American Journal of Human Biology最新文献

{"title":"Testosterone, 8-Oxo-2′-Deoxyguanosine (8-OHdG) and Cu/Zn Superoxide Dismutase (SOD) in Adult Shuar Males of Amazonian Ecuador: A Test for Evidence of Trade-Offs Between Reproductive Effort and Oxidative Stress","authors":"R. G. Bribiescas,&nbsp;A. Sancilio,&nbsp;D. Amir,&nbsp;T. J. Cepon-Robins,&nbsp;T. Gildner,&nbsp;M. A. Liebert,&nbsp;F. Madimenos,&nbsp;S. S. Urlacher,&nbsp;J. Snodgrass,&nbsp;L. Sugiyama","doi":"10.1002/ajhb.70042","DOIUrl":"https://doi.org/10.1002/ajhb.70042","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Reproductive effort incurs the cost of biological aging and morbidity by compromising somatic maintenance when key resources are limited. Oxidative stress is positively correlated with reproductive effort in adult human females and non-human male animal models, but human males are understudied. We hypothesized that due to its anabolic and metabolic promotion of reproductive effort in human males, testosterone would be positively associated with biomarkers of oxidative stress.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Urinary testosterone in adult Shuar males of Amazonia Ecuador, a foraging/horticultural population, was measured with urinary 8-hydroxy-2′ -deoxyguanosine (8-OHdG), a biomarker of oxidative stress, and Cu/Zn superoxide dismutase (Cu/Zn SOD), a protective antioxidant against oxidative stress. Age and anthropometric measures were included in multivariate models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No significant correlation was observed between testosterone and 8-OHdG, <i>r</i>² = 0.01, <i>p</i> = 0.61, <i>n</i> = 29, or Cu/Zn SOD, <i>r</i>² = 0.0005, <i>p</i> = 0.93, <i>n</i> = 17. Multiple linear regression models including testosterone, Cu/Zn SOD, anthropometrics, and age, with 8-OHdG as the dependent variable, were modestly supportive of an association. The most parsimonious 8-OHdG model included age, Cu/Zn SOD, and testosterone (<i>R</i>^{2 adjusted} = 0.38, <i>p</i> = 0.04, AICc = 141.95). All multivariate models for Cu/Zn SOD were not significant (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Oxidative stress may not be a cost of reproductive effort in this population of adult males; perhaps due to consistently low testosterone levels in non-industrialized populations, differences in the metabolic cost of reproductive effort between males and females (i.e., aerobic metabolism), and/or study limitations based on cross-sectional measures of oxidative stress and testosterone.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"37 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Origin of the Nuñoa, Perú High Altitude Field Research Site and How It Shaped Our Understanding of Functional Adaptation to High-Altitude Stressors","authors":"A. Roberto Frisancho","doi":"10.1002/ajhb.70031","DOIUrl":"https://doi.org/10.1002/ajhb.70031","url":null,"abstract":"<p>The study of physical growth and development of Indigenous children from Nuñoa, Perú, in the 1960s showed that growth in body size and skeletal maturation was slow and delayed, while growth in lung volume, measured by forced vital capacity (FVC), was accelerated. Hence, I proposed that the high functional adaptation of high-altitude natives was influenced by developmental processes. To test this hypothesis, my co-investigators and I conducted two sets of major physiological studies at high altitudes. The first studies were conducted in Cusco (3400 m) and Puno (3840 m), Perú. This research showed that the FVC and aerobic capacity of low-altitude Peruvian urban natives acclimatized to high altitudes during the developmental period were similar to those of high-altitude urban natives. In contrast, Peruvian and US participants acclimatized during adulthood did not have the same FVC and aerobic capacity as the high-altitude urban natives. The second set of studies was carried out in the city of La Paz, Bolivia (3752 m), and included Europeans who were acclimatized to high altitudes at different ages. This research confirmed that acclimatization during the developmental period was a major component of the high functional adaptation among high-altitude urban natives. These conclusions have been confirmed by epigenetic studies, which demonstrated that acclimatization to high altitude leads to modifications in the activity of the DNA that facilitate adaptation during the developmental period.</p>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"37 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajhb.70031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Precision Medicine” and the Failed Search for Binary Brain Sex Differences to Address Gender Behavioral Health Disparities","authors":"Lise Eliot","doi":"10.1002/ajhb.70041","DOIUrl":"https://doi.org/10.1002/ajhb.70041","url":null,"abstract":"<p>Human brain imaging took off in the 1980s and has since flooded the zone in the analysis of gender differences in behavior and mental health. Couched in the aims of “precision medicine,” the vast majority of this research has taken a binary approach, dividing participants according to the M/F box at intake and asserting that the sex differences found in neuroimaging will lead to important advances for treating neuropsychiatric disorders. However, the actual findings from this 40-year project have not lived up to its promise, in part because of the over-binarization of sex and general ignorance of gender as a complex variable influencing human behavior and brain function. This paper reviews the history of failed claims about male–female brain difference in the modern era, illuminates the deep-pocketed incentives driving such research, and examines the limitations of this binary approach for understanding gender-related behavior and health disparities. It then considers more recent efforts to “break the binary” by using measures of “gender” in addition to “sex” as an independent variable in brain imaging studies. Given the multidimensional nature of gender—as identity, expression, roles and relations—this is challenging to implement, with initial efforts producing little of substance. Better approaches to addressing male–female disparities in brain health will require focusing on specific behaviors (e.g., anxiety, risk-taking, verbal memory, spatial navigation) and specific components of sex and gender (e.g., body size, hormone levels, gene expression, caregiver role, financial independence, discrimination) when seeking brain-behavior correlates in a diverse population.</p>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"37 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajhb.70041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delaying Motherhood—An Increasingly Common but Risky Trend in High-Income Countries","authors":"Magdalena Kraus,&nbsp;Beda Hartmann,&nbsp;Sylvia Kirchengast","doi":"10.1002/ajhb.70037","DOIUrl":"https://doi.org/10.1002/ajhb.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Maternal age at first birth is increasing in most high-income countries. The associations between advanced maternal age and perinatal complications, as well as newborn parameters, were analyzed using a dataset of 6831 singleton births among first-time mothers taking place in Vienna, Austria, between 2010 and 2019.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this single-center medical records-based retrospective study, the following obstetrical parameters have been included: conception mode, preterm birth (&lt; 37th gestational week), labor induction, planned or emergency cesarean sections, adverse child presentation, newborn size, and Apgar scores. The outcomes of first-time mothers older than 35 and 40 years, respectively, were compared to a reference group of first-time mothers aged between 20 and 34 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>First-time mothers aged 35 and older show a significantly (<i>p</i> &lt; 0.009 resp. <i>p</i> &lt; 0.001) higher risk of preterm births, with a 1.32-fold risk for women between 35 and 39 years and a 2.35-fold risk for women aged 40 and older. Maternal age is also significantly (<i>p</i> &lt; 0.001) associated with an increased rate of medically induced labor, cesarean sections, and low-weight newborns (&lt; 2500 g). In contrast, there was no significant difference in Apgar scores among the newborns of different maternal age groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Advanced maternal age at first birth is a relevant risk factor for certain obstetric and neonatal complications. Delaying motherhood is a risky trend.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"37 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajhb.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Search of Environmental Factors Associated With Global Differences in Birth Weight and BMI","authors":"Per M. Jensen,&nbsp;Marten Sørensen","doi":"10.1002/ajhb.70038","DOIUrl":"https://doi.org/10.1002/ajhb.70038","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The “fetal origin of adult diseases hypothesis” encompasses the notion that intrauterine growth restriction (IUGR) alters fetal development trajectories. Various neonatal metrics inform IUGR, but not all contributors to IUGR have an impact on development trajectories. Chronic IUGR (twins) and slowly varying IUGR (seasonal) have little to no effect on later life trajectories. Perhaps development trajectories may evolve through other mechanisms, as for example, multiple short-lived periods of IUGR and repeated stimulation of metabolic pathways.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Daily temperature variation could deliver a frequent IUGR as pregnant women would experience some degree of placental vasoconstriction during maximum/midday temperatures. We assessed the association with daily temperature amplitudes for globally distributed records of crude fetal growth rates (CFGR) and BMI. Paired birthweight (BW) and gestational age (GA) data permitted analyses of CFGR in 70 countries and subsequent analysis of CFGR for association with daily temperature amplitude, seasonal temperature amplitude, mean annual temperature, calorie intake per day per⁻¹ person⁻¹, BMI, height, and socioeconomic conditions. Analog analyses were performed for gestational age, calorie intake, BMI, and height.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>CFGR and BMI showed a clear association with daily temperature amplitudes, which was not the case for gestational age, calorie intake, and height.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We show that daily temperature amplitudes are associated with both CFGR and BMI. These results permit a wider ecological appreciation of the hypothesis because daily temperature amplitudes inform environmental aridity and food scarcity. We discuss how scarcity, affluence, and the epidemiological environment influence the prevalence of afflictions associated with the fetal origin of adult disease hypothesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"37 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajhb.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Digit Ratio (2D:4D) and Aspects of Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis","authors":"Bethany Gower,&nbsp;Matthew Russell,&nbsp;Jordan M. Tomkinson,&nbsp;Samantha J. Peterson,&nbsp;Marilyn G. Klug,&nbsp;Grant R. Tomkinson","doi":"10.1002/ajhb.70040","DOIUrl":"https://doi.org/10.1002/ajhb.70040","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Digit ratio (2D:4D), a proxy of prenatal testosterone exposure, is a putative marker of physical fitness. No study has comprehensively synthesized studies examining associations between 2D:4D and cardiorespiratory fitness (CRF). We aimed to systematically review and meta-analyze studies reporting associations between 2D:4D and aspects of CRF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We systematically searched the literature for full text, refereed, cross-sectional studies reporting Pearson's correlation coefficients between objectively measured 2D:4D and at least one aspect of CRF. CRF was objectively assessed using field-based measures (maximal long-duration exercise performance) or laboratory-based measures (maximal oxygen uptake [VO_2max], ventilatory threshold [VT], or mechanical efficiency [ME]). We used random-effects meta-analysis to estimate the pooled correlation and 95% confidence interval (95% CI) for aspects of CRF, and moderator analyses to estimate the influence of sex and age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Data from 22 studies, representing 5293 individuals (54% male; mean age range = 10.1–40.2 years) from 12 countries were included. We found a significant strong negative correlation for VT (<i>r</i> = −0.61, 95% CI = −0.78, −0.37) and a significant weak negative correlation for exercise performance (<i>r</i> = −0.18, 95% CI = −0.25, −0.10), indicating that individuals with lower 2D:4Ds had higher VT and better exercise performance. No significant correlations were found for VO_2max or ME. Neither sex nor age were significant moderators, except for age which moderated the correlation for exercise performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>2D:4D is a proxy for some aspects of CRF like exercise tolerance (i.e., VT) and performance, but not other aspects like aerobic capacity and efficiency.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"37 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajhb.70040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Status and Somatotype of School-Aged Youth (5–17 Years) Residing at Moderate Altitude in the Ambato Department of Catamarca Province, Argentina","authors":"Rosario Elizabeth Pacheco Agüero,&nbsp;Lautaro Daniel Andrade,&nbsp;Norma Beatriz Dip,&nbsp;Delia Beatriz Lomaglio","doi":"10.1002/ajhb.70035","DOIUrl":"https://doi.org/10.1002/ajhb.70035","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To analyze the somatotype and its relationship with nutritional status, determined by Body Mass Index (BMI), in populations from moderate altitude in the province of Catamarca, Argentina.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional descriptive study was conducted on 139 schoolchildren aged 5–17 years (51.79% girls) from the rural localities of Las Juntas and Las Piedras Blancas (1609 m above sea level), Ambato Department, Catamarca province. Anthropometric measurements were taken to calculate BMI and the three somatotype components: endomorphy, mesomorphy, and ectomorphy, according to Heath and Carter. Participants were classified based on WHO categories: underweight, normal weight, overweight, and obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overweight was observed in 16.5% of the participants. Obesity (7.5%) was present only in boys. The average somatotype profile was 3.9–2.5–2.2, indicating moderate adiposity, low musculoskeletal development, and relative linearity. Regression analysis showed that BMI increased with the first two components and decreased with the third. Differences in somatotype distribution by sex and age were observed, along with low concordance between obesity categories (BMI) and high endomorphy. Boys tended to exhibit more mesomorphic somatotypes, while girls showed predominantly endomorphic somatotypes as BMI increased.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The analyzed population of children and adolescents showed a predominantly endomorphic somatotype with a low prevalence of obesity. The low concordance between nutritional status (BMI) and somatotype highlights the need for complementary criteria to evaluate body composition.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"37 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Anemia in Schoolchildren Aged 6–18 Years With Hematocrit Percentile Charts and the Impact of Economic Status in Southern Brazil","authors":"Vanessa Regina Jung,&nbsp;Nikolas Mateus Pereira de Souza,&nbsp;Dhuli Kimberli Abeg da Rosa,&nbsp;João Francisco de Castro Silveira,&nbsp;Cézane Priscila Reuter,&nbsp;Alexandre Rieger","doi":"10.1002/ajhb.70034","DOIUrl":"https://doi.org/10.1002/ajhb.70034","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To generate hematocrit percentile charts for schoolchildren aged 6–18 years and determine the prevalence of anemia by socioeconomic status class in southern Brazil.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a cross-sectional study utilizing data collected between 2014 and 2017 from southern Brazil. The study's sample consists of 4802 schoolchildren, aged 6 to 18 years. The percentile charts for sex-specific hematocrit were developed using the LMS (Lambda-Mu-Sigma) method. The simplified economic classification, based on ABEP criteria, was used to group individuals into A + B (high), C (middle), and D + E (low) income classes. Anemia was defined as hematocrit z-score ≤ −1.96 for age and sex.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among boys, 58 (2.86%) were anemic, 1955 (94.81%) had normal hematocrit levels, and 48 (2.33%) had high hematocrit. Girls showed a similar pattern, with 73 (2.73%) anemic, 2534 (94.90%) with normal hematocrit, and 63 (2.36%) with high hematocrit. For girls, a higher prevalence of non-anemic hematocrit was observed in class A (39.33%) compared to anemic children (23.28%), with significant standardized residuals. For boys, significant residuals were observed for a higher prevalence of anemic children in the lower socioeconomic class DE (13.79%) compared to non-anemic children (5.18%), and a higher prevalence of non-anemic children in the upper socioeconomic class A (42.63%) compared to anemic children (22.41%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The percentile charts generated from hematocrit levels enabled the comparison of anemia prevalence across socioeconomic status classes. A higher prevalence of anemia was found among boys in lower socioeconomic classes, while girls in higher socioeconomic classes showed a lower prevalence of anemia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"37 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajhb.70034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Complex Interplay of Irisin Levels, Low Birth Weight, and Blood Pressure in Prepubescent Children","authors":"Raissa Munhão Serra,&nbsp;Franciele De Meneck,&nbsp;Fernanda Thomazini,&nbsp;Paula Regina Pereira de Souza,&nbsp;Maria Franco","doi":"10.1002/ajhb.70036","DOIUrl":"https://doi.org/10.1002/ajhb.70036","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Irisin regulates various metabolic, inflammatory, and oxidative stress processes. It has been considered a promising target in the context of the development and maintenance of cardiovascular diseases. We conducted a study to evaluate the levels of plasma irisin in prepubertal children, examining its relationship with birth weight, anthropometric parameters, biochemical profile, and blood pressure levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted involving 136 prepubertal children aged 6 to 11 years, with 27.9% born at a low weight. Anthropometric parameters, blood pressure, and biochemical profiles were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Children with low birth weight had significantly lower irisin levels compared to those with normal birth weight (<i>p</i> &lt; 0.001). Birth weight was negatively correlated with blood pressure levels (systolic: <i>r</i> = −0.213, <i>p =</i> 0.013; diastolic: <i>r</i> = −0.223, <i>p =</i> 0.009) and positively correlated with irisin levels (<i>p</i> &lt; 0.001). Irisin levels were positively associated with systolic blood pressure, even after adjusting for birth weight, BMI, and physical activity (<i>p</i> &lt; 0.001). The linear regression analysis indicated that low birth weight and high plasma levels of irisin were recognized as predictive factors of elevated blood pressure levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The positive correlation observed between circulating irisin and systolic blood pressure levels in children with low birth weight, despite their lower irisin levels, suggests a complex interplay between birth weight, irisin, cardiovascular regulation, and metabolic function. Understanding this relationship may require considering that irisin may play dual roles in different tissues, compensatory mechanisms, and the broader context of cardiometabolic programming in children with low birth weight.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"37 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Insecurity and Nutritional Status Among Pregnant Women Living in Socio-Economic Vulnerability in the Metropolitan Area of Buenos Aires (Argentina)","authors":"Noelia Bonfili,&nbsp;Lara Garnis,&nbsp;Mariela Nievas,&nbsp;Paula N. Gonzalez,&nbsp;Jimena Barbeito-Andrés","doi":"10.1002/ajhb.70033","DOIUrl":"https://doi.org/10.1002/ajhb.70033","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To analyze food insecurity (FI) in pregnant women from the Metropolitan Area of Buenos Aires (AMBA) and its association with socio-economic variables and nutritional status, as well as to identify dietary patterns in women experiencing moderate and severe FI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Between July 2021 and September 2023, an observational and cross-sectional study was performed. Data from 349 women was recorded in public health centers of disadvantaged urban areas. FI was assessed with the Food Insecurity Experience Scale (FIES), and the nutritional status was evaluated using the body mass index by gestational age. Chi-square, Spearman, and Wilcoxon tests were used to examine associations between FI, nutritional status, socioeconomic conditions, and dietary patterns.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Only 30% of interviewed women were classified as food secure, while 31% experienced moderate FI and 11.5% severe FI. Among socio-economic variables, fewer years of formal education and critical overcrowding were significantly associated with FI. A large part of the sample (68%) had some type of malnutrition (overweight or obesity: 52.7%, undernutrition: 11.2%), which was also significantly associated with FI. Dietary patterns differed between women with moderate and severe FI, with the latter consuming less healthy and more processed foods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our results suggest that women in reproductive ages living in urban areas from the AMBA region have elevated levels of FI, especially moderate FI, even when compared with other vulnerable populations from Latin America. This study confirmed that FI is related to different types of maternal malnutrition, which constitutes a prenatal adversity with diverse potential effects on the offspring.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"37 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}