Annals of Allergy Asthma & Immunology最新文献_第2页

Sex Differences in Urinary Mast Cell Mediators: Implications for Diagnosing Atopic and Mast Cell Disorders. 尿肥大细胞介质的性别差异：诊断特应性和肥大细胞疾病的意义。

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-06-04 DOI: 10.1016/j.anai.2025.05.028

Valerie Jaroenpuntaruk, Sarah M Jenkins, Carin Y Smith, Alexei Gonzalez-Estrada, Lyda Cuervo-Pardo, Miguel A Park, Elina Jerschow, Rohit Divekar, Avni Y Joshi, Thanai Pongdee, Dayne H Voelker, Joseph H Butterfield, Sergio E Chiarella

{"title":"Sex Differences in Urinary Mast Cell Mediators: Implications for Diagnosing Atopic and Mast Cell Disorders.","authors":"Valerie Jaroenpuntaruk, Sarah M Jenkins, Carin Y Smith, Alexei Gonzalez-Estrada, Lyda Cuervo-Pardo, Miguel A Park, Elina Jerschow, Rohit Divekar, Avni Y Joshi, Thanai Pongdee, Dayne H Voelker, Joseph H Butterfield, Sergio E Chiarella","doi":"10.1016/j.anai.2025.05.028","DOIUrl":"https://doi.org/10.1016/j.anai.2025.05.028","url":null,"abstract":"<p><strong>Background: </strong>Urinary mast cell mediators aid in diagnosing atopic and mast cell disorders, yet sex differences in these mediators remain unreported despite known sex-specific variations in eicosanoid pathways.</p><p><strong>Objective: </strong>To characterize sex differences in urinary mast cell mediators 2,3-dinor-11β-prostaglandin F2α (2,3-BPG), N-methylhistamine (NMH), and leukotriene E4 (LTE4).</p><p><strong>Methods: </strong>This retrospective chart review of 4,033 patients of all ages at Mayo Clinic from June 1, 2019, to May 31, 2024, included demographic and clinical data. Urine mast cell mediators 2,3-BPG, NMH, and LTE4 were quantified using liquid chromatography-tandem mass spectrometry and normalized to creatinine (Cr) levels. Statistical analyses were performed using R.</p><p><strong>Results: </strong>Among patients tested for urinary mast cell mediators, 78.8% were female. Compared to females, males were older at testing (mean 48.0 vs 40.1 years), more likely to report ever smoking (33.5% vs 22.7%), had higher BMI (mean 28.6 vs 27.7), more often had an atopic condition (82.6% vs 71.0%) or comorbidity (46.1% vs 30.3%), and had higher median LTE4 levels (102.5 vs 90.0 pg/mg Cr) (P < 0.001 for all). Males also more commonly had elevated 2,3-BPG (8.0% vs 3.7%) and eosinophil counts (17.0% vs 5.9%) and higher median tryptase levels (5.1 vs 4.3 pg/mL) (P < 0.001 for all). Multivariable analysis revealed a sex-by-atopy interaction for LTE4, with higher levels in atopic males (M/F ratio 1.15, [95% CI: 1.07-1.25], P < 0.001) and lower levels in non-atopic females (M/F ratio 0.86, [95% CI: 0.76-0.97], P = 0.02).</p><p><strong>Conclusion: </strong>Sex differences in testing rates and urinary mediator levels highlight the need to consider sex in optimizing the diagnostic utility of these mediators.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body Mass Index Is Not Associated with Clinical Severity in Chronic Rhinosinusitis. 体重指数与慢性鼻窦炎的临床严重程度无关。

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-06-03 DOI: 10.1016/j.anai.2025.05.032

Aaron D Smith, Catherine E Lyons, Maria Amelia Perozo, Aaron J Stein, Larry Borish

引用次数: 0

When life gets complicated: Food allergy, food insecurity, mental health, and substance use disorder. 当生活变得复杂：食物过敏，食物不安全，心理健康和物质使用障碍。

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-06-02 DOI: 10.1016/j.anai.2025.05.030

Elena Gupta, Alexandra E Conway, Navya Kartha, Marylee Verdi, Juliette Madan, Aikaterini Anagnostou, Elissa M Abrams, Matthew Greenhawt, Andrew White, S Shahzad Mustafa, Alastair P Huntley, Jakobi A Johnson, Marcus Shaker

{"title":"When life gets complicated: Food allergy, food insecurity, mental health, and substance use disorder.","authors":"Elena Gupta, Alexandra E Conway, Navya Kartha, Marylee Verdi, Juliette Madan, Aikaterini Anagnostou, Elissa M Abrams, Matthew Greenhawt, Andrew White, S Shahzad Mustafa, Alastair P Huntley, Jakobi A Johnson, Marcus Shaker","doi":"10.1016/j.anai.2025.05.030","DOIUrl":"10.1016/j.anai.2025.05.030","url":null,"abstract":"<p><p>Patients seen in allergy-immunology clinics may experience a myriad of socioeconomic problems that intersect with both social determinants of health and allergic and immunologic disease. Although not a primary focus of allergist-immunologist management, all clinicians must be ready and able to express compassion and understanding for patients who struggle with conditions that affect their adherence to recommended therapies. Food allergy in particular can have complex interactions with food insecurity, mental health, and substance use disorder because each of these comorbidities affects allergen avoidance and risk of anaphylaxis. This review outlines key considerations and provides resources to connect patients with needed assistance. Approaching patients who have challenging psychosocial and socioeconomic comorbidities with a willingness to help connect them with needed resources-from primary care providers, counselors, and allergen-aware food banks-can have a positive impact on health and well-being.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Where to challenge? 挑战在哪里？

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-06-01 DOI: 10.1016/j.anai.2025.02.015

Lisa M. Bartnikas MD , Theresa A. Bingemann MD

引用次数: 0

Can central registries adequately track severe adverse reactions to allergen immunotherapy? 中央登记系统能否充分追踪对过敏原免疫治疗的严重不良反应？

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-06-01 DOI: 10.1016/j.anai.2025.03.023

David I. Bernstein MD

引用次数: 0

Allergen immunotherapy-induced anaphylaxis 过敏原免疫疗法诱发的过敏性休克--来自欧洲过敏性休克登记处的数据。

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-06-01 DOI: 10.1016/j.anai.2025.02.012

Meslina Almaci MD , Regina Treudler MD , Maria Breiding MD , Alice Köhli MD , Lars Lange MD , Claudia Pföhler MD , Christian Vogelberg MD , Margitta Worm MD

{"title":"Allergen immunotherapy-induced anaphylaxis","authors":"Meslina Almaci MD , Regina Treudler MD , Maria Breiding MD , Alice Köhli MD , Lars Lange MD , Claudia Pföhler MD , Christian Vogelberg MD , Margitta Worm MD","doi":"10.1016/j.anai.2025.02.012","DOIUrl":"10.1016/j.anai.2025.02.012","url":null,"abstract":"<div><h3>Background</h3><div>Data on anaphylaxis due to allergen immunotherapy (AIT) are limited. This study assessed AIT-induced anaphylaxis using data from the European Anaphylaxis Registry.</div></div><div><h3>Objective</h3><div>To analyze the characteristics, symptoms, severity, and emergency management of AIT-induced anaphylactic reactions across age groups and the administered allergenic source.</div></div><div><h3>Methods</h3><div>Data were obtained from 54 allergy centers across 10 European countries from 2007 to 2023. Anaphylactic reactions involving at least 2 organ systems were analyzed for symptoms, severity, associated diseases, administration routes, and emergency treatment. Statistical methods included χ<sup>2</sup> and Fisher's exact tests.</div></div><div><h3>Results</h3><div>AIT accounted for 1.1% of the cases in the anaphylaxis registry (173/15,748), of which 1.8% were pediatric and 0.7% were adults. Respiratory symptoms were more frequent in children/adolescents (92%) than in adults (66%) among AIT-related anaphylaxis, whereas cardiovascular and gastrointestinal symptoms were more common in adults (40% vs 78% and 20% vs 42%, respectively). Only a few sublingual immunotherapy-related cases were documented, including 2 grade III reactions, with no fatalities (sublingual immunotherapy [n = 8] vs subcutaneous immunotherapy (SCIT) [n = 153]). One fatality due to SCIT was reported (grass pollen). Delayed reactions (>30 minutes) were reported in 22 cases, predominantly after SCIT. All delayed grade III reactions that occurred more than 120 minutes were reported in children. Adrenaline was underused in emergency management and administered in 30% of grade II and 50% of grade III reactions.</div></div><div><h3>Conclusion</h3><div>Our study highlights the importance of age-specific monitoring and appropriate emergency treatment to enhance patient safety during AIT.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 6","pages":"Pages 724-730"},"PeriodicalIF":5.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can exclusive breastfeeding in the first 4 months reduce food allergy? 头 4 个月纯母乳喂养能否减少食物过敏？一项回顾性问卷调查研究。

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-06-01 DOI: 10.1016/j.anai.2025.02.011

Nadira Musallam MD, Meital Almog MD, Roni Wagner RD, Larisa Epov MD, Vika Dor MD, Aharon Kessel MD

{"title":"Can exclusive breastfeeding in the first 4 months reduce food allergy?","authors":"Nadira Musallam MD, Meital Almog MD, Roni Wagner RD, Larisa Epov MD, Vika Dor MD, Aharon Kessel MD","doi":"10.1016/j.anai.2025.02.011","DOIUrl":"10.1016/j.anai.2025.02.011","url":null,"abstract":"<div><h3>Background</h3><div>IgE-mediated food allergy (FA) is a major global health concern. Although the early introduction of allergenic foods and breastfeeding are potential preventive strategies, the role of breast milk in reducing the incidence of FAs remains inconclusive.</div></div><div><h3>Objective</h3><div>To investigate the impact of exclusive breastfeeding for the first 4 months compared with partial breastfeeding or cow's milk formula (CMF) on the development of IgE-mediated FAs in an Israeli cohort.</div></div><div><h3>Methods</h3><div>A cross-sectional online survey in 3030 mothers with infants aged 6 to 24 months collected data on early feeding practices, allergen introduction, atopic conditions, and family history. It documented suspected allergic reactions, symptoms, and diagnostic procedures.</div></div><div><h3>Results</h3><div>Of the 3030 mothers surveyed, 2920 provided complete feeding data for the first 4 months. Among them, 39.0% exclusively breastfed, 12.1% used CMF, and 48.9% partially breastfed. There were 392 infants with FAs, totaling 480 cases involving cow's milk, sesame, egg, or peanut. Of these cases, 122 (25.4%) were in the breastfeeding group, and 358 (74.6%) were in the other groups. Exclusively breastfed infants had lower odds of egg (odds ratio [OR] = 0.53), sesame (OR = 0.58), and peanut (OR = 0.53) allergies than others. The interaction between feeding patterns and atopic dermatitis (AD) related to these FAs was not significant. Exposure to CMF in the nursery, exclusively breastfed, was associated with higher odds of developing a cow's milk allergy. Delayed exposure to sesame in infants with AD has been linked to increased odds of developing a sesame allergy.</div></div><div><h3>Conclusion</h3><div>Exclusive breastfeeding may reduce the risk of IgE-mediated FA development, regardless of AD status.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 6","pages":"Pages 713-718.e10"},"PeriodicalIF":5.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of asthma severity on surgical outcomes in patients with chronic rhinosinusitis comorbid with asthma 哮喘严重程度对慢性鼻窦炎合并哮喘患者手术结果的影响。

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-06-01 DOI: 10.1016/j.anai.2024.11.022

Bo Zhang MD , Min Yan MD , Cong Li MD , Jiashu Zhao MD , Yang Liu MD , Xiaomei Yang MD , Xuelan Zeng MD , Zhiying Nie MD , Zhaoyang Ke MD , Wei Zhang MD , Yuanyuan Guo MD , Jianbo Shi MD, PhD , Fenghong Chen MD

{"title":"Impact of asthma severity on surgical outcomes in patients with chronic rhinosinusitis comorbid with asthma","authors":"Bo Zhang MD , Min Yan MD , Cong Li MD , Jiashu Zhao MD , Yang Liu MD , Xiaomei Yang MD , Xuelan Zeng MD , Zhiying Nie MD , Zhaoyang Ke MD , Wei Zhang MD , Yuanyuan Guo MD , Jianbo Shi MD, PhD , Fenghong Chen MD","doi":"10.1016/j.anai.2024.11.022","DOIUrl":"10.1016/j.anai.2024.11.022","url":null,"abstract":"<div><h3>Background</h3><div>Patients with chronic rhinosinusitis with nasal polyps comorbid with asthma often experience poor outcomes after endoscopic sinus surgery.</div></div><div><h3>Objective</h3><div>To evaluate the impact of asthma severity on the long-term outcomes after surgery in these patients.</div></div><div><h3>Methods</h3><div>A total of 83 patients with chronic rhinosinusitis with nasal polyps comorbid with asthma who underwent endoscopic sinus surgery were prospectively enrolled in this study. Patients were classified into mild, moderate, and severe asthma groups based on their preoperative asthma severity. Clinical symptom scores, nasal endoscopy scores, and asthma control test results were recorded preoperatively and at 1 year and 12 years postoperatively.</div></div><div><h3>Results</h3><div>A total of 71 patients completed the 12-year follow-up. All patients had significant improvement in nasal symptom scores and nasal endoscopy scores. However, 48 of 71 patients (67.6%) experienced nasal polyp recurrence, and 22 of them (31.0%) underwent revision surgery. Patients in the severe asthma group had the highest rate of nasal polyp recurrence (<em>P</em> = .02) and revision surgery (<em>P</em> = .01) and the least improvement in smell disturbance (<em>P</em> = .04) and general symptom (<em>P</em> = .02) compared with the other asthma groups.</div></div><div><h3>Conclusion</h3><div>Preoperative asthma severity significantly influenced the outcome of endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyps comorbid with asthma, in whom endoscopic sinus surgery had a long-term beneficial effect.</div></div><div><h3>Trial Registration</h3><div><span><span>https://www.chictr.org.cn/</span><svg><path></path></svg></span>: ChiCTR2100050583.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 6","pages":"Pages 676-684.e1"},"PeriodicalIF":5.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene therapy for inborn errors of immunity 基因治疗先天性免疫缺陷的临床进展

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-06-01 DOI: 10.1016/j.anai.2025.02.026

Sathi Wijeyesinghe MD, PhD, Javier Chinen MD, PhD

{"title":"Gene therapy for inborn errors of immunity","authors":"Sathi Wijeyesinghe MD, PhD, Javier Chinen MD, PhD","doi":"10.1016/j.anai.2025.02.026","DOIUrl":"10.1016/j.anai.2025.02.026","url":null,"abstract":"<div><div>Hematopoietic stem cell transplant has been the single curative treatment for inborn errors of immunity (IEI) and is recommended for the most severe IEI conditions, such as severe combined immunodeficiency. However, adverse outcomes primarily due to histocompatibility differences between the donor and the patient are still of concern. Progress in genetic and molecular mechanisms, including new technology to insert DNA sequences in cell genomes, has allowed the development of strategies to treat genetic diseases by correcting gene defect in patients’ cells. This technology is named gene therapy. Gene therapy approaches being developed for IEI are mediated by gene insertion, using a retroviral vector, or by gene editing, using a combination of a nuclease and a DNA template. After the unexpected occurrence of oncogenesis associated with the initial retroviral vector designs, significant advances have led to successful gene therapy clinical trials for 3 forms of severe combined immunodeficiency, which demonstrated the safety and efficacy of this approach. Active preclinical and clinical studies are ongoing for diverse IEI, including chronic granulomatous disease, leukocyte adhesion deficiency, severe congenital neutropenia, Wiskott-Aldrich syndrome, X-linked agammaglobulinemia, and familial forms of hemophagocytic lymphohistiocytosis.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 6","pages":"Pages 630-638"},"PeriodicalIF":5.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refining asthma disparity research 改进哮喘差异研究

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-06-01 DOI: 10.1016/j.anai.2025.02.022

Yinfang Wu MSc , Weixing Xu MSc

引用次数: 0