Effect of a 12-mo intervention with whey protein powder on cognitive function in older adults with mild cognitive impairment: a randomized controlled trial.

IF 6.5 1区医学 Q1 NUTRITION & DIETETICS

American Journal of Clinical Nutrition Pub Date : 2024-11-20 DOI:10.1016/j.ajcnut.2024.11.019

Fengping Li, Ruikun He, Zhongbao Yue, Haoran Yi, Likang Lu, Longbang Zhang, Jiahui Shi, Chenchen Zheng, Jiayi Jiao, Jianying Peng, Benchao Li, Shuang Rong

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引用次数: 0

Abstract

Background: Our previous animal study revealed that supplementation with milk fat globule membrane (MFGM) alleviated Alzheimer's disease pathology in mice. We hypothesized that supplementation with whey protein powder rich in MFGM, taurine, and B vitamins would improve cognitive function in subjects with mild cognitive impairment (MCI).

Objectives: We conducted a 12-mo randomized controlled trial to investigate the effects of whey protein powder on cognitive function in older adults with MCI.

Methods: Participants were randomly assigned in a 1:1 ratio to either the active intervention group (whey protein powder, 15 g/d) or the control group (placebo, 15 g/d). We performed comprehensive cognitive function tests at baseline, 6 mo, and 12 mo. The primary outcome was global cognitive function determined by the Montreal Cognitive Assessment (MoCA). Secondary outcomes included other cognitive subdomains, and body composition. The data were analyzed using the intention-to-treat (ITT) principle.

Results: A total of 107 participants [mean (standard deviation) age 62.94 (4.33) y] were randomly assigned to the active intervention group (n = 53), or control group (n = 54). In the ITT analysis, the mean change in MoCA score at 12 mo was 3.23 [95% confidence interval (CI): 2.17, 4.30] in the active intervention group and 1.42 (95% CI: 0.36, 2.48) in the control group, with the mean difference between groups (group × time interaction) in change of MoCA score was 1.81 (95% CI: 0.32, 3.30). The modified ITT and per-protocol analyses showed similar results. The results also found a significant beneficial effect of the active intervention for several secondary cognitive outcomes such as Digit Symbol Substitution Test score, and the mean difference between groups in the ITT analysis was 2.72 (95% CI: 0.20, 5.23). Few side effects were reported during the study, and there was no statistically significant difference between groups (P = 0.74).

Conclusions: Supplementation with whey protein powder rich in MFGM, taurine, and B vitamins for 12 mo improve cognitive function in older adults with MCI. This trial was registered at the https://www.chictr.org.cn/showproj.html?proj=150871 as ChiCTR2200062705.

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为期 12 个月的乳清蛋白粉干预对轻度认知障碍老年人认知功能的影响：随机对照试验。

背景：我们之前的动物实验发现，补充牛奶脂肪球膜（MFGM）可减轻小鼠阿尔茨海默病的病理变化。我们假设，补充富含牛奶脂肪球膜、牛磺酸和 B 族维生素的乳清蛋白粉可改善轻度认知障碍（MCI）患者的认知功能：我们进行了一项为期 12 个月的随机对照试验，研究乳清蛋白粉对患有 MCI 的老年人认知功能的影响：参与者按1:1的比例随机分配到积极干预组（乳清蛋白粉，15克/天）或对照组（安慰剂，15克/天）。我们在基线、6 个月和 12 个月时进行了全面认知功能测试。主要结果是通过蒙特利尔认知评估（MoCA）确定的总体认知功能。次要结果包括其他认知子域和身体成分。数据采用意向治疗（ITT）原则进行分析：共有 107 名参与者（平均 [标准差，SD] 年龄为 62.94 [4.33] 岁）被随机分配到积极干预组（53 人）或对照组（54 人）。在ITT分析中，积极干预组12个月时MoCA评分的平均变化为3.23（95%CI，2.17-4.30），对照组为1.42（95%CI，0.36-2.48），组间MoCA评分变化的平均差异（组×时间交互作用）为1.81（95%CI，0.32-3.30）。修改后的 ITT 分析和按协议分析显示了相似的结果。结果还发现，积极干预对一些次要认知结果（如 DSST 评分）也有明显的益处，ITT 分析中各组之间的平均差异为 2.72（95%CI，0.20-5.23）。研究期间几乎没有出现副作用，组间差异无统计学意义（P=0.74）：结论：连续12个月补充富含MFGM、牛磺酸和B族维生素的乳清蛋白粉可改善患有MCI的老年人的认知功能：本试验已在 www.chictr.org.cn 注册，注册号为 ChiCTR2200062705。本试验已在 https://www.chictr.org.cn/showproj.html?proj=150871 注册，注册号为 ChiCTR2200062705。

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来源期刊

American Journal of Clinical Nutrition 医学-营养学

CiteScore

12.40

自引率

4.20%

发文量

332

审稿时长

38 days

期刊介绍： American Journal of Clinical Nutrition is recognized as the most highly rated peer-reviewed, primary research journal in nutrition and dietetics.It focuses on publishing the latest research on various topics in nutrition, including but not limited to obesity, vitamins and minerals, nutrition and disease, and energy metabolism. Purpose: The purpose of AJCN is to: Publish original research studies relevant to human and clinical nutrition. Consider well-controlled clinical studies describing scientific mechanisms, efficacy, and safety of dietary interventions in the context of disease prevention or health benefits. Encourage public health and epidemiologic studies relevant to human nutrition. Promote innovative investigations of nutritional questions employing epigenetic, genomic, proteomic, and metabolomic approaches. Include solicited editorials, book reviews, solicited or unsolicited review articles, invited controversy position papers, and letters to the Editor related to prior AJCN articles. Peer Review Process: All submitted material with scientific content undergoes peer review by the Editors or their designees before acceptance for publication.