病原体和宿主遗传学支持隐球菌病。

4区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-03-18 DOI:10.1016/bs.adgen.2020.02.001
Carolina Coelho, Rhys A Farrer
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引用次数: 4

摘要

隐球菌病是一种严重的真菌疾病,每年导致22万例隐球菌性脑膜炎。隐球菌病的病原在分类学上分为至少两个属于隐球菌属的物种复合体。所有这些酵母菌都是环境中普遍存在的真菌(通常存在于土壤、树叶、腐烂的木头、树洞中,并与鸟类粪便,特别是鸽子的粪便有关)。包括人类在内的一系列动物在吸入孢子或雾化酵母菌后开始感染。最近的进展提供了从病原体和宿主影响发病和疾病的因素的基本见解。由于有了更好的基因组工具和数据集,导致哺乳动物宿主疾病的复杂相互作用也得到了更新。本文综述了近年来隐球菌的遗传学研究,包括流行病学、生态学和隐球菌致病性物种的进化。我们还讨论了从最新的遗传修饰宿主模型中获得的宿主免疫反应的见解以及从人类单基因疾病中获得的见解。最后,我们强调了在不久的将来使用生物信息学和基因组学工具可以回答的突出问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathogen and host genetics underpinning cryptococcal disease.

Cryptococcosis is a severe fungal disease causing 220,000 cases of cryptococcal meningitis yearly. The etiological agents of cryptococcosis are taxonomically grouped into at least two species complexes belonging to the genus Cryptococcus. All of these yeasts are environmentally ubiquitous fungi (often found in soil, leaves and decaying wood, tree hollows, and associated with bird feces especially pigeon guano). Infection in a range of animals including humans begins following inhalation of spores or aerosolized yeasts. Recent advances provide fundamental insights into the factors from both the pathogen and its hosts which influence pathogenesis and disease. The complex interactions leading to disease in mammalian hosts have also updated from the availability of better genomic tools and datasets. In this review, we discuss recent genetic research on Cryptococcus, covering the epidemiology, ecology, and evolution of Cryptococcus pathogenic species. We also discuss the insights into the host immune response obtained from the latest genetic modified host models as well as insights from monogenic disorders in humans. Finally we highlight outstanding questions that can be answered in the near future using bioinformatics and genomic tools.

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来源期刊
Advances in Genetics
Advances in Genetics 生物-遗传学
CiteScore
5.70
自引率
0.00%
发文量
1
审稿时长
1 months
期刊介绍: Advances in Genetics presents an eclectic mix of articles of use to all human and molecular geneticists. They are written and edited by recognized leaders in the field and make this an essential series of books for anyone in the genetics field.
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