{"title":"[Hematologic malignancies of the breast].","authors":"Léa El Khoury, Peggy Dartigues, Natacha Joyon","doi":"10.1016/j.annpat.2025.01.014","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.01.014","url":null,"abstract":"<p><p>Hematolymphoid tumors of the breast are uncommon. They either represent a secondary site of a known hematological malignancy or a primary disease (sometimes linked to systemic treatment such as chemotherapy for other cancers). The majority of primary breast lymphomas are B-cell lymphomas, with diffuse large B-cell lymphoma being the most prevalent. T-cell lymphomas (potentially associated with certain breast implants), plasmacytomas, and myeloid sarcomas have also been reported. The prognosis and treatment depend on the specific type of hematolymphoid neoplasm. It is crucial to identify the hematolymphoid nature of a breast lesion on biopsy to ensure appropriate management and avoid unnecessary surgeries. This situation is a classic challenge due to its rarity, and the pathologists should consider it when dealing with any malignant breast lesion with a \"triple-negative\" phenotype.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Case 1. Drug hypersensitivity syndrome or \"drug reaction with eosinophilia and systemic symptoms\"].","authors":"Nicolas Ortonne","doi":"10.1016/j.annpat.2025.01.009","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.01.009","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejandro Álvarez-Muñoz, Jesús Machuca-Aguado, Rosa Rendón-García, Francisco Javier Rubio-Garrido
{"title":"[What the Hookah hides: An unknown cause of acute organized fibrinous pneumonia?]","authors":"Alejandro Álvarez-Muñoz, Jesús Machuca-Aguado, Rosa Rendón-García, Francisco Javier Rubio-Garrido","doi":"10.1016/j.annpat.2025.01.012","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.01.012","url":null,"abstract":"<p><p>Acute organized fibrinous pneumonia (AOFP) is a rare entity, initially characterized by Beasley et al. in 2002. This report highlights an undocumented case of AOFP in a habitual hookah smoker. AOFP is distinguished by inflammatory infiltrates and intra-alveolar fibrin deposits, often associated with infectious and autoimmune processes, and recently linked to the use of electronic cigarettes and vaping. The involvement of hookah in this pathogenic mechanism suggests that inhalation of oil-rich compounds and high-temperature gases could cause similar alveolar damage. Early recognition of AOFP is essential in patients presenting with sudden dyspnea and pulmonary infiltrates unresponsive to antibiotic therapy. Diagnosis relies on biopsies confirming fibrin deposits, and prompt treatment with corticosteroids can lead to effective clinical and radiological resolution.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catherine Guettier, Mylène Sebagh, Astrid Laurent-Bellue
{"title":"[Antibody-mediated rejection in liver pathology].","authors":"Catherine Guettier, Mylène Sebagh, Astrid Laurent-Bellue","doi":"10.1016/j.annpat.2025.01.008","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.01.008","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guillaume Abitbol, Thomas Forzini, Philippe de Sousa, Clémence Barthomeuf, Quentin Doosterlinck, Christophe Attencourt, Emma Freyssinet, Jean-René Tesson
{"title":"[Prognosis of Gleason 7 (3+4) prostatic adenocarcinoma with a low rate of grade 4 - Retrospective study of 104 cases].","authors":"Guillaume Abitbol, Thomas Forzini, Philippe de Sousa, Clémence Barthomeuf, Quentin Doosterlinck, Christophe Attencourt, Emma Freyssinet, Jean-René Tesson","doi":"10.1016/j.annpat.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.01.002","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to compare the prognosis of Gleason Score (GS) 7 (3+4) prostatic adenocarcinoma with a low percentage of grade 4 to that of GS6 (3+3) prostatic adenocarcinoma.</p><p><strong>Methods: </strong>All patients with GS6 or GS7 prostatic adenocarcinoma who underwent prostatectomy between 2014 and 2018 were selected. The prostate biopsy (PB) and prostatectomy resection specimen (RS) slides were reviewed by 2 pathologists. A statistical analysis was carried out to evaluate the relationship between the clinical, paraclinical and histological characteristics of the patients on biopsies and prostatectomies with the risk of recurrence.</p><p><strong>Results: </strong>One hundred and four patients were included. A recurrence occurred in 21 patients (20.2%). In univariate analysis, an association was observed between the risk of recurrence and the GS (P=0.014 for PB / P=0.006 for RS), grade 4 percentage (P=0.020/P=0.002), especially by applying the thresholds of 5% (P=0.008/P=0.018) and 10% (P=0.015/P<0.001), the tumor stage pT (P=0.045), the quality of surgical resection R (P=0.015) and the size of the tumor focus in contact with the limits (P<0.001). In multivariate analysis, grade 4 percentage greater than 10% was associated with the risk of recurrence on biopsy and prostatectomy (respectively OR 4.83 [IC95 1.38; 16.88]; P=0.014 and OR 6.29 [IC95 1.96; 20.20]; P=0.002), as well as R1 resection (OR 3.65 [IC95 1.24; 10.76]; P=0.019 and OR 4.06 [IC95 1.27; 13.03]; P=0.018).</p><p><strong>Conclusion: </strong>Our study suggests that GS7 (3+4) tumors with less than 10% of grade 4 have a similar prognosis to that of GS6 (3+3) tumors. This could allow some GS7 (3+4) patients to benefit from the active surveillance therapy, instead of undergoing more aggressive treatments such as surgery or radiotherapy.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}