American Journal of Alzheimers Disease and Other Dementias最新文献

{"title":"Effect of Multiple Medicines on Dementia Initial Treatment: Experience and Thinking.","authors":"Jinghuan Gan, Meng Wang, Shuai Liu, Zhichao Chen, Xiao-Dan Wang, Yong Ji","doi":"10.1177/15333175211053134","DOIUrl":"10.1177/15333175211053134","url":null,"abstract":"<p><p>Little is known about multiple medicines and initial therapy among people with dementia. To examine the effect of multiple medicines on the initiation of anti-dementia therapy in patients diagnosed with cognitive impairment (CI), a retrospective study with 2742 CI patients was conducted based on the outpatients' medical records. The dementias receiving 1-2 drugs were more likely to be prescribed with anti-dementia (one drug: OR = 1.877; two drugs: OR = 1.770) and psychotropic (one drug: OR = 1.980) treatment, whereas had lower chances of receiving psychotropic medication with the combinations of more than three drugs (Alzheimer's disease: OR = .365; vascular dementia: OR = .940; frontotemporal lobe degeneration: OR = .957; and dementia with Lewy bodies/Parkinson's disease dementia: OR = .952). Multiple medicines can affect anti-dementia therapy initiation in dementia patients and should be paid extreme caution.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"36 ","pages":"15333175211053134"},"PeriodicalIF":3.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10535457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontotemporal Dementia and Suicide; Could Genetics be a Key Factor?","authors":"Rachel Fremont,&nbsp;Jordan Grafman,&nbsp;Edward D Huey","doi":"10.1177/1533317520925982","DOIUrl":"https://doi.org/10.1177/1533317520925982","url":null,"abstract":"Frontotemporal dementia (FTD) is a neurodegenerative syndrome characterized by degenerative changes in behavior, executive function, and/or language that are accompanied by volume loss in frontal and anterior temporal brain regions. Neuropsychiatric symptoms are a prominent feature of this disorder and can include apathy, behavioral disinhibition, loss of empathy, compulsive behaviors, and others. Overall frequency of formal current or past psychiatric disorder diagnosis is not thought to be increased in patients with FTD although this is somewhat controversial. Regarding depression, a meta-analysis in 2015 exploring the prevalence of depressive symptoms in FTD found that depressed mood is likely elevated in patients compared to healthy age matched controls and as prevalent in FTD as in other dementias including Alzheimer disease, vascular dementia, and dementia with Lewy bodies. Also, it is known that patients with dementia have a 3 to 10-fold increased risk of death by suicide. However, there have been few studies examining the prevalence of suicidality in FTD patients specifically. Addressing this knowledge gap, a recent paper reported that patients with behavioral variant frontotemporal dementia (bvFTD) have significantly elevated suicidal ideation and suicide attempts when compared to healthy age and education matched controls. An earlier 2014 retrospective study of suicidal behavior in FTD patients similarly reported that suicidal behaviors were increased in FTD patients when compared to age and gender matched controls. However, both of these studies focused on patients with significant dementia and did not explore whether genetics might play a role in suicidality of FTD patients. We wondered whether a similar increase in suicidality would be present in early/prodromal FTD patients with MAPT mutations that result in behavioral variant (bv)FTD with a high prevalence. We performed structured clinical psychiatric interviews on 12 prodromal MAPT mutation carriers, CDR 1⁄4 0 to 0.5, and 46 control nonmutation carriers from the same families. We found that 8% of MAPT mutation carriers (1/12) had suicidal ideation in their lifetime, whereas 15% of control nonmutation carriers (7/46) from the same families had a lifetime history of suicidal ideation; 8% of MAPT mutation carriers (1/12) and 7% of control nonmutation carriers (3/46) reported current suicidal ideation. We were also interested in examining suicidality in patients who met full criteria for FTD in an independent and North American sample and so we examined suicidality measures on the Personality Assessment Inventory in 21 patients with sporadic FTD (n 1⁄4 18 bvFTD and n 1⁄4 3 primary progressive aphasia) enrolled in an ongoing study at National Institutes of Health / National Institute of Neurological Disorders and Stroke (NIH/NINDS). These participants had mild to moderate FTD (mean Mattis Dementia Rating Scale 2 scores were 123 with a standard deviation of 10 for the bvFTD, and 110 wit","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"35 ","pages":"1533317520925982"},"PeriodicalIF":3.4,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1533317520925982","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9406398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to Assess Executive Functions in a Low-Educated and Multicultural Population Using a Switching Verbal Fluency Test (the TFA-93) in Neurodegenerative Diseases?","authors":"Pauline Narme, Didier Maillet, Juliette Palisson, Hervé Le Clésiau, Christine Moroni, Catherine Belin","doi":"10.1177/1533317519833844","DOIUrl":"10.1177/1533317519833844","url":null,"abstract":"<p><p>Few neuropsychological tests are available to assess executive dysfunction in low-educated and multicultural populations. To address this issue, the TFA-93, a switching verbal fluency test to assess cognitive flexibility, was administered to 70 healthy controls, 57 patients with a clinical diagnosis of Alzheimer's disease, and 21 with a clinical diagnosis of a neurodegenerative disease associated with frontal disorders. Most of the participants were low-educated and nonnative French speakers. The TFA-93 comprises 2 categorical fluency tasks (animals and fruits) and a fluency task in which participants have to switch between animals and fruits. Correct responses and errors were collected, and a flexibility index expressed the switching cost. Results showed that correct responses were lower, and the switching cost was greater in both patient groups. In low-educated and multicultural populations, the TFA-93 seems to be a good alternative to assess flexibility compared to the standard neuropsychological tools based on academic abilities.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 7-8","pages":"469-477"},"PeriodicalIF":3.4,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37017512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purkinje Cells Pathology in Alzheimer's Disease.","authors":"Ioannis Mavroudis, Foivos Petridis, Dimitrios Kazis, Samuel N Njau, Vasiliki Costa, Stavros J Baloyannis","doi":"10.1177/1533317519859200","DOIUrl":"10.1177/1533317519859200","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is one of the main causes of dementia in senium and presenium. It is clinically characterized by memory impairment, deterioration of intellectual faculties, and loss of professional skills. The cerebellum is a critical part in the distributed neural circuits participating not only in motor function but also in autonomic, limbic, and cognitive behaviors. In present study, we aim to investigate the morphological changes in the Purkinje cells in different cerebellar regions in AD and to correlate them with the underlying AD pathology. Purkinje cells exhibit significant morphometric alterations in AD and prominently in the anterior lobe which is related to higher cognitive functions. The present study gives new insights into the cerebellar pathology in AD and confirms that Purkinje cells pathology is a key finding in AD brains and that AD is characterized by regional-specific atrophy picked in the anterior cerebellar lobe.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 7-8","pages":"439-449"},"PeriodicalIF":3.4,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37376285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Severity of Neuropsychiatric Symptoms in Early- Versus Late-Onset Alzheimer's Disease.","authors":"Sarah Baillon, Amy Gasper, Frances Wilson-Morkeh, Megan Pritchard, Amala Jesu, Latha Velayudhan","doi":"10.1177/1533317519841191","DOIUrl":"10.1177/1533317519841191","url":null,"abstract":"<p><strong>Background: </strong>The study aimed to compare neuropsychiatric symptoms (NPS) in people with early-onset Alzheimer's disease (EOAD) and late-onset AD (LOAD).</p><p><strong>Methods: </strong>Fifty-six participants with LOAD and 24 participants with EOAD having mild dementia were assessed for NPS for their frequency, severity, and caregiver distress as measured by Neuropsychiatry Inventory (NPI) along with assessments of cognition and functional dependence.</p><p><strong>Results: </strong>Participants with EOAD and LOAD were not significantly different for total NPI score (<i>P</i> = .057). Early-onset Alzheimer disease had greater prevalence of all the NPS except apathy. Participants with EOAD were significantly worse on anxiety (<i>P</i> = .03), irritability (<i>P</i> = .01), and sleep (<i>P</i> < .01) subscales and their carers significantly more distressed by their irritability (<i>P</i> = .002) and sleeping patterns (<i>P</i> = .005). Regression analysis showed that higher NPI score was associated with longer duration of illness in EOAD and higher functional dependence in LOAD.</p><p><strong>Conclusions: </strong>The NPS severity was similar between EOAD and LOAD although EOAD had higher symptom prevalence and carer distress.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 7-8","pages":"433-438"},"PeriodicalIF":3.4,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37285660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Dementia Among Older Patients: A Hospital-Based Study in Iran.","authors":"Leila Kamalzadeh, Moein Moghaddamnia, Seyed Kazem Malakouti, Vahid Rashedi, Sara Bahrampour, Niloufar Sharifi, Mina Talebi, Farzad Sina, Behnam Shariati","doi":"10.1177/1533317519848234","DOIUrl":"10.1177/1533317519848234","url":null,"abstract":"<p><strong>Background: </strong>Dementia constitutes a public health hazard in developing countries. The aim of this study was to evaluate the prevalence of dementia and its associated factors in older hospitalized patients.</p><p><strong>Methods: </strong>The participants of this cross-sectional study consisted of older patients admitted to medical wards in Rasoul-e Akram hospital in Tehran, Iran. Mini-Mental State Examination, Mini-Cog test, Geriatric Depression Scale, Activities of Daily Living-Instrumental Activities of Daily Living (ADL-IADL) scale, and socioeconomic questionnaires were used.</p><p><strong>Results: </strong>A total of 205 elderly inpatients were included. The mean age was 71.33 ± 7.35 years; 63.4% of the participants had normal cognitive function, while 36.6% had some degree of cognitive impairment. There was a statistically significant relationship between gender, age, number of children, and occupation and the prevalence of dementia.</p><p><strong>Conclusion: </strong>Appropriate cognitive screening of older patients upon admission to hospitals could help identify potential adverse events and enhance the quality of care for patients with comorbid dementia.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 7-8","pages":"500-506"},"PeriodicalIF":3.4,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37217905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone-Based Interventions to Foster Simple Activity and Personal Satisfaction in People With Advanced Alzheimer's Disease.","authors":"Giulio E Lancioni, Nirbhay N Singh, Mark F O'Reilly, Jeff Sigafoos, Fiora D'Amico, Barbara Turnone, Dominga Laporta, Antonella Scordamaglia, Katia Pinto","doi":"10.1177/1533317519844144","DOIUrl":"10.1177/1533317519844144","url":null,"abstract":"<p><strong>Objectives: </strong>This study assessed a smartphone-based program to promote practical and mildly demanding arm responses and personal satisfaction and increase physical exertion (heart rates) in people with advanced Alzheimer's disease.</p><p><strong>Methods: </strong>The program relied on a Samsung Galaxy A3 smartphone with Android 6.0 operating system. Two groups of 10 and 11 participants, respectively, were assigned different responses (ie, placing cards into an elevated box and moving bottles with water from a table into a container). Responses activated the smartphone, which produced brief periods of preferred stimulation. Lack of responding led the smartphone to produce a verbal prompt.</p><p><strong>Results: </strong>All participants had significant increases in independent response frequencies, level of personal satisfaction, and heart rates during program sessions as opposed to baseline or control sessions.</p><p><strong>Conclusion: </strong>A smartphone-based program may help people with advanced Alzheimer's disease increase independent occupation with possible benefits in terms of satisfaction and physical condition.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 7-8","pages":"478-485"},"PeriodicalIF":3.4,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37175918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Coexisting Overactive Bladder in Medicare Patients With Dementia on Clinical and Economic Outcomes.","authors":"Eleanor O Caplan, Ibrahim M Abbass, Brandon T Suehs, Daniel B Ng, Katherine Gooch, Derek van Amerongen","doi":"10.1177/1533317519841164","DOIUrl":"10.1177/1533317519841164","url":null,"abstract":"<p><strong>Background: </strong>Patients with dementia commonly suffer from symptoms of overactive bladder (OAB); however, limited research exists on the clinical impact of coexisting OAB among patients with dementia. As such, the objective of this study was to examine the impact of OAB on clinical outcomes, health-care resource use, and associated costs among patients with dementia.</p><p><strong>Methods: </strong>We conducted a retrospective cohort analysis of patients with dementia using 3861 matched pairs of patients with and without OAB. Analyses were based on administrative claims data from January 1, 2007, to September 30, 2015, and compared clinical outcomes, health services use, and associated costs.</p><p><strong>Results: </strong>Patients with dementia and OAB were more likely than those without OAB to have least one fall (incidence rate ratio [IRR]: 1.43, 95% confidence interval [CI], 1.22-1.68, <i>P</i> < .001), fracture (IRR: 1.23, 95% CI, 1.05-1.44, <i>P</i> = .008), combined fall/fracture (IRR: 1.25, 95% CI, 1.11-1.42, <i>P</i> < .001), or urinary tract infection (IRR: 2.75, 95% CI, 2.55-2.96, <i>P</i> < .001). Patients with dementia and OAB demonstrated greater utilization of all-cause encounter types compared to similar patients without coexisting OAB (<i>P</i> < .01). All-cause and dementia-related total health-care costs were approximately 23% (95% CI, 0.19-0.28, <i>P</i> < .001) and 13% (95% CI, 0.05-0.20, <i>P</i> = .001), respectively, greater than similar patients without coexisting OAB.</p><p><strong>Conclusion: </strong>Coexisting OAB was associated with impacts on clinical outcomes, health-care resource utilization, and costs in patients with dementia.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 7-8","pages":"492-499"},"PeriodicalIF":3.4,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37300198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of General Practitioner Assessment of Cognition in Chinese Elders Aged 80 and Older.","authors":"Fang Xu, Juan Juan Ma, Fei Sun, Jaewon Lee, David W Coon, Qiang Xiao, Yong Huang, Lei Zhang, Zhi Hou Liang","doi":"10.1177/1533317519860333","DOIUrl":"10.1177/1533317519860333","url":null,"abstract":"<p><strong>Objectives: </strong>This study examined the efficacy of the General Practitioner Assessment of Cognition-Chinese version (GPCOG-C) in screening dementia and mild cognitive impairment (MCI) among older Chinese.</p><p><strong>Methods: </strong>Survey questionnaires were administered to 293 participants aged 80 or above from a university hospital in mainland China. Alzheimer disease and MCI were diagnosed in light of the National Institute on Aging and the Alzheimer's Association (NIA/AA) criteria. The sensitivity and specificity of GPCOG-C and Mini-Mental State Examination (MMSE) in screening dementia and MCI were compared to the NIA/AA criteria.</p><p><strong>Results: </strong>The GPCOG-C had the sensitivity of 62.3% and specificity of 84.6% in screening MCI, which had comparable efficacy as the NIA/AA criteria. In screening dementia, GPCOG-C had a lower sensitivity (63.7%) than the MMSE and a higher specificity (82.6%) higher than the MMSE.</p><p><strong>Conclusions: </strong>The GPCOG-C is a useful and efficient tool to identify dementia and MCI in older Chinese in outpatient clinical settings.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 7-8","pages":"523-529"},"PeriodicalIF":3.4,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37111980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Implementation of Dementia Care Mapping in a Randomized Controlled Trial in Long-Term Care: Results of a Process Evaluation.","authors":"Claire A Surr, Alys W Griffiths, Rachael Kelley, Ivana Holloway, Rebecca E A Walwyn, Adam Martin, Joanne McDermid, Lynn Chenoweth, Amanda J Farrin","doi":"10.1177/1533317519845725","DOIUrl":"10.1177/1533317519845725","url":null,"abstract":"<p><p>This study explored intervention implementation within a pragmatic, cluster randomized controlled trial of Dementia Care Mapping™ (DCM) in UK care homes. DCM is a practice development tool comprised of a 5 component cycle (staff briefing, mapping observations, data analysis and reporting, staff feedback, and action planning) that supports delivery of person-centered care. Two staff from the 31 intervention care homes were trained in DCM and asked to deliver 3 cycles over a 15-month period, supported by a DCM expert during cycle 1. Implementation data were collected after each mapping cycle. There was considerable variability in DCM implementation fidelity, dose, and reach. Not all homes trained 2 mappers on schedule, and some found it difficult to retain mappers. Only 26% of homes completed more than 1 cycle. Future DCM trials in care home settings should consider additional methods to support intervention completion including intervention delivery being conducted with ongoing external support.</p>","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 6","pages":"390-398"},"PeriodicalIF":3.4,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37211753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}