Prevalence and phenotype of food allergy in children with cystic fibrosis

IF 4.7 2区医学 Q1 ALLERGY

Annals of Allergy Asthma & Immunology Pub Date : 2025-10-01 DOI:10.1016/j.anai.2025.06.024

Hang P. Nguyen BS , Veronika Shabanova PhD , Sarah McCollum MPH , Brooke Polk MD , Tricia Lee MD , Kyle Whittington MD , Priscila Cunha MD , Emanuela M. Bruscia PhD , Marie E. Egan MD , Marc Emmenegger PhD , Stephanie Leeds MD, MHS

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引用次数: 0

Abstract

Background

Nonspecific gastrointestinal symptoms associated with cystic fibrosis (CF) may be misdiagnosed as food allergy (FA). There is a paucity of data regarding the prevalence and phenotype of IgE–mediated FA in CF.

Objective

To determine the prevalence and characteristics of pediatric FA in CF.

Methods

We conducted a retrospective pediatric cohort study using the CF foundation registries and electronic medical records from (redacted names A and B). Demographic, biometric, and medical information were collected, and individuals suspected of having FA were identified through multiple inclusion criteria. A convincing FA diagnosis was established on the basis of a priori criteria, including medical history, testing results, and management. The estimated prevalence was calculated as a percentage and compared with the most recently reported pediatric FA prevalence in the United States.

Results

Among 289 patients (51.21% male sex, median age = 12.40 years), 11 (3.81%, 95% CI 1.91-6.71) had at least 1 convincing FA, yielding a smaller prevalence than the most recent estimate in the US pediatric population (7.60%, 95% CI 7.10-8.10, P = .015). Male patients with CF (6.08% vs 1.42%, P = .038) and patients without pancreatic enzyme replacement (9.09% vs 2.25%, P = .020) had a higher prevalence of convincing FA.

Conclusion

Our study of pediatric patients with CF found a lower prevalence of FA compared with the general pediatric population in the United States. Stringent criteria should be used when labeling patients with CF who have FA to minimize overdiagnosis. Further studies are needed to investigate whether CF could potentially be protective against the development of FA.

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囊性纤维化儿童食物过敏的患病率和表型。

背景：与囊性纤维化（CF）相关的非特异性胃肠道症状可能被误诊为食物过敏（FA）。关于cf中ige介导的FA的患病率和表型的数据缺乏。目的：我们旨在确定cf中儿童FA的患病率和特征。方法：我们进行了一项回顾性儿科队列研究，使用囊性纤维化基金会登记处和来自[编辑名称a和B]的电子医疗记录。收集了人口统计学、生物统计学和医学信息，并通过多种纳入标准确定疑似患有FA的个体。一个令人信服的FA诊断是建立在先验的标准，包括病史，检查结果和管理。估计患病率以百分比计算，并与最近报道的美国儿童FA患病率进行比较。结果：289例患者中（51.21%为男性，中位年龄为12.40岁），11例（3.81%，95%可信区间[CI] 1.91-6.71）至少有一种令人信服的FA，其患病率低于美国儿科人群的最新估计（7.60%,95% CI 7.10-8.10, p=0.015）。男性CF患者（6.08%比1.42%,p=0.038）和没有胰酶替代的患者（9.09%比2.25%,p=0.020）有更高的可信FA患病率。结论：我们对儿童CF患者的研究发现，与美国普通儿科人群相比，FA的患病率较低。将CF患者标记为FA时应采用严格的标准，以减少过度诊断。CF是否对FA的发生有潜在的保护作用还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Allergy Asthma & Immunology 医学-过敏

CiteScore

6.50

自引率

6.80%

发文量

437

审稿时长

33 days

期刊介绍： Annals of Allergy, Asthma & Immunology is a scholarly medical journal published monthly by the American College of Allergy, Asthma & Immunology. The purpose of Annals is to serve as an objective evidence-based forum for the allergy/immunology specialist to keep up to date on current clinical science (both research and practice-based) in the fields of allergy, asthma, and immunology. The emphasis of the journal will be to provide clinical and research information that is readily applicable to both the clinician and the researcher. Each issue of the Annals shall also provide opportunities to participate in accredited continuing medical education activities to enhance overall clinical proficiency.