma, a rare benign tumor of adulthood. This case illustrates the difficulty of preoperative cytological diagnosis of this entity and the importance of recognizing its morphological and immunohistochemical features to avoid surgical overtreatment.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Case #1. Pulmonary MALT lymphoma: A diagnosis not to be missed in the presence of a slowly progressive lung lesion].","authors":"Diane Damotte","doi":"10.1016/j.annpat.2026.09.005","DOIUrl":"https://doi.org/10.1016/j.annpat.2026.09.005","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[New developments in grading of astrocytomas, IDH-mutant: Study of the impact of update 12 of cIMPACT-NOW].","authors":"Arnault Tauziède-Espariat, Alice Métais, Farah Sassi, Raphaël Saffroy, Pascale Varlet","doi":"10.1016/j.annpat.2026.09.001","DOIUrl":"https://doi.org/10.1016/j.annpat.2026.09.001","url":null,"abstract":"<p><strong>Introduction: </strong>The 2021 World Health Organisation (WHO) classification of the Central Nervous System tumors introduced, for the first time, a molecular biomarker (homozygous deletion of CDKN2A/B) into the grading of astrocytomas, IDH-mutant. Since then, the cIMPACT-NOW expert group has proposed a new prognostic algorithm (published in the update 12), incorporating epigenetic and genetic data. The aim of this study was to report on the experience of integrating this algorithm into the grading of astrocytomas, IDH-mutant diagnosed in routine practice.</p><p><strong>Materials and methods: </strong>This study included astrocytomas, IDH-mutant diagnosed between 1st January 2024 and 1st June 2026, for which molecular analyses were recommended according to the cIMPACT-NOW update 12. Next-generation sequencing and DNA-methylation analyses (methylation class and copy number abnormalities) were carried out for each case.</p><p><strong>Results: </strong>During this period, 81 astrocytomas, IDH-mutant were diagnosed, of which 50 required exploratory molecular testing (the remaining 31 cases being grade 4 tumors). In 24% of cases (12/50), the grade was revised following the incorporation of genetic and epigenetic data: seven grade 2 tumors were reclassified as grade 3, two grade 2 tumors as grade 4, and three grade 3 tumors as grade 4.</p><p><strong>Discussion and conclusions: </strong>In our study, 24% of astrocytomas, IDH-mutant graded as grade 2 based on their mitotic index were reclassified as grade 3 or 4 tumors. The change in grading resulted from NGS analysis in three tumors (which led to the upgrading of three astrocytomas, IDH-mutant grade 2 to grade 3 on the basis of mutations in the CDKN2A, PIK3CA and PIK3R1 genes), from the copy number profile derived from the methylation array in eight tumors (which led to the reclassification of three astrocytomas, IDH-mutant grade 2 to grade 3, two astrocytomas, IDH-mutant grade 2 to grade 4 and three astrocytomas, IDH-mutant grade 3 to grade 4), and from methylation class analysis in one case. These changes highlight the value of carrying out molecular analyses or sending samples to a centre of expertise: NGS and DNA-methylation analysis (for astrocytomas, IDH-mutant grade 2) and a technique capable of detecting homozygous deletion of CDKN2A/B and amplification of PDGFRA in astrocytomas, IDH-mutant grade 3 (NGS, DNA-methylation analysis, SNP- or CGH-array). The cIMPACT-NOW Update 12 revolutionises the practice of pathologists in the grading of astrocytomas, IDH-mutant, who must now integrate genetic and epigenetic data with histopathological features.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case report of anogenital in situ adenocarcinoma of mammary gland type].","authors":"Marie Lopez, Nathan Grivel, Benjamin Ieong, Rodolphe Dupuis, Thibault Kervarrec, Antoine Taillandier","doi":"10.1016/j.annpat.2026.08.002","DOIUrl":"https://doi.org/10.1016/j.annpat.2026.08.002","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cas no 7 . Carcinome anaplasique de la thyroïde. Selon le système de Bethesda 2023 : Malin (catégorie VI)","authors":"Myriam Decaussin-Petrucci","doi":"10.1016/j.annpat.2025.12.012","DOIUrl":"10.1016/j.annpat.2025.12.012","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"46 5","pages":"Pages 477-481"},"PeriodicalIF":0.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cas no 3. Néoplasme folliculaire (catégorie IV) selon le système de Bethesda 2023","authors":"Laetitia Lacoste-Collin","doi":"10.1016/j.annpat.2026.01.015","DOIUrl":"10.1016/j.annpat.2026.01.015","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"46 5","pages":"Pages 453-455"},"PeriodicalIF":0.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction à l’histoséminaire SFCC/SFP : corrélation cytologie-pathologie en pathologie thyroïdienne","authors":"Myriam Decaussin-Petrucci,&nbsp;Laetitia Lacoste-Collin","doi":"10.1016/j.annpat.2025.11.009","DOIUrl":"10.1016/j.annpat.2025.11.009","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"46 5","pages":"Pages 369-371"},"PeriodicalIF":0.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}