我们自身进化的诱变源和力量。

4区生物学 Q2 Biochemistry, Genetics and Molecular Biology

Advances in Genetics Pub Date : 2020-01-01 Epub Date: 2020-07-14 DOI:10.1016/bs.adgen.2020.05.001

Robyn A Lindley

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引用次数: 0

摘要

本章讨论了基因组，特别是哺乳动物基因组在正常发育和患病状态下可能发生的众多诱变的分子机制和来源。通过胞嘧啶(AID/APOBEC)和腺苷(ADAR)脱氨酶的作用，对病原体和其他诱导疾病的先天免疫的核心作用进行了深入的综述。脱氨酶介导突变的普遍性是理解宇宙遗传进化过程的重要关键。

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The mutagenic source and power of our own evolution.

This chapter addresses the molecular mechanism and source of the numerous mutagenic changes that genomes, particularly mammalian genomes, can undergo during normal development and in diseased states. The central role of pathogen and other disease-inducing innate immunity via the action of the cytosine (AID/APOBEC) and adenosine (ADAR) deaminases is reviewed in some depth. The general and universal nature of deaminase-mediated mutagenesis is an important key to understanding cosmic genetic evolutionary processes.

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来源期刊

Advances in Genetics 生物-遗传学

CiteScore

5.70

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Advances in Genetics presents an eclectic mix of articles of use to all human and molecular geneticists. They are written and edited by recognized leaders in the field and make this an essential series of books for anyone in the genetics field.