Annals of Allergy Asthma & Immunology最新文献_第3页

Dupilumab efficacy in relation to changes in club cell secretory protein 16 Dupilumab疗效与俱乐部细胞分泌蛋白变化的关系

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-05-01 DOI: 10.1016/j.anai.2025.02.019

Yui Murai MD, Toshiyuki Koya MD, PhD, Hiroki Koda MD, Wakana Uji MD, Moe Tanaka MD, Masahiro Endo MD, Kyoichiro Oshima MD, Takahiro Matsuda MD, Hiroshi Ueno MD, PhD, Ami Aoki MD, PhD, Kenjiro Shima MD, PhD, Yosuke Kimura MD, PhD, Toshiaki Kikuchi MD, PhD

{"title":"Dupilumab efficacy in relation to changes in club cell secretory protein 16","authors":"Yui Murai MD, Toshiyuki Koya MD, PhD, Hiroki Koda MD, Wakana Uji MD, Moe Tanaka MD, Masahiro Endo MD, Kyoichiro Oshima MD, Takahiro Matsuda MD, Hiroshi Ueno MD, PhD, Ami Aoki MD, PhD, Kenjiro Shima MD, PhD, Yosuke Kimura MD, PhD, Toshiaki Kikuchi MD, PhD","doi":"10.1016/j.anai.2025.02.019","DOIUrl":"10.1016/j.anai.2025.02.019","url":null,"abstract":"<div><h3>Background</h3><div>Although the performance of dupilumab in severe asthma has been evaluated, the detailed mechanism underlying its effect remains unclear.</div></div><div><h3>Objective</h3><div>To analyze the effect of dupilumab on serum club cell secretory protein 16 (CC16).</div></div><div><h3>Methods</h3><div>A total of 25 patients who were administered dupilumab and underwent computed tomography before and approximately 4 months after the introduction of dupilumab were included. Clinical and computed tomography parameters before and after dupilumab administration, such as mucus plug score and wall area measurement, were compared along with serum CC16 levels. The correlation between the clinical background and treatment effects was also evaluated.</div></div><div><h3>Results</h3><div>The number of mucus plugs and airway wall area decreased significantly after dupilumab introduction. The number of mucus plugs was positively correlated with both age and serum IgE levels. The number of mucus plugs and airway wall area was inversely correlated with percent of predicted forced expiratory volume in 1 second (FEV<sub>1</sub>) and maximal mid-expiratory flow. Dupilumab treatment resulted in a significant increase in serum CC16 levels and led to a significant improvement in asthma symptoms, quality-of-life scores, FEV<sub>1</sub>, and exacerbation frequency. In addition, changes in CC16 were significantly correlated with changes in the fraction of exhaled nitric oxide, IgE, quality-of-life score, FEV<sub>1</sub>, maximal mid-expiratory flow, and mucus plug score.</div></div><div><h3>Conclusion</h3><div>These data suggest that dupilumab improves symptoms and respiratory functions by altering the airway epithelial environment.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 5","pages":"Pages 556-562.e2"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-induced enterocolitis syndrome to amoxicillin-clavulanic acid in an adult patient with markers of gastrointestinal inflammation 阿莫西林-克拉维酸在成人胃肠道炎症标志物中的药物性小肠结肠炎综合征。

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-05-01 DOI: 10.1016/j.anai.2025.02.021

Anna Moshkovich MD , Bradley Sabin MD , Katharine Foster Nehme MD , Madeline Schutt MD

引用次数: 0

What to carry? Understanding the health economic costs of nasal spray vs injectable epinephrine and a need for shared decision-making 要带什么?了解鼻喷雾剂与注射肾上腺素的健康经济成本和共同决策的必要性

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-05-01 DOI: 10.1016/j.anai.2025.01.025

Jennifer L.P. Protudjer PhD

引用次数: 0

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-05-01 DOI: 10.1016/j.anai.2025.01.019

Tia C. Dowling MPhil , Melisa M. Shah MD, MPH , Danielle L. Moulia MPH , Joy Hsu MD, MS

引用次数: 0

A call to action to use icatibant down to age 2 for hereditary angioedema 呼吁2岁以下儿童使用伊卡替班治疗遗传性血管性水肿

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-05-01 DOI: 10.1016/j.anai.2024.11.029

Alisha Mutch PharmD, BCPS , Tiffany Truong MD , Sana Master BA , Timothy Craig DO

引用次数: 0

Vanishing Allergen: Addressing the Crisis of American Elm Pollen Extracts in Allergy Treatment. 消失的过敏原：解决美国榆树花粉提取物过敏治疗的危机。

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-04-05 DOI: 10.1016/j.anai.2025.04.001

Maureen M Petersen, Joseph P Forester, Richard Lankow, Rosemary Moak, J Allen Meadows

引用次数: 0

Healthcare-Seeking Behaviors for Acute Asthma: A US Cross-sectional Survey. 寻求医疗保健的行为急性哮喘：美国横断面调查。

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-04-03 DOI: 10.1016/j.anai.2025.03.025

Donna D Gardner, Raj Gokani, Juliana Hey-Hadavi, Dennis Williams, Mario Castro, Elliot Israel, Andres Quintero

{"title":"Healthcare-Seeking Behaviors for Acute Asthma: A US Cross-sectional Survey.","authors":"Donna D Gardner, Raj Gokani, Juliana Hey-Hadavi, Dennis Williams, Mario Castro, Elliot Israel, Andres Quintero","doi":"10.1016/j.anai.2025.03.025","DOIUrl":"https://doi.org/10.1016/j.anai.2025.03.025","url":null,"abstract":"<p><strong>Background: </strong>Understanding patient motivations for acute care-seeking behavior for asthma attacks could guide interventions to improve outcomes and mitigate healthcare resource use.</p><p><strong>Objective: </strong>To characterize healthcare seeking behaviors and motivations of patients in the US who obtain care for an asthma attack in urgent care (UC), emergency department (ED), or hospital settings.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted online between July-August 2023 among adults in a market research panel treated for asthma in the past 12 months and who had experienced an asthma attack that required care in an UC, ED, or hospital or an oral corticosteroid prescription.</p><p><strong>Results: </strong>Of the 504 survey participants (female=72%; White=79%; Hispanic=12%), 68% self-reported asthma of moderate severity and 72% had uncontrolled asthma. Oral corticosteroids were prescribed an average of 4.2 times over the past year. During their last asthma attack, 37% of participants took medicines at home, 20% went to UC, 15% went to the ED, and 5% were hospitalized. Participants who were younger, Asian, Hispanic, or with severe asthma were the most likely to go to the ED. Using a rescue inhaler was the most common action taken when first experiencing symptoms (72%). When participants considered seeking acute care, the severity of asthma symptoms was the most common factor considered (76%), followed by fast access to help (29%) and medication access (28%).</p><p><strong>Conclusion: </strong>The majority of patients seeking acute asthma care reported moderately severe, uncontrolled disease. Seeking acute care appears to be motivated by symptom severity and the need for fast access to care after trying rescue medications. It would be of interest in a future study to also evaluate the acute care seeking needs of patients who are at lower-risk of seeking acute care.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Mast Cell Activation Disorders and Hereditary Alpha Tryptasemia Amongst POTS and EDS Patients: A Systematic Review. POTS和EDS患者中肥大细胞活化障碍和遗传性α色氨酸血症的患病率：系统回顾

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-04-02 DOI: 10.1016/j.anai.2025.03.022

Matthew Farley, Ricardo J Estrada-Mendizabal, Emily A Gansert, Dayne Voelker, Lisa A Marks, Alexei Gonzalez-Estrada

{"title":"Prevalence of Mast Cell Activation Disorders and Hereditary Alpha Tryptasemia Amongst POTS and EDS Patients: A Systematic Review.","authors":"Matthew Farley, Ricardo J Estrada-Mendizabal, Emily A Gansert, Dayne Voelker, Lisa A Marks, Alexei Gonzalez-Estrada","doi":"10.1016/j.anai.2025.03.022","DOIUrl":"https://doi.org/10.1016/j.anai.2025.03.022","url":null,"abstract":"<p><strong>Background: </strong>Postural Orthostatic Tachycardia Syndrome (POTS) and Ehlers-Danlos Syndrome (EDS) are often reported to occur concurrently with Mast Cell Activation Disorders (MCADs) and Hereditary Alpha Tryptasemia (HAT). However, it remains unclear whether evidence supporting this relationship exists.</p><p><strong>Objective: </strong>To determine the prevalence of MCADs and HAT in patients diagnosed with EDS and or POTS.</p><p><strong>Methods: </strong>We conducted a systematic search of MEDLINE (OVID), EMBASE (OVID), Scopus, and Web of Science with the assistance of an experienced medical librarian. We focused on patients with any MCAD or HAT in conjunction with a diagnosis of POTS and/or EDS.</p><p><strong>Results: </strong>A total of 200 records were screened, 107 were excluded based on the title or abstract, 92 full texts were reviewed, and one record was not retrieved. No studies were identified that met our primary criterion of including patients diagnosed with any MCAD or HAT alongside POTS and/or EDS based on our pre-specified diagnostic criteria.</p><p><strong>Conclusion: </strong>Our review did not find evidence to confirm a relationship between MCADs, HAT, POTS, and EDS. However, it must be mentioned that one study showed an association between MCAS, POTS, and EDS and came close to meeting the full diagnostic criteria for MCAS, unlike other studies. This indicates that further research using strict and validated diagnostic criteria is needed to clarify whether a true association between conditions exists.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From the pages of AllergyWatch 来自过敏症观察的页面。

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-04-01 DOI: 10.1016/j.anai.2025.01.016

Stanley M. Fineman MD , Shyam R. Joshi MD , Gerald B. Lee MD , Timothy Chow MD

引用次数: 0

Authors' response 作者的回应

IF 5.8 2区医学

Annals of Allergy Asthma & Immunology Pub Date : 2025-04-01 DOI: 10.1016/j.anai.2025.01.008

Rory Chan PhD, FRCPE , Carlo Lombardi MD , Pasquale Comberiati MD , Alvise Berti MD , Francesco Menzella MD , Ronald J. Dandurand MD , Zuzana Diamant MD, PhD , Marcello Cottini MD

引用次数: 0