Annals of Allergy Asthma & Immunology最新文献

{"title":"Safety and Pharmacokinetics of Long-Acting Plasma Kallikrein Inhibitor Navenibart (STAR-0215) in Healthy Adults.","authors":"William Lumry, Michele Gunsior, Theodora Cohen, Kristine Bernard, Pamela Gustafson, Jou-Ku Chung, Christopher Morabito","doi":"10.1016/j.anai.2025.03.016","DOIUrl":"https://doi.org/10.1016/j.anai.2025.03.016","url":null,"abstract":"<p><strong>Background: </strong>Hereditary angioedema (HAE) is a rare, autosomal dominant disorder characterized by bradykinin-mediated episodic, localized swelling that can be fatal. Currently approved long-term prophylactic therapies for HAE attacks incur substantial treatment burden through frequent dosing. Navenibart (STAR-0215) is a monoclonal antibody inhibitor of plasma kallikrein modified to extend circulating half-life and is under investigation for HAE prophylaxis.</p><p><strong>Objective: </strong>The aim of this study was to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of a single dose of navenibart in healthy adults and to assess feasibility of every 3- and 6-month dosing.</p><p><strong>Methods: </strong>In this phase 1a study, participants were randomized 3:1 to receive placebo or navenibart in escalating (100 mg to 1200 mg) dosing cohorts. Safety outcomes, including treatment-emergent adverse events (TEAEs) and serious AEs, were monitored through end of study (Day 224). Additional endpoints included PK parameters and inhibition of plasma kallikrein activity.</p><p><strong>Results: </strong>In total, 31 participants received navenibart and 10 received placebo. The median age of participants was 36 years; 53.7% were male; 51.2% were Black or African American. Rates of TEAEs were similar between navenibart and placebo, and no serious AEs were reported. Navenibart-related TEAEs included injection-site reactions, inclusive of erythema, pruritic, and swelling, that resolved without intervention. For all doses ≥300 mg, navenibart mean half-life ranged from 82 to 105 days and inhibition of factor XIIa-induced plasma kallikrein activity versus placebo was statistically significant (P<0.05) Statistically significant inhibition of factor XIIa-induced plasma kallikrein activity versus placebo (P<0.05) was observed with all doses of navenibart.</p><p><strong>Conclusion: </strong>In this first-in-human study, up to 1200 mg of navenibart was well tolerated and demonstrated an extended half-life with durable plasma kallikrein inhibition.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Worse airflow obstruction but not type 2 biomarkers identifies super-responders to tezepelumab in real-life.","authors":"Robert Greig, Rory Chan, Brian J Lipworth","doi":"10.1016/j.anai.2025.03.013","DOIUrl":"https://doi.org/10.1016/j.anai.2025.03.013","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Long-term Air Pollution and Allergen Exposure with Endotype Shift in Chronic Rhinosinusitis with nasal polyps.","authors":"Mengyu Chen, Zhaofeng Xu, Yiwei Fu, Nan Zhang, Wendong Liu, Lishuo Shi, Tong Lu, Zhengqi Li, Zhaoxu Tu, Jian Li, Claus Bachert, Weiping Wen, Yihui Wen","doi":"10.1016/j.anai.2025.03.014","DOIUrl":"https://doi.org/10.1016/j.anai.2025.03.014","url":null,"abstract":"<p><strong>Background: </strong>Chronic rhinosinusitis with nasal polyps (CRSwNP) is classified into Type 2 and non-Type 2 inflammation based on mucosal cytokine level. Over 20 years, the Type 2/non-Type 2 ratio has increased, potentially influenced by air pollution and aeroallergens.</p><p><strong>Objective: </strong>This study investigates the association between long-term exposure to air pollutants and aeroallergens and the endotype shift in CRSwNP.</p><p><strong>Methods: </strong>We enrolled 2,358 CRSwNP patients from Guangzhou and 416 from Ghent. Endotypes were defined using a diagnostic model or IL-5 levels in nasal polyps. Pollutant exposure was estimated based on residential ZIP code. Generalized additive models with restricted cubic splines and generalized linear mixed models were used to assess the effects of PM2.5, PM10, NO2, SO2, O3, and aeroallergen exposure on Type 2 CRSwNP risk compared to non-Type 2.</p><p><strong>Results: </strong>Higher air pollutant exposure was linked to a lower Type 2/non-Type 2 ratio. In Guangzhou, every 1 μg/m³ increase in 3-year cumulative PM2.5 exposure was associated with an OR of 0.97 (95% CI: 0.96-0.98, P < 0.001) for Type 2 CRSwNP. In Ghent, the Relative Risk (RR) was 0.78 (95% CI: 0.65-0.94, P = 0.009) for the same exposure increase. Elevated total IgE and Dermatophagoides pteronyssinus sensitization increase Type 2 risk over non-Type 2 CRSwNP in Guangzhou, while allergic rhinitis, elevated total IgE, pollen sensitization, and multi-allergens sensitization increased Type 2 CRSwNP risk in Ghent.</p><p><strong>Conclusion: </strong>Decreasing long-term air pollution exposure and increasing allergen sensitization is associated with higher Type 2/non-T 2 CRSwNP ratio, highlighting the role of environmental factors in endotype shifting.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergy to okra with cross-reactivity to medlar.","authors":"Patricia Gutiérrez-Canales, Carlos Fernández-Lozano, Belén de-la-Hoz-Caballer, Laura Díaz-Montalvo, David González-de-Olano","doi":"10.1016/j.anai.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.anai.2025.03.010","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Disruption in Chronic Rhinosinusitis Improves with Exhalation-Delivery Nasal Steroid Therapy.","authors":"Donyea L Moore, Rachel Nolte, Shreya Maharana, Evan A Patel, Christopher Codispoti, Pete S Batra, Mahboobeh Mahdavinia","doi":"10.1016/j.anai.2025.03.012","DOIUrl":"https://doi.org/10.1016/j.anai.2025.03.012","url":null,"abstract":"<p><strong>Background: </strong>Chronic rhinosinusitis is a common inflammatory condition that often leads to significant sleep disturbances, negatively affecting quality of life. While intranasal steroids are a standard treatment, their effect on sleep disturbances in chronic rhinosinusitis has not been extensively studied.</p><p><strong>Objective: </strong>This study aimed to determine whether a nasal steroid delivered via exhalation could improve sleep quality in chronic rhinosinusitis.</p><p><strong>Methods: </strong>Patients with chronic rhinosinusitis were treated with nasal fluticasone via an exhalation delivery system for four months. Sleep assessments were conducted at baseline, and at two- and four-months post-treatment using comprehensive sleep and quality of life measures. Blood samples were taken at baseline to assess interleukin-6 levels. Regression analysis compared baseline and post-treatment data, adjusting for demographics. The influence of interleukin-6 levels and allergic comorbidities on treatment response was also evaluated.</p><p><strong>Results: </strong>Significant improvements were observed in sinonasal symptoms and sleep quality at two and four months (P < 0.05). Daytime sleepiness showed trends toward improvement. Interleukin-6 levels below 6 ng/mL and absence of asthma were associated with response to treatment in terms of sleep quality.</p><p><strong>Conclusion: </strong>High-distribution nasal steroids delivered via an exhalation system significantly improved sleep quality in patients with chronic rhinosinusitis. However, certain subgroups, such as those with lower interleukin-6 and those without comorbid asthma, benefit more significantly in terms of sleep quality.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical Considerations in Food Allergy Management: A Focus on Infants and Toddlers.","authors":"Timothy M Buckey, Aikaterini Anagnostou","doi":"10.1016/j.anai.2025.03.011","DOIUrl":"https://doi.org/10.1016/j.anai.2025.03.011","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and anxiety in patients with atopic dermatitis: Recognizing and addressing mental health burden.","authors":"Jennifer S LeBovidge, Lynda C Schneider","doi":"10.1016/j.anai.2025.02.017","DOIUrl":"https://doi.org/10.1016/j.anai.2025.02.017","url":null,"abstract":"<p><p>The psychosocial burden of atopic dermatitis (AD) is extensive, stemming from intense itch, sleep disturbance, unpredictable flares, lifestyle restrictions and missed activities, social stigma, and treatment burden. Overall, adults with AD are at a 2- to 3-fold greater risk for depression and anxiety compared with individuals without AD and children at a 1.5-fold greater risk, with greatest risk for those with more severe disease. A number of mechanisms seem to affect the relationship between AD and mental health, including poorly controlled disease, sleep disturbance, stress-induced itch, inflammation, and coping patterns. In some cases, the mental health burden of AD may also negatively affect AD management and course, creating a reinforcing cycle of psychosocial burden. Although depression and anxiety are known comorbidities of AD, the mental health burden of AD often goes unaddressed, which may further a sense of isolation for patients and families. Given the strong association between symptom severity and increased mental health burden, optimizing AD treatment and reducing itch are critical. Health care professionals can support patients with AD and their caregivers by encouraging open conversations about mental health, addressing common areas of condition-related stress, screening for depression and anxiety, and facilitating referrals to mental health professionals for further assessment and evidence-based care. Existing research supports use of cognitive-behavioral interventions to help manage the physical and mental health burden of AD. Further research is needed to evaluate psychological interventions for pediatric patients with AD and for patients with clinical diagnoses of depression and anxiety to better guide shared decision-making around support for these patients.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated oxidative stress and steroid insensitivity in patients with asthma and high body fat percentage.","authors":"Masako To, Yoshihito Arimoto, Natsue Honda, Naho Furusho, Toru Kinouchi, Yuichiro Takeshita, Kosuke Haruki, Yasuo To","doi":"10.1016/j.anai.2025.03.009","DOIUrl":"https://doi.org/10.1016/j.anai.2025.03.009","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a risk factor for poor asthma control. Previous research suggests that patients with asthma and obesity have reduced responsiveness to corticosteroids. Recent studies indicate that body fat percentage may be more strongly associated with obesity-related diseases compared with body mass index. However, the relationship between body fat percentage and asthma, particularly regarding steroid sensitivity, remains unclear.</p><p><strong>Objective: </strong>This study aimed to investigate the association between body fat percentage and steroid sensitivity in patients with asthma and elucidate the potential mechanisms underlying this association.</p><p><strong>Methods: </strong>Adult patients with asthma were enrolled and categorised into high body fat percentage (HBF) and control (CONT) groups. Peripheral blood mononuclear cells (PBMCs) were isolated from blood samples. These cells were cultured with dexamethasone followed by stimulation with tumour necrosis factor (TNF-α) to assess the half-maximal inhibitory concentration of dexamethasone (IC50-Dex). Serum adipocytokines and oxidative stress markers were also measured. The effects of metformin on steroid sensitivity and oxidative stress in PBMCs were evaluated ex vivo.</p><p><strong>Results: </strong>The HBF group exhibited significantly higher IC50-Dex values than the CONT group. In the HBF group, IC50-Dex correlated with the number of acute exacerbations per year and serum oxidative stress marker levels. Treatment with metformin significantly reduced both IC50-Dex and oxidative stress marker levels in the HBF group.</p><p><strong>Conclusion: </strong>Oxidative stress associated with increased body fat may contribute to impaired steroid sensitivity in patients with asthma. Metformin may improve steroid sensitivity by reducing oxidative stress, suggesting a potential therapeutic approach in this patient population.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased asthma burden during and post the COVID-19 pandemic among U.S. adults.","authors":"Hongxuan Fan, Zhaoyu Ren, Ping Zhang, Boda Zhou","doi":"10.1016/j.anai.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.anai.2025.03.007","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Want to help your patients with food allergy anxiety? Do proximity challenges!","authors":"Katherine K Dahlsgaard, Megan O Lewis","doi":"10.1016/j.anai.2025.02.020","DOIUrl":"10.1016/j.anai.2025.02.020","url":null,"abstract":"<p><p>Excessive anxiety regarding the potential for accidental and fatal cross-contamination is very common among patients and families with food allergy and contributes significantly to burden, reduced quality of life, and poorer management. In their landmark paper published nearly a decade ago, Dr Chitra Dinakar and colleagues recommended that food allergists incorporate proximity food challenges such as smelling or touching an allergen into regular clinical practice to improve patient knowledge regarding safety and relative risk and reduce anxiety. Such proximity challenges are akin to the exposure tasks routinely used to treat anxiety in cognitive-behavioral therapy, the first-line psychosocial intervention for anxiety disorders. Exposure is a highly evidence-based therapy technique in which patients-guided and encouraged by their providers-directly and strategically confront a feared object, situation, or activity. Anxiety eventually diminishes and erroneous beliefs are corrected when exposures happen repeatedly in the absence of the feared negative outcome. Following a summary of the history and evidence base for exposure in both the psychiatric and food allergy literature, we review several considerations related to conducting in-office proximity challenges. Topics include in-office assessment of food allergy anxiety and medically unnecessary avoidance; choosing appropriate, individualized proximity challenges based on patient presentation; and practical considerations in carrying out in-office proximity challenges to maximize benefits to anxious patients.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}