Advances in Anatomy Embryology and Cell Biology最新文献_第4页

Angular and Linear Accelerations, Ear, and the Skeletal Muscle. 角加速度和线加速度，耳朵和骨骼肌。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-38215-4_7

You Sung Nam, Paul Hong

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Building a Co-ordinated Musculoskeletal System: The Plasticity of the Developing Skeleton in Response to Muscle Contractions. 建立协调的肌肉骨骼系统:肌肉收缩时骨骼发育的可塑性。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-38215-4_4

Paula Murphy, Rebecca A Rolfe

{"title":"Building a Co-ordinated Musculoskeletal System: The Plasticity of the Developing Skeleton in Response to Muscle Contractions.","authors":"Paula Murphy, Rebecca A Rolfe","doi":"10.1007/978-3-031-38215-4_4","DOIUrl":"10.1007/978-3-031-38215-4_4","url":null,"abstract":"The skeletal musculature and the cartilage, bone and other connective tissues of the skeleton are intimately co-ordinated. The shape, size and structure of each bone in the body is sculpted through dynamic physical stimuli generated by muscle contraction, from early development, with onset of the first embryo movements, and through repair and remodelling in later life. The importance of muscle movement during development is shown by congenital abnormalities where infants that experience reduced movement in the uterus present a sequence of skeletal issues including temporary brittle bones and joint dysplasia. A variety of animal models, utilising different immobilisation scenarios, have demonstrated the precise timing and events that are dependent on mechanical stimulation from movement. This chapter lays out the evidence for skeletal system dependence on muscle movement, gleaned largely from mouse and chick immobilised embryos, showing the many aspects of skeletal development affected. Effects are seen in joint development, ossification, the size and shape of skeletal rudiments and tendons, including compromised mechanical function. The enormous plasticity of the skeletal system in response to muscle contraction is a key factor in building a responsive, functional system. Insights from this work have implications for our understanding of morphological evolution, particularly the challenging concept of emergence of new structures. It is also providing insight for the potential of physical therapy for infants suffering the effects of reduced uterine movement and is enhancing our understanding of the cellular and molecular mechanisms involved in skeletal tissue differentiation, with potential for informing regenerative therapies.","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89720354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanics of Lung Development. 肺发育机制。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-38215-4_6

Mark Baguma-Nibasheka, Boris Kablar

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External and Environmental Effects on Centrosomes. 外部和环境对中心体的影响。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_8

Heide Schatten

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The Centrosome and its Functions and Dysfunctions 中心体及其功能和功能障碍

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5

H. Schatten

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The Centrosome Cycle within the Cell Cycle. 细胞周期中的中心体周期。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_2

Heide Schatten

引用次数: 0

Centrosomes in Reproduction. 生殖中的中心体。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_6

Heide Schatten

引用次数: 0

Centrosome Dysfunctions in Cancer. 癌症中的中心体功能障碍。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_4

Heide Schatten

引用次数: 0

Transitions from Centrosomal to Non-centrosomal Microtubule Organization During Cellular Polarization. 细胞极化过程中中心体向非中心体微管组织的转变。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_7

Heide Schatten

引用次数: 1

Centrosome as Center for Proteolytic Activity and Dysfunctions Associated with Pathogenesis of Human Disease. 中心体作为与人类疾病发病机制相关的蛋白水解活性和功能障碍的中心。

4区生物学

Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-20848-5_3

Heide Schatten

{"title":"Centrosome as Center for Proteolytic Activity and Dysfunctions Associated with Pathogenesis of Human Disease.","authors":"Heide Schatten","doi":"10.1007/978-3-031-20848-5_3","DOIUrl":"https://doi.org/10.1007/978-3-031-20848-5_3","url":null,"abstract":"Among the multiple and intriguing roles of centrosomes in cellular functions is the ubiquitin-proteasome-mediated protein degradation. It has been shown that proteasomes are concentrated at the mammalian centrosome which led to further studies to view the centrosome as a proteolytic center (Wojcik et al. 1996; Wigley et al. 1999; reviewed in Badano et al. 2005). Proteasomal components that are concentrated around the centrosome include ubiquitin, the 20S and 19S subunits of the proteasome, as well as the E3 enzyme parkin. These proteasomal components colocalize with the centrosomal marker γ-tubulin and co-purify with γ-tubulin in the centrosomal fractions after sucrose-gradient ultracentrifugation (Wigley et al. 1999). The localization, accumulation, and concentration of proteasomal components around centrosomes appear to be microtubule independent which has been shown experimentally by inhibiting microtubule functions. When intracellular levels of misfolded proteins were experimentally increased by either proteasome inhibition with drugs such as lactacystin, or by overexpression of misfolded mutant proteins, the centrosome-associated proteasome network became expanded and proteolytic components were recruited from the cytosol without involvement of microtubules. These studies revealed a critical role of centrosomes in the organization and subcellular localization of proteasomes (Wigley et al. 1999; Fabunmi et al. 2000).","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10445421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0