Eric Zhang, Jennifer Smiechowski, Emma E M Spence, Stefana Pancic, Irene W Y Ma
{"title":"Macaroni Sign: Point-of-care Ultrasound Identification of Takayasu Arteritis.","authors":"Eric Zhang, Jennifer Smiechowski, Emma E M Spence, Stefana Pancic, Irene W Y Ma","doi":"10.1016/j.amjmed.2025.06.008","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.06.008","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmet Onat Özdemir, Mauro Cozzolino, Osman Gurdal, Ivonne Carosi Arcangeli, Stefania Mancone, Giovanna Celia
{"title":"A Decade of Hypnotherapy Research for Multiple Sclerosis Symptom Management: A Systematic Review.","authors":"Ahmet Onat Özdemir, Mauro Cozzolino, Osman Gurdal, Ivonne Carosi Arcangeli, Stefania Mancone, Giovanna Celia","doi":"10.1016/j.amjmed.2025.05.049","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.05.049","url":null,"abstract":"<p><p>This systematic review investigates the effectiveness of hypnotherapy for symptom control in multiple sclerosis (MS) patients. Following PRISMA guidelines, eight research (N=423 participants, sample sizes 15-173) were assessed using the PEDro scale. Hypnotherapy showed significant benefits, including a 30-45% reduction in pain intensity (p<0.01), an 8.19 point decrease in Multidimensional Fatigue Inventory scores (p<0.05), a 1.98-point improvement in Pittsburgh Sleep Quality Index scores (p<0.05), and a 3.7-point reduction in DASS-21 depression subscale. Optimal protocols included 8-10 weekly 45-60-minute sessions, with coupled treatments (hypnotherapy with neurofeedback or mindfulness) producing better results (additional 15-20% improvement). Follow-ups revealed that psychological advantages persisted, although pain alleviation decreased after 6 months without maintenance. The evidence suggests that hypnotherapy can be an effective additional strategy for MS symptom management, with hypnotic cognitive treatment exhibiting notable efficacy for tiredness and psychosocial problems. Methodological limitations demand larger trials with standardized methodologies.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Integrative Approach to HPA Axis Dysfunction: From Recognition to Recovery.","authors":"Melinda Ring","doi":"10.1016/j.amjmed.2025.05.044","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.05.044","url":null,"abstract":"<p><p>The hypothalamic-pituitary-adrenal (HPA) axis plays a central role in the stress response and is implicated in a wide range of chronic health conditions. This review explores evidence-based perspectives on HPA axis dysregulation, its pathophysiology, diagnostic strategies, and integrative therapeutic approaches. Key contributing factors include psychological stress, genetic and epigenetic influences, dietary factors, gut health, immune system interactions, inflammation, toxins, and hormonal influences. Diagnostic methods such as serum cortisol levels, diurnal salivary cortisol profiles, and other tests are outlined. Therapeutic approaches emphasize the importance of the patient-provider relationship, stress reduction techniques, lifestyle modifications, dietary interventions, supplements, adaptogenic herbs, and other integrative therapies. Understanding HPA axis dysfunction through an integrative lens fosters individualized care and bridges the gap between conventional endocrinology and functional models, empowering providers to support patients with often-dismissed symptoms of fatigue, insomnia, mood instability, and impaired stress tolerance.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David S Schade, Allen Adolphe, Samuel Wann, R Philip Eaton
{"title":"Elevated Lipoprotein(a): A Treatment Challenge and a Practical Solution.","authors":"David S Schade, Allen Adolphe, Samuel Wann, R Philip Eaton","doi":"10.1016/j.amjmed.2025.05.035","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.05.035","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yao Jiang, Han Zhang, Chujie Zhang, Yingyang Geng, Yin Zhang, Changdong Guan, Kefei Dou, Yuejin Yang, Shubin Qiao, Yongjian Wu, Lei Song
{"title":"Impact of dual antiplatelet therapy duration on long-term outcomes following chronic total occlusion percutaneous coronary intervention.","authors":"Yao Jiang, Han Zhang, Chujie Zhang, Yingyang Geng, Yin Zhang, Changdong Guan, Kefei Dou, Yuejin Yang, Shubin Qiao, Yongjian Wu, Lei Song","doi":"10.1016/j.amjmed.2025.05.038","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.05.038","url":null,"abstract":"<p><strong>Background: </strong>Optimal dual antiplatelet therapy (DAPT) duration after percutaneous coronary intervention for coronary chronic total occlusion remains unclear. Thus, we aim to determine the optimal DAPT duration in this high-risk cohort with complex anatomy and procedures.</p><p><strong>Methods: </strong>Between January 2010 and December 2013, 2659 consecutive chronic total occlusion patients undergoing percutaneous coronary intervention at Fu Wai Hospital were enrolled, and those without adverse events within 12 months were categorized into long (>12 months) or short-term (≤12 months) groups according to DAPT duration. The primary endpoint was a composite of cardiac death and spontaneous myocardial infarction at 5 years. The safety endpoint was the rate of Bleeding Academic Research Consortium (BARC) 2, 3 or 5 type bleeding at 5 years.</p><p><strong>Results: </strong>Overall, 1923 patients were included in the final analysis, of which 1104 (57.4%) continued DAPT beyond 12 months. Compared with short-term DAPT, long-term DAPT was associated with a lower rate of primary outcome (3.6% vs. 6.3%; adjusted hazard ratio[aHR]: 0.58 [95% CI, 0.38 to 0.89], p=0.01), primarily driven by fewer cardiac death (0.1% vs. 4.0%, aHR:0.02 [95% CI, 0.00 to 0.17]; p<0.001); and a higher risk of BARC 2-5 bleeding (3.8% vs. 1.5%; aHR: 2.61 [95% CI, 1.37 to 4.97], p<0.01), whereas the risk of BARC 3 or greater was comparable between groups.</p><p><strong>Conclusion: </strong>In patients undergoing chronic total occlusion percutaneous coronary intervention, prolonged DAPT was associated with a reduced risk of cardiac death and myocardial infarction, but with an increased risk of minor bleeding.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Trust and Value in AI-Driven Medicine.","authors":"Ruchi Bhatia","doi":"10.1016/j.amjmed.2025.06.001","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.06.001","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Call for Healthcare Providers to Address Faith, Religiosity, and Spirituality among Older Adults.","authors":"Hawa O Abu","doi":"10.1016/j.amjmed.2025.05.048","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.05.048","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diana Hsiao, Adithi A Tirumalai, Justina John, Sohum Sheth, Beth Frates, Dean Ornish, Monica Aggarwal
{"title":"Physician Mental Health: Understanding Physician Burnoutand Solutions for Well-Being.","authors":"Diana Hsiao, Adithi A Tirumalai, Justina John, Sohum Sheth, Beth Frates, Dean Ornish, Monica Aggarwal","doi":"10.1016/j.amjmed.2025.05.039","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.05.039","url":null,"abstract":"<p><p>Physician burnout has become increasingly prevalent in the United States, and it has significant consequences on the patient, physician, and healthcare system levels. Increasing physician burnout has led to greater physician turnover rates, medical errors, and financial burdens on our healthcare system. This review of physician mental health and burnout discusses key contributing factors, potential solutions, and investigates the benefits of love, social connection, and joy. This paper also addresses burnout specific to female physicians and compares burnout by subspecialty. Understanding the root causes of physician burnout can help us implement meaningful change to mitigate the consequences by reducing stigma, fostering resilience strategies, improving quality of life for physicians, enhancing patient care, and reducing the financial strain on healthcare systems.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The performance of biomarkers for the diagnosis of Parkinson's disease: A systematic review.","authors":"Jaden Lim, Yeonglong Ay","doi":"10.1016/j.amjmed.2025.05.047","DOIUrl":"https://doi.org/10.1016/j.amjmed.2025.05.047","url":null,"abstract":"<p><strong>Background: </strong>Early diagnosis of Parkinson's disease remains challenging due to the current clinical diagnostic approach. With machine learning emerging as a powerful tool for biomarker discovery, we aim to determine whether biomarkers processed by machine learning models can enable earlier detection of Parkinson's disease.</p><p><strong>Methods: </strong>We conducted a literature search with a 10-year limit that yielded 161 biomarkers derived from serum, cerebrospinal fluid and genes. Initially, biomarkers were classified into four groups according to the biological timeline of Parkinson's disease pathogenesis. Subsequently, we further organised the biomarkers into two categories: pre-motor phase and motor phase biomarkers. Two analyses were then conducted according to the aforementioned classifications, with the performance of biomarkers evaluated via their AUC values as derived from machine learning models.</p><p><strong>Results: </strong>No significant differences were found in either analysis, suggesting that all biomarkers, regardless of their role in the biological sequences underpinning Parkinson's disease pathogenesis, nor their association with the pre-motor or motor phases of Parkinson's disease, have the potential to serve as equally valid diagnostic predictors. Additionally, we identified 26 top-performing biomarkers with high AUC values (>0.8).</p><p><strong>Conclusion: </strong>The main finding in our analyses was that pre-motor phase biomarkers, which offer the advantage of enabling an earlier diagnosis compared to clinical methods, can achieve a comparably high level of diagnostic accuracy as motor phase biomarkers. Therefore, our foremost suggestion is further research into the clinical viability of pre-motor phase biomarkers that compose part of the aforementioned 26 top-performing biomarkers.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}