Advances in Genetics最新文献_第7页

Origin of new emergent Coronavirus and Candida fungal diseases-Terrestrial or cosmic? 新型冠状病毒和念珠菌真菌疾病的起源——陆地还是宇宙?

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-07-14 DOI: 10.1016/bs.adgen.2020.04.002

Edward J Steele, Reginald M Gorczynski, Robyn A Lindley, Gensuke Tokoro, Robert Temple, N Chandra Wickramasinghe

引用次数: 16

Application of yeast to studying amyloid and prion diseases. 酵母在淀粉样蛋白和朊病毒疾病研究中的应用。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-05-04 DOI: 10.1016/bs.adgen.2020.01.002

Yury O Chernoff, Anastasia V Grizel, Aleksandr A Rubel, Andrew A Zelinsky, Pavithra Chandramowlishwaran, Tatiana A Chernova

{"title":"Application of yeast to studying amyloid and prion diseases.","authors":"Yury O Chernoff, Anastasia V Grizel, Aleksandr A Rubel, Andrew A Zelinsky, Pavithra Chandramowlishwaran, Tatiana A Chernova","doi":"10.1016/bs.adgen.2020.01.002","DOIUrl":"10.1016/bs.adgen.2020.01.002","url":null,"abstract":"Amyloids are fibrous cross-β protein aggregates that are capable of proliferation via nucleated polymerization. Amyloid conformation likely represents an ancient protein fold and is linked to various biological or pathological manifestations. Self-perpetuating amyloid-based protein conformers provide a molecular basis for transmissible (infectious or heritable) protein isoforms, termed prions. Amyloids and prions, as well as other types of misfolded aggregated proteins are associated with a variety of devastating mammalian and human diseases, such as Alzheimer's, Parkinson's and Huntington's diseases, transmissible spongiform encephalopathies (TSEs), amyotrophic lateral sclerosis (ALS) and transthyretinopathies. In yeast and fungi, amyloid-based prions control phenotypically detectable heritable traits. Simplicity of cultivation requirements and availability of powerful genetic approaches makes yeast Saccharomyces cerevisiae an excellent model system for studying molecular and cellular mechanisms governing amyloid formation and propagation. Genetic techniques allowing for the expression of mammalian or human amyloidogenic and prionogenic proteins in yeast enable researchers to capitalize on yeast advantages for characterization of the properties of disease-related proteins. Chimeric constructs employing mammalian and human aggregation-prone proteins or domains, fused to fluorophores or to endogenous yeast proteins allow for cytological or phenotypic detection of disease-related protein aggregation in yeast cells. Yeast systems are amenable to high-throughput screening for antagonists of amyloid formation, propagation and/or toxicity. This review summarizes up to date achievements of yeast assays in application to studying mammalian and human disease-related aggregating proteins, and discusses both limitations and further perspectives of yeast-based strategies.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"105 ","pages":"293-380"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.adgen.2020.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38068530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

A cosmic virosphere. 一个宇宙病毒圈。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-10-03 DOI: 10.1016/bs.adgen.2020.06.001

Predrag Slijepcevic, N Chandra Wickramasinghe

引用次数: 1

Is the 2019 novel coronavirus related to a spike of cosmic rays? 2019年新型冠状病毒与宇宙射线峰值有关吗?

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-10-01 DOI: 10.1016/bs.adgen.2020.06.003

N Chandra Wickramasinghe

{"title":"Is the 2019 novel coronavirus related to a spike of cosmic rays?","authors":"N Chandra Wickramasinghe","doi":"10.1016/bs.adgen.2020.06.003","DOIUrl":"https://doi.org/10.1016/bs.adgen.2020.06.003","url":null,"abstract":"WHO's pronouncement of the 2019 novel coronavirus outbreak as a pandemic disease came months after we published a warning that the present deepest minimum of the sunspot cycle would be likely to facilitate the onset of a viral pandemic. During a deep sunspot minimum (deepest in 100 years) such as we are now witnessing, two space related phenomena could have an effect on the disposition of viral disease and potential pandemics. With the weakening of the magnetic field in the Earth's vicinity, there would be a high flux of mutagenic cosmic rays. These processes would be likely to herald the onset of new pandemics. Neutron counts from Moscow Neutron Monitor show that the flux of cosmic rays reaching Earth in 2019 was indeed at a maximum over a timespan of half a century since 1962. It is of interest to note that immediately prior to the first recorded cases of the novel Corona virus in China a peak of cosmic rays was measured as is indicated by the Huon neutron monitor data. Recent research revealed that estimates of the timing of the most recent common ancestor of COVID-19 made with current sequence data point to emergence of the virus in late November 2019 to early December 2019, compatible with the earliest retrospectively confirmed cases and the cosmic ray spike in late November 2019. In our view, this strong cosmic ray spike was in some way connected with the onset of the outbreak.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"106 ","pages":"119-122"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.adgen.2020.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38509956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The efficient Lamarckian spread of life in the cosmos. 拉马克式的宇宙中生命的高效传播。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-07-07 DOI: 10.1016/bs.adgen.2020.03.004

Edward J Steele, Reginald M Gorczynski, Robyn A Lindley, Yongsheng Liu, Robert Temple, Gensuke Tokoro, Dayal T Wickramasinghe, N Chandra Wickramasinghe

{"title":"The efficient Lamarckian spread of life in the cosmos.","authors":"Edward J Steele, Reginald M Gorczynski, Robyn A Lindley, Yongsheng Liu, Robert Temple, Gensuke Tokoro, Dayal T Wickramasinghe, N Chandra Wickramasinghe","doi":"10.1016/bs.adgen.2020.03.004","DOIUrl":"https://doi.org/10.1016/bs.adgen.2020.03.004","url":null,"abstract":"In this Chapter we discuss the various mechanisms that are available for the possible transfer of cosmic microbial living systems from one cosmic habitat to another. With the 100 or so habitable planets that are now known to exist in our galaxy alone transfers of cometary dust carrying life including fragments of icy planetoids/asteroids would be expected to occur on a routine basis. It is thus easy to view the galaxy as a single connected \"biosphere\" of which our planet Earth is a minor component. The Hoyle-Wickramasinghe Panspermia paradigm provides a cogent biological rationale for the actual widespread existence of Lamarckian modes of inheritance in terrestrial systems (which we review here). Thus the Panspermia paradigm provides the raison d'etre for Lamarckian Inheritance. Under a terrestrially confined neoDarwinian viewpoint such an association may have been thought spurious in the past. Our aim here is to outline the main evidence for rapid terrestrial-based Lamarckian-based evolutionary hypermutation processes dependent on reverse transcription-coupled mechanisms among others. Such rapid adaptation mechanisms would be consistent with the effective cosmic spread of living systems. For example, a viable, or cryo-preserved, living system traveling through space in a protective matrix will of necessity need to adapt rapidly and proliferate on landing in a new cosmic niche. Lamarckian mechanisms thus come to the fore and supersede the slow (blind and random) genetic processes expected under neoDarwinian Earth centred theories.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"106 ","pages":"21-43"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.adgen.2020.03.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38509960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antibiotic drug discovery: Challenges and perspectives in the light of emerging antibiotic resistance. 抗生素药物发现:新出现的抗生素耐药性的挑战和前景。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-05-06 DOI: 10.1016/bs.adgen.2019.12.002

Keshab Bhattarai, Rina Bastola, Bikash Baral

{"title":"Antibiotic drug discovery: Challenges and perspectives in the light of emerging antibiotic resistance.","authors":"Keshab Bhattarai, Rina Bastola, Bikash Baral","doi":"10.1016/bs.adgen.2019.12.002","DOIUrl":"https://doi.org/10.1016/bs.adgen.2019.12.002","url":null,"abstract":"Amid a rising threat of antimicrobial resistance in a global scenario, our huge investments and high-throughput technologies injected for rejuvenating the key therapeutic scaffolds to suppress these rising superbugs has been diminishing severely. This has grasped world-wide attention, with increased consideration being given to the discovery of new chemical entities. Research has now proven that the relatively tiny and simpler microbes possess enhanced capability of generating novel and diverse chemical constituents with huge therapeutic leads. The usage of these beneficial organisms could help in producing new chemical scaffolds that govern the power to suppress the spread of obnoxious superbugs. Here in this review, we have explicitly focused on several appealing strategies employed for the generation of new chemical scaffolds. Also, efforts on providing novel insights on some of the unresolved questions in the production of metabolites, metabolic profiling and also the serendipity of getting \"hit molecules\" have been rigorously discussed. However, we are highly aware that biosynthetic pathway of different classes of secondary metabolites and their biosynthetic route is a vast topic, thus we have avoided discussion on this topic.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"105 ","pages":"229-292"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.adgen.2019.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38069056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The sociology of science and generality of the DNA/RNA/protein paradigm throughout the cosmos. 整个宇宙中DNA/RNA/蛋白质范式的科学社会学和普遍性。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-07-07 DOI: 10.1016/bs.adgen.2020.03.005

N Chandra Wickramasinghe, Edward J Steele, Brig Klyce, Gensuke Tokoro, Dayal T Wickramasinghe

引用次数: 0

Series Page 系列页面

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Advances in Genetics Pub Date : 2020-01-01 DOI: 10.1016/s0065-2660(20)30016-x

引用次数: 0

Pathogen and host genetics underpinning cryptococcal disease. 病原体和宿主遗传学支持隐球菌病。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-03-18 DOI: 10.1016/bs.adgen.2020.02.001

Carolina Coelho, Rhys A Farrer

{"title":"Pathogen and host genetics underpinning cryptococcal disease.","authors":"Carolina Coelho, Rhys A Farrer","doi":"10.1016/bs.adgen.2020.02.001","DOIUrl":"10.1016/bs.adgen.2020.02.001","url":null,"abstract":"Cryptococcosis is a severe fungal disease causing 220,000 cases of cryptococcal meningitis yearly. The etiological agents of cryptococcosis are taxonomically grouped into at least two species complexes belonging to the genus Cryptococcus. All of these yeasts are environmentally ubiquitous fungi (often found in soil, leaves and decaying wood, tree hollows, and associated with bird feces especially pigeon guano). Infection in a range of animals including humans begins following inhalation of spores or aerosolized yeasts. Recent advances provide fundamental insights into the factors from both the pathogen and its hosts which influence pathogenesis and disease. The complex interactions leading to disease in mammalian hosts have also updated from the availability of better genomic tools and datasets. In this review, we discuss recent genetic research on Cryptococcus, covering the epidemiology, ecology, and evolution of Cryptococcus pathogenic species. We also discuss the insights into the host immune response obtained from the latest genetic modified host models as well as insights from monogenic disorders in humans. Finally we highlight outstanding questions that can be answered in the near future using bioinformatics and genomic tools.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":"105 ","pages":"1-66"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612911/pdf/EMS146178.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38069055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mutagenic source and power of our own evolution. 我们自身进化的诱变源和力量。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-07-14 DOI: 10.1016/bs.adgen.2020.05.001

Robyn A Lindley

引用次数: 0