Annals of Allergy Asthma & Immunology最新文献

{"title":"Incorporating type 2 inflammation status with clinical diagnosis and transcriptomics data in asthma risk classification","authors":"Zi Ye PhD , Solomon W. Harrar PhD , Joseph Beyene PhD , Tesfaye B. Mersha PhD","doi":"10.1016/j.anai.2025.06.029","DOIUrl":"10.1016/j.anai.2025.06.029","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 329-332"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On a wheeze and a prayer","authors":"Mitchell H. Grayson MD","doi":"10.1016/j.anai.2025.05.015","DOIUrl":"10.1016/j.anai.2025.05.015","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 243-244"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“And the Pathy goes to…”","authors":"Erin L. Reigh MD, MS","doi":"10.1016/j.anai.2025.04.010","DOIUrl":"10.1016/j.anai.2025.04.010","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 276-277"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful venom immunotherapy with avapritinib in a patient with systemic mastocytosis","authors":"Leandra Depina BA , Shriya N. Karmarkar BS , Sydney Moeller BS , Mark Lazarovich MD , Alice Rocha de Magalhães MD , Mariana Castells MD, PhD , Matthew P. Giannetti MD","doi":"10.1016/j.anai.2025.06.015","DOIUrl":"10.1016/j.anai.2025.06.015","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 343-344"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing hidden patterns in hereditary angioedema","authors":"Chun-Chieh Chen MD, PhD , Shiuan-Chih Chen MD, PhD","doi":"10.1016/j.anai.2025.05.029","DOIUrl":"10.1016/j.anai.2025.05.029","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Page 351"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of respiratory syncytial virus on asthma development and exacerbation","authors":"Ruixue Ma PhD ,&nbsp;Chenyu Zhang BA ,&nbsp;Yi Zhang BA ,&nbsp;Hong Tan BA ,&nbsp;Yao Zhang PhD ,&nbsp;Qiuhong Li BA ,&nbsp;Yumei Bai PhD ,&nbsp;Xin Sun PhD","doi":"10.1016/j.anai.2025.05.011","DOIUrl":"10.1016/j.anai.2025.05.011","url":null,"abstract":"<div><div>Asthma is a chronic inflammatory disorder of the lower airways clinically characterized by recurrent wheezing, breathlessness, cough, and dyspnea and the most prevalent chronic disease among children and adolescents. Respiratory viral infections are implicated in asthma inception and exacerbation, with respiratory syncytial virus (RSV) emerging as a key contributor. RSV is a leading cause of acute lower respiratory tract infections, particularly infant bronchiolitis, and is associated with a type 2-biased immune response, diminished interferon activity, epithelial barrier dysfunction, and altered airway microbiome. Although the causal relationship between RSV and asthma remains debated, early life RSV lower respiratory tract infections are increasingly recognized as a significant risk factor for recurrent wheezing and asthma-like symptoms in childhood. This review comprehensively evaluates existing evidence on the long-term respiratory outcomes of infant RSV infection, elucidates the pathophysiological mechanisms connecting RSV infection to asthma development—such as immune dysregulation, chronic airway inflammation, and gene-environment interplay—and highlights novel preventive strategies. Recent advancements, such as maternal RSV vaccines and long-acting monoclonal antibodies, demonstrate efficacy in reducing severe RSV disease burden and subsequent wheeze in high-risk infants. By bridging clinical observations with mechanistic insights, this review underpins the development of future clinical therapies.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 268-275"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining avenues for improved food allergy support and safety on college campuses","authors":"Pranav M. Bajaj BA ,&nbsp;Madeleine Kanaley MPH ,&nbsp;Samantha Sansweet MPH ,&nbsp;Kethan Bajaj BA ,&nbsp;Julia Auerbach BA ,&nbsp;Eirene Fithian BA ,&nbsp;Khalid Ibrahim MS ,&nbsp;Ruchi Gupta MD, MPH","doi":"10.1016/j.anai.2025.06.005","DOIUrl":"10.1016/j.anai.2025.06.005","url":null,"abstract":"<div><h3>Background</h3><div><span>Food Allergy (FA) is a </span>chronic disease<span> with public health importance affecting an estimated 1 in 13 children and 1 in 10 adults. Limited research is available on policies and support available at the college level.</span></div></div><div><h3>Objective</h3><div>To better understand the experiences of college students with and without FA to determine avenues to improve safety and quality of life for college students with FA.</div></div><div><h3>Methods</h3><div>An online, cross-sectional survey was distributed to college students with and without FA in the United States from 2021 to 2023. Descriptive statistics<span> were used to determine respondent demographics, FA knowledge, student reaction history, effects of FA on social life, and recommendations for improvement of FA safety and awareness on campus.</span></div></div><div><h3>Results</h3><div>A total of 204 students—78 with FA—completed the survey from 72 US universities. Of the students with FA, 41% reported that their university was not aware of their FA and 28% experienced a food allergic reaction in their campus dining hall, with the most common cause being food mislabeled with allergen (43%). Students with FA mostly endorsed wanting regular FA training for campus dining staff (71%) and increased availability of stock epinephrine in the dining halls (59%) to improve safety on campus.</div></div><div><h3>Conclusion</h3><div>To ensure the safety of students with FA and reduce reactions on campus, it is imperative that universities improve the identification of students with FA, increase regular FA training for dining staff, and increase the availability of stock epinephrine in dining halls.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 297-302.e11"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccine hesitancy for allergist-immunologists","authors":"Charlotte A. Moser MS","doi":"10.1016/j.anai.2025.06.009","DOIUrl":"10.1016/j.anai.2025.06.009","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 245-246"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in urinary mast cell mediators","authors":"Valerie Jaroenpuntaruk MD ,&nbsp;Sarah M. Jenkins MS ,&nbsp;Carin Y. Smith BS ,&nbsp;Alexei Gonzalez-Estrada MD ,&nbsp;Lyda Cuervo-Pardo MD ,&nbsp;Miguel A. Park MD ,&nbsp;Elina Jerschow MD, MS ,&nbsp;Rohit Divekar MBBS, PhD ,&nbsp;Avni Y. Joshi MD, MS ,&nbsp;Thanai Pongdee MD ,&nbsp;Dayne H. Voelker MD ,&nbsp;Joseph H. Butterfield MD ,&nbsp;Sergio E. Chiarella MD","doi":"10.1016/j.anai.2025.05.028","DOIUrl":"10.1016/j.anai.2025.05.028","url":null,"abstract":"<div><h3>Background</h3><div>Urinary<span> mast cell mediators aid in diagnosing atopic and mast cell disorders, yet sex differences in these mediators remain unreported despite known sex-specific variations in eicosanoid pathways.</span></div></div><div><h3>Objective</h3><div>To characterize sex differences in urinary mast cell mediators 2,3-dinor-11β-prostaglandin F2α (2,3-BPG), N-methylhistamine, and leukotriene E4 (LTE4).</div></div><div><h3>Methods</h3><div>This retrospective chart review of 4033 patients of all ages at Mayo Clinic from June 1, 2019 to May 31, 2024 including demographic and clinical data. Urine mast cell mediators 2,3-BPG, N-methylhistamine, and LTE4 were quantified using liquid chromatography-tandem mass spectrometry and normalized to creatinine levels. Statistical analyses were performed using R software (R Core Team, Vienna, Austria).</div></div><div><h3>Results</h3><div><span>Among patients tested for urinary mast cell mediators, 78.8% were female sex. Compared with females, males were older at testing (mean 48.0 vs 40.1 years), more likely to report ever smoking (33.5% vs 22.7%), had higher body mass index (mean 28.6 vs 27.7), more often had an atopic condition (82.6% vs 71.0%) or comorbidity (46.1% vs 30.3%), and had higher median LTE4 levels (102.5 vs 90.0 pg/mg creatinine) (</span><em>P</em><span><span> &lt; .001 for all). Males also more typically had elevated 2,3-BPG (8.0% vs 3.7%) and eosinophil counts (17.0% vs 5.9%) and higher median </span>tryptase levels (5.1 vs 4.3 pg/mL) (</span><em>P</em> &lt; .001 for all). Multivariable analysis revealed a sex-by-atopy interaction for LTE4, with higher levels in atopic males (male/female ratio 1.15 [95% CI: 1.07-1.25], <em>P</em> &lt; .001) and higher levels in nonatopic females (male/female ratio 0.86 [95% CI: 0.76-0.97], <em>P</em> = .02).</div></div><div><h3>Conclusion</h3><div>Sex differences in testing rates and urinary mediator levels highlight the need to consider sex in optimizing the diagnostic utility of these mediators.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 320-327.e2"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body mass index not associated with clinical severity in chronic rhinosinusitis","authors":"Aaron D. Smith BS ,&nbsp;Catherine E. Lyons BS, BA ,&nbsp;Maria Amelia Perozo MD ,&nbsp;Aaron J. Stein BS ,&nbsp;Larry Borish MD","doi":"10.1016/j.anai.2025.05.032","DOIUrl":"10.1016/j.anai.2025.05.032","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 338-340"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}