Advances in Genetics最新文献_第6页

The efficient Lamarckian spread of life in the cosmos. 拉马克式的宇宙中生命的高效传播。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-07-07 DOI: 10.1016/bs.adgen.2020.03.004

Edward J Steele, Reginald M Gorczynski, Robyn A Lindley, Yongsheng Liu, Robert Temple, Gensuke Tokoro, Dayal T Wickramasinghe, N Chandra Wickramasinghe

{"title":"The efficient Lamarckian spread of life in the cosmos.","authors":"Edward J Steele, Reginald M Gorczynski, Robyn A Lindley, Yongsheng Liu, Robert Temple, Gensuke Tokoro, Dayal T Wickramasinghe, N Chandra Wickramasinghe","doi":"10.1016/bs.adgen.2020.03.004","DOIUrl":"https://doi.org/10.1016/bs.adgen.2020.03.004","url":null,"abstract":"In this Chapter we discuss the various mechanisms that are available for the possible transfer of cosmic microbial living systems from one cosmic habitat to another. With the 100 or so habitable planets that are now known to exist in our galaxy alone transfers of cometary dust carrying life including fragments of icy planetoids/asteroids would be expected to occur on a routine basis. It is thus easy to view the galaxy as a single connected \"biosphere\" of which our planet Earth is a minor component. The Hoyle-Wickramasinghe Panspermia paradigm provides a cogent biological rationale for the actual widespread existence of Lamarckian modes of inheritance in terrestrial systems (which we review here). Thus the Panspermia paradigm provides the raison d'etre for Lamarckian Inheritance. Under a terrestrially confined neoDarwinian viewpoint such an association may have been thought spurious in the past. Our aim here is to outline the main evidence for rapid terrestrial-based Lamarckian-based evolutionary hypermutation processes dependent on reverse transcription-coupled mechanisms among others. Such rapid adaptation mechanisms would be consistent with the effective cosmic spread of living systems. For example, a viable, or cryo-preserved, living system traveling through space in a protective matrix will of necessity need to adapt rapidly and proliferate on landing in a new cosmic niche. Lamarckian mechanisms thus come to the fore and supersede the slow (blind and random) genetic processes expected under neoDarwinian Earth centred theories.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.adgen.2020.03.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38509960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pathogen and host genetics underpinning cryptococcal disease. 病原体和宿主遗传学支持隐球菌病。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-03-18 DOI: 10.1016/bs.adgen.2020.02.001

Carolina Coelho, Rhys A Farrer

{"title":"Pathogen and host genetics underpinning cryptococcal disease.","authors":"Carolina Coelho, Rhys A Farrer","doi":"10.1016/bs.adgen.2020.02.001","DOIUrl":"https://doi.org/10.1016/bs.adgen.2020.02.001","url":null,"abstract":"Cryptococcosis is a severe fungal disease causing 220,000 cases of cryptococcal meningitis yearly. The etiological agents of cryptococcosis are taxonomically grouped into at least two species complexes belonging to the genus Cryptococcus. All of these yeasts are environmentally ubiquitous fungi (often found in soil, leaves and decaying wood, tree hollows, and associated with bird feces especially pigeon guano). Infection in a range of animals including humans begins following inhalation of spores or aerosolized yeasts. Recent advances provide fundamental insights into the factors from both the pathogen and its hosts which influence pathogenesis and disease. The complex interactions leading to disease in mammalian hosts have also updated from the availability of better genomic tools and datasets. In this review, we discuss recent genetic research on Cryptococcus, covering the epidemiology, ecology, and evolution of Cryptococcus pathogenic species. We also discuss the insights into the host immune response obtained from the latest genetic modified host models as well as insights from monogenic disorders in humans. Finally we highlight outstanding questions that can be answered in the near future using bioinformatics and genomic tools.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.adgen.2020.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38069055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Antibiotic drug discovery: Challenges and perspectives in the light of emerging antibiotic resistance. 抗生素药物发现:新出现的抗生素耐药性的挑战和前景。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-05-06 DOI: 10.1016/bs.adgen.2019.12.002

Keshab Bhattarai, Rina Bastola, Bikash Baral

{"title":"Antibiotic drug discovery: Challenges and perspectives in the light of emerging antibiotic resistance.","authors":"Keshab Bhattarai, Rina Bastola, Bikash Baral","doi":"10.1016/bs.adgen.2019.12.002","DOIUrl":"https://doi.org/10.1016/bs.adgen.2019.12.002","url":null,"abstract":"Amid a rising threat of antimicrobial resistance in a global scenario, our huge investments and high-throughput technologies injected for rejuvenating the key therapeutic scaffolds to suppress these rising superbugs has been diminishing severely. This has grasped world-wide attention, with increased consideration being given to the discovery of new chemical entities. Research has now proven that the relatively tiny and simpler microbes possess enhanced capability of generating novel and diverse chemical constituents with huge therapeutic leads. The usage of these beneficial organisms could help in producing new chemical scaffolds that govern the power to suppress the spread of obnoxious superbugs. Here in this review, we have explicitly focused on several appealing strategies employed for the generation of new chemical scaffolds. Also, efforts on providing novel insights on some of the unresolved questions in the production of metabolites, metabolic profiling and also the serendipity of getting \"hit molecules\" have been rigorously discussed. However, we are highly aware that biosynthetic pathway of different classes of secondary metabolites and their biosynthetic route is a vast topic, thus we have avoided discussion on this topic.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.adgen.2019.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38069056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The sociology of science and generality of the DNA/RNA/protein paradigm throughout the cosmos. 整个宇宙中DNA/RNA/蛋白质范式的科学社会学和普遍性。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-07-07 DOI: 10.1016/bs.adgen.2020.03.005

N Chandra Wickramasinghe, Edward J Steele, Brig Klyce, Gensuke Tokoro, Dayal T Wickramasinghe

引用次数: 0

Series Page 系列页面

4区生物学

Advances in Genetics Pub Date : 2020-01-01 DOI: 10.1016/s0065-2660(20)30016-x

引用次数: 0

The mutagenic source and power of our own evolution. 我们自身进化的诱变源和力量。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-07-14 DOI: 10.1016/bs.adgen.2020.05.001

Robyn A Lindley

引用次数: 0

"Electrifying dysmorphology": Potassium channelopathies causing dysmorphic syndromes. “电性畸形”:钾通道病变引起畸形综合征。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-05-26 DOI: 10.1016/bs.adgen.2020.03.002

Mark James Hamilton, Mohnish Suri

{"title":"\"Electrifying dysmorphology\": Potassium channelopathies causing dysmorphic syndromes.","authors":"Mark James Hamilton, Mohnish Suri","doi":"10.1016/bs.adgen.2020.03.002","DOIUrl":"https://doi.org/10.1016/bs.adgen.2020.03.002","url":null,"abstract":"Potassium channels are a heterogeneous group of membrane-bound proteins, whose functions support a diverse range of biological processes. Genetic disorders arising from mutations in potassium channels are classically recognized by symptoms arising from acute channel dysfunction, such as periodic paralysis, ataxia, seizures, or cardiac conduction abnormalities, often in a patient with otherwise normal examination findings. In this chapter, we review a distinct subgroup of rare potassium channelopathies whose presentations are instead suggestive of a developmental disorder, with features including intellectual disability, craniofacial dysmorphism or other physical anomalies. Known conditions within this subgroup are: Andersen-Tawil syndrome, Birk-Barel syndrome, Cantú syndrome, Keppen-Lubinsky syndrome, Temple-Baraitser syndrome, Zimmerman-Laband syndrome and a very similar disorder called Bauer-Tartaglia or FHEIG syndrome. Ion channelopathies are unlikely to be routinely considered in the differential diagnosis of children presenting with developmental concerns, and so detailed description and photographs of the clinical phenotype are provided to aid recognition. For several of these disorders, functional characterization of the genetic mutations responsible has led to identification of candidate therapies, including drugs already commonly used for other indications, which adds further impetus to their prompt recognition. Together, these cases illustrate the potential for mechanistic insights gained from genetic diagnosis to drive translational work toward targeted, disease-modifying therapies for rare disorders.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.adgen.2020.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38069053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

FMRP ribonucleoprotein complexes and RNA homeostasis. FMRP核糖核蛋白复合物与RNA稳态。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-02-06 DOI: 10.1016/bs.adgen.2020.01.001

Gabriela Aparecida Marcondes Suardi, Luciana Amaral Haddad

{"title":"FMRP ribonucleoprotein complexes and RNA homeostasis.","authors":"Gabriela Aparecida Marcondes Suardi, Luciana Amaral Haddad","doi":"10.1016/bs.adgen.2020.01.001","DOIUrl":"https://doi.org/10.1016/bs.adgen.2020.01.001","url":null,"abstract":"The Fragile Mental Retardation 1 gene (FMR1), at Xq27.3, encodes the fragile mental retardation protein (FMRP), and displays in its 5'-untranslated region a series of polymorphic CGG triplet repeats that may undergo dynamic mutation. Fragile X syndrome (FXS) is the leading cause of inherited intellectual disability among men, and is most frequently due to FMR1 full mutation and consequent transcription repression. FMR1 premutations may associate with at least two other clinical conditions, named fragile X-associated primary ovarian insufficiency (FXPOI) and tremor and ataxia syndrome (FXTAS). While FXPOI and FXTAS appear to be mediated by FMR1 mRNA accumulation, relative reduction of FMRP, and triplet repeat translation, FXS is due to the lack of the RNA-binding protein FMRP. Besides its function as mRNA translation repressor in neuronal and stem/progenitor cells, RNA editing roles have been assigned to FMRP. In this review, we provide a brief description of FMR1 transcribed microsatellite and associated clinical disorders, and discuss FMRP molecular roles in ribonucleoprotein complex assembly and trafficking, as well as aspects of RNA homeostasis affected in FXS cells.","PeriodicalId":50949,"journal":{"name":"Advances in Genetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.adgen.2020.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38069058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Role of RNA-interacting proteins in modulating plant-microbe interactions. rna相互作用蛋白在调节植物与微生物相互作用中的作用。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-01-27 DOI: 10.1016/bs.adgen.2019.12.001

Saurabh Pandey, Namisha Sharma, Manoj Prasad

引用次数: 0

Preface. 前言。

4区生物学

Advances in Genetics Pub Date : 2020-01-01 DOI: 10.1016/S0065-2660(20)30021-3

Dhavendra Kumar

引用次数: 0