American Journal of Clinical Nutrition最新文献

{"title":"Dietary polyphenols and risk of breast cancer in a predominantly low-income population: a prospective analysis in the Southern Community Cohort Study (SCCS)","authors":"Lei Fan ,&nbsp;Landon T Fike ,&nbsp;Heather Munro ,&nbsp;Danxia Yu ,&nbsp;Hongwei Si ,&nbsp;Martha J Shrubsole ,&nbsp;Qi Dai","doi":"10.1016/j.ajcnut.2025.03.017","DOIUrl":"10.1016/j.ajcnut.2025.03.017","url":null,"abstract":"<div><h3>Background</h3><div>Few studies have examined the associations of specific dietary polyphenols with breast cancer (BC) risks or among non-Hispanic Black (NHB) female individuals in the United States.</div></div><div><h3>Objectives</h3><div>We aim to evaluate the associations between total and subclasses of polyphenol intake and BC risk, stratified by body mass index (BMI), estrogen receptor (ER)/progesterone receptor (PR) status, menopausal status, and racial and ethnic subgroups.</div></div><div><h3>Methods</h3><div>The study included 42,260 female participants from the Southern Community Cohort Study, a large prospective cohort of predominantly low-income NHB Americans. The dietary polyphenol components were assessed using a validated culturally sensitive 89-item food frequency questionnaire designed specifically for nutrient intakes in the South. Cox proportional hazards model was used to assess the associations after adjustment for confounders including sociodemographic and lifestyle factors.</div></div><div><h3>Results</h3><div>Intakes of total polyphenols were higher in non-Hispanic white (1122 ± 727 mg/d) than in NHB female individuals (535±349 mg/d). Intakes of total polyphenol, particularly phenolic acids, were associated with reduced risk of BC incidence among female individuals with the ER+ and PR+ BC type comparing the highest to the lowest quintile [hazard ratio (HR) 0.69; 95% confidence interval (CI): 0.51, 0.94; <em>P</em>_-trend = 0.003; HR 0.70; 95% CI: 0.53, 0.95; <em>P</em>_-trend = 0.005, respectively]. Phenolic acid was inversely related to BC among postmenopausal female individuals (HR 0.76; 95% CI: 0.59, 0.97; <em>P</em>_-trend = 0.02) and female individuals with a BMI ≥ 25 kg/m² (HR 0.77; 95% CI: 0.60, 0.98; <em>P</em>_-trend = 0.01) comparing the highest to the lowest quintile. Intakes of tyrosols were associated with increased risk of BC among NHB female individuals (HR 1.34; 95% CI: 1.03, 1.73; <em>P</em>_-trend = 0.01) and female individuals with a BMI ≥ 25 kg/m² (HR 1.31; 95% CI: 1.04, 1.65; <em>P</em>_-trend = 0.004).</div></div><div><h3>Conclusions</h3><div>In this predominantly low-income United States population, intakes of total polyphenol and phenolic acids were associated with reduced risk of BC among those with ER+ and PR+ BC type, postmenopausal, and female individuals with overweight/obesity.</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 6","pages":"Pages 1335-1345"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the acute and chronic effects of a multistrain probiotic supplement on cognitive function and mood in healthy older adults: a randomized controlled trial","authors":"Jessica Eastwood ,&nbsp;Saskia van Hemert ,&nbsp;Maria Stolaki ,&nbsp;Claire Williams ,&nbsp;Gemma Walton ,&nbsp;Daniel Lamport","doi":"10.1016/j.ajcnut.2025.04.002","DOIUrl":"10.1016/j.ajcnut.2025.04.002","url":null,"abstract":"<div><h3>Background</h3><div>Aging is associated with a decline in cognitive function and vulnerability to depression. Probiotic supplements have shown beneficial effects on cognition and mood in clinical populations, but the potential benefit for healthy older adults experiencing age-related decline in cognition remains unclear.</div></div><div><h3>Objectives</h3><div>The primary aim of the present work was to explore the effect of a chronic (long-term) multispecies probiotic intervention on cognition in healthy aging adults. Secondary aims included exploring the chronic effect on mood outcomes and gut microbiota community, as well as a novel investigation into the acute effect of supplementation on cognition and mood.</div></div><div><h3>Methods</h3><div>The study employed a randomized, placebo-controlled, cross-over trial in 30 healthy older adults to explore the acute (1 d) and chronic (8 wk) effects of a probiotic supplement on cognitive domains of memory and executive function, alongside mood measures of stress, anxiety, depression, and cognitive reactivity to sad mood. 16s rRNA sequencing of stool samples was also performed pre- and postchronic intervention to assess potential effects on the gut microbiota.</div></div><div><h3>Results</h3><div>Acute probiotic supplementation was associated with faster reaction times on cognitively demanding trials during a task of executive function [–64.91 ms, 95% confidence interval (CI): –115.70, –14.15]. Chronic supplementation was associated with improvement in cognitive biases such as hopelessness (–0.97, 95% CI: –1.72, –0.23), rumination (–1.58, 95% CI: –2.86, –0.29), and aggression (–1.57, 95% CI: –2.63, –0.51) that contribute to reactivity to sad mood and therefore vulnerability to depression, and may improve executive function under higher cognitive demand (0.43%, 95% CI: –0.53%, 1.38%).</div></div><div><h3>Conclusions</h3><div>The current work provides novel evidence for an acute effect of probiotics on reaction times during executive function, which should be replicated in future work. Additionally, this work replicates previous findings of improved cognitive reactivity to sad mood following chronic probiotic supplementation, indicating probiotics may reduce risk of developing depression in a healthy aging population.</div><div>This study was registered at clinicaltrials.gov as NCT04951687.</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 6","pages":"Pages 1268-1280"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Identifying cancer cachexia in patients without weight loss information: machine learning approaches to address a real-world challenge” Am J Clin Nutr 116 (2022) 1229–1239","authors":"Liangyu Yin ,&nbsp;Jiuwei Cui ,&nbsp;Xin Lin ,&nbsp;Na Li ,&nbsp;Yang Fan ,&nbsp;Ling Zhang ,&nbsp;Jie Liu ,&nbsp;Feifei Chong ,&nbsp;Chang Wang ,&nbsp;Tingting Liang ,&nbsp;Xiangliang Liu ,&nbsp;Li Deng ,&nbsp;Mei Yang ,&nbsp;Jiami Yu ,&nbsp;Xiaojie Wang ,&nbsp;Minghua Cong ,&nbsp;Zengning Li ,&nbsp;Min Weng ,&nbsp;Qinghua Yao ,&nbsp;Pingping Jia ,&nbsp;Hongxia Xu","doi":"10.1016/j.ajcnut.2025.02.005","DOIUrl":"10.1016/j.ajcnut.2025.02.005","url":null,"abstract":"","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 6","pages":"Page 1437"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary intake of polyunsaturated fatty acids, their food sources and fertility in females and males: a preconception prospective population-based cohort study","authors":"Mireille C Schipper ,&nbsp;Vincent WV Jaddoe ,&nbsp;Eline L Bekkers ,&nbsp;Annemarie GMGJ Mulders ,&nbsp;Romy Gaillard","doi":"10.1016/j.ajcnut.2025.04.006","DOIUrl":"10.1016/j.ajcnut.2025.04.006","url":null,"abstract":"<div><h3>Background</h3><div>Seafood, nuts, and seeds are key dietary sources of polyunsaturated fatty acids (PUFAs), which may benefit reproductive health.</div></div><div><h3>Objectives</h3><div>This study aims to investigate associations of periconception dietary intake of PUFA-rich foods and omega-3 and omega-6 PUFAs with fecundability and subfertility in females and males.</div></div><div><h3>Methods</h3><div>Among 830 females and 651 males, participating in a population-based prospective cohort study from preconception onwards, we assessed periconception dietary intake at median 12.4-wk gestation (95% range: 10.9, 18.4) and time to pregnancy via questionnaires. Fecundability was defined as the probability of conceiving within 1 mo and subfertility as time to pregnancy ≥12 mo or use of assisted reproductive technology. Cox proportional hazards and logistic regression were used to assess associations between PUFA(-rich foods) with fecundability and subfertility.</div></div><div><h3>Results</h3><div>In females, PUFA-rich food intake was not significantly associated with fertility. Higher omega-3 PUFA intake, especially docosahexaenoic acid and alpha-linolenic acid, but not omega-6 PUFA, was per standard deviation score (SDS) increase associated with increased fecundability and reduced subfertility. Strongest effects were observed for females in the highest quartile. A lower omega-6 to omega-3 PUFA ratio was associated with increased fecundability and lower subfertility risk [fecundability ratio (FR): 0.92, 95% confidence interval (CI): 0.87, 0.96; odds ratio (OR): 1.14, 95% CI: 1.02, 1.26, per unit increase in omega-6:omega-3 PUFA ratio]. In males, higher intake of nuts/seeds, but not seafood, was associated with increased fecundability and lower subfertility (FR: 1.10, 95% CI: 1.01, 1.20; OR: 0.78, 95% CI: 0.63, 0.97 per SDS increase in nuts/seeds). Strongest effects were present for those who consumed the highest amount. No associations were observed for omega-3 or omega-6 PUFA intake in males.</div></div><div><h3>Conclusions</h3><div>In females, higher dietary omega-3 PUFAs intake may benefit fertility. Increased nuts and seeds consumption may improve fertility in males, independent of PUFA intake. These findings suggest potential for gender-specific dietary interventions to support reproductive health.</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 6","pages":"Pages 1354-1364"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective: operation stork speed: strategies for reviewing and advising on infant formula","authors":"Steven A Abrams ,&nbsp;Nan Du","doi":"10.1016/j.ajcnut.2025.04.008","DOIUrl":"10.1016/j.ajcnut.2025.04.008","url":null,"abstract":"<div><div>A new federal initiative, called “Operation Stork Speed” has been proposed by the federal government to perform a comprehensive evaluation of infant formula regulation and safety in the United States. This initiative has the potential to update many aspects of infant formula content and evaluation but will require an extensive process including numerous federal agencies and the private sector. No single group, including the Food and Drug Administration, has the capacity to perform this evaluation independently, and no simplified process for obtaining public comments can adequately facilitate a comprehensive and unbiased review and recommendations.</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 6","pages":"Pages 1220-1223"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory and insulinemic dietary and lifestyle patterns and incidence of endometrial cancer: the multiethnic cohort","authors":"Talar S Habeshian ,&nbsp;Song-Yi Park ,&nbsp;David Conti ,&nbsp;Lynne R Wilkens ,&nbsp;Loïc Le Marchand ,&nbsp;Veronica Wendy Setiawan","doi":"10.1016/j.ajcnut.2025.04.020","DOIUrl":"10.1016/j.ajcnut.2025.04.020","url":null,"abstract":"<div><h3>Background</h3><div>The incidence of endometrial cancer (EC) is increasing, particularly among racial and ethnic minority groups. Obesity is an established EC risk factor, and obesity-related inflammation and hyperinsulinemia may play an important role in EC etiology.</div></div><div><h3>Objectives</h3><div>We examined the association of 5 empirical hypothesis-oriented dietary and lifestyle indices, which assess the inflammatory and insulinemic potentials of diet and lifestyle, with risk of EC in ethnically diverse females.</div></div><div><h3>Methods</h3><div>We included 60,441 female participants from the multiethnic cohort study, a cohort-based in the United States, who were African American, Japanese American, Latino, Native Hawaiian, or White, aged 45–75 y at baseline in 1993–1996. Using a quantitative food frequency questionnaire at baseline, we computed the empirical dietary inflammatory pattern (EDIP), empirical dietary index for hyperinsulinemia (EDIH), empirical lifestyle index for hyperinsulinemia (ELIH), empirical dietary index for insulin resistance (EDIR), and empirical lifestyle index for insulin resistance (ELIR). Multivariable Cox models adjusting for known risk factors for EC were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between each index (using quintiles) and EC risk.</div></div><div><h3>Results</h3><div>We identified 1328 incident EC cases with a median follow-up of 25.2 y (IQR = 7.4 y). Females with higher ELIH had an increased risk of EC (HR_Q5vsQ1 = 2.58, 95% CI: 2.16, 3.09; <em>P</em>_trend &lt; 0.01). Similarly, higher ELIR was significantly associated with an increased risk of EC (HR_Q5vsQ1 = 2.89, 95% CI: 2.37, 3.53; <em>P</em>_trend &lt; 0.01). EDIP, EDIH, and EDIR were not associated with EC risk. Increased risk of EC with ELIH (all <em>P</em>_trend &lt; 0.01) and ELIR (all <em>P</em>_trend &lt; 0.01) was found in all racial and ethnic groups.</div></div><div><h3>Conclusions</h3><div>In this ethnically diverse cohort, lifestyle patterns with higher insulinemic potential were associated with an increased risk of EC. Lifestyle changes that include more physical activity and achieving a healthy body weight, in addition to reducing insulinemic and diets, may lower EC risk.</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 6","pages":"Pages 1236-1245"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of immune function in individuals without and with obesity and normoglycemia, glucose intolerance, or type 2 diabetes: primary findings of the NutrIMM study, a single-arm controlled feeding trial","authors":"Jenneffer Rayane Braga Tibaes ,&nbsp;Maria Inês Barreto Silva ,&nbsp;Jessy Azarcoya-Barrera ,&nbsp;Paulina Blanco Cervantes ,&nbsp;Alexander Makarowski ,&nbsp;Laurie Mereu ,&nbsp;Caroline Richard","doi":"10.1016/j.ajcnut.2025.03.003","DOIUrl":"10.1016/j.ajcnut.2025.03.003","url":null,"abstract":"<div><h3>Background</h3><div>Obesity and type 2 diabetes (T2D) are associated with immune dysfunction, increasing infection susceptibility and impairing immune responses. However, the independent effects of obesity and hyperglycemia on immune dysregulation remain unclear, particularly under controlled dietary conditions.</div></div><div><h3>Objectives</h3><div>The Nutrition and Immunity study investigated the effects of obesity and hyperglycemia on immune cell function, phenotype, and systemic inflammation in individuals with obesity with or without T2D, compared with lean individuals with normoglycemia.</div></div><div><h3>Methods</h3><div>This single-arm controlled feeding trial included 112 participants across 4 groups: lean-normoglycemic (Lean-NG), obese-normoglycemic (OB-NG), obese-glucose intolerant (OB-GI), and obese-T2D. Participants followed a standardized isocaloric North American diet for 4 wk. Blood samples were collected at baseline and week 4. One-way and repeated measures analysis of variance assessed group differences and/or dietary effects. Linear regression analyses examined associations between glucose control and immune function.</div></div><div><h3>Results</h3><div>C-reactive protein levels were higher in the OB-NG group [mean difference (MD): 4.1 mg/L; 95% confidence interval (CI): 1.7, 6.6], OB-GI group (MD: 3.1 mg/L; 95% CI: 0.82, 5.4), and OB-T2D (MD: 2.7 mg/L; 95% CI: 0.3, 5.1) compared with Lean-NG, whereas interleukin (IL)-2 secretion was lower in OB-T2D group (MD: –2086.4 pg/mL; 95% CI: –4375.9, –37.4). OB-T2D also exhibited higher neutrophils (MD: 0.7%; 95% CI: 0.01, 0.12), Systemic Immune-Inflammation Index (MD: 155.3; 95% CI: 0.90, 309.7), and system inflammation response index (MD: 0.58, 95% CI: 0.20, 0.97) compared with Lean-NG, and a lower proportion of naïve CD8+ T cells than OB-NG (MD: –13.7%; 95% CI: –27.3, –0.14). Regression analysis showed an association between hyperglycemia and reduced immune function, particularly for IL-2 (<em>β</em> = –0.296, <em>P</em> = 0.037) and interferon-gamma secretion (<em>β</em> = –0.325, <em>P</em> = 0.017).</div></div><div><h3>Conclusions</h3><div>Immune function is compromised in obesity and worsens in T2D, suggesting both obesity and poor glucose control drive immune dysfunction. Addressing metabolic health may help mitigate immune dysfunction and inflammation in obesity-related conditions.</div></div><div><h3>Trial registration number</h3><div>This trial was registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> as NCT04291391 (<span><span>https://www.clinicaltrials.gov/study/NCT04291391?term=NCT04291391&amp;rank=1</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 6","pages":"Pages 1315-1327"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-chain fatty acid kinetics and concentrations are higher after inulin supplementation in young and older adults: a randomized trial","authors":"Sarah K Kirschner ,&nbsp;Mariëlle PKJ Engelen ,&nbsp;Paula Haas ,&nbsp;Stephan C Bischoff ,&nbsp;Nicolaas EP Deutz","doi":"10.1016/j.ajcnut.2025.04.018","DOIUrl":"10.1016/j.ajcnut.2025.04.018","url":null,"abstract":"<div><h3>Background</h3><div>Beneficial short-chain fatty acids (SCFAs) are produced through intestinal microbial fiber fermentation. Using stable tracer methodology and compartmental modeling, we observed lower SCFA production in older (OAs) than in young adults (YAs) in both an accessible [that is, systemic circulation; whole-body production] and inaccessible [potentially representing intestine absorbing microbially produced SCFAs (<em>U</em>₂)] pool.</div></div><div><h3>Objectives</h3><div>We now investigated whether fiber supplementation increases SCFA production in OAs and whether concentrations reflect production rate changes.</div></div><div><h3>Methods</h3><div>In this randomized, placebo-controlled, double-blind crossover study, 21 YAs (20–29 y) and 40 OAs (59–87 y) adults were supplemented with inulin or placebo (maltodextrin) for 7 d (final intake: 30 g/d). Before and after interventions, participants collected stool and received an intravenous pulse containing [U-¹³C]-labeled SCFAs followed by blood draws. We measured plasma tracer enrichments, plasma and fecal concentrations by gas chromatography–mass spectrometry and performed compartmental analysis. Data are mean (95% confidence interval).</div></div><div><h3>Results</h3><div>Inulin evoked a 44% increase in butyrate production (μmol/min) in the inaccessible pool {YA: 28–44 [+16.2 (4.3, 28.1); <em>P =</em> 0.038], OA: 14–20 [+6.1 (2.2, 9.9); <em>P =</em> 0.011]} and were not different between YAs and OAs. In addition, a 34% increase in propionate production in YA only. We found a 50%–60% increase in fecal acetate, propionate, and butyrate and a 34% increase in plasma butyrate in OA, whereas in YA only 34% increase in fecal acetate. Plasma but not fecal concentrations correlated positively with SCFA production in the inaccessible pool (<em>R</em>² = 0.20–0.45; <em>P &lt;</em> 0.001).</div></div><div><h3>Conclusions</h3><div>OAs have a lower SCFA production. Inulin intake increases SCFA production. Tracer pulse approach detects SCFA metabolism changes more sensitively than plasma or fecal concentration measurements (NCT04459156).</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 6","pages":"Pages 1224-1235"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Obbagy and Stoody","authors":"Alexandra M Bodnaruc ,&nbsp;Hassan Khan ,&nbsp;Nicole Shaver ,&nbsp;Alexandria Bennett ,&nbsp;Yiu Lin Wong ,&nbsp;Catherine Gracey ,&nbsp;Valentina Ly ,&nbsp;Beverley Shea ,&nbsp;Julian Little ,&nbsp;Melissa Brouwers ,&nbsp;Dennis Bier ,&nbsp;David Moher","doi":"10.1016/j.ajcnut.2025.03.019","DOIUrl":"10.1016/j.ajcnut.2025.03.019","url":null,"abstract":"","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 6","pages":"Pages 1428-1429"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Compass Score-10: validation of a method for evaluating the healthfulness of foods and beverages using ingredient list information","authors":"Eden M Barrett ,&nbsp;Frederick Cudhea ,&nbsp;Erin Washbon ,&nbsp;Zoe Levitan ,&nbsp;Julia Reedy Sharib ,&nbsp;Jeffrey B Blumberg ,&nbsp;Renata Micha ,&nbsp;Dariush Mozaffarian","doi":"10.1016/j.ajcnut.2025.03.015","DOIUrl":"10.1016/j.ajcnut.2025.03.015","url":null,"abstract":"<div><h3>Background</h3><div>The Food Compass, a novel food profiling system, provides a holistic, validated assessment of the healthfulness of foods, beverages, and meals using 54 attributes across 9 domains. However, information on several of these attributes is not commonly available.</div></div><div><h3>Objectives</h3><div>We aimed to develop and validate an approach, Food Compass Score-10 (FCS-10), to estimate FCSs using information commonly available on package labels.</div></div><div><h3>Methods</h3><div>Missing attributes were calculated using weighted scores of each product’s ingredients, derived from a dataset of ∼10,000 foods and beverages. The final FCS-10 was scaled from 1 (least healthful) to 10 (most healthful). As part of this validation study, diagnostic accuracy analysis was conducted to evaluate the performance of the FCS-10 compared with the original score. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated by comparing the FCS-10 recommendation categorizations with the FCS recommendation categorizations (≥7 for foods to encourage, 4–6 for foods to consume in moderation, ≤3 for foods to limit).</div></div><div><h3>Results</h3><div>FCS-10 produced scores within 1 unit of the original score (when rescaled 1–10 for comparison) for 89% of products (<em>n =</em> 481/538); none deviated &gt;2 units. The correlation between FCS-10 and the original score was high (<em>r =</em> 0.93). FCS-10 also performed well in identifying products to encourage, moderate, or limit, with overall sensitivity and specificity of 87% and 93%, respectively.</div></div><div><h3>Conclusions</h3><div>FCS-10 offers a practical approach for estimating the healthfulness of diverse packaged foods and beverages using readily available label data while maintaining the strengths of the original system.</div></div>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":"121 6","pages":"Pages 1328-1334"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}