American Journal of Medicine最新文献_第10页

A Day in March. 三月的一天。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-04-26 DOI: 10.1016/j.amjmed.2025.04.020

Kathleen R Page

引用次数: 0

Controversies in Hypertension VI: Paroxysmal Hypertension. 高血压的争议VI：阵发性高血压。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-04-25 DOI: 10.1016/j.amjmed.2025.04.023

Edward J Filippone, Gerald V Naccarelli, Andrew J Foy

{"title":"Controversies in Hypertension VI: Paroxysmal Hypertension.","authors":"Edward J Filippone, Gerald V Naccarelli, Andrew J Foy","doi":"10.1016/j.amjmed.2025.04.023","DOIUrl":"10.1016/j.amjmed.2025.04.023","url":null,"abstract":"Paroxysmal hypertension is characterized by a sudden and significant increase in blood pressure that may have coexisting hyperadrenergic symptoms (headache, palpitations, diaphoresis) with or without an obvious precipitating cause. Pheochromocytoma is suggested, although less than 1% of such patients have the tumor. Four syndromes should be considered, including labile hypertension, panic attacks, pseudopheochromocytoma, and baroreflex failure. Labile hypertension includes paroxysms that are provoked by obvious stress or anxiety; they may be asymptomatic or have hyperadrenergic symptoms. Similarly, panic attacks are precipitated by fear or anxiety. Pseudopheochromocytoma is characterized by paroxysms without obvious precipitating stress or anxiety, although anxiety may result from the paroxysm, and the paroxysms are invariably symptomatic; abnormal repression of emotions underlies most cases. Afferent baroreflex failure presents as symptomatic hypertensive paroxysms often precipitated by emotional or environmental stress alternating with periods of frank hypotension; orthostatic hypotension frequently coexists. No guidelines specify therapy of paroxysmal hypertension and no randomized controlled trials with hard endpoints exist for this syndrome. We discuss in detail the 4 pheochromocytoma mimics in the differential diagnosis of paroxysmal hypertension with recommendations on diagnosis and therapy.","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Challenges of Cavitary Lung Lesions: A Case of Mycobacterium xenopi. 肺空腔性病变的诊断挑战：一例异种分枝杆菌。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-04-24 DOI: 10.1016/j.amjmed.2025.04.018

Maressa Cumbermack, Geraldine Brusca-Augello, Paul Barone, Sydney Katz

引用次数: 0

Disseminated Coccidioidomycosis With Extensive Soft Tissue Abscesses in an Immunocompetent Male. 播散性球孢子菌病伴广泛软组织脓肿一例免疫正常男性。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-04-22 DOI: 10.1016/j.amjmed.2025.04.015

Ellie Tsang, Shalin Desai, Lucy Z Shi

引用次数: 0

The Efficient Route. 高效路线。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-04-18 DOI: 10.1016/j.amjmed.2025.04.008

Michelle Izmaylov

引用次数: 0

Colchicine in Coronary Artery Disease. When to Use? 秋水仙碱与冠状动脉疾病什么时候使用？

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-04-17 DOI: 10.1016/j.amjmed.2025.04.011

Daniel M Gelfman

引用次数: 0

Multiple Pulmonary Cement Embolisms Complicating Percutaneous Vertebroplasty. 多发性肺水泥栓塞并发经皮椎体成形术。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-04-15 DOI: 10.1016/j.amjmed.2025.04.010

Leizhi Ku, Yuhang Wang, Zheng Liu, Xiaojing Ma

引用次数: 0

Killing the Science Golden Goose. 杀死科学的金鹅。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-04-15 DOI: 10.1016/j.amjmed.2025.04.003

William G Kaelin

引用次数: 0

It's not Always Molluscum: A Case of Disseminated Cryptococcosis. 它并不总是软体虫：播散性隐球菌病一例。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-04-12 DOI: 10.1016/j.amjmed.2025.04.007

Sachin Joseph, Yamilette Borja, Panagiotis Gavathas, Hussam Ammar

引用次数: 0

Understanding Coproporphyrins and Their Disposition: Coproporphyrinuria is Common, of Diverse Cause, and Rarely Indicates Porphyria. 了解比例卟啉及其处置：比例卟啉尿是常见的，原因多样，很少提示卟啉症。

IF 2.5 3区医学

American Journal of Medicine Pub Date : 2025-04-12 DOI: 10.1016/j.amjmed.2025.04.004

Herbert L Bonkovsky, Christopher D Ma, Manuela Araque, Jacqueline B Tiley, Kim L R Brouwer, Ulrich Stölzel

{"title":"Understanding Coproporphyrins and Their Disposition: Coproporphyrinuria is Common, of Diverse Cause, and Rarely Indicates Porphyria.","authors":"Herbert L Bonkovsky, Christopher D Ma, Manuela Araque, Jacqueline B Tiley, Kim L R Brouwer, Ulrich Stölzel","doi":"10.1016/j.amjmed.2025.04.004","DOIUrl":"10.1016/j.amjmed.2025.04.004","url":null,"abstract":"Coproporphyrins (CPs) are often mildly increased in plasma and urine, which leads to erroneous overdiagnosis of porphyrias. Herein we provide an overview of normal CP metabolism and factors that influence its disposition. We reviewed extant literature and here summarize and put into context current knowledge of CP metabolism and its disposition. CPs are formed as byproducts of normal heme synthesis. Normally they are removed chiefly by hepatocytes into bile and then stool. Organic anion-transporting peptides (OATPs) and multidrug resistance-associated proteins facilitate the uptake of CPs into epithelial cells and removal. Xenobiotics inhibit the activities of multidrug resistance-associated proteins and/or OATPs and affect the metabolism and disposition of CPs. CP concentrations are used as endogenous probes for assessing altered functions of OATPs. Diverse liver diseases and disorders lead to decreased secretion of CPs into bile and thus to increased concentrations of CPs in plasma and urine. Usually, mild to moderate increases in urinary CPs are due to alcohol, heavy metals, drug effects on transporters, or nonporphyric liver diseases not to porphyrias or to other inherited syndromes.","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0