The Correlations Between Serum Hcy Level and Seizures and Cognitive Function in Patients After Stroke.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI:10.1177/15333175221146738

Chen Lan, Zhiqiang Huang, Xinxin Luo, Yongcheng Zhang

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引用次数: 0

Abstract

Backgrounds: Post-stroke cognitive dysfunction (PSCI), a set of illnesses ranging from moderate cognitive impairment to dementia, which is one of the most prevalent consequences following a stroke. Homocysteine (Hcy) has been related to a number of neurological and systemic diseases. It's also a known risk factor for cardiovascular disease and systemic atherosclerosis (CVD). The link between Hcy and PSCI, on the other hand, is unknown.

Methods: Our hospital evaluated 325 patients with acute cerebral infarction between January 1, 2018 and December 1, 2021. There are biological markers and baseline data available. Patients were divided into two groups based on the results of the Montreal Cognitive Assessment (MoCA). The researchers performed logistic regression analysis to find variables that may be linked to PSCI.

Results: HCY levels were significantly higher in PSCI patients than in non-PSCI patients. Age, education, seizure manifestation, and income level were all shown to be independent risk variables for PSCI in a multivariate logistic analysis. Hcy levels in PSCI patients differed considerably between the high and low groups. The high and low Hcy levels groups had significantly varied hypertension histories and urine levels. Hcy levels in PSCI patients differed considerably between the high and low groups. The high and low Hcy levels groups had significantly varied hypertension histories and urine levels.

Conclusion: Serum Hcy levels have been linked to PSCI in post-stroke patients, and researchers believe that serum Hcy levels will diminish PSCI.

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脑卒中后患者血清 Hcy 水平与癫痫发作和认知功能的关系

背景：脑卒中后认知功能障碍（PSCI）是指从中度认知障碍到痴呆的一系列疾病，是脑卒中后最常见的后果之一。同型半胱氨酸（Hcy）与多种神经和系统疾病有关。它也是心血管疾病和全身性动脉粥样硬化（CVD）的已知风险因素。而 Hcy 与脑梗死之间的关系尚不清楚：我院对2018年1月1日至2021年12月1日期间的325例急性脑梗死患者进行了评估。有生物标记物和基线数据可用。根据蒙特利尔认知评估（MoCA）结果将患者分为两组。研究人员进行了逻辑回归分析，以寻找可能与PSCI相关的变量：PSCI患者的HCY水平明显高于非PSCI患者。在多变量逻辑分析中，年龄、教育程度、癫痫发作表现和收入水平均被证明是 PSCI 的独立风险变量。PSCI 患者的 Hcy 水平在高低组之间有很大差异。高 Hcy 水平组和低 Hcy 水平组的高血压病史和尿液水平差异显著。PSCI 患者的 Hcy 水平在高、低两组之间存在很大差异。结论：血清 Hcy 水平与高血压病史和尿液水平有关：结论：血清 Hcy 水平与脑卒中后患者的 PSCI 有关，研究人员认为血清 Hcy 水平会减轻 PSCI。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Alzheimers Disease and Other Dementias GERIATRICS & GERONTOLOGY-CLINICAL NEUROLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).