American Journal of Alzheimers Disease and Other Dementias最新文献_第4页

Opposite Roles of Co-enzyme Q10 and Formaldehyde in Neurodegenerative Diseases. 辅酶 Q10 和甲醛在神经退行性疾病中的相反作用。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221143274

Jinan Xu, Xingjiang Jin, Zuting Ye, Dandan Wang, Hang Zhao, Zhiqian Tong

{"title":"Opposite Roles of Co-enzyme Q10 and Formaldehyde in Neurodegenerative Diseases.","authors":"Jinan Xu, Xingjiang Jin, Zuting Ye, Dandan Wang, Hang Zhao, Zhiqian Tong","doi":"10.1177/15333175221143274","DOIUrl":"10.1177/15333175221143274","url":null,"abstract":"Most of neurodegenerative diseases (NDD) have no cure. The common etiology of neurodegenerations is unclear. Air pollutant-gaseous formaldehyde is notoriously known to induce demyelination and cognitive impairments. Unexpectedly, an amount of formaldehyde has been detected in the brains. Multiple factors can induce the generation and accumulation of endogenous formaldehyde. Excessive formaldehyde can induce oxidative stress to generate H2O2; in turn, H2O2 promote formaldehyde production. Clinical investigations have shown that an abnormal high level of formaldehyde but low level of coenzyme Q10 (coQ10) was observed in patients with NDD. Further studies have proven that excessive formaldehyde directly inactivates coQ10, reduces the ATP generation, enhances oxidative stress, initiates inflammation storm, induces demyelination; subsequently, it results in neurodegeneration. Although the low water solubility of coQ10 limits its clinical application, nanomicellar water-soluble coQ10 exhibits positive therapeutical effects. Hence, nanopackage of coQ10 may be a promising strategy for treating NDD.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"37 ","pages":"15333175221143274"},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10381359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Long-Term Shift Work Increase the Risk of Dementia? A Systematic Review and Meta-Analysis. 长期轮班工作会增加痴呆症风险吗？系统回顾与元分析》。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221141535

Yang Hai, Ying Xue, Yu-Hong Wang

{"title":"Does Long-Term Shift Work Increase the Risk of Dementia? A Systematic Review and Meta-Analysis.","authors":"Yang Hai, Ying Xue, Yu-Hong Wang","doi":"10.1177/15333175221141535","DOIUrl":"10.1177/15333175221141535","url":null,"abstract":"Background: Shift work is associated with impaired sleep quality and disrupted circadian rhythms, but the way in which it increases the risk of dementia remains controversial. We conducted a systematic review and meta-analysis to assess the integrated risk of dementia with shift work. Methods: Searching in PubMed, Cochrane Library, and the Web of Science databases, the relative risks of dementia with shift work were extracted from 12 included studies with 3975 dementia cases from 84 492 participants. The subgroup analysis was stratified by age, gender, sample size, dementia cases, shift schedule, occupation, and follow-up time. Heterogeneity analysis and publication bias analysis were conducted for quality control. Results: The pooled risk ratios (RRs) of dementia with shift work were 1.15 (95%CI = 1.02-1.30). The subgroup analysis found that continuous evening shifts reversibly reduced the risk, but continuous night shifts remarkedly increased the risk of dementia. In addition, a larger cohort and longer follow-up significantly increased the risk of dementia with shift work. Conclusion: Shift work shows mild increases in the risk of dementia using meta-analysis.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"37 ","pages":"15333175221141535"},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10435518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prophylactic Effects of Sub-anesthesia Ketamine on Cognitive Decline, Neuroinflammation, and Oxidative Stress in Elderly Mice. 麻醉下氯胺酮对老年小鼠认知能力下降、神经炎症和氧化应激的预防性影响

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221141531

Minmin Chen, Yinqiu Han, Bin Que, Rong Zhou, Jianhui Gan, Xiaoyun Dong

{"title":"Prophylactic Effects of Sub-anesthesia Ketamine on Cognitive Decline, Neuroinflammation, and Oxidative Stress in Elderly Mice.","authors":"Minmin Chen, Yinqiu Han, Bin Que, Rong Zhou, Jianhui Gan, Xiaoyun Dong","doi":"10.1177/15333175221141531","DOIUrl":"10.1177/15333175221141531","url":null,"abstract":"Cognitive dysfunction is a very common postoperative complication. The study aimed at investigating the effects of ketamine on the cognition of elderly mice after anesthesia and surgery (AS). We reported that AS impaired the cognition of elderly mice, while ketamine helped to maintain the cognitive function. Ketamine decreased the levels of TNF-α, IL-6, IL-1β and the expression of p-TAU, S100B in hippocampal induced by AS. In addition, AS triggered severe oxidative stress in hippocampal, while ketamine inhibited it. Oxidative stress induced autophagy of hippocampal neurons via inhibiting PI3K/AKT/mTOR pathway. Ketamine could activate PI3K pathway and inhibit autophagy in hippocampal, thus maintain the loss of hippocampal neurons. The study suggested that ketamine inhibited the neuroinflammation and oxidative stress, reduced the autophagy of hippocampal neurons via PI3K/AKT/mTOR pathway. It may provide novel methods for the protection of cognitive function in elderly during perioperative period.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"37 ","pages":"15333175221141531"},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10615334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotion Processing Dysfunction in Alzheimer's Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology. 阿尔茨海默病的情绪处理功能障碍:行为发现、系统神经关联和潜在神经生物学综述。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221082834

Shefali Chaudhary, Simon Zhornitsky, Herta H Chao, Christopher H van Dyck, Chiang-Shan R Li

{"title":"Emotion Processing Dysfunction in Alzheimer's Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology.","authors":"Shefali Chaudhary, Simon Zhornitsky, Herta H Chao, Christopher H van Dyck, Chiang-Shan R Li","doi":"10.1177/15333175221082834","DOIUrl":"https://doi.org/10.1177/15333175221082834","url":null,"abstract":"We described behavioral studies to highlight emotional processing deficits in Alzheimer's disease (AD). The findings suggest prominent deficit in recognizing negative emotions, pronounced effect of positive emotion on enhancing memory, and a critical role of cognitive deficits in manifesting emotional processing dysfunction in AD. We reviewed imaging studies to highlight morphometric and functional markers of hippocampal circuit dysfunction in emotional processing deficits. Despite amygdala reactivity to emotional stimuli, hippocampal dysfunction conduces to deficits in emotional memory. Finally, the reviewed studies implicating major neurotransmitter systems in anxiety and depression in AD supported altered cholinergic and noradrenergic signaling in AD emotional disorders. Overall, the studies showed altered emotions early in the course of illness and suggest the need of multimodal imaging for further investigations. Particularly, longitudinal studies with multiple behavioral paradigms translatable between preclinical and clinical models would provide data to elucidate the time course and underlying neurobiology of emotion processing dysfunction in AD.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"37 ","pages":"15333175221082834"},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f8/a1/nihms-1816494.PMC9212074.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10825798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Acetoacetate Improves Memory in Alzheimer's Mice via Promoting Brain-Derived Neurotrophic Factor and Inhibiting Inflammation. 乙酰乙酸通过促进脑源性神经营养因子和抑制炎症改善阿尔茨海默氏症小鼠的记忆力

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221124949

Xiao-Jun Wu, Qin-Qin Shu, Bin Wang, Lan Dong, Bin Hao

{"title":"Acetoacetate Improves Memory in Alzheimer's Mice via Promoting Brain-Derived Neurotrophic Factor and Inhibiting Inflammation.","authors":"Xiao-Jun Wu, Qin-Qin Shu, Bin Wang, Lan Dong, Bin Hao","doi":"10.1177/15333175221124949","DOIUrl":"10.1177/15333175221124949","url":null,"abstract":"The ketone bodies, especially the β-hydroxybutyrate, had been shown to modulate the function of the central nervous system and prevent the pathological progression of Alzheimer's disease (AD). However, little is known about the role of acetoacetate in the AD brain. Thus, we intraventricularly injected acetoacetate into familial AD mice (APPSWE) for 14 days and monitored their memory and biochemical changes. During the behavior test, acetoacetate at 100 mg/kg led to significant improvement in both Y-maze and novel object recognition tests (NORTs) (both P < .05), indicating ameliorating spatial and recognition memory, respectively. Biomedical tests revealed two mechanisms were involved. Firstly, acetoacetate inhibited the GPR43-pERK pathway, which led to apparent inhibition in tumor necrosis factor-α and Interleukin-6 expression in the hippocampus in a concentration-dependent manner. Secondarily, acetoacetate stimulated the expression of hippocampal brain-derived neurotrophic factor (BDNF). We concluded that acetoacetate could ameliorate AD symptoms and exhibited promising features as a therapeutic for AD.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"37 ","pages":"15333175221124949"},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10742217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association Between Dextromethorphan Use and the Risk of Dementia. 使用右美沙芬与痴呆症风险之间的关系

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221124952

Chia-Yuan Chen, Chi-Hsiang Chung, Wu-Chien Chien, Hsin-Chien Chen

引用次数: 0

Physical Exercise Exerts Neuroprotective Effect on Memory Impairment by Mitigate the Decline of Striatum Catecholamine and Spine Density in a Vascular Dementia Rat Model. 在血管性痴呆大鼠模型中，体育锻炼通过缓解纹状体儿茶酚胺和脊柱密度的下降对记忆损伤具有神经保护作用

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221144367

Hangzhou Ren, Zhongyuan Zhang, Jianwei Zhang

{"title":"Physical Exercise Exerts Neuroprotective Effect on Memory Impairment by Mitigate the Decline of Striatum Catecholamine and Spine Density in a Vascular Dementia Rat Model.","authors":"Hangzhou Ren, Zhongyuan Zhang, Jianwei Zhang","doi":"10.1177/15333175221144367","DOIUrl":"10.1177/15333175221144367","url":null,"abstract":"Objective: The present study aims to investigate the underlying neurochemical mechanism of physical exercise on striatum synapsis and memory function in vascular dementia model.Methods: 32 Sprague-Dawley (SD) rats were randomly divided into 4 groups: control group (C group, n = 6), vascular dementia group (Vascular dementia group, n = 7), physical exercise and vascular dementia group (Exe-VD group, n = 6), physical exercise and black group (Exe group, n = 6). 4 weeks of voluntary wheel running were used as pre-exercise training. Vascular dementia model was established by bilateral common carotid arteries occlusion (BCCAo) for 1 week. Passive avoidance test (PAT) were used to test memory function. The level of striatum catecholamine in the microdialysate were detected by enzyme linked immunosorbent assy (ELISA). Golgi staining was used to analyze striatum neuronal spine density.Results: Behavioral data indicated that 4 weeks of physical exercise ameliorated memory impairment in vascular dementia model. Striatum catecholamine level significantly decreased in VD group when compared with C group (P < .001). But this phenomenon can be rescue by physical exercise (P < .001). In addition, compared with C group, neuronal spine density significantly decreased in VD group (P < .01), but 4 weeks of physical exercise can rescue this phenomenon (P < .05).Conclusion: 4 weeks of physical exercise improves memory function by mitigate the decline of striatum catecholamine and spine density in VD model.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"37 ","pages":"15333175221144367"},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10670284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Willingness to Help People With Dementia Symptoms Among Four Occupation Practitioners in Macao. 澳門四名職業治療師對協助有老年癡呆症症狀人士的意願。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221139172

Sok Leng Che, Jianwei Wu, Yao-Chen Chuang, Iat Kio Van, Sok Man Leong

{"title":"The Willingness to Help People With Dementia Symptoms Among Four Occupation Practitioners in Macao.","authors":"Sok Leng Che, Jianwei Wu, Yao-Chen Chuang, Iat Kio Van, Sok Man Leong","doi":"10.1177/15333175221139172","DOIUrl":"10.1177/15333175221139172","url":null,"abstract":"Background: Dementia-friendly community has been promoted in Macao since 2016. There is no study investigating the understanding of nor attitudes towards dementia among public contact staff in Macao. This study aimed to (i) understand the level of knowledge of dementia, (ii) examine the attitudes towards people living with dementia, and (iii) explore the associated factors of the willingness to help people with dementia symptoms among police officers, bank officers, bus drivers, and building superintendents.Methods: A cross-sectional survey was conducted between January and May 2019 using a structured questionnaire.Results: A total of 351 valid questionnaires were received. Building superintendents had more knowledge while police officers and bank officers had more positive attitudes. All practitioners were more willing to help people with dementia symptoms when they were on official duty. Participants who had more knowledge about dementia were associated with a higher willingness to help people with dementia symptoms.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"37 ","pages":"15333175221139172"},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10375071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Tree Drawing Test in Evolution: An Explorative Longitudinal Study in Alzheimer's Disease. 进化中的树图测试：阿尔茨海默病的探索性纵向研究

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221129381

Michelangelo Stanzani Maserati, Marialaura Matacena, Flavia Baccari, Corrado Zenesini, Roberto Gallassi, Sabina Capellari, Corrado Matacena

{"title":"The Tree Drawing Test in Evolution: An Explorative Longitudinal Study in Alzheimer's Disease.","authors":"Michelangelo Stanzani Maserati, Marialaura Matacena, Flavia Baccari, Corrado Zenesini, Roberto Gallassi, Sabina Capellari, Corrado Matacena","doi":"10.1177/15333175221129381","DOIUrl":"10.1177/15333175221129381","url":null,"abstract":"Objective: To study the evolution of the Tree Drawing Test (TDT) in a group of Alzheimer's disease (AD) patients.Methods: A total of 33 AD patients were consecutively evaluated by Mini Mental State Evaluation (MMSE) and TDT. The evolution of the TDT parameters, trunk-to-crown (TC) and space occupation (SO) index, were analyzed.Results: The median age at first visit was 79 years. Globally, trees drawn by patients showed an evolution characterized by a progressive reduction of the crown compared to the trunk. TC index showed a significant linear growth change (2.52 points per year) while SO index did not significantly increase. No significant associations were found examining the relations between MMSE and TC and SO index.Conclusions: TDT could represent a complementary technique to the main neuropsychological screening tests for orienting cognitive impairment diagnosis and an aid in following the evolution of cognitive impairment over time in AD patients.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"37 ","pages":"15333175221129381"},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10435478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Correlations Between Serum Hcy Level and Seizures and Cognitive Function in Patients After Stroke. 脑卒中后患者血清 Hcy 水平与癫痫发作和认知功能的关系

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221146738

Chen Lan, Zhiqiang Huang, Xinxin Luo, Yongcheng Zhang

{"title":"The Correlations Between Serum Hcy Level and Seizures and Cognitive Function in Patients After Stroke.","authors":"Chen Lan, Zhiqiang Huang, Xinxin Luo, Yongcheng Zhang","doi":"10.1177/15333175221146738","DOIUrl":"10.1177/15333175221146738","url":null,"abstract":"Backgrounds: Post-stroke cognitive dysfunction (PSCI), a set of illnesses ranging from moderate cognitive impairment to dementia, which is one of the most prevalent consequences following a stroke. Homocysteine (Hcy) has been related to a number of neurological and systemic diseases. It's also a known risk factor for cardiovascular disease and systemic atherosclerosis (CVD). The link between Hcy and PSCI, on the other hand, is unknown.Methods: Our hospital evaluated 325 patients with acute cerebral infarction between January 1, 2018 and December 1, 2021. There are biological markers and baseline data available. Patients were divided into two groups based on the results of the Montreal Cognitive Assessment (MoCA). The researchers performed logistic regression analysis to find variables that may be linked to PSCI.Results: HCY levels were significantly higher in PSCI patients than in non-PSCI patients. Age, education, seizure manifestation, and income level were all shown to be independent risk variables for PSCI in a multivariate logistic analysis. Hcy levels in PSCI patients differed considerably between the high and low groups. The high and low Hcy levels groups had significantly varied hypertension histories and urine levels. Hcy levels in PSCI patients differed considerably between the high and low groups. The high and low Hcy levels groups had significantly varied hypertension histories and urine levels.Conclusion: Serum Hcy levels have been linked to PSCI in post-stroke patients, and researchers believe that serum Hcy levels will diminish PSCI.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"37 ","pages":"15333175221146738"},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10615358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0