{"title":"Metabolomic profiles in allergic rhinitis: a systematic review and meta-analysis.","authors":"Qin-Dong Liu, Guang-Xia Pan, Jing-Wei Li, Jia-Jun Zhang, Hao-Lan Liu, Chun-Qiao Li, Yu Meng, Yuan-Xian Liu, Ya-Jie Yan, Yan Ruan","doi":"10.1016/j.anai.2024.12.022","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Allergic rhinitis (AR) is a prevalent chronic inflammatory condition that significantly impacts patient quality of life and poses a substantial public health burden. Recent advancements in metabolomics have facilitated a deeper understanding of the metabolic pathways involved in AR, offering potential for new biomarkers and therapeutic targets.</p><p><strong>Objective: </strong>This article aims to conduct a systematic review and meta-analysis of clinical studies summarizing the metabolomic profiles of allergic rhinitis (AR) to gain deeper insights into the metabolic changes and pathological processes underlying AR.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across PubMed, Embase, Scopus, and Web of Science databases up to October 2024. A qualitative review of the screened studies was performed, followed by meta-analyses of metabolites reported in at least two studies. High-impact targets, pathways, and their associations were identified using bioinformatic analyses.</p><p><strong>Results: </strong>A total of 21 studies, encompassing 84 metabolites associated with AR, met the inclusion criteria. Seven metabolites consistently exhibited upregulation in AR across multiple studies and were included in the meta-analysis. Pathway enrichment analyses revealed significant involvement of pathways such as \"Valine, leucine, and isoleucine biosynthesis\" and \"Linoleic acid metabolism\" in AR pathogenesis. The metabolite-pathway-gene network analysis highlighted key functional connections between metabolites, pathways, and immune response genes.</p><p><strong>Conclusion: </strong>This comprehensive analysis indicates that differential metabolites may play pivotal roles in AR pathogenesis, offering potential biomarkers and therapeutic targets. Further studies are necessary to validate these findings and elucidate the complex metabolic pathways involved in AR.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8000,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Allergy Asthma & Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.anai.2024.12.022","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Allergic rhinitis (AR) is a prevalent chronic inflammatory condition that significantly impacts patient quality of life and poses a substantial public health burden. Recent advancements in metabolomics have facilitated a deeper understanding of the metabolic pathways involved in AR, offering potential for new biomarkers and therapeutic targets.
Objective: This article aims to conduct a systematic review and meta-analysis of clinical studies summarizing the metabolomic profiles of allergic rhinitis (AR) to gain deeper insights into the metabolic changes and pathological processes underlying AR.
Methods: A comprehensive literature search was conducted across PubMed, Embase, Scopus, and Web of Science databases up to October 2024. A qualitative review of the screened studies was performed, followed by meta-analyses of metabolites reported in at least two studies. High-impact targets, pathways, and their associations were identified using bioinformatic analyses.
Results: A total of 21 studies, encompassing 84 metabolites associated with AR, met the inclusion criteria. Seven metabolites consistently exhibited upregulation in AR across multiple studies and were included in the meta-analysis. Pathway enrichment analyses revealed significant involvement of pathways such as "Valine, leucine, and isoleucine biosynthesis" and "Linoleic acid metabolism" in AR pathogenesis. The metabolite-pathway-gene network analysis highlighted key functional connections between metabolites, pathways, and immune response genes.
Conclusion: This comprehensive analysis indicates that differential metabolites may play pivotal roles in AR pathogenesis, offering potential biomarkers and therapeutic targets. Further studies are necessary to validate these findings and elucidate the complex metabolic pathways involved in AR.
背景：变应性鼻炎（AR）是一种常见的慢性炎症性疾病，严重影响患者的生活质量，并造成严重的公共卫生负担。代谢组学的最新进展促进了对AR代谢途径的深入了解，为新的生物标志物和治疗靶点提供了潜力。目的：对变应性鼻炎（allergic rhinitis， AR）代谢组学特征的临床研究进行系统回顾和荟萃分析，以深入了解变应性鼻炎的代谢变化和病理过程。方法：综合检索PubMed、Embase、Scopus和Web of Science数据库，检索截止到2024年10月的文献。对筛选的研究进行定性回顾，然后对至少两项研究中报告的代谢物进行荟萃分析。利用生物信息学分析确定了高影响靶点、途径及其关联。结果：共有21项研究，包括84种与AR相关的代谢物，符合纳入标准。在多个研究中，7种代谢物在AR中一致表现出上调，并被纳入meta分析。途径富集分析显示，“缬氨酸、亮氨酸和异亮氨酸生物合成”和“亚油酸代谢”等途径在AR发病机制中有重要作用。代谢物-途径-基因网络分析强调了代谢物、途径和免疫反应基因之间的关键功能联系。结论：这项综合分析表明，差异代谢物可能在AR发病机制中发挥关键作用，提供了潜在的生物标志物和治疗靶点。需要进一步的研究来验证这些发现并阐明AR中涉及的复杂代谢途径。
期刊介绍：
Annals of Allergy, Asthma & Immunology is a scholarly medical journal published monthly by the American College of Allergy, Asthma & Immunology. The purpose of Annals is to serve as an objective evidence-based forum for the allergy/immunology specialist to keep up to date on current clinical science (both research and practice-based) in the fields of allergy, asthma, and immunology. The emphasis of the journal will be to provide clinical and research information that is readily applicable to both the clinician and the researcher. Each issue of the Annals shall also provide opportunities to participate in accredited continuing medical education activities to enhance overall clinical proficiency.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
