American Journal of Alzheimers Disease and Other Dementias最新文献_第3页

Usability and Acceptability of Social Robot Pets Among Community-Dwelling Veterans Living With Dementia and Their Caregivers. 社区老年痴呆退伍军人及其护理人员社交机器人宠物的可用性和可接受性。

IF 2.7 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI: 10.1177/15333175231200973

Melissa L Harris-Gersten, Judith M Davagnino, Edwin R Alcorn, S Nicole Hastings

{"title":"Usability and Acceptability of Social Robot Pets Among Community-Dwelling Veterans Living With Dementia and Their Caregivers.","authors":"Melissa L Harris-Gersten, Judith M Davagnino, Edwin R Alcorn, S Nicole Hastings","doi":"10.1177/15333175231200973","DOIUrl":"10.1177/15333175231200973","url":null,"abstract":"Social robot pets promote engagement and psychosocial well-being among older adults, yet little is known about their use among community-dwelling Veterans living with dementia. This programmatic evaluation used a within subjects, pre-post design to examine the usability (frequency of use, frequency of caregiver reminders) and acceptability (benefit, satisfaction) of social robot pets among Veterans with dementia (N = 20). An intervention usability and acceptability tool was completed by telephone with family caregivers 3 months after delivery of the pet to the home. Overall, 80% of Veterans used the pet often or daily, while 7 caregivers provided reminders for the Veteran to use the pet. Caregivers indicated that Veterans experienced benefit with the pet, as well themselves. Regarding satisfaction, 89% reported they would recommend a social robot pet to others. Research is needed to expand generalizability, evaluate effects on outcomes, and enhance implementation of social robot pets among Veteran families with dementia.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10557925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dendrobium Nobile Polysaccharides Attenuates Ferroptosis and Improves Cognitive Function in Vascular Dementia Rats. 石斛多糖减轻血管性痴呆大鼠的铁下垂并改善其认知功能。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI: 10.1177/15333175231185236

Min Ming, Weihua Hu, Gaosheng Xie, Jianping Chen, Ying Huang

{"title":"Dendrobium Nobile Polysaccharides Attenuates Ferroptosis and Improves Cognitive Function in Vascular Dementia Rats.","authors":"Min Ming, Weihua Hu, Gaosheng Xie, Jianping Chen, Ying Huang","doi":"10.1177/15333175231185236","DOIUrl":"10.1177/15333175231185236","url":null,"abstract":"Introduction: To investigate the neuroprotective effect and mechanism of Dendrobium nobile polysaccharide (DNP) on vascular dementia (VD) rats.Methods: VD model rats were prepared by permanent ligation of bilateral common carotid arteries. Cognitive function was tested by morris water maze test, mitochondrial morphology and ultrastructure of hippocampal synapses were tested by transmission electron microscopy, GSH, xCT, GPx4, and PSD-95 expressions were tested by western blot and PCR.Results: The number of platform crossing was significantly increased, and the escape latency was significantly shorter in DNP group. The expressions of GSH, xCT and GPx4 in the hippocampus were up-regulated in DNP group. Moreover, the synapses of DNP group were relatively intact and synaptic vesicles increased, the length of synaptic active zone and PSD thickness were significantly increased, and PSD-95 protein expression was significantly up-regulated compared VD group.Conclusion: DNP may take a neuroprotective effect by inhibiting ferroptosis in VD.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10050249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between Abdominal Obesity, Chewing Difficulty and Cognitive Impairment in Dementia-Free Chinese Elderly. 中国无痴呆老年人腹部肥胖、咀嚼困难与认知障碍的关系。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI: 10.1177/15333175231167118

Ziyue Sheng, Binte Xia, Jing Wu, Xuhao Zhao, Xindi He, Xu Wen, Changzheng Yuan, Ting Pang, Xin Xu

{"title":"Associations Between Abdominal Obesity, Chewing Difficulty and Cognitive Impairment in Dementia-Free Chinese Elderly.","authors":"Ziyue Sheng, Binte Xia, Jing Wu, Xuhao Zhao, Xindi He, Xu Wen, Changzheng Yuan, Ting Pang, Xin Xu","doi":"10.1177/15333175231167118","DOIUrl":"10.1177/15333175231167118","url":null,"abstract":"Objective: To investigate the independent and synergistic associations between abdominal obesity, chewing difficulty and cognitive impairment in a community-dwelling older adults sample in China.Methods: Cognitive function was measured by the 5 min- Montreal Cognitive Assessment (5 min-MoCA) and abdominal obesity was measured by A Body Shape Index (ABSI) in 572 participants recruited from local communities. Chewing difficulty was assessed via a self-report questionnaire. Linear regression and general logistic regression were performed to investigate the association of chewing difficulty and abdominal obesity with cognition.Results: Chewing difficulty score [β (95% CI) = -.30 (-.49, -.11)] and ABSI [β (95%CI) = -.30 (-.55, -.05)] were independently associated with worse performance on the 5 min-MoCA. Whilst ABSI was not associated with cognitive impairment, the co-existence of chewing difficulty and abdominal obesity [OR (95% CI) = 2.22 (1.18, 4.17)] was found associated with the presence of cognitive impairment.Conclusion: Chewing difficulty and abdominal obesity were independently associated with cognition. Abdominal obesity and chewing may have an additive effect on cognitive function.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9491306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Psychometric Evaluation of a Chinese Instrument of Knowledge, Attitude and Preventive Practice on Dementia Care in Macao. 澳门失智症护理知识、态度和预防实践中文工具的开发和心理计量学评估。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI: 10.1177/15333175221149358

Sio Mui Wong, Wen Zeng, Iek Long Lo, Chong Lam, Hong Lei Lou

{"title":"Development and Psychometric Evaluation of a Chinese Instrument of Knowledge, Attitude and Preventive Practice on Dementia Care in Macao.","authors":"Sio Mui Wong, Wen Zeng, Iek Long Lo, Chong Lam, Hong Lei Lou","doi":"10.1177/15333175221149358","DOIUrl":"10.1177/15333175221149358","url":null,"abstract":"Background: Very few instruments to integrate knowledge, attitude and practice into dementia care as a holistic perspective were available to the Chinese.Method: This article documented the development of a 30-item self-administered Chinese instrument of knowledge, attitude and preventive practice on dementia care and reported the results of psychometric testing among 1500 Chinese in Macao Special Administrative Region (SAR), including 234 primary health professionals, 272 staff working at day-care centers and nursing homes, 586 high school students and 408 community-dwelling older people. The Chinese instrument was developed through literature review and committee review. The psychometric methods were used to evaluate the reliability and validity of the Chinese instrument as measures of knowledge, attitude and preventive practice on dementia care for the Chinese.Results: The preliminary results indicated that the Content Validity Index of the Chinese instrument was .973 and Cronbach's alpha coefficient of the Chinese instrument was .842, among which Knowledge subscale, Attitude subscale and Preventive Practice subscale were .749, .633 and .845 respectively. The means and standard deviation were 65.13 ± 24.56 for Knowledge subscale, 74.76 ± 8.37 for Attitude subscale, 73.22 ± 14.05 for Preventative Practice subscale, and 70.99 ± 11.27 for the Chinese instrument.Conclusion: The 30-item self-administered Chinese instrument of knowledge, attitude and preventive practice on dementia care had satisfied the psychometric evaluation well enough to warrant further use, and could also have particular implications for other Chinese populations all over the world.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10758318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Burden of Illness Among Patients with Psychosis due to Dementia with Lewy Bodies and Other Dementias. 路易体痴呆症和其他痴呆症所致精神病患者的疾病负担。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI: 10.1177/15333175231163521

Monica Frazer, Nazia Rashid, Scott Bunner, Ben Skoog, Victor Abler

{"title":"Burden of Illness Among Patients with Psychosis due to Dementia with Lewy Bodies and Other Dementias.","authors":"Monica Frazer, Nazia Rashid, Scott Bunner, Ben Skoog, Victor Abler","doi":"10.1177/15333175231163521","DOIUrl":"10.1177/15333175231163521","url":null,"abstract":"Limited research is available on the real-world experiences of patients with dementia with Lewy bodies (DLB). This study evaluated clinical events, healthcare utilization, and healthcare costs of patients with DLB vs other dementia types with psychosis (ODP). Study patients included commercial and Medicare Advantage with Part D enrollees aged ≥40 years with evidence of DLB and ODP from 6/01/2015‒5/31/2019. Compared with patients with ODP, more patients with DLB had clinical events including anticholinergic effects, neurologic effects, and cognitive decline. Patients with DLB used more healthcare resources with greater dementia-related office and outpatient visits and psychosis-related inpatient stays and office, outpatient, and emergency visits compared with their ODP patient counterparts. Patients with DLB also incurred higher healthcare costs for all-cause and dementia-related office visits and pharmacy fills, and psychosis-related total costs. Understanding the clinical and economic impact of DLB and ODP is important to improve care for patients with dementia.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9471866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Physical Exercise Program for Older Family Caregivers of Persons With Dementia. 体育锻炼计划对老年痴呆症家庭护理人员的影响。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI: 10.1177/15333175231178384

Ji-Yeon Kim, Sunghee H Tak, Jaegyeong Lee, Hyein Choi

引用次数: 0

Population-Based Studies in Dementia and Ageing Research: A Local and National Experience in Cambridgeshire and the UK. 基于人口的痴呆症和老龄化研究：剑桥郡和英国的地方和国家经验。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221104347

Carol Brayne, Yu-Tzu Wu

{"title":"Population-Based Studies in Dementia and Ageing Research: A Local and National Experience in Cambridgeshire and the UK.","authors":"Carol Brayne, Yu-Tzu Wu","doi":"10.1177/15333175221104347","DOIUrl":"10.1177/15333175221104347","url":null,"abstract":"Dementia has been recognised as a key challenge in many ageing societies across the world. Several population-based studies have been developed to investigate dementia and cognitive ageing from perspectives of biology, health, psychology and social sciences. However, there is a need to provide a better understanding of 'contexts', the circumstance where these ageing populations existed, and heterogeneity within and across the populations in different time and places. In this article, we summarise some examples of earlier population-based studies undertaken by our research groups in England and Wales and their contribution to the epidemiology of dementia, neuropathology, cognitive and mental health in older age. We also describe how these studies illustrated variation among ageing populations and changes in their health conditions across time and place. These findings highlight the contribution that population-based studies can make, along with the vital to incorporate contexts in ageing research. A lifecourse approach within social context is needed to integrate life experiences, social circumstances, and multiple dimensions of cognition, functioning, physical health and wellbeing over the ageing process. We also discuss how evidence from population-based studies can support various international initiatives on dementia, healthy ageing and Sustainable Development Goals and facilitate tailored approaches for diverse populations across global societies.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9151414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of the Late Onset alzheimer's Disease Associated HLA-DQA1/DRB1 Expression. 晚期阿尔茨海默病相关 HLA-DQA1/DRB1 表达的调控。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221085066

Xiaoyu Zhang, Meijaun Zou, Yuwei Wu, Danli Jiang, Ting Wu, Yihan Zhao, Di Wu, Jing Cui, Gang Li

{"title":"Regulation of the Late Onset alzheimer's Disease Associated HLA-DQA1/DRB1 Expression.","authors":"Xiaoyu Zhang, Meijaun Zou, Yuwei Wu, Danli Jiang, Ting Wu, Yihan Zhao, Di Wu, Jing Cui, Gang Li","doi":"10.1177/15333175221085066","DOIUrl":"10.1177/15333175221085066","url":null,"abstract":"(Genome-wide Association Studies) GWAS have identified ∼42 late-onset Alzheimer's disease (LOAD)-associated loci, each of which contains multiple single nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD) and most of these SNPs are in the non-coding region of human genome. However, how these SNPs regulate risk gene expression remains unknown. In this work, by using a set of novel techniques, we identified 6 functional SNPs (fSNPs) rs9271198, rs9271200, rs9281945, rs9271243, and rs9271247 on the LOAD-associated HLA-DRB1/DQA1 locus and 42 proteins specifically binding to five of these 6 fSNPs. As a proof of evidence, we verified the allele-specific binding of GATA2 and GATA3, ELAVL1 and HNRNPA0, ILF2 and ILF3, NFIB and NFIC, as well as CUX1 to these five fSNPs, respectively. Moreover, we demonstrate that all these nine proteins regulate the expression of both HLA-DQA1 and HLA-DRB1 in human microglial cells. The contribution of HLA class II to the susceptibility of LOAD is discussed.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9388756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cohort Profile: The Dementia Registry in Macao. 队列简介：澳门失智症资料库》。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175211067124

Sio Mui Wong, Wen Zeng, Iek Long Lo

引用次数: 0

The Influence of Dementia Beliefs and Knowledge on Perceived Dementia Worry: An Empirical Study Among Adults in Rural China. 痴呆信念和知识对痴呆忧虑感的影响：中国农村成年人的实证研究》。

IF 3.4 4区医学

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI: 10.1177/15333175221112143

Meng Liu, Fei Sun, Chuntian Lu, Jinchen Xie

引用次数: 0