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Study Protocol for the Daasanach Human Biology Project: A Longitudinal Study of the Impact of Drinking Water Salinity and Heat Stress on Water Insecurity, Hydration, Energetics, Hypertension, and Kidney Function in Northern Kenya Daasanach人类生物学项目研究方案:肯尼亚北部饮用水盐度和热应激对水不安全、水合作用、能量学、高血压和肾功能影响的纵向研究。
IF 1.9 4区 医学
American Journal of Human Biology Pub Date : 2026-10-12 DOI: 10.1002/ajhb.70343
Alfredo J. Rojas Jr., Emmanuel Ndiema, Rosemary Nzunza, Michael Hunter, Jeff M. Sands, William Farquhar, W. Larry Kenney, Kedir Teji Roba, Amanda McGrosky, Matthew Douglass, Herman Pontzer, Asher Y. Rosinger
{"title":"Study Protocol for the Daasanach Human Biology Project: A Longitudinal Study of the Impact of Drinking Water Salinity and Heat Stress on Water Insecurity, Hydration, Energetics, Hypertension, and Kidney Function in Northern Kenya","authors":"Alfredo J. Rojas Jr.,&nbsp;Emmanuel Ndiema,&nbsp;Rosemary Nzunza,&nbsp;Michael Hunter,&nbsp;Jeff M. Sands,&nbsp;William Farquhar,&nbsp;W. Larry Kenney,&nbsp;Kedir Teji Roba,&nbsp;Amanda McGrosky,&nbsp;Matthew Douglass,&nbsp;Herman Pontzer,&nbsp;Asher Y. Rosinger","doi":"10.1002/ajhb.70343","DOIUrl":"10.1002/ajhb.70343","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Increasing salinity of groundwater is a global environmental health threat that has been overlooked in human biology and may increase the risk of water insecurity, dehydration, chronic kidney disease (CKD), and hypertension in humans. However, no health standards exist for salinity levels in drinking water. This protocol paper describes the Daasanach Human Biology Project, which is testing how water salinity exposure and heat stress impact hydration, kidney disease, and blood pressure among Daasanach pastoralists in a hot-arid environment in northern Kenya.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods/design</h3>\u0000 \u0000 <p>This study expands the Daasanach Human Biology Project, an existing longitudinal study, to recruit 600 adults across approximately 450 households in 12 communities in Illeret Sub-County, Marsabit County, Kenya across six study waves. Data collection will occur seasonally during the wet (March–April) and dry (June–July) seasons. Household survey, anthropometric, dietary, doubly labeled water, point-of-care, lab-based biomarker, and water quality data will be collected to assess the impact of water salinity, heat stress, and other relevant exposures on health. Multi-level regression will be used to account for the longitudinal and nested nature of the data to determine how water salinity coupled with environmental exposures like heat impact hydration, kidney, and cardiometabolic function, and hypertension among Daasanach pastoralists.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Exploring how water salinity in hot environments impacts human health can help uncover the environmental and social pathways to CKD and cardiovascular diseases facing populations around the world dealing with freshwater salinization. The data generated will provide dose-specific health standards for sodium-chloride in water.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"38 10","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patterns of Mortality for Children and Adolescents in Early 20th-Century Alaska 20世纪早期阿拉斯加儿童和青少年的死亡率模式。
IF 1.9 4区 医学
American Journal of Human Biology Pub Date : 2026-10-11 DOI: 10.1002/ajhb.70347
Taylor P. van Doren, Delaney Glass, Christiane Scheffler, Michael Hermanussen, Lisa Sattenspiel
{"title":"Patterns of Mortality for Children and Adolescents in Early 20th-Century Alaska","authors":"Taylor P. van Doren,&nbsp;Delaney Glass,&nbsp;Christiane Scheffler,&nbsp;Michael Hermanussen,&nbsp;Lisa Sattenspiel","doi":"10.1002/ajhb.70347","DOIUrl":"10.1002/ajhb.70347","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Odds of death from specific causes in infants, children, and adolescents in Alaska have not been quantified with vital records. We analyze the odds of death from 12 causes in individuals ≤ 18 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We fit a multinomial logistic regression model (<i>n</i> = 12 904 death records) controlling for Indigeneity, age, sex, and year of death to predict the odds of specific causes of death.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Alaska Native individuals were most likely to die from tuberculosis and respiratory infections, while non-Alaska Native individuals were most likely to die from early infant health problems and accidents/violence. Infectious diseases and nutritional and endocrine disorders were most likely in ages 0–5, while accidents/violence, cardiovascular issues, and tuberculosis were most likely in ages 10–18.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Proportionate mortality and odds of death differed significantly, reflecting the different structures of Alaska Native versus non-Alaska Native populations in the 20th century and reinforcing demographic observations in the historical record.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"38 10","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between 2D/4D Digit Ratio and Age at Menarche: A Study on the Algerian Population 2D/4D数字比例与初潮年龄的关系:阿尔及利亚人口的研究
IF 1.9 4区 医学
American Journal of Human Biology Pub Date : 2026-10-09 DOI: 10.1002/ajhb.70344
Ismahane Laanani
{"title":"Association Between 2D/4D Digit Ratio and Age at Menarche: A Study on the Algerian Population","authors":"Ismahane Laanani","doi":"10.1002/ajhb.70344","DOIUrl":"https://doi.org/10.1002/ajhb.70344","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The ratio between the length of second and fourth digits (2D/4D) is a putative biomarker for prenatal testosterone and estrogen exposure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of the present study was to examine the association between 2D/4D digit ratio and age at menarche in Algerian women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study included 111 women with mean age of 26.49 ± 8.30 years. The 2D/4D was measured directly in both hands using a digital caliper. Multiple linear regression and Mann–Whitney U-tests were used to assess the associations between the digit ratio and the variables studied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 111 women reported a mean age at menarche of 12.89 years ±1.25. The left-hand digit ratio was negatively related to age at menarche. Statistical analyses revealed a significant negative correlation between the left-hand 2D/4D ratio and age at menarche, suggesting that a more feminine digit ratio is associated with an earlier age at menarche.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings support the evidence for the role of prenatal hormonal influence on reproductive development and contribute to the growing interest in research on digit ratio and female reproductive health. Further studies are needed to confirm these associations in different populations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"38 10","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tracing the Thematic Evolution of the American Journal of Human Biology (1989–2025) Using a Mixed-Methods Approach That Combines BERT, a Large Language Model, With Qualitative Expert Review 追踪美国人类生物学杂志的主题演变(1989-2025)使用混合方法,结合BERT,一个大的语言模型,与定性专家评论
IF 1.9 4区 医学
American Journal of Human Biology Pub Date : 2026-10-09 DOI: 10.1002/ajhb.70346
L. Yin, D. L. Dufour, M. A. Little, S. S. Downey, B. A. Piperata
{"title":"Tracing the Thematic Evolution of the American Journal of Human Biology (1989–2025) Using a Mixed-Methods Approach That Combines BERT, a Large Language Model, With Qualitative Expert Review","authors":"L. Yin,&nbsp;D. L. Dufour,&nbsp;M. A. Little,&nbsp;S. S. Downey,&nbsp;B. A. Piperata","doi":"10.1002/ajhb.70346","DOIUrl":"https://doi.org/10.1002/ajhb.70346","url":null,"abstract":"<div>\u0000 \u0000 <p>The <i>American Journal of Human Biology</i> (AJHB), the flagship journal of the Human Biology Association, has published research on human biology, health, and disease since 1989. The goal of this study is to identify the dominant research themes published in the journal and track their evolution over this 36-year period. To achieve this goal, we adopted a mixed-methods approach that combined large language model (LLM) topic modeling, using Bidirectional Encoder Representations from Transformers (BERT), with qualitative expert review. Our dataset comprised 3348 abstracts and metadata (e.g., author, year, title) published between 1989 and April 2025 retrieved from PubMed. We used BERT-based clustering as a first-pass classifier and then expert consensus to consolidate the clusters into themes. Fifteen major themes emerged. We then examined temporal changes in these 15 themes. Two themes that have and continue to dominate are <i>Growth and Development</i> and <i>Body Composition</i>. In contrast, <i>Genetics</i>, while common, declined in recent years. <i>Maternal, Fetal, and Infant Health,</i> and <i>Demography and Reproduction,</i> while always well-represented, increased, especially since 2010. Meanwhile, the less-prevalent themes <i>Stress Biology</i>, <i>Nutrition</i>, and <i>Human Biology Frameworks</i> have shown gradual growth. Overall, while a set of themes dominate the journal's corpus of scholarship, the trends we found indicate a transition toward more theory-driven analyses of health and disease and underscore the journal's responsiveness to emerging scientific paradigms and global health challenges, offering a roadmap for future scholarship.</p>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"38 10","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secular Trends Beyond Stature: Sex-Specific Changes in Body Dimensions and Proportions Among South Korean Adults Aged 20–49 Years, 1986–2021 身高以外的长期趋势:1986-2021年韩国20-49岁成年人身体尺寸和比例的性别变化。
IF 1.9 4区 医学
American Journal of Human Biology Pub Date : 2026-10-07 DOI: 10.1002/ajhb.70342
Jang-Hyeon Kim
{"title":"Secular Trends Beyond Stature: Sex-Specific Changes in Body Dimensions and Proportions Among South Korean Adults Aged 20–49 Years, 1986–2021","authors":"Jang-Hyeon Kim","doi":"10.1002/ajhb.70342","DOIUrl":"10.1002/ajhb.70342","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Whether adult body proportions keep changing once stature gains slow, and how this differs by sex, is unresolved. This study quantified 35-year change in 28 dimensions and 14 proportion indices of South Korean adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seven national anthropometric surveys (Size Korea, 1986–2021; 24 979 adults aged 20–49) were harmonized on official measurement codes. Survey-wave rates were estimated with allometric adjustment for stature, a three-part sensitivity analysis for the 2003–2004 protocol change, paired sex contrasts, and age-adjusted cohort means.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Stature rose 75 mm in men and 63 mm in women, while the sitting height ratio moved less than 0.1 points per decade. Transverse change was concentrated at the hip: sitting hip breadth rose 14% in men and 12% in women, biacromial breadth showed no detectable change, and the female hip–shoulder breadth index rose 1.59 points per decade. Girth change was mass-led in men (body weight+21%; BMI 22.8 to 25.1 kg/m<sup>2</sup>) and shape-led in women, whose waist circumference, waist-to-height ratio and waist-to-hip ratio rose at flat BMI. The male cephalic index fell 0.55 points per decade. Girth and hip results held at fixed stature; sitting hip breadth in both sexes and the male waist, hip, thigh and calf girths also held after protocol adjustment. Cohort stature was flat after the 1980–1984 birth cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Secular change left segment proportions little altered, concentrated transverse change at the hip, and separated the sexes in the girths: mass-led in men, shape-led in women. Stature and BMI alone do not register it.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"38 10","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Deprivation to Deficiency: Examining the Nexus Between Multidimensional Poverty and Anemia in India. 从剥夺到匮乏:审视多维贫困与印度贫血之间的关系。
IF 1.9 4区 医学
American Journal of Human Biology Pub Date : 2026-10-01 DOI: 10.1002/ajhb.70350
Niranjan Debnath, Bikash Das, Daksha Parmar
{"title":"From Deprivation to Deficiency: Examining the Nexus Between Multidimensional Poverty and Anemia in India.","authors":"Niranjan Debnath, Bikash Das, Daksha Parmar","doi":"10.1002/ajhb.70350","DOIUrl":"https://doi.org/10.1002/ajhb.70350","url":null,"abstract":"<p><p>Anemia in India is shaped by intersecting socio-economic inequalities; however, its relationship with multidimensional deprivation remains insufficiently understood.</p><p><strong>Objectives: </strong>This study uses a multidimensional poverty framework, situated within the social determinants of health perspective, to examine the association between overlapping deprivations and anemia in India. It assesses how this association varies across demographic, social, spatial, behavioral, and dietary characteristics and over time.</p><p><strong>Methods: </strong>We analyzed pooled cross-sectional data from NFHS-3 (2005-06), NFHS-4 (2015-16), and NFHS-5 (2019-21), comprising 2 232 138 individuals with hemoglobin information. Multidimensional poverty was measured using the Alkire-Foster approach comprising health, education, and standard-of-living dimensions. Associations with anemia were examined using survey-weighted logistic regression with demographic, socioeconomic, spatial, behavioral, and dietary covariates.</p><p><strong>Results: </strong>Anemia prevalence increased from 48.18% in 2005-06 to 56.03% in 2019-21, while multidimensional poverty declined from 47.56% to 14.33%. Individuals living in multidimensionally poor households had higher odds of anemia than those in non-poor households (OR = 1.328; marginal effect = 5.7 percentage points, 95% CI: 5.2-6.2). This association remained significant among men (OR = 1.426) and women (OR = 1.269) and varied significantly across survey rounds (adjusted Wald F = 33.61, p < 0.001). Anemia was also patterned by gender, caste, and rural residence.</p><p><strong>Conclusions: </strong>The findings support a multidimensional perspective on anemia, showing that its distribution is associated with overlapping social and socioeconomic deprivation. A social determinants approach can complement nutritional and biomedical strategies by drawing attention to the broader conditions in which anemia occurs.</p>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"38 10","pages":"e70350"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experiences and Expressions of Stress Among US Food Industry Workers During the 2020 Covid-19 Pandemic. 2020年Covid-19大流行期间美国食品工业工人的压力经历和表达
IF 1.9 4区 医学
American Journal of Human Biology Pub Date : 2026-10-01 DOI: 10.1002/ajhb.70338
Elizabeth Koselka
{"title":"Experiences and Expressions of Stress Among US Food Industry Workers During the 2020 Covid-19 Pandemic.","authors":"Elizabeth Koselka","doi":"10.1002/ajhb.70338","DOIUrl":"https://doi.org/10.1002/ajhb.70338","url":null,"abstract":"<p><strong>Introduction: </strong>The Coronavirus pandemic (Covid-19) exposed legacies of deep inequality, including who could afford protection from exposure. As part of the essential workforce, food industry workers continued fully in-person work throughout the pandemic and associated shutdowns.</p><p><strong>Objective: </strong>To qualitatively examine US food worker experiences and stressors during the 2020 Covid-19 pandemic.</p><p><strong>Methods: </strong>Thirty-four open-ended phone interviews were conducted from May through September 2020 with people who grew (n = 2), processed (n = 5), cooked (n = 9), sold (n = 17), and/or delivered (n = 5) food in the United States. Audio recordings were transcribed and coded for themes of stress, health, and workplace environment.</p><p><strong>Results: </strong>Interviewees reported widespread disruption across US food system workplaces (e.g., reduced staffing, role changes, and increased workloads). Expressions of stress clustered into 4 themes: financial strain, concern about getting/transmitting Covid-19, sustained uncertainty, and overburdening. Workers' experiences revealed a need for self-reliance while their work and life environments were repeatedly overhauled.</p><p><strong>Conclusion: </strong>Results align with similar investigations into food workers' stress and limited protections before, during, and after the pandemic. The study contributes evidence for stronger worker support systems and positions food workers' lived experiences as vital to research and policy.</p>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"38 10","pages":"e70338"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placental DNA Methylation of HSD11B2 and IGF2 Is Associated With Fetal Growth in the Cebu Longitudinal Health and Nutrition Survey 宿务纵向健康和营养调查显示,胎盘HSD11B2和IGF2 DNA甲基化与胎儿生长有关
IF 1.9 4区 医学
American Journal of Human Biology Pub Date : 2026-09-29 DOI: 10.1002/ajhb.70336
Eleanor Klibaner-Schiff, Julienne Rutherford, Victoria deMartelly, Fe Lagardo, William Gundling, Derek E. Wildman, Nanette R. Lee, Christopher Kuzawa
{"title":"Placental DNA Methylation of HSD11B2 and IGF2 Is Associated With Fetal Growth in the Cebu Longitudinal Health and Nutrition Survey","authors":"Eleanor Klibaner-Schiff,&nbsp;Julienne Rutherford,&nbsp;Victoria deMartelly,&nbsp;Fe Lagardo,&nbsp;William Gundling,&nbsp;Derek E. Wildman,&nbsp;Nanette R. Lee,&nbsp;Christopher Kuzawa","doi":"10.1002/ajhb.70336","DOIUrl":"https://doi.org/10.1002/ajhb.70336","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The intrauterine environment exerts lasting impacts on fetal growth and development, with potential long-term effects on later health. We examined whether placental DNA methylation at <i>HSD11B2</i> and <i>IGF2</i>—two key regulators of the intrauterine environment—is associated with fetal growth among participants in the Cebu Longitudinal Health and Nutrition Survey (CLHNS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed DNA methylation in placental samples from 19 births in the CLHNS using the Illumina Infinium HumanMethylation450 BeadChip. Focusing on CpG sites within <i>HSD11B2</i> and the <i>IGF2/H19</i> imprinting control region (ICR), we used linear regression models adjusted for gestational age to assess associations of DNA methylation with birth weight, head circumference, length, and neonatal adiposity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Higher methylation at three CpG sites within <i>HSD11B2</i> was significantly associated with reduced fetal growth: one site was associated with reduced birth weight and head circumference, and two sites were associated with shorter birth length. Within the <i>IGF2/H19</i> ICR, two CpG sites were significantly associated with both increased birth weight and head circumference. Both CpGs overlapped with predicted CCCTC-binding factor (CTCF) binding sites, consistent with known regulatory mechanisms linking increased methylation at the ICR to increased <i>IGF2</i> expression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings support the hypothesis that DNA methylation at regulatory regions of <i>HSD11B2</i> and <i>IGF2</i> contributes to variation in fetal growth, linking placental epigenetic patterns to birth outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"38 10","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149072542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Body Proportions and Cardiometabolic Risk Factors in Rural Indian Adults 印度农村成年人的身体比例和心脏代谢危险因素。
IF 1.9 4区 医学
American Journal of Human Biology Pub Date : 2026-09-24 DOI: 10.1002/ajhb.70340
Mugdha Deshpande, Isha Shah, Nikhil Shah, Vaman Khadilkar, Anuradha Khadilkar
{"title":"Body Proportions and Cardiometabolic Risk Factors in Rural Indian Adults","authors":"Mugdha Deshpande,&nbsp;Isha Shah,&nbsp;Nikhil Shah,&nbsp;Vaman Khadilkar,&nbsp;Anuradha Khadilkar","doi":"10.1002/ajhb.70340","DOIUrl":"10.1002/ajhb.70340","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Body proportions may reflect early-life growth and developmental exposures associated with later cardiometabolic risk, but evidence from rural India is limited. We assessed cardiometabolic risk factors and their associations with sitting height, leg length, and sitting-height ratio among rural Indian adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study analyzed baseline data from 2196 adults (1098 men and 1098 women) enrolled in YUVAAN multigenerational cohort in rural Pune, Maharashtra. Anthropometric, body-composition, clinical, biochemical, and dietary assessments were performed. Associations between body-proportion measures and cardiometabolic risk factors were examined. Sitting-height and leg-length models were adjusted for age, sex, and standing height; and sitting-height ratio for age and sex.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Low HDL cholesterol was the most prevalent lipid abnormality (75.5%); hyperglycemia, hypertriglyceridemia, and hypercholesterolemia affected 19.5%, 18.3%, and 11.1% of participants, respectively. Adiposity and central obesity were more prevalent among participants with sitting height above the sex-specific 75th percentile than counterparts (68.2% vs. 54.5% and 71.8% vs. 54.5%, respectively). In unadjusted analyses, each 1-cm increase in sitting height was associated with higher odds of dyslipidemia, hypertension, obesity, adiposity, and elevated waist circumference. Greater leg length was associated with lower odds of dyslipidemia, obesity, and adiposity, while high sitting-height ratio was associated with obesity and elevated waist circumference. After adjustment, greater sitting height and sitting-height ratio remained associated with an adverse cardiometabolic profile, whereas greater leg length was inversely associated with these outcomes but not hyperglycemia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Greater sitting height and sitting-height ratio, and shorter leg length, were associated with an adverse cardiometabolic profile among rural Indian adults.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"38 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
American Journal of Human Biology Now Accepting Study Protocol Manuscripts 美国人类生物学杂志现在接受研究方案手稿。
IF 1.9 4区 医学
American Journal of Human Biology Pub Date : 2026-09-24 DOI: 10.1002/ajhb.70339
William R. Leonard
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