American Journal of Medicine最新文献

{"title":"A 65-year-old man with end-stage renal disease and lytic bone lesions.","authors":"Roba Abousaway, Nima Rahman, Alejandro Moreno","doi":"10.1016/j.amjmed.2025.09.013","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.09.013","url":null,"abstract":"<p><p>Schmorl's nodes; lytic bone lesions; end-stage renal disease; hyperparathyroidism; diagnostic imaging.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative Does Not Mean Safe: Virulent CA-MRSA in Young Worker.","authors":"Krison Rs Sum, Wilson Gw Goh, Isaac Ks Ng, Priscillia Ps Lye, Sai Meng Tham","doi":"10.1016/j.amjmed.2025.09.014","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.09.014","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Sun-Moon Sign in Adenocarcinoma-to-Meningioma Metastasis.","authors":"Jyun-Yuan Huang, Yu-Duan Tsai","doi":"10.1016/j.amjmed.2025.09.009","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.09.009","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pagophagia caused by iron deficiency without anemia.","authors":"Mutsuka Kurihara, Yasutaka Yanagita, Daiki Yokokawa, Hirotoshi Fujii, Takanori Uehara","doi":"10.1016/j.amjmed.2025.09.016","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.09.016","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the Crab Bites Back - Dinner Party Turned Tragedy.","authors":"Hui Yang, Isaac Ks Ng, Wilson Gw Goh","doi":"10.1016/j.amjmed.2025.09.023","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.09.023","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Cardiopulmonary Effects of Tirzepatide in Atrial Fibrillation and Comorbid Chronic Obstructive Pulmonary Disease.","authors":"Min Choon Tan, Ming Fong Yee, Aravinthan Vignarajah, Girish Pathangey, Mahmoud Abdelnabi, Christopher V DeSimone, Abhishek J Deshmukh, Dan Sorajja, Hicham El-Masry, Justin Z Lee","doi":"10.1016/j.amjmed.2025.09.018","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.09.018","url":null,"abstract":"<p><strong>Background: </strong>The coexistence of atrial fibrillation and chronic obstructive pulmonary disease often leads to worse clinical outcomes. Tirzepatide is a promising therapy for diabetes and weight management, with potential cardiovascular benefits via anti-inflammatory effects. However, its impact in patients with both atrial fibrillation and chronic obstructive pulmonary disease is unknown.</p><p><strong>Methods: </strong>Using the TriNetX Analytics Research Network, patients aged ≥18 years with atrial fibrillation and chronic obstructive pulmonary disease between 6/1/2022 and 1/1/2024 were included. Patients were divided into tirzepatide and control groups. Propensity score matching included demographics, comorbidities, cardiovascular medications, and left ventricular ejection fraction. Outcomes were all-cause mortality, cardiac events, and chronic obstructive pulmonary disease exacerbation over one year.</p><p><strong>Results: </strong>A total of 3,728 tirzepatide users and 499,199 controls were identified; 3,726 patients remained in each group after matching. Tirzepatide use was associated with lower odds of 1-year all-cause mortality (OR: 0.145; 95% CI: 0.115-0.184), hospitalization (OR: 0.284; 95% CI: 0.258-0.313), stroke (OR: 0.619; 95% CI: 0.519-0.738), cardiac arrest (OR: 0.491; 95% CI: 0.362-0.667), heart failure exacerbation (OR: 0.270; 95% CI: 0.236-0.308), and chronic obstructive pulmonary disease exacerbation (OR: 0.586; 95% CI: 0.513-0.671). Lower odds of anti-arrhythmic drug initiation, cardioversion, and atrial fibrillation ablation were also observed.</p><p><strong>Conclusion: </strong>Tirzepatide use was associated with improved mortality and cardiovascular outcomes in patients with atrial fibrillation and chronic obstructive pulmonary disease and reduced need for rhythm control interventions. Prospective studies are needed to validate these findings.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Myasthenia Gravis Meets Autoimmunity: Cause or Confounder?","authors":"Christian Messina","doi":"10.1016/j.amjmed.2025.09.005","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.09.005","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Face in Flare: A Severe Case of Eczema Herpeticum.","authors":"Suzie Kim, John Woller","doi":"10.1016/j.amjmed.2025.09.021","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.09.021","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reimagining the White Coat Ceremony: The Stethoscope as a Patient-Centered Alternative.","authors":"Eliyahu Y Lehmann","doi":"10.1016/j.amjmed.2025.09.006","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.09.006","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Frailty Scale Refines Prognosis in Acute Pulmonary Embolism Beyond Traditional Risk Scores.","authors":"Jorge Sinclair De Frias, Agostina Velo, Abdul Rehman, Avinash Singh, Madeline Ehrlich, David J Steiger","doi":"10.1016/j.amjmed.2025.09.011","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.09.011","url":null,"abstract":"<p><strong>Background: </strong>The European Society of Cardiology (ESC) risk class and Pulmonary Embolism Severity Index (PESI) score can predict outcomes of patients with acute pulmonary embolism. However, whether the Clinical Frailty Scale (CFS) improves risk prediction in acute pulmonary embolism remains uncertain.</p><p><strong>Methods: </strong>We retrospectively reviewed patients aged ≥ 50 years with acute pulmonary embolism managed by the Pulmonary Embolism Response Team (PERT) at three hospitals within the Mount Sinai Health System (New York, NY) from January 2020 to June 2024. Frailty was defined as CFS >4. Multivariable regression assessed association between outcomes (mortality, bleeding, 30-day readmission and hospital length of stay and risk scores (ESC, PESI and CFS).</p><p><strong>Results: </strong>Among 291 patients (median age: 69 years; 153 female), 99 (34.0%) were frail. Frailty was associated with higher odds of in-hospital mortality (odds ratio [OR]: 2.50), 30-day mortality (OR: 2.39), 30-day readmission (OR: 1.77) and longer length of stay (incidence rate ratio: 1.21). Incorporating CFS to models with ESC and PESI score improved prediction for 30-day mortality (net reclassification improvement [NRI]: 8.2%), 30-day major bleeding (NRI: 29.3%) and 30-day readmission (NRI: 29.3%).</p><p><strong>Conclusion: </strong>Frailty was independently associated with adverse outcomes in acute pulmonary embolism. Incorporating CFS improved the predictive performance of existing scores in patients with acute pulmonary embolism.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}