Prevalence and Severity of Neuropsychiatric Symptoms in Early- Versus Late-Onset Alzheimer's Disease.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-11-01 Epub Date: 2019-04-01 DOI:10.1177/1533317519841191

Sarah Baillon, Amy Gasper, Frances Wilson-Morkeh, Megan Pritchard, Amala Jesu, Latha Velayudhan

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引用次数: 0

Abstract

Background: The study aimed to compare neuropsychiatric symptoms (NPS) in people with early-onset Alzheimer's disease (EOAD) and late-onset AD (LOAD).

Methods: Fifty-six participants with LOAD and 24 participants with EOAD having mild dementia were assessed for NPS for their frequency, severity, and caregiver distress as measured by Neuropsychiatry Inventory (NPI) along with assessments of cognition and functional dependence.

Results: Participants with EOAD and LOAD were not significantly different for total NPI score (P = .057). Early-onset Alzheimer disease had greater prevalence of all the NPS except apathy. Participants with EOAD were significantly worse on anxiety (P = .03), irritability (P = .01), and sleep (P < .01) subscales and their carers significantly more distressed by their irritability (P = .002) and sleeping patterns (P = .005). Regression analysis showed that higher NPI score was associated with longer duration of illness in EOAD and higher functional dependence in LOAD.

Conclusions: The NPS severity was similar between EOAD and LOAD although EOAD had higher symptom prevalence and carer distress.

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早发与晚发阿尔茨海默病的神经精神症状发生率和严重程度

背景：该研究旨在比较早发型阿尔茨海默病（EOAD）和晚发型阿尔茨海默病（LOAD）患者的神经精神症状（NPS）：该研究旨在比较早发性阿尔茨海默病（EOAD）和晚发性阿尔茨海默病（LOAD）患者的神经精神症状（NPS）：对56名轻度痴呆症阿尔茨海默病（LOAD）患者和24名中度痴呆症阿尔茨海默病（EOAD）患者进行了神经精神症状（NPS）的频率、严重程度和护理者痛苦的评估，评估采用神经精神症状量表（NPI）以及认知和功能依赖评估：结果：EOAD 和 LOAD 患者的 NPI 总分无明显差异（P = .057）。除冷漠外，早发性阿尔茨海默病患者的所有 NPS 患病率都更高。EOAD患者的焦虑（P = .03）、烦躁（P = .01）和睡眠（P < .01）分量表明显更差，而他们的照顾者则因他们的烦躁（P = .002）和睡眠模式（P = .005）而明显更苦恼。回归分析表明，NPI得分越高，EOAD的病程越长，LOAD的功能依赖性越高：结论：EOAD 和 LOAD 的 NPS 严重程度相似，但 EOAD 的症状发生率和照顾者的痛苦程度更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Alzheimers Disease and Other Dementias GERIATRICS & GERONTOLOGY-CLINICAL NEUROLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).