American Journal of Alzheimers Disease and Other Dementias最新文献_第4页

The Role of Preparedness for Caregiving on the Relationship Between Caregiver Distress and Potentially Harmful Behaviors. 为照顾他人做好准备对照顾者苦恼与潜在有害行为之间关系的作用。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221141552

David W Hancock, Sara Czaja, Richard Schulz

引用次数: 0

Association of Dementia Severity and Caregiver Support With Early Discharge From Home Health. 痴呆症严重程度和护理人员的支持与提前脱离家庭医疗服务的关系。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221129384

Sara Knox, Allen Haas, Brian Downer, Kenneth J Ottenbacher

{"title":"Association of Dementia Severity and Caregiver Support With Early Discharge From Home Health.","authors":"Sara Knox, Allen Haas, Brian Downer, Kenneth J Ottenbacher","doi":"10.1177/15333175221129384","DOIUrl":"10.1177/15333175221129384","url":null,"abstract":"Introduction: The objective of this study was to examine the relationship between dementia severity and early discharge from home health.Methods: This was a retrospective study of 100% national Medicare home health da ta files (2016-2017). Multilevel logistic regression was used to study the relationship of dementia severity, caregiver support, and medication assistance with early discharge from home health.Results: The final cohort consisted of 91 302 Medicare beneficiaries with an ADRD diagnosis. A pattern of early discharge rates across dementia severity levels was not demonstrated. The relative risk for early discharge was lower for individuals who needed assistance with medication and for those with unmet caregiver needs.Discussion: The findings of this study do not support the hypothesis that dementia severity contributes to early discharge from home health. Further research is needed to fully understand key factors contributing to early discharge from home health.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33540403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opposite Roles of Co-enzyme Q10 and Formaldehyde in Neurodegenerative Diseases. 辅酶 Q10 和甲醛在神经退行性疾病中的相反作用。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221143274

Jinan Xu, Xingjiang Jin, Zuting Ye, Dandan Wang, Hang Zhao, Zhiqian Tong

{"title":"Opposite Roles of Co-enzyme Q10 and Formaldehyde in Neurodegenerative Diseases.","authors":"Jinan Xu, Xingjiang Jin, Zuting Ye, Dandan Wang, Hang Zhao, Zhiqian Tong","doi":"10.1177/15333175221143274","DOIUrl":"10.1177/15333175221143274","url":null,"abstract":"Most of neurodegenerative diseases (NDD) have no cure. The common etiology of neurodegenerations is unclear. Air pollutant-gaseous formaldehyde is notoriously known to induce demyelination and cognitive impairments. Unexpectedly, an amount of formaldehyde has been detected in the brains. Multiple factors can induce the generation and accumulation of endogenous formaldehyde. Excessive formaldehyde can induce oxidative stress to generate H2O2; in turn, H2O2 promote formaldehyde production. Clinical investigations have shown that an abnormal high level of formaldehyde but low level of coenzyme Q10 (coQ10) was observed in patients with NDD. Further studies have proven that excessive formaldehyde directly inactivates coQ10, reduces the ATP generation, enhances oxidative stress, initiates inflammation storm, induces demyelination; subsequently, it results in neurodegeneration. Although the low water solubility of coQ10 limits its clinical application, nanomicellar water-soluble coQ10 exhibits positive therapeutical effects. Hence, nanopackage of coQ10 may be a promising strategy for treating NDD.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10381359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Long-Term Shift Work Increase the Risk of Dementia? A Systematic Review and Meta-Analysis. 长期轮班工作会增加痴呆症风险吗？系统回顾与元分析》。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221141535

Yang Hai, Ying Xue, Yu-Hong Wang

{"title":"Does Long-Term Shift Work Increase the Risk of Dementia? A Systematic Review and Meta-Analysis.","authors":"Yang Hai, Ying Xue, Yu-Hong Wang","doi":"10.1177/15333175221141535","DOIUrl":"10.1177/15333175221141535","url":null,"abstract":"Background: Shift work is associated with impaired sleep quality and disrupted circadian rhythms, but the way in which it increases the risk of dementia remains controversial. We conducted a systematic review and meta-analysis to assess the integrated risk of dementia with shift work. Methods: Searching in PubMed, Cochrane Library, and the Web of Science databases, the relative risks of dementia with shift work were extracted from 12 included studies with 3975 dementia cases from 84 492 participants. The subgroup analysis was stratified by age, gender, sample size, dementia cases, shift schedule, occupation, and follow-up time. Heterogeneity analysis and publication bias analysis were conducted for quality control. Results: The pooled risk ratios (RRs) of dementia with shift work were 1.15 (95%CI = 1.02-1.30). The subgroup analysis found that continuous evening shifts reversibly reduced the risk, but continuous night shifts remarkedly increased the risk of dementia. In addition, a larger cohort and longer follow-up significantly increased the risk of dementia with shift work. Conclusion: Shift work shows mild increases in the risk of dementia using meta-analysis.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10435518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive Assessment in Culturally, Linguistically, and Educationally Diverse Older Populations in Europe. 欧洲不同文化、语言和教育背景老年人群的认知评估。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221117006

T Rune Nielsen

{"title":"Cognitive Assessment in Culturally, Linguistically, and Educationally Diverse Older Populations in Europe.","authors":"T Rune Nielsen","doi":"10.1177/15333175221117006","DOIUrl":"10.1177/15333175221117006","url":null,"abstract":"Due to increasing cultural, linguistic, and educational diversity in older populations across Europe, accurate assessment of cognitive functioning in people from diverse backgrounds becomes increasingly important. This paper aims to provide a state-of-the-art review of cognitive assessment in culturally, linguistically, and educationally diverse older populations in Europe, focusing on challenges and recent advances in cross-cultural assessment. Significant work has been carried out on the identification of challenges in cognitive assessment in culturally, linguistically, and educationally diverse older populations and on development and validation of cross-cultural cognitive tests. Most research has addressed the influences of language barriers, education and literacy, and culture and acculturation and in particular, the European Cross-Cultural Neuropsychological Test Battery (CNTB) and the Rowland Universal Dementia Assessment Scale (RUDAS) are well-validated across European countries. However, cross-cultural cognitive assessment is largely still a developing field in Europe, and there is a continuing need for developments within the field.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10374629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Auditory P50 Gating in Mild Cognitive Impairment: A Case-Control Study. 轻度认知障碍的听觉 P50 门控：病例对照研究

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175211068966

Weidong Song, Xiaohui Hu, Guohua Xie, Wentao Lai, Yang Wang, Donghui Wu

引用次数: 0

Improving Prediction of Amyloid Deposition in Mild Cognitive Impairment With a Timed Motor Task. 通过定时运动任务改进对轻度认知障碍患者淀粉样蛋白沉积的预测

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175211048262

Sydney Y Schaefer, Kevin Duff, Andrew Hooyman, John M Hoffman

{"title":"Improving Prediction of Amyloid Deposition in Mild Cognitive Impairment With a Timed Motor Task.","authors":"Sydney Y Schaefer, Kevin Duff, Andrew Hooyman, John M Hoffman","doi":"10.1177/15333175211048262","DOIUrl":"10.1177/15333175211048262","url":null,"abstract":"Cortical amyloid deposition is one of the hallmark biomarkers of Alzheimer's disease (AD). However, given how cost- and time-intensive amyloid imaging can be, there is a continued need for a low-cost, non-invasive, and accessible enrichment strategy to pre-screen individuals for their likelihood of amyloid prior to imaging. Previous work supports the use of coordinated limb movement as a potential screening tool, even after controlling for cognitive and daily function. Thirty-six patients diagnosed with amnestic mild cognitive impairment over the age of 65 underwent 18F-Flutemetamol amyloid-positron emission tomography (PET) imaging and then completed a timed motor task involving upper limb coordination. This task takes ∼5 minutes to administer and score. Multivariate linear regression and receiver operator characteristic analyses showed that including motor task performance improved model prediction of amyloid burden. Results support the rationale for including functional upper extremity motor assessment as a cost- and time-effective means to screen participants for amyloid deposition.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39824809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2-Mediated Neuropathogenesis, Deterioration of Hippocampal Neurogenesis and Dementia. SARS-CoV-2介导的神经发病机制、海马神经发生退化和痴呆症

IF 2.7 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221078418

Risna K Radhakrishnan, Mahesh Kandasamy

{"title":"SARS-CoV-2-Mediated Neuropathogenesis, Deterioration of Hippocampal Neurogenesis and Dementia.","authors":"Risna K Radhakrishnan, Mahesh Kandasamy","doi":"10.1177/15333175221078418","DOIUrl":"10.1177/15333175221078418","url":null,"abstract":"A significant portion of COVID-19 patients and survivors display marked clinical signs of neurocognitive impairments. SARS-CoV-2-mediated peripheral cytokine storm and its neurotropism appear to elicit the activation of glial cells in the brain proceeding to neuroinflammation. While adult neurogenesis has been identified as a key cellular basis of cognitive functions, neuroinflammation-induced aberrant neuroregenerative plasticity in the hippocampus has been implicated in progressive memory loss in ageing and brain disorders. Notably, recent histological studies of post-mortem human and experimental animal brains indicate that SARS-CoV-2 infection impairs neurogenic process in the hippocampus of the brain due to neuroinflammation. Considering the facts, this article describes the prominent neuropathogenic characteristics and neurocognitive impairments in COVID-19 and emphasizes a viewpoint that neuroinflammation-mediated deterioration of hippocampal neurogenesis could contribute to the onset and progression of dementia in COVID-19. Thus, it necessitates the unmet need for regenerative medicine for the effective management of neurocognitive deficits in COVID-19.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39899515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prophylactic Effects of Sub-anesthesia Ketamine on Cognitive Decline, Neuroinflammation, and Oxidative Stress in Elderly Mice. 麻醉下氯胺酮对老年小鼠认知能力下降、神经炎症和氧化应激的预防性影响

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221141531

Minmin Chen, Yinqiu Han, Bin Que, Rong Zhou, Jianhui Gan, Xiaoyun Dong

{"title":"Prophylactic Effects of Sub-anesthesia Ketamine on Cognitive Decline, Neuroinflammation, and Oxidative Stress in Elderly Mice.","authors":"Minmin Chen, Yinqiu Han, Bin Que, Rong Zhou, Jianhui Gan, Xiaoyun Dong","doi":"10.1177/15333175221141531","DOIUrl":"10.1177/15333175221141531","url":null,"abstract":"Cognitive dysfunction is a very common postoperative complication. The study aimed at investigating the effects of ketamine on the cognition of elderly mice after anesthesia and surgery (AS). We reported that AS impaired the cognition of elderly mice, while ketamine helped to maintain the cognitive function. Ketamine decreased the levels of TNF-α, IL-6, IL-1β and the expression of p-TAU, S100B in hippocampal induced by AS. In addition, AS triggered severe oxidative stress in hippocampal, while ketamine inhibited it. Oxidative stress induced autophagy of hippocampal neurons via inhibiting PI3K/AKT/mTOR pathway. Ketamine could activate PI3K pathway and inhibit autophagy in hippocampal, thus maintain the loss of hippocampal neurons. The study suggested that ketamine inhibited the neuroinflammation and oxidative stress, reduced the autophagy of hippocampal neurons via PI3K/AKT/mTOR pathway. It may provide novel methods for the protection of cognitive function in elderly during perioperative period.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10615334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotion Processing Dysfunction in Alzheimer's Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology. 阿尔茨海默病的情绪处理功能障碍:行为发现、系统神经关联和潜在神经生物学综述。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221082834

Shefali Chaudhary, Simon Zhornitsky, Herta H Chao, Christopher H van Dyck, Chiang-Shan R Li

{"title":"Emotion Processing Dysfunction in Alzheimer's Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology.","authors":"Shefali Chaudhary, Simon Zhornitsky, Herta H Chao, Christopher H van Dyck, Chiang-Shan R Li","doi":"10.1177/15333175221082834","DOIUrl":"https://doi.org/10.1177/15333175221082834","url":null,"abstract":"We described behavioral studies to highlight emotional processing deficits in Alzheimer's disease (AD). The findings suggest prominent deficit in recognizing negative emotions, pronounced effect of positive emotion on enhancing memory, and a critical role of cognitive deficits in manifesting emotional processing dysfunction in AD. We reviewed imaging studies to highlight morphometric and functional markers of hippocampal circuit dysfunction in emotional processing deficits. Despite amygdala reactivity to emotional stimuli, hippocampal dysfunction conduces to deficits in emotional memory. Finally, the reviewed studies implicating major neurotransmitter systems in anxiety and depression in AD supported altered cholinergic and noradrenergic signaling in AD emotional disorders. Overall, the studies showed altered emotions early in the course of illness and suggest the need of multimodal imaging for further investigations. Particularly, longitudinal studies with multiple behavioral paradigms translatable between preclinical and clinical models would provide data to elucidate the time course and underlying neurobiology of emotion processing dysfunction in AD.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f8/a1/nihms-1816494.PMC9212074.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10825798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9