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Cardioesophageal Reflex. Should it trigger clinician's response?
IF 2.5 3区 医学
American Journal of Medicine Pub Date : 2025-01-27 DOI: 10.1016/j.amjmed.2025.01.004
Irakli Todua, Deeb N Salem
{"title":"Cardioesophageal Reflex. Should it trigger clinician's response?","authors":"Irakli Todua, Deeb N Salem","doi":"10.1016/j.amjmed.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.01.004","url":null,"abstract":"<p><p>Cardiologists and gastroenterologists often encounter the coexistence of symptoms and functional abnormalities, but determining causation is more difficult.​​ In 1962 Smith and Papp first coined the term \"linked angina\". Their statement was preceded by the experiment whereby increase in bile duct pressure elicited the typical chest pain in patients with ischemic heart disease.​ It was demonstrated that dysphagia can be associated with ventricular arrhythmia suggestive of possible cardioesophageal reflex involvement. A potential association between gastroesophageal reflux disease and atrial fibrillation development has been proposed due to the close anatomic vicinity of the esophagus and the left atrium. It has been demonstrated that the patients suffering from prolonged gastro-esophageal acid reflux episodes and coronary spasm may be at higher risk for the development of linked-angina and acute myocardial infarction.​ We believe cardioesophageal reflex is a probable mediator of the linked angina. We recommend early treatment of gastroesophageal disorders in patients with symptomatic coronary arterial disease to alleviate the associated ischemic and arrhythmic burden.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caught in Transit: Thrombus Trapped in a Patent Foramen Ovale.
IF 2.5 3区 医学
American Journal of Medicine Pub Date : 2025-01-23 DOI: 10.1016/j.amjmed.2024.12.032
Ji Mei May Wong, Mihai Romanovschi, Pallavi Kawatra, David A Cohen, Roberto Rodriguez
{"title":"Caught in Transit: Thrombus Trapped in a Patent Foramen Ovale.","authors":"Ji Mei May Wong, Mihai Romanovschi, Pallavi Kawatra, David A Cohen, Roberto Rodriguez","doi":"10.1016/j.amjmed.2024.12.032","DOIUrl":"https://doi.org/10.1016/j.amjmed.2024.12.032","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The "Silk Road" that leads to Infliximab: A severe case of Behçet's disease.
IF 2.5 3区 医学
American Journal of Medicine Pub Date : 2025-01-22 DOI: 10.1016/j.amjmed.2025.01.013
Allysha K Yasuda, Joshua O Hendin, Julianna R Sabo, David C Pfeiffer
{"title":"The \"Silk Road\" that leads to Infliximab: A severe case of Behçet's disease.","authors":"Allysha K Yasuda, Joshua O Hendin, Julianna R Sabo, David C Pfeiffer","doi":"10.1016/j.amjmed.2025.01.013","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.01.013","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut Microbiome Modulation in Allergy Treatment: The Role of Fecal Microbiota Transplantation.
IF 2.5 3区 医学
American Journal of Medicine Pub Date : 2025-01-22 DOI: 10.1016/j.amjmed.2025.01.005
Henry Sutanto, Elisa Elisa, Betty Rachma, Deasy Fetarayani
{"title":"Gut Microbiome Modulation in Allergy Treatment: The Role of Fecal Microbiota Transplantation.","authors":"Henry Sutanto, Elisa Elisa, Betty Rachma, Deasy Fetarayani","doi":"10.1016/j.amjmed.2025.01.005","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.01.005","url":null,"abstract":"<p><p>The prevalence of allergic diseases has been rising, paralleling lifestyle changes and environmental exposures that have altered human microbiome composition. This review article examines the intricate relationship between the gut microbiome and allergic diseases, emphasizing the potential of fecal microbiota transplantation as a promising novel treatment approach. It explains how reduced microbial exposure in modern societies contributes to immune dysregulation and the increasing incidence of allergies. The discussion also addresses immune homeostasis and its modulation by the gut microbiome, highlighting the shift from eubiosis to dysbiosis in allergic conditions. Furthermore, this article reviews existing studies and emerging research on the role of fecal microbiota transplantation in restoring microbial balance, providing insights into its mechanisms, efficacy, and safety.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical characteristics and outcomes of patients with nonrheumatic streptococcal pharyngitis associated myocarditis.
IF 2.5 3区 医学
American Journal of Medicine Pub Date : 2025-01-22 DOI: 10.1016/j.amjmed.2025.01.003
Wesam Mulla, Anan Younis, Sana Zahalka, Anat Wieder, Dafna Yahav, Amitai Segev, Israel Mazin, Raphael Kuperstein, Michael Arad, Shlomi Matetzky, Roy Beigel
{"title":"Clinical characteristics and outcomes of patients with nonrheumatic streptococcal pharyngitis associated myocarditis.","authors":"Wesam Mulla, Anan Younis, Sana Zahalka, Anat Wieder, Dafna Yahav, Amitai Segev, Israel Mazin, Raphael Kuperstein, Michael Arad, Shlomi Matetzky, Roy Beigel","doi":"10.1016/j.amjmed.2025.01.003","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.01.003","url":null,"abstract":"<p><strong>Background: </strong>Reports of nonrheumatic streptococcal pharyngitis associated myocarditis (SPAM) are rare, and its incidence, pathophysiology, and clinical features remain unclear. We evaluated the clinical course and outcome of patients diagnosed with nonrheumatic SPAM, with a particular focus on differentiating it from other etiologies of myocarditis.</p><p><strong>Methods: </strong>Seventy-nine consecutive individuals (age 32±9 years, 71 men) with clinically diagnosed SPAM were evaluated. None satisfied the revised Jones criteria for diagnosis of acute rheumatic fever.</p><p><strong>Results: </strong>Average onset of symptoms prior to hospitalization was 5.44±5.16 days, all had sore throat and were treated with antibiotics for 10 days; Clinical presentation consisted mostly with chest pain (91%), fever (90%), electrocardiographic ST-segment elevation (80%), and biochemical evidence of myocyte necrosis (100%). In 27 cases, coronary angiography was performed and in all either normal or nonsignificant coronary artery disease was found. Cardiac magnetic resonance imaging was done in 61 cases and demonstrated subepicardial late gadolinium enhancement (90%) predominantly in the lateral (85%) and inferior (75%) sides.</p><p><strong>Conclusions: </strong>Nonrheumatic SPAM may not be as infrequent as thought and should be considered in the differential diagnosis of acute ST-segment elevation myocardial infarction, especially in male patients with sore throat and fever.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lost in Translation.
IF 2.5 3区 医学
American Journal of Medicine Pub Date : 2025-01-21 DOI: 10.1016/j.amjmed.2025.01.009
Sophia Ruser
{"title":"Lost in Translation.","authors":"Sophia Ruser","doi":"10.1016/j.amjmed.2025.01.009","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.01.009","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging the Healthcare Gap in Rural Populations: Challenges, Innovations, and Solutions.
IF 2.5 3区 医学
American Journal of Medicine Pub Date : 2025-01-21 DOI: 10.1016/j.amjmed.2025.01.008
Ayesha Javed
{"title":"Bridging the Healthcare Gap in Rural Populations: Challenges, Innovations, and Solutions.","authors":"Ayesha Javed","doi":"10.1016/j.amjmed.2025.01.008","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.01.008","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Masquerading Cavity: Delayed Diagnosis of Pulmonary Embolism.
IF 2.5 3区 医学
American Journal of Medicine Pub Date : 2025-01-20 DOI: 10.1016/j.amjmed.2025.01.012
Yusuke Ito
{"title":"Masquerading Cavity: Delayed Diagnosis of Pulmonary Embolism.","authors":"Yusuke Ito","doi":"10.1016/j.amjmed.2025.01.012","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.01.012","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thrombotic Thrombocytopenic Purpura presenting as a Thunderclap Headache!
IF 2.5 3区 医学
American Journal of Medicine Pub Date : 2025-01-20 DOI: 10.1016/j.amjmed.2024.12.031
Dr Katelyn Chiu, Dr Pak Ling Lui, Dr Sandra Tan
{"title":"Thrombotic Thrombocytopenic Purpura presenting as a Thunderclap Headache!","authors":"Dr Katelyn Chiu, Dr Pak Ling Lui, Dr Sandra Tan","doi":"10.1016/j.amjmed.2024.12.031","DOIUrl":"https://doi.org/10.1016/j.amjmed.2024.12.031","url":null,"abstract":"<p><p>A 35-year-old male with a history of hypertension presented with a thunderclap headache. Laboratory tests revealed isolated mild thrombocytopenia and plain brain imaging was normal. Subsequently he developed chest pain and breathlessness, accompanied with an acute kidney injury, elevated troponins and worsening thrombocytopenia. The constellation of features prompted consideration of thrombotic thrombocytopenic purpura.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"The Song of lce and Fire" in the Cerebellopontine Angle Running head:meningioma, schwannomas.
IF 2.5 3区 医学
American Journal of Medicine Pub Date : 2025-01-20 DOI: 10.1016/j.amjmed.2025.01.014
Ming Liang, Zhilin Lyu, Benqi Zhao, Yongquan Yu
{"title":"\"The Song of lce and Fire\" in the Cerebellopontine Angle Running head:meningioma, schwannomas.","authors":"Ming Liang, Zhilin Lyu, Benqi Zhao, Yongquan Yu","doi":"10.1016/j.amjmed.2025.01.014","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.01.014","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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