Annals of Allergy Asthma & Immunology最新文献

{"title":"Worse airflow obstruction but not type 2 biomarkers identifies super-responders to tezepelumab in real life.","authors":"Robert Greig, Rory Chan, Brian J Lipworth","doi":"10.1016/j.anai.2025.03.013","DOIUrl":"10.1016/j.anai.2025.03.013","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Long-term Air Pollution and Allergen Exposure with Endotype Shift in Chronic Rhinosinusitis with nasal polyps.","authors":"Mengyu Chen, Zhaofeng Xu, Yiwei Fu, Nan Zhang, Wendong Liu, Lishuo Shi, Tong Lu, Zhengqi Li, Zhaoxu Tu, Jian Li, Claus Bachert, Weiping Wen, Yihui Wen","doi":"10.1016/j.anai.2025.03.014","DOIUrl":"https://doi.org/10.1016/j.anai.2025.03.014","url":null,"abstract":"<p><strong>Background: </strong>Chronic rhinosinusitis with nasal polyps (CRSwNP) is classified into Type 2 and non-Type 2 inflammation based on mucosal cytokine level. Over 20 years, the Type 2/non-Type 2 ratio has increased, potentially influenced by air pollution and aeroallergens.</p><p><strong>Objective: </strong>This study investigates the association between long-term exposure to air pollutants and aeroallergens and the endotype shift in CRSwNP.</p><p><strong>Methods: </strong>We enrolled 2,358 CRSwNP patients from Guangzhou and 416 from Ghent. Endotypes were defined using a diagnostic model or IL-5 levels in nasal polyps. Pollutant exposure was estimated based on residential ZIP code. Generalized additive models with restricted cubic splines and generalized linear mixed models were used to assess the effects of PM2.5, PM10, NO2, SO2, O3, and aeroallergen exposure on Type 2 CRSwNP risk compared to non-Type 2.</p><p><strong>Results: </strong>Higher air pollutant exposure was linked to a lower Type 2/non-Type 2 ratio. In Guangzhou, every 1 μg/m³ increase in 3-year cumulative PM2.5 exposure was associated with an OR of 0.97 (95% CI: 0.96-0.98, P < 0.001) for Type 2 CRSwNP. In Ghent, the Relative Risk (RR) was 0.78 (95% CI: 0.65-0.94, P = 0.009) for the same exposure increase. Elevated total IgE and Dermatophagoides pteronyssinus sensitization increase Type 2 risk over non-Type 2 CRSwNP in Guangzhou, while allergic rhinitis, elevated total IgE, pollen sensitization, and multi-allergens sensitization increased Type 2 CRSwNP risk in Ghent.</p><p><strong>Conclusion: </strong>Decreasing long-term air pollution exposure and increasing allergen sensitization is associated with higher Type 2/non-T 2 CRSwNP ratio, highlighting the role of environmental factors in endotype shifting.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergy to okra with cross-reactivity to medlar.","authors":"Patricia Gutiérrez-Canales, Carlos Fernández-Lozano, Belén de-la-Hoz-Caballer, Laura Díaz-Montalvo, David González-de-Olano","doi":"10.1016/j.anai.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.anai.2025.03.010","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Disruption in Chronic Rhinosinusitis Improves with Exhalation-Delivery Nasal Steroid Therapy.","authors":"Donyea L Moore, Rachel Nolte, Shreya Maharana, Evan A Patel, Christopher Codispoti, Pete S Batra, Mahboobeh Mahdavinia","doi":"10.1016/j.anai.2025.03.012","DOIUrl":"https://doi.org/10.1016/j.anai.2025.03.012","url":null,"abstract":"<p><strong>Background: </strong>Chronic rhinosinusitis is a common inflammatory condition that often leads to significant sleep disturbances, negatively affecting quality of life. While intranasal steroids are a standard treatment, their effect on sleep disturbances in chronic rhinosinusitis has not been extensively studied.</p><p><strong>Objective: </strong>This study aimed to determine whether a nasal steroid delivered via exhalation could improve sleep quality in chronic rhinosinusitis.</p><p><strong>Methods: </strong>Patients with chronic rhinosinusitis were treated with nasal fluticasone via an exhalation delivery system for four months. Sleep assessments were conducted at baseline, and at two- and four-months post-treatment using comprehensive sleep and quality of life measures. Blood samples were taken at baseline to assess interleukin-6 levels. Regression analysis compared baseline and post-treatment data, adjusting for demographics. The influence of interleukin-6 levels and allergic comorbidities on treatment response was also evaluated.</p><p><strong>Results: </strong>Significant improvements were observed in sinonasal symptoms and sleep quality at two and four months (P < 0.05). Daytime sleepiness showed trends toward improvement. Interleukin-6 levels below 6 ng/mL and absence of asthma were associated with response to treatment in terms of sleep quality.</p><p><strong>Conclusion: </strong>High-distribution nasal steroids delivered via an exhalation system significantly improved sleep quality in patients with chronic rhinosinusitis. However, certain subgroups, such as those with lower interleukin-6 and those without comorbid asthma, benefit more significantly in terms of sleep quality.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical Considerations in Food Allergy Management: A Focus on Infants and Toddlers.","authors":"Timothy M Buckey, Aikaterini Anagnostou","doi":"10.1016/j.anai.2025.03.011","DOIUrl":"https://doi.org/10.1016/j.anai.2025.03.011","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated oxidative stress and steroid insensitivity in patients with asthma and high body fat percentage.","authors":"Masako To, Yoshihito Arimoto, Natsue Honda, Naho Furusho, Toru Kinouchi, Yuichiro Takeshita, Kosuke Haruki, Yasuo To","doi":"10.1016/j.anai.2025.03.009","DOIUrl":"10.1016/j.anai.2025.03.009","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a risk factor for poor asthma control. Previous research suggests that patients with asthma and obesity have reduced responsiveness to corticosteroids. Recent studies indicate that body fat percentage may be more strongly associated with obesity-related diseases compared with body mass index. However, the relationship between body fat percentage and asthma, particularly regarding steroid sensitivity, remains unclear.</p><p><strong>Objective: </strong>To investigate the association between body fat percentage and steroid sensitivity in patients with asthma and elucidate the potential mechanisms underlying this association.</p><p><strong>Methods: </strong>Adult patients with asthma were enrolled and categorized into patients with high body fat percentage (HBF) and control groups. Peripheral blood mononuclear cells were isolated from the blood samples. These cells were cultured with dexamethasone followed by stimulation with tumor necrosis factor-α to assess the half-maximal inhibitory concentration of dexamethasone (IC₅₀-Dex). Serum adipocytokines and oxidative stress markers were also measured. The effects of metformin on steroid sensitivity and oxidative stress in peripheral blood mononuclear cells were evaluated ex vivo.</p><p><strong>Results: </strong>The HBF group exhibited significantly higher IC₅₀-Dex values than the control group. In the HBF group, IC₅₀-Dex correlated with the number of acute exacerbations per year and serum oxidative stress marker levels. Treatment with metformin significantly reduced both IC₅₀-Dex and oxidative stress marker levels in the HBF group.</p><p><strong>Conclusion: </strong>Oxidative stress associated with increased body fat may contribute to impaired steroid sensitivity in patients with asthma. Metformin may improve steroid sensitivity by reducing oxidative stress, suggesting a potential therapeutic approach in this patient population.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased asthma burden during and after the COVID-19 pandemic among US adults.","authors":"Hongxuan Fan, Zhaoyu Ren, Ping Zhang, Boda Zhou","doi":"10.1016/j.anai.2025.03.007","DOIUrl":"10.1016/j.anai.2025.03.007","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do not wait to challenge children: Results of a standard operating procedure for low-risk antibiotic challenges.","authors":"Grace Koo, Anjali Sundar, Kimberly B Woodward, Cosby A Stone, Allison E Norton","doi":"10.1016/j.anai.2025.03.006","DOIUrl":"10.1016/j.anai.2025.03.006","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How we treat severe atopic dermatitis.","authors":"Ellen Chinchilli, Anna De Benedetto, Lisa A Beck","doi":"10.1016/j.anai.2025.03.005","DOIUrl":"10.1016/j.anai.2025.03.005","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protease-activated receptor 2 and interleukin-13 receptor α1 activation is linked to eosinophilic chronic rhinosinusitis.","authors":"En-Chih Liao, Huai-Pao Lee, Ching-Chih Lee","doi":"10.1016/j.anai.2025.02.025","DOIUrl":"10.1016/j.anai.2025.02.025","url":null,"abstract":"<p><strong>Background: </strong>Protease-activated receptor 2 (PAR-2) and interleukin (IL)-13 receptor α1 (Rα1) play major roles in type 2 inflammation. However, most of the literature was limited to allergic asthma.</p><p><strong>Objective: </strong>To evaluate ways these receptors contribute to upper respiratory tract inflammation and to explore potential therapeutic targets in patients with eosinophilic chronic rhinosinusitis.</p><p><strong>Methods: </strong>Using protein interaction analysis, animal experiments, and human tissue samples, we assessed the effects of exposure to house dust mite allergen on PAR-2 and IL-13Rα1 activation and inflammatory markers, and the impact of the PAR-2 antagonist GB88. A fluorescent multiplex staining kit was used, along with specific antibodies, to label and detect proteins in the immunofluorescence tissue samples.</p><p><strong>Results: </strong>A close relationship among PAR-2 (coagulation factor II receptor-like 1), SPI-1, IL-13Rα1, and RNASE2 (eosinophil-derived neurotoxin) was noted in protein interaction analysis. House dust mite exposure significantly activated PAR-2 and IL-13Rα1 in nasal epithelial cells, leading to T_H2 cytokine release (IL-25, IL-33, and thymic stromal lymphopoietin) and elevation of eosinophil proteins (eosinophil cationic protein and eosinophil-derived neurotoxin) that intensify upper respiratory tract inflammation. The PAR-2 antagonist GB88 reduced house dust mite allergen-induced PAR-2 and IL-13Rα1 expression, signal transducer and activator of transcription 6 phosphorylation, and eosinophil infiltration, and decreased inflammatory markers. PAR-2/SPI-1/IL-13Rα1 was validated in immunohistochemistry and immunofluorescence analysis of human chronic rhinosinusitis specimens.</p><p><strong>Conclusion: </strong>The PAR-2/IL-13Rα1 pathway is a promising target for treating upper respiratory tract inflammation. PAR-2 inhibitors could reduce inflammation and improve the outcomes of upper respiratory tract diseases, such as eosinophilic chronic rhinosinusitis.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}