Annals of Allergy Asthma & Immunology最新文献

{"title":"Food allergy and eosinophilic esophagitis: Oral immunotherapy reveals a disease in flux.","authors":"Colby S Sharlin, Alfred D Doyle, Benjamin L Wright","doi":"10.1016/j.anai.2025.02.007","DOIUrl":"10.1016/j.anai.2025.02.007","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mannitol provocation enhances laryngoscopic diagnosis of suspected inducible laryngeal obstruction.","authors":"Stephanie Stojanovic, Asger Sverrild, Tunn Ren Tay, Eve Denton, Kavitha Garuna Murthee, Tiffany Lin, Logan Gardner, Melanie Wong, Brigitte Borg, Janine Mahoney B Speech, Joy Lee, Mark Hew","doi":"10.1016/j.anai.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.anai.2025.02.001","url":null,"abstract":"<p><strong>Background: </strong>Inducible laryngeal obstruction (ILO) is confirmed by observing paradoxical vocal fold movement (PVFM) on laryngoscopy, but test sensitivity is reduced by its intermittent nature. Specificity of isolated expiratory PVFM is also unclear, possibly denoting a physiologic response to lower airway obstruction.</p><p><strong>Objective: </strong>To clarify laryngoscopic diagnosis in suspected ILO through mannitol provocation.</p><p><strong>Methods: </strong>In patients with suspected ILO, we assessed rates of laryngoscopic PVFM, both at baseline and following mannitol provocation, defined as; any inspiratory adduction, ≥50% expiratory adduction, or both. We also studied accentuation of laryngoscopic findings following mannitol provocation, defined as new, or increased, PVFM. We explored relationships between isolated expiratory PVFM, lower airway obstruction on spirometry, and bronchial hyperresponsiveness to mannitol. We also studied healthy volunteers.</p><p><strong>Results: </strong>Among 80 patients with suspected ILO, PVFM rates were 42/80 (52.5%) at baseline and 58/80 (72.5%) following mannitol. Mannitol accentuated laryngoscopic findings in 45/80 (56%), with new PVFM in 17/80 (21%) and increased PVFM in 28/80 (35%), 28/42 (67%) of patients with PVFM at baseline. Among patients with baseline isolated expiratory PVFM; 21/30 had accentuation by mannitol; there was no relationship with airway obstruction or bronchial hyperresponsiveness. Among healthy volunteers; PVFM rates were identical at baseline and following mannitol (4/15, 27%, all four with isolated expiratory PVFM); none (0/15) had accentuation by mannitol.</p><p><strong>Conclusion: </strong>Accentuation of laryngoscopic findings following mannitol provocation is more useful than PVFM at baseline laryngoscopy to distinguish patients with suspected ILO from healthy volunteers. Isolated expiratory PVFM without accentuation by mannitol can be a normal finding, and unrelated to bronchial obstruction or hyperresponsiveness.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation of adult food-protein–induced enterocolitis syndrome diagnostic scoring system differentiating from immediate-type food allergy","authors":"Sho Watanabe MD, PhD ,&nbsp;Ayako Sato MD, PhD ,&nbsp;Keitaro Shibuya MD ,&nbsp;Rina Kusuda DDS ,&nbsp;Hiroko Suzuki MD, PhD ,&nbsp;Saori Nagashima MD ,&nbsp;Tsunehito Yauchi MD ,&nbsp;Tatsuki Fukuie MD, PhD ,&nbsp;Kiwako Yamamoto-Hanada MD, PhD ,&nbsp;Yukihiro Ohya MD, PhD ,&nbsp;Ichiro Nomura MD, PhD","doi":"10.1016/j.anai.2024.09.019","DOIUrl":"10.1016/j.anai.2024.09.019","url":null,"abstract":"<div><h3>Background</h3><div>Adult food-protein–induced enterocolitis syndrome (FPIES) has recently been recognized, and there are no international diagnostic criteria for this disease. Differentiating adult FPIES from immediate-type food allergy reactions and providing specific treatment for each in an emergency are important, but methods have not been developed.</div></div><div><h3>Objective</h3><div>To develop a diagnostic scoring system for adult FPIES by comparing it with an immediate-type food allergy (IgE-mediated food allergy [IgE-FA]).</div></div><div><h3>Methods</h3><div>This retrospective cohort study of food-avoidant adults based on diagnostic criteria for adult FPIES was conducted through telephone interviews. We compared the clinical profiles of the patients with FPIES and IgE-FA. Adult FPIES-associated factors were extracted using multivariate analysis, and a diagnostic scoring system was developed based on odds ratios.</div></div><div><h3>Results</h3><div>A total of 48 (16.7%) of 288 adults with food allergies were diagnosed with FPIES; of these, 240 (83.3%) had IgE-FA. Seafood was the most common cause of FPIES in adults (68.8%). Multivariate analysis identified an age of onset older than 26 years, more than 10 episodes, a longer latency period, cold sweat, abdominal distention, and vomiting as adult FPIES-associated factors. An adult FPIES diagnostic scoring system was developed using odds ratios with a high area under the curve (0.978), 100% sensitivity, and 87.0% specificity.</div></div><div><h3>Conclusion</h3><div>Clinical profiles and an adult FPIES diagnostic scoring system were developed for the first time. This scoring system can be useful in differentiating adult FPIES and IgE-FA when treating food-related acute reactions.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 2","pages":"Pages 215-222.e2"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘A systematic review and expert Delphi Consensus recommendation on the use of vaccines in patients receiving dupilumab: A position paper of the American College of Allergy, Asthma and Immunology’ [Annals of Allergy, Asthma & Immunology 133/3 (2024) 286-94]","authors":"Jay A. Lieberman MD ,&nbsp;Derek K. Chu MD, PhD ,&nbsp;Tasnuva Ahmed MBBS, MPH, MSc ,&nbsp;Timothy E. Dribin MD ,&nbsp;Elissa M. Abrams MD ,&nbsp;Aikaterini Anagnostou MD, MSc, PhD ,&nbsp;Kimberly G. Blumenthal MD, MSc ,&nbsp;Mark Boguniewicz MD ,&nbsp;Nicole M. Chase MD ,&nbsp;David B.K. Golden MDCM ,&nbsp;Nicholas L. Hartog MD ,&nbsp;Jennifer R. Heimall MD ,&nbsp;Tina Ho MD, PhD ,&nbsp;Monica G. Lawrence MD ,&nbsp;David A. Khan MD ,&nbsp;Timothy Dean Minniear MD, MSc ,&nbsp;S. Shahzad Mustafa MD ,&nbsp;John J. Oppenheimer MD ,&nbsp;Elizabeth J. Phillips MD ,&nbsp;Allison Ramsey MD ,&nbsp;Matthew J. Greenhawt MD, MBA, MSc","doi":"10.1016/j.anai.2024.10.023","DOIUrl":"10.1016/j.anai.2024.10.023","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 2","pages":"Pages 242-243"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How best to choose an oscillometer and reference equations for your patients with asthma","authors":"Laura Gochicoa-Rangel MD, PhD,&nbsp;Mario H. Vargas MD, MSc","doi":"10.1016/j.anai.2024.11.009","DOIUrl":"10.1016/j.anai.2024.11.009","url":null,"abstract":"<div><div>The use of oscillometry has significantly advanced in recent years, thanks to the availability of more robust and portable measurement devices. However, a major drawback is the variability among different devices, which leads to noninterchangeable results. This lack of standardization has prevented the establishment of widely accepted reference equations, complicating the implementation of oscillometry in clinical practice. This review aims to clarify these areas, suggesting the adoption of specific guidelines based on the context.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 2","pages":"Pages 159-164"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oscillometry-determined small airway dysfunction as a significant risk for poor asthma control and exacerbations","authors":"Stanley P. Galant MD","doi":"10.1016/j.anai.2024.12.002","DOIUrl":"10.1016/j.anai.2024.12.002","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 2","pages":"Pages 123-124"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S1081-1206(24)01753-8","DOIUrl":"10.1016/S1081-1206(24)01753-8","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 2","pages":"Page A4"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143158694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial differences in odds of asthma exacerbations among Aspergillus fumigatus–sensitized adults with asthma","authors":"Patrick K. Gleeson MD, MSCE ,&nbsp;Knashawn H. Morales ScD ,&nbsp;Meeta Prasad Kerlin MD, MSCE ,&nbsp;Olajumoke O. Fadugba MD ,&nbsp;Andrea J. Apter MD, MSc, MA ,&nbsp;Jason D. Christie MD, MSCE ,&nbsp;Blanca E. Himes PhD","doi":"10.1016/j.anai.2024.08.959","DOIUrl":"10.1016/j.anai.2024.08.959","url":null,"abstract":"<div><h3>Background</h3><div>Allergic sensitization to mold is a risk factor for poor asthma outcomes, but whether it accounts for disparities in asthma outcomes according to race or socioeconomic status is not well-studied.</div></div><div><h3>Objective</h3><div>To identify factors associated with allergic sensitization to molds and evaluate associations of sensitization to molds with asthma exacerbations after stratifying by race.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of adults with asthma who had an outpatient visit to a large health system between January 1, 2017 and June 30, 2023 and received aeroallergen testing to <em>Aspergillus fumigatus, Penicillium, Alternaria</em>, and <em>Cladosporium</em>. We used logistic regression models to evaluate factors associated with mold sensitization and the effect of mold sensitization on asthma exacerbations in the 12 months before testing, overall and then stratified by race.</div></div><div><h3>Results</h3><div>A total of 2732 patients met the inclusion criteria. Sensitization to each mold was negatively associated with being a woman (odds ratios [ORs] ≤ 0.59, <em>P</em> ≤ .001 in 5 models) and positively associated with the Black race (ORs ≥ 2.16 vs White, <em>P</em> &lt; .0005 in 5 models). In the full cohort, sensitization to molds was not associated with asthma exacerbations (ORs = 0.95-1.40, <em>P</em> ≥ .003 in 5 models and all above the corrected <em>P</em> value threshold). Among 1032 Black patients, sensitization to <em>A fumigatus</em>, but not to other molds, was associated with increased odds of asthma exacerbations (OR = 2.04, <em>P</em> &lt; .0005).</div></div><div><h3>Conclusion</h3><div>Being a man and Black race were associated with allergic sensitization to molds. Sensitization to <em>A fumigatus</em> was associated with asthma exacerbations among Black patients but not the overall cohort, suggesting that <em>A fumigatus</em> allergy is a source of disparities in asthma outcomes according to race.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 2","pages":"Pages 190-197.e10"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142209606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proximity to fast-food restaurants and pediatric asthma outcomes","authors":"Rohan Rao MD ,&nbsp;Yueh-Ying Han PhD ,&nbsp;Laury A. Valentín-Rodríguez BS ,&nbsp;Albert A. Presto PhD ,&nbsp;Juan C. Celedón MD, DrPH ,&nbsp;Franziska Rosser MD, MPH","doi":"10.1016/j.anai.2024.10.024","DOIUrl":"10.1016/j.anai.2024.10.024","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 2","pages":"Pages 233-234"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral feeding problems and parenting stress in toddlers with food protein–induced allergic proctocolitis","authors":"Pelin Celik MD ,&nbsp;Deniz Yilmaz MD ,&nbsp;Fadime Yuksel MD ,&nbsp;Funda Akpinar MD ,&nbsp;Kezban Karabag MD ,&nbsp;Aysun Kara Uzun MD ,&nbsp;Emine Dibek Misirlioglu MD","doi":"10.1016/j.anai.2024.11.003","DOIUrl":"10.1016/j.anai.2024.11.003","url":null,"abstract":"<div><h3>Background</h3><div>Food protein–induced allergic proctocolitis (FPIAP) typically develops in infancy, a critical period for taste preference and feeding skill development. Eliminating culprit foods, along with limited food options and the child's distressing symptoms, can significantly impact the mothers' parenting roles. However, research on behavioral feeding problems and parenting stress in toddlers with FPIAP is lacking.</div></div><div><h3>Objective</h3><div>To assess feeding behaviors and parenting stress levels in toddlers with FPIAP compared with healthy controls.</div></div><div><h3>Methods</h3><div>In this case-control study, parents of toddlers with FPIAP (n = 89) and healthy controls (n = 93) completed a socio-demographic form, the Behavioral Pediatrics Feeding Assessment Scale (BPFAS), and the Parenting Stress Index–Short Form.</div></div><div><h3>Results</h3><div>Seventy-five percent of toddlers with FPIAP had single food allergies, and cow's milk (95.5%) was the most common trigger. Children with FPIAP initiated complementary feeding later than controls (<em>P</em> = .001) and preferred vegetables (<em>P</em> &lt; .001). They experienced more challenges during the transition to complementary foods (<em>P</em> &lt; .001). Whereas BPFAS total and child-related frequency and restriction scores were similar between groups (<em>P</em> &gt; .05), the FPIAP group had significantly higher parent-related frequency, total problem, child-related problem, parent-related problem, and poor strategies scores (<em>P</em> &lt; .05). In addition, the FPIAP group exhibited higher levels of parental distress, parent-child dysfunctional interaction, difficult child, and total stress scores (<em>P</em> &lt; .001). Multivariate logistic regression analysis revealed that increased maternal total stress scores were associated with higher BPFAS total frequency scores (≥85) (odds ratio [OR]: 1.065, 95% CI: 1.031-1.101, <em>P</em> &lt; .001) and total problem scores (≥10) (OR: 1.049, 95% CI: 1.021-1.077, <em>P</em> &lt; .001). In addition, following social media accounts related to allergic proctocolitis was negatively associated with having higher BPFAS total frequency scores (≥85) (OR: 0.253, 95% CI: 0.073-0.878, <em>P</em> = .030).</div></div><div><h3>Conclusion</h3><div>Toddlers with FPIAP and their parents experience greater mealtime challenges compared with healthy controls, correlating with higher levels of parenting stress. Clinicians should recognize and address these challenges.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 2","pages":"Pages 223-230"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}