Annals of Allergy Asthma & Immunology最新文献

{"title":"A Case of Ichthyosis Prematurity Syndrome Mimicking Hyper-IgE Syndrome.","authors":"Saniye Yasemin Yilmaz, İlknur Külhaş Çelik, Hasibe Artaç","doi":"10.1016/j.anai.2025.07.009","DOIUrl":"https://doi.org/10.1016/j.anai.2025.07.009","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Albuterol-budesonide rescue inhaler for asthma: patterns of use and safety in the MANDALA trial.","authors":"Bradley E Chipps, Reynold A Panettieri, Neil Skolnik, Christy Cappelletti, Sami Z Daoud, Lynn Dunsire, Ileen A Gilbert, Alberto Papi","doi":"10.1016/j.anai.2025.07.008","DOIUrl":"https://doi.org/10.1016/j.anai.2025.07.008","url":null,"abstract":"<p><strong>Background: </strong>The MANDALA study (NCT03769090) in moderate-to-severe asthma served as the basis of the Food and Drug Administration's 2023 approval of albuterol-budesonide 180/160 µg pressurized metered-dose inhaler for the as-needed treatment or prevention of bronchoconstriction and to reduce exacerbation risk in patients with asthma ≥18 years of age. Clinicians would benefit from an understanding of the patterns of use of albuterol-budesonide versus albuterol and overall inhaled corticosteroid (ICS) exposure when ICS-containing rescue therapies are utilized alongside ICS-based maintenance therapies.</p><p><strong>Objective: </strong>To evaluate patterns of as-needed use and safety profiles of albuterol-budesonide 180/160 µg versus albuterol 180 µg, using data from MANDALA.</p><p><strong>Methods: </strong>Study medication use was patient-documented via electronic diary. Safety was assessed as adverse events (AEs). Patterns of study medication use (2 inhalations = 1 dose) were summarized as mean percentages of days where inhalations/day fell within pre-defined categories (0, 1-2, 3-4, 5-6, 7-8, 9-10, 11-12, >12).</p><p><strong>Results: </strong>The safety population included 981 patients randomized to as-needed albuterol-budesonide and 981 to as-needed albuterol. Patients adhered to maintenance therapy regimens on a mean of ≥75% of days. Use of as-needed study drug was similar in both groups (mean of 2.6 and 2.8 inhalations/day of albuterol-budesonide and albuterol, respectively). High daily use (≥8 inhalations/day) or long-term high-daily use (≥7 consecutive days) was rare. AE frequencies (ICS-associated and not) were low and comparable between groups, regardless of mean daily as-needed use.</p><p><strong>Conclusion: </strong>Patterns of use and safety profiles were similar between as-needed albuterol-budesonide and albuterol.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of removing race from spirometry reference equations in children with asthma.","authors":"Lina Z Mahmood, Tamara T Perry, Akilah A Jefferson, Ariel Berlinski","doi":"10.1016/j.anai.2025.07.003","DOIUrl":"https://doi.org/10.1016/j.anai.2025.07.003","url":null,"abstract":"<p><strong>Background: </strong>The Global Lung Initiative (GLI) recently developed a race-neutral reference equation in 2022 (GLI-2022); however, the implications of its use in children with asthma, especially Latino children, have not been extensively studied.</p><p><strong>Objective: </strong>Assess the difference in spirometry results, asthma severity and airways obstruction classification for African American (AA), Latino and White children with asthma after implementing GLI-2022.</p><p><strong>Methods: </strong>This retrospective cross-sectional study evaluated the first spirometry performed by children with asthma aged 5-17 years between 01/01/2018 and 12/31/2023. Z-scores and percent predicted (pp) values for forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1 /FVC were calculated using GLI-2022 and race-adjusted Global Lung Function Initiative 2012 (GLI-2012) equations.</p><p><strong>Results: </strong>A total of 7138 children: 3543 AA, 2795 White, and 800 Latino were included (median age = 10.3 years). FEV1 z-score median difference was -0.872, -0.360, and +0.267 in AA, Latino, and White children, respectively (p < 0.0001) after implementing GLI-2022. FVC z-scores, ppFEV1 and ppFVC values showed similar patterns. Adopting GLI-2022 worsened asthma severity (based on ppFEV1) and degree of airways obstruction (based on FEV1 z-score) classifications in AA children, improved them in White children, and did not affect Latino children.</p><p><strong>Conclusion: </strong>Implementing GLI-2022 impacted asthma severity and airway obstruction classifications and resulted in a lower FVC and FEV1 in AA and Latino children and greater values in White children. Using GLI-2022 may uncover more cases of underdiagnosed asthma in AA and Latino children, which may contribute to alleviating disparate asthma outcomes.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the Pages of Allergy Watch.","authors":"Stanley Fineman, Vivian Hernandez-Trujillo, Gerald Lee, Shyam R Joshi","doi":"10.1016/j.anai.2025.07.001","DOIUrl":"https://doi.org/10.1016/j.anai.2025.07.001","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FRESH CLOTHES, HARD BREATHS: Laundry washing habits, Detergents, Softeners, and Impaired Respiratory Functions in Wheezy Children.","authors":"Gülten Tunçerler, Simge Atar Beşe, Cihangir Şahin, Nur Törer, Duygu Erge, Pinar Uysal","doi":"10.1016/j.anai.2025.07.006","DOIUrl":"https://doi.org/10.1016/j.anai.2025.07.006","url":null,"abstract":"<p><strong>Background: </strong>Early childhood wheezing may indicate asthma risk, making assessment of environmental triggers crucial. Recent research has identified potential effects of laundry product chemicals on airway epithelial barriers.</p><p><strong>Objective: </strong>To evaluate the relationship between the chemical contents and usage habits of household laundry products and pulmonary function in preschool children with recurrent wheezing and the effect of using soap-based detergent without additives on respiratory parameters measured by impulse oscillometry.</p><p><strong>Methods: </strong>This prospective case-control study enrolled 80 recently diagnosed wheezy children (CW) and 80 healthy children (HC) between August 2023-February 2024. Laundry habits and product chemical ingredients were recorded. Respiratory function was measured by impulse oscillometry (IOS), assessing airway resistance (zR5, zR20, R5-20) and reactance (zX5, zX20, Fres, AX).</p><p><strong>Results: </strong>Softener use was higher in the CW group (p=0.011). Chemical analysis revealed significantly higher frequency of sodium laurylsulphate (SLS), nonionic active substances, cocoglicoside, methylsotilozlolinone, butylphenylmethylpropional, linolol, coumarin, and oxygen-based bleaching agents in detergents used by the CW group compared to HCs (p<0.05). Similarly, cationic active substances, coumarin, linolol, and benzisotizolinone were more prevalent in softeners used by CW families (p<0.05). The CW group exhibited higher resistance values (zR5, zR20, R5-20, Fres, AX) and lower zX5 compared to HC (p<0.05). Children using additive-free detergents showed lower airway resistance (zR5, zR20) (p<0.05), while those using soap-free products had higher resistance measurements (p<0.05).</p><p><strong>Conclusion: </strong>Wheezy children have greater exposure to laundry softener chemicals than healthy counterparts. Additive-containing products were associated with increased airway resistance, while soap-based detergents showed no detectable impact on respiratory function. These findings suggest a potential link between chemical laundry products and impaired respiratory function in preschool wheezy children.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALERT (ChAracterizing uncontroLled sevERe asThma in Canada): oral corticosteroid and short-acting β₂-agonist overuse.","authors":"Andréanne Côté, Jeffrey Beach, Jenna Reynolds, Koyo Usuba, Joshua Tusin, Muthu Kg Jayakumar, Tim Tian Yu Han, Susan Waserman","doi":"10.1016/j.anai.2025.07.005","DOIUrl":"https://doi.org/10.1016/j.anai.2025.07.005","url":null,"abstract":"<p><strong>Background: </strong>Approximately 230,000-465,000 patients in Canada have severe asthma; of these, 4-31% are uncontrolled. Despite increased availability of biologics, many rely on oral corticosteroids (OCS) or short-acting β2-agonists (SABA), which are associated with substantial short- and long-term adverse effects.</p><p><strong>Objective: </strong>ALERT aimed to characterize the demographics of patients with severe asthma and uncontrolled severe asthma with and/or without biologics in Canada and describe OCS/SABA and biologic treatment patterns.</p><p><strong>Methods: </strong>ALERT was a retrospective descriptive study using longitudinal claims data from IQVIA's private drug plan database and the Ontario drug benefits database. Adult patients with an inferred asthma diagnosis were assessed and selected using a rule-based inference algorithm and further classified as having severe asthma, uncontrolled severe asthma and uncontrolled severe asthma without biologics, based on eligibility criteria including inhaled therapies and OCS use. Patients were assessed for OCS, SABA and biologic use in the 12-month analysis period; regional variation was described.</p><p><strong>Results: </strong>Patients with severe asthma, uncontrolled severe asthma and uncontrolled severe asthma without biologics had a mean of 2.7, 4.4 and 4.2 OCS claims per patient/year, respectively. Of patients with uncontrolled severe asthma, 8.3% had ≥10 OCS claims. Combined OCS/SABA overuse (≥2 OCS/≥3 SABA claims in the study period) was recorded in 6.1% of patients with severe asthma. Most patients with uncontrolled severe asthma (71.8%) had no biologic claims. Regional disparities in OCS use were observed.</p><p><strong>Conclusion: </strong>Optimization of asthma management through improved diagnosis, patient education, earlier specialist referral and region-specific improvements is needed to reduce OCS/SABA use and increase biologic uptake for eligible patients.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflight Epinephrine Access During Allergic Emergencies: The Allergists Experience.","authors":"Sangeetha M Kodoth, Niraj C Patel, Hyun J Park, Joel P Brooks","doi":"10.1016/j.anai.2025.07.004","DOIUrl":"https://doi.org/10.1016/j.anai.2025.07.004","url":null,"abstract":"<p><p>XXX.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oh Eosinophil, what can you tell us about asthma?","authors":"William W Busse","doi":"10.1016/j.anai.2025.07.007","DOIUrl":"https://doi.org/10.1016/j.anai.2025.07.007","url":null,"abstract":"<p><p>XXX.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the Pages of Allergy Watch.","authors":"Stanley Fineman, Gerald Lee, Shyam R Joshi, Iris Otani","doi":"10.1016/j.anai.2025.06.035","DOIUrl":"https://doi.org/10.1016/j.anai.2025.06.035","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding Clinical Phenotype of Truncating Activation-Induced Cytidine Deaminase variants.","authors":"Connor Kuipers, Lawrence Hennessey, Nicholas L Hartog","doi":"10.1016/j.anai.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.anai.2025.07.002","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}