American Journal of Alzheimers Disease and Other Dementias最新文献_第5页

Acetoacetate Improves Memory in Alzheimer's Mice via Promoting Brain-Derived Neurotrophic Factor and Inhibiting Inflammation. 乙酰乙酸通过促进脑源性神经营养因子和抑制炎症改善阿尔茨海默氏症小鼠的记忆力

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221124949

Xiao-Jun Wu, Qin-Qin Shu, Bin Wang, Lan Dong, Bin Hao

{"title":"Acetoacetate Improves Memory in Alzheimer's Mice via Promoting Brain-Derived Neurotrophic Factor and Inhibiting Inflammation.","authors":"Xiao-Jun Wu, Qin-Qin Shu, Bin Wang, Lan Dong, Bin Hao","doi":"10.1177/15333175221124949","DOIUrl":"10.1177/15333175221124949","url":null,"abstract":"The ketone bodies, especially the β-hydroxybutyrate, had been shown to modulate the function of the central nervous system and prevent the pathological progression of Alzheimer's disease (AD). However, little is known about the role of acetoacetate in the AD brain. Thus, we intraventricularly injected acetoacetate into familial AD mice (APPSWE) for 14 days and monitored their memory and biochemical changes. During the behavior test, acetoacetate at 100 mg/kg led to significant improvement in both Y-maze and novel object recognition tests (NORTs) (both P < .05), indicating ameliorating spatial and recognition memory, respectively. Biomedical tests revealed two mechanisms were involved. Firstly, acetoacetate inhibited the GPR43-pERK pathway, which led to apparent inhibition in tumor necrosis factor-α and Interleukin-6 expression in the hippocampus in a concentration-dependent manner. Secondarily, acetoacetate stimulated the expression of hippocampal brain-derived neurotrophic factor (BDNF). We concluded that acetoacetate could ameliorate AD symptoms and exhibited promising features as a therapeutic for AD.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10742217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary AD7c-NTP Evaluates Cognition Impairment and Differentially Diagnoses AD and MCI. 尿液 AD7c-NTP 可评估认知障碍，并对注意力缺失症和 MCI 进行鉴别诊断。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221115247

Ming-Ran Xu, Rong-Fang Dai, Qing-Qi Wei, Jun Wang, Yue-Ying Feng, Ying Hu

引用次数: 0

The Association Between Dextromethorphan Use and the Risk of Dementia. 使用右美沙芬与痴呆症风险之间的关系

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221124952

Chia-Yuan Chen, Chi-Hsiang Chung, Wu-Chien Chien, Hsin-Chien Chen

引用次数: 0

Progesterone Receptor Membrane Component-1 May Promote Survival of Human Brain Microvascular Endothelial Cells in Alzheimer's Disease. 孕酮受体膜成分-1 可促进阿尔茨海默氏症患者脑微血管内皮细胞的存活

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221109749

Xin Xu, Xiangyan Ruan, Rui Ju, Zhikun Wang, Yu Yang, Jiaojiao Cheng, Muqing Gu, Alfred O Mueck

{"title":"Progesterone Receptor Membrane Component-1 May Promote Survival of Human Brain Microvascular Endothelial Cells in Alzheimer's Disease.","authors":"Xin Xu, Xiangyan Ruan, Rui Ju, Zhikun Wang, Yu Yang, Jiaojiao Cheng, Muqing Gu, Alfred O Mueck","doi":"10.1177/15333175221109749","DOIUrl":"10.1177/15333175221109749","url":null,"abstract":"Cerebrovascular changes occur in Alzheimer's disease (AD). The progesterone receptor membrane component-1 (PGRMC1) is a well identified hormone receptor with multiple functions in AD. This study aims to explore the involvement of PGRMC1 in the regulation of vascular endothelial function, providing new therapy options for AD. Single-cell sequencing revealed that the expression of PGRMC1 is lower in AD. By bioinformatics analysis, we found PGRMC1 was associated with regulation of cell proliferation, angiogenesis and etc. To understand the functional significance of PGRMC1, knockdown and overexpression were performed using human brain microvascular endothelial cells (HBMVECs), respectively. Cell proliferation assay, migration assay, tube formation assay were performed in experiments. We demonstrated that the overexpression of PGRMC1 promoted the cellular processes associated with endothelia cell proliferation, migration, and angiogenesis, significantly. In conclusion, PGRMC1 may contribute to the modulation of HBMVECs function in AD. This finding may offer novel targets for AD treatment.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40163462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical Exercise Exerts Neuroprotective Effect on Memory Impairment by Mitigate the Decline of Striatum Catecholamine and Spine Density in a Vascular Dementia Rat Model. 在血管性痴呆大鼠模型中，体育锻炼通过缓解纹状体儿茶酚胺和脊柱密度的下降对记忆损伤具有神经保护作用

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221144367

Hangzhou Ren, Zhongyuan Zhang, Jianwei Zhang

{"title":"Physical Exercise Exerts Neuroprotective Effect on Memory Impairment by Mitigate the Decline of Striatum Catecholamine and Spine Density in a Vascular Dementia Rat Model.","authors":"Hangzhou Ren, Zhongyuan Zhang, Jianwei Zhang","doi":"10.1177/15333175221144367","DOIUrl":"10.1177/15333175221144367","url":null,"abstract":"Objective: The present study aims to investigate the underlying neurochemical mechanism of physical exercise on striatum synapsis and memory function in vascular dementia model.Methods: 32 Sprague-Dawley (SD) rats were randomly divided into 4 groups: control group (C group, n = 6), vascular dementia group (Vascular dementia group, n = 7), physical exercise and vascular dementia group (Exe-VD group, n = 6), physical exercise and black group (Exe group, n = 6). 4 weeks of voluntary wheel running were used as pre-exercise training. Vascular dementia model was established by bilateral common carotid arteries occlusion (BCCAo) for 1 week. Passive avoidance test (PAT) were used to test memory function. The level of striatum catecholamine in the microdialysate were detected by enzyme linked immunosorbent assy (ELISA). Golgi staining was used to analyze striatum neuronal spine density.Results: Behavioral data indicated that 4 weeks of physical exercise ameliorated memory impairment in vascular dementia model. Striatum catecholamine level significantly decreased in VD group when compared with C group (P < .001). But this phenomenon can be rescue by physical exercise (P < .001). In addition, compared with C group, neuronal spine density significantly decreased in VD group (P < .01), but 4 weeks of physical exercise can rescue this phenomenon (P < .05).Conclusion: 4 weeks of physical exercise improves memory function by mitigate the decline of striatum catecholamine and spine density in VD model.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10670284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening of Crucial Differentially-Methylated/Expressed Genes for Alzheimer's Disease. 筛查阿尔茨海默病的关键差异甲基化/表达基因

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221116220

Haiyuan Qiu, Qiuyan Weng

{"title":"Screening of Crucial Differentially-Methylated/Expressed Genes for Alzheimer's Disease.","authors":"Haiyuan Qiu, Qiuyan Weng","doi":"10.1177/15333175221116220","DOIUrl":"10.1177/15333175221116220","url":null,"abstract":"Background: We aimed to make an integrated analysis of published transcriptome and DNA methylation dataset to ascertain the key differentially methylated and differentially expressed genes for Alzherimer's disease (AD). Methods: Two gene expression microarrays and 1 gene methylation microarray were downloaded for identification of differentially expressed genes and differentially methylated genes. Then, we used various biological information databases to annotate the functions of the differentially-methylated/expressed genes, and screen out key genes and important signaling pathways. Finally, we validate the differentially-methylated/expressed genes in the additional online datasets and in blood from AD patients.Results: A total of 8 hub hypomethylated-high expression genes were obtained, including Rac family small GTPase 2, FGR proto-oncogene, Src family tyrosine kinase, LYN proto-oncogene, Src family tyrosine kinase, protein kinase C delta, myosin IF, integrin subunit alpha 5, semaphorin 4D, and growth arrest specific protein 7. Some enriched signaling pathways of hypomethylated-high expression genes were identified, including regulation of actin cytoskeleton, chemokine signaling pathway, Fc gamma R-mediated phagocytosis, and axon guidance. Conclusion: Differentially-methylated/expressed genes are likely to be associated with AD.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40515481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Willingness to Help People With Dementia Symptoms Among Four Occupation Practitioners in Macao. 澳門四名職業治療師對協助有老年癡呆症症狀人士的意願。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221139172

Sok Leng Che, Jianwei Wu, Yao-Chen Chuang, Iat Kio Van, Sok Man Leong

{"title":"The Willingness to Help People With Dementia Symptoms Among Four Occupation Practitioners in Macao.","authors":"Sok Leng Che, Jianwei Wu, Yao-Chen Chuang, Iat Kio Van, Sok Man Leong","doi":"10.1177/15333175221139172","DOIUrl":"10.1177/15333175221139172","url":null,"abstract":"Background: Dementia-friendly community has been promoted in Macao since 2016. There is no study investigating the understanding of nor attitudes towards dementia among public contact staff in Macao. This study aimed to (i) understand the level of knowledge of dementia, (ii) examine the attitudes towards people living with dementia, and (iii) explore the associated factors of the willingness to help people with dementia symptoms among police officers, bank officers, bus drivers, and building superintendents.Methods: A cross-sectional survey was conducted between January and May 2019 using a structured questionnaire.Results: A total of 351 valid questionnaires were received. Building superintendents had more knowledge while police officers and bank officers had more positive attitudes. All practitioners were more willing to help people with dementia symptoms when they were on official duty. Participants who had more knowledge about dementia were associated with a higher willingness to help people with dementia symptoms.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10375071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Tree Drawing Test in Evolution: An Explorative Longitudinal Study in Alzheimer's Disease. 进化中的树图测试：阿尔茨海默病的探索性纵向研究

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221129381

Michelangelo Stanzani Maserati, Marialaura Matacena, Flavia Baccari, Corrado Zenesini, Roberto Gallassi, Sabina Capellari, Corrado Matacena

{"title":"The Tree Drawing Test in Evolution: An Explorative Longitudinal Study in Alzheimer's Disease.","authors":"Michelangelo Stanzani Maserati, Marialaura Matacena, Flavia Baccari, Corrado Zenesini, Roberto Gallassi, Sabina Capellari, Corrado Matacena","doi":"10.1177/15333175221129381","DOIUrl":"10.1177/15333175221129381","url":null,"abstract":"Objective: To study the evolution of the Tree Drawing Test (TDT) in a group of Alzheimer's disease (AD) patients.Methods: A total of 33 AD patients were consecutively evaluated by Mini Mental State Evaluation (MMSE) and TDT. The evolution of the TDT parameters, trunk-to-crown (TC) and space occupation (SO) index, were analyzed.Results: The median age at first visit was 79 years. Globally, trees drawn by patients showed an evolution characterized by a progressive reduction of the crown compared to the trunk. TC index showed a significant linear growth change (2.52 points per year) while SO index did not significantly increase. No significant associations were found examining the relations between MMSE and TC and SO index.Conclusions: TDT could represent a complementary technique to the main neuropsychological screening tests for orienting cognitive impairment diagnosis and an aid in following the evolution of cognitive impairment over time in AD patients.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10435478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Correlations Between Serum Hcy Level and Seizures and Cognitive Function in Patients After Stroke. 脑卒中后患者血清 Hcy 水平与癫痫发作和认知功能的关系

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221146738

Chen Lan, Zhiqiang Huang, Xinxin Luo, Yongcheng Zhang

{"title":"The Correlations Between Serum Hcy Level and Seizures and Cognitive Function in Patients After Stroke.","authors":"Chen Lan, Zhiqiang Huang, Xinxin Luo, Yongcheng Zhang","doi":"10.1177/15333175221146738","DOIUrl":"10.1177/15333175221146738","url":null,"abstract":"Backgrounds: Post-stroke cognitive dysfunction (PSCI), a set of illnesses ranging from moderate cognitive impairment to dementia, which is one of the most prevalent consequences following a stroke. Homocysteine (Hcy) has been related to a number of neurological and systemic diseases. It's also a known risk factor for cardiovascular disease and systemic atherosclerosis (CVD). The link between Hcy and PSCI, on the other hand, is unknown.Methods: Our hospital evaluated 325 patients with acute cerebral infarction between January 1, 2018 and December 1, 2021. There are biological markers and baseline data available. Patients were divided into two groups based on the results of the Montreal Cognitive Assessment (MoCA). The researchers performed logistic regression analysis to find variables that may be linked to PSCI.Results: HCY levels were significantly higher in PSCI patients than in non-PSCI patients. Age, education, seizure manifestation, and income level were all shown to be independent risk variables for PSCI in a multivariate logistic analysis. Hcy levels in PSCI patients differed considerably between the high and low groups. The high and low Hcy levels groups had significantly varied hypertension histories and urine levels. Hcy levels in PSCI patients differed considerably between the high and low groups. The high and low Hcy levels groups had significantly varied hypertension histories and urine levels.Conclusion: Serum Hcy levels have been linked to PSCI in post-stroke patients, and researchers believe that serum Hcy levels will diminish PSCI.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10615358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Dementia Development and COVID-19 among Individuals Who Tested Negative for COVID-19 in South Korea: A Nationwide Cohort Study. 在韩国COVID-19检测呈阴性的个体中，痴呆症发展与COVID-19之间的关系:一项全国性队列研究

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175211072387

Namwoo Kim, Sungtaek Son, Saemina Kim, Jieun Lee, Yong Min Ahn, Dong Keon Yon, Bong-Jin Hahm

{"title":"Association Between Dementia Development and COVID-19 among Individuals Who Tested Negative for COVID-19 in South Korea: A Nationwide Cohort Study.","authors":"Namwoo Kim, Sungtaek Son, Saemina Kim, Jieun Lee, Yong Min Ahn, Dong Keon Yon, Bong-Jin Hahm","doi":"10.1177/15333175211072387","DOIUrl":"https://doi.org/10.1177/15333175211072387","url":null,"abstract":"We aim to assess whether the number of newly diagnosed dementia increases and whether comorbid psychiatric symptoms of patients with dementia worsen, in people who were tested for COVID-19. We used electronic medical records from a nationwide cohort consisting of people who tested positive (positive group), tested negative (negative group), and those who did not receive the test (control group) for COVID-19. For people with neither a history of dementia nor mild cognitive disorder (MCI), the negative group was more likely to develop dementia than the control group, and less likely to develop MCI than the positive group. For people who already had dementia, the negative group was more likely to develop comorbid psychiatric disorders than the control group, but less likely than the positive group. These findings suggest the necessity of managing mental health not only for patients with COVID-19 but also for people who tested negative for COVID-19.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/2c/10.1177_15333175211072387.PMC8905049.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39698707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4