Annals of Allergy Asthma & Immunology最新文献

{"title":"Increased asthma burden during and after the COVID-19 pandemic among US adults","authors":"Hongxuan Fan PhD , Zhaoyu Ren MM , Ping Zhang MD , Boda Zhou MD","doi":"10.1016/j.anai.2025.03.007","DOIUrl":"10.1016/j.anai.2025.03.007","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 6","pages":"Pages 731-732"},"PeriodicalIF":5.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergy to okra with cross-reactivity to medlar","authors":"Patricia Gutiérrez-Canales MD , Carlos Fernández-Lozano MsC , Belén de-la-Hoz-Caballer MD, PhD , Laura Díaz-Montalvo MsC , David González-de-Olano MD, PhD","doi":"10.1016/j.anai.2025.03.010","DOIUrl":"10.1016/j.anai.2025.03.010","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 6","pages":"Pages 734-736"},"PeriodicalIF":5.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The LEARN (Learning Educator's Anaphylaxis Response Needs) Early Project","authors":"Kelsey Kaman MD ,&nbsp;Ashley Lahoud MA ,&nbsp;Chris Flessner PhD ,&nbsp;Kelly Butler MD Candidate ,&nbsp;Sarah Jane Lowery BA ,&nbsp;Alice Hoyt MD","doi":"10.1016/j.anai.2025.03.018","DOIUrl":"10.1016/j.anai.2025.03.018","url":null,"abstract":"<div><h3>Background</h3><div>Food allergies are a growing public health problem, and young children in preschools and early childhood education centers face a significant risk of in-school allergic reactions. Food allergies also disproportionately affect children in underserved communities.</div></div><div><h3>Objective</h3><div>To assess food allergy knowledge and preparedness at federally funded Head Start Centers, the LEARN (Learning Educator's Anaphylaxis Response Needs) Early Project was designed.</div></div><div><h3>Methods</h3><div>On partnership with Head Start Centers in Connecticut and Louisiana, program directors and health care managers completed an Allergy Preparedness Questionnaire and the Food Allergy Knowledge Test (FAKT). Additional questions evaluated rates of food allergies and feelings of preparedness to manage food allergy emergencies.</div></div><div><h3>Results</h3><div>In a review of food allergy management policies at the centers, we identified multiple areas for potential policy improvement. We also found that the average FAKT score was only 67.2% correct despite high levels of self-reported preparedness. There was no positive correlation between self-reported preparedness and FAKT score. These results suggest underpreparedness and overconfidence, which may create a barrier in motivating centers to pursue additional food allergy training. Indeed, we found that nearly half of the teachers declined the need for additional education when asked what additional training would be helpful, and only 20% of center staff cited training as something that would help them feel more prepared in managing food allergy emergencies.</div></div><div><h3>Conclusion</h3><div>Initial surveys demonstrate multiple barriers and knowledge gaps that exist surrounding food allergy and Head Start Centers. This reveals an opportunity that could be key in improving health care outcomes among children in underserved communities.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 6","pages":"Pages 694-699"},"PeriodicalIF":5.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene therapies relevant for the allergists are coming","authors":"Jay A. Lieberman MD","doi":"10.1016/j.anai.2025.03.017","DOIUrl":"10.1016/j.anai.2025.03.017","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 6","pages":"Page 621"},"PeriodicalIF":5.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of casein skin prick test and IgE values in predicting anaphylaxis and reactivity to baked milk","authors":"Mujde Tuba Cogurlu MD ,&nbsp;Nezihe Nefise Uluc MD ,&nbsp;Ismail Ozanli MD ,&nbsp;Yeşim Ece Ozkan MD ,&nbsp;Nagihan Iskender MD ,&nbsp;Sibel Balci MD ,&nbsp;Isıl Eser Simsek MD ,&nbsp;Metin Aydogan MD","doi":"10.1016/j.anai.2025.03.020","DOIUrl":"10.1016/j.anai.2025.03.020","url":null,"abstract":"<div><h3>Background</h3><div>Most children with milk allergy can tolerate baked milk (BM); however, a small percent still react to it. Identifying indicators that might forecast potential reactions to baked goods is essential.</div></div><div><h3>Objective</h3><div>To determine the predictive factors and some decision points for estimation of BM reactivity and severe reactions.</div></div><div><h3>Methods</h3><div>A cross-sectional study was performed. Participants who were reactive to unheated milk underwent an oral food challenge with BM. The reactive group was classified into anaphylactic and non-anaphylactic reaction categories. The IgE and skin prick test (SPT) levels of milk and its components were compared among these groups.</div></div><div><h3>Results</h3><div>The study was conducted with 110 patients. The median age of participants was 16 (IQR: 12-31) months. BM reactivity was observed in 41% (n = 46/110) of the patients. The optimal cutoff point for BM reactivity was 4.68 kIU/L for casein specific IgE (sIgE) (84% specificity, 75% sensitivity, area under the curve [AUC]: 0.827) and 7 mm for casein SPT (87.2% specificity, 51.1% sensitivity, AUC: 0.721) (<em>P</em> &lt; .001, <em>P</em> &lt; .001). The positive decision point for anaphylaxis for casein sIgE was 34 kIU/L (95% specificity, 47.6% sensitivity, AUC: 0.707). In the group younger than 24 months old, the cutoff values for casein sIgE were found to be 5.4 kIU/L (95% specificity, 66.6% sensitivity, AUC: 0.844) and casein SPT at 7 mm (91% specificity, 37% sensitivity, AUC: 0.708) (<em>P</em> &lt; .001, <em>P</em> = .002).</div></div><div><h3>Conclusion</h3><div>Our investigation revealed that the most accurate indicator for BM reactivity was casein sIgE and SPT. Although we established a threshold for severe reaction with BM in our study population, we consider that our findings require validation before therapeutic implementation.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 6","pages":"Pages 700-705.e1"},"PeriodicalIF":5.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediation of pediatric atopic dermatitis in emotional and behavioral outcomes by sleep disturbance.","authors":"Aaron Bao, Patrick G Sockler, Cyd K Eaton, Sarah Radtke, Adam P Spira, Joy Wan","doi":"10.1016/j.anai.2025.05.026","DOIUrl":"https://doi.org/10.1016/j.anai.2025.05.026","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is associated with increased risk of emotional and behavioral problems in children, but the mechanisms underlying this relationship are not fully understood.</p><p><strong>Objective: </strong>To evaluate sleep disturbance and sleep duration as potential mediators between AD and emotional/behavioral problems in children across childhood.</p><p><strong>Methods: </strong>We performed mediation analyses at three timepoints using data from the Avon Longitudinal Study of Parents and Children birth cohort in the United Kingdom. The exposure was child's AD status, categorized as no AD, inactive AD, mild active AD, or moderate/severe active AD. Mediators were maternal-reported child sleep disturbances and total 24-hour sleep duration. Outcomes were emotional and behavioral problems assessed via the parent-reported Strengths and Difficulties Questionnaire (SDQ) and depressive symptoms via the Short Moods and Feelings Questionnaire (SMFQ). Analyses were adjusted for sociodemographic factors.</p><p><strong>Results: </strong>More active/severe AD was associated with greater sleep disturbance and higher levels of emotional/behavioral problems across all timepoints. Mediation models revealed significant direct effects of active AD on SDQ total difficulties. Indirect effects mediated by sleep duration were minimal (<1% of total effect), while those mediated by sleep disturbance were significant across AD severity strata for SDQ (6.5-26.7% of total effect) and SMFQ (10.9-14.0% of total effect). Bedtime refusal and early awakenings were most strongly associated with clinically-concerning SDQ scores.</p><p><strong>Conclusion: </strong>Sleep disturbance significantly mediates the association between AD and emotional/behavioral problems in children. Interventions targeting sleep may be one approach to reducing the psychological burden of AD in pediatric populations.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the pages of AllergyWatch.","authors":"Stanley M Fineman, Timothy Chow, Shyam R Joshi, Iris Otani","doi":"10.1016/j.anai.2025.05.025","DOIUrl":"10.1016/j.anai.2025.05.025","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting severe and early-onset reactions with the tahini-lip dose challenge.","authors":"Melike Ocak, Alp Kazancioglu, Umit Murat Sahiner, Ozge Soyer, Bulent Enis Sekerel","doi":"10.1016/j.anai.2025.05.023","DOIUrl":"10.1016/j.anai.2025.05.023","url":null,"abstract":"<p><strong>Background: </strong>Tahini, a sesame seed paste, is often used in skin prick tests (SPTs) and oral food challenges (OFCs) to diagnose sesame allergy, although OFCs are limited owing to resource demands and the inherent risk of allergic reactions.</p><p><strong>Objective: </strong>To evaluate the diagnostic utility of the tahini-lip dose challenge (LDC) as a preliminary step before OFC by comparing its performance with conventional tests and exploring its efficacy across patient subgroups.</p><p><strong>Methods: </strong>This retrospective study reviewed patients with suspected sesame allergy who underwent tahini-LDC before OFC.</p><p><strong>Results: </strong>Overall, 95 children (median age: 2.4 years; IQR: 1.3-4.9) underwent tahini-LDC before OFC. Of these, 49 (51.6%) had positive LDC test results, including 1 patient who experienced anaphylaxis during LDC. Among patients who showed positive for LDC, only 2 (4.2%) had negative OFC outcomes. Conversely, among the 46 patients who showed LDC-negative, 16 (34.8%) had positive OFC outcomes. The LDC revealed higher specificity than did SPT and specific IgE but lower sensitivity. Combining LDC with standard sesame or tahini SPT did not change sensitivity, specificity, or positive likelihood ratio, whereas combining LDC with optimal SPTs yielded a positive likelihood ratio of up to 23.4 and a specificity of 96.9%, highlighting a strong diagnostic utility. Tahini-LDC positivity was associated with younger age and higher SPT values. In children with sesame allergy, the tahini-LDC positive subgroup experienced more frequent systemic reactions and reactions at earlier stages of the OFC, and required adrenaline more often than did the negative subgroup.</p><p><strong>Conclusion: </strong>The inclusion of tahini-LDC may help improve diagnostic accuracy in the evaluation of sesame allergy, particularly in identifying patients at high/low risk. Although LDC can not replace OFC, further research is warranted to refine its protocols and expand its application across diverse populations and age groups.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the pages of AllergyWatch.","authors":"Stanley Fineman, Samantha M Knox, Sarah Spriet, Iris Otani","doi":"10.1016/j.anai.2025.05.020","DOIUrl":"10.1016/j.anai.2025.05.020","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selected inborn errors of immunity associated with severe atopic phenotypes: Implications for the practicing allergist.","authors":"Joseph A Bellanti","doi":"10.1016/j.anai.2025.05.024","DOIUrl":"10.1016/j.anai.2025.05.024","url":null,"abstract":"<p><strong>Background: </strong>Food allergies and inborn errors of immunity (IEIs) were once viewed as distinct disorders-hypersensitivity vs infection susceptibility. However, IEIs are now recognized to include immune dysregulation with autoimmunity, autoinflammation, lymphoproliferation, and severe atopy. Understanding the overlap between food allergies and IEIs is critical, given that allergic inflammation often complicates immune deficiencies.</p><p><strong>Objective: </strong>To evaluate the shared immunologic mechanisms linking food allergies and IEIs, with a focus on immune dysregulation, barrier defects, microbial dysbiosis, and impaired regulatory T cell (Treg) function.</p><p><strong>Methods: </strong>A comprehensive literature review was conducted using PubMed applying search terms including food allergy, primary immunodeficiency, IEI, Treg cells, immune dysregulation, autoimmunity, autoinflammation, epithelial barrier dysfunction, and microbiome. Particular focus was placed on identifying studies describing monogenic IEIs characterized by severe allergic phenotypes and elevated IgE levels. Articles were selected on the basis of relevance to the themes of the review, quality of study design, and their contribution to advancing understanding in the field. Priority was given to original research articles, systematic reviews, meta-analyses, and key historical studies.</p><p><strong>Results: </strong>Allergic symptoms, including food allergy and atopic dermatitis, frequently present early in IEIs and may precede infection susceptibility. Common features include Treg dysfunction, cytokine signaling defects, epithelial barrier compromise, and microbiome alterations. Recognition of these pathways has enhanced diagnosis and led to targeted therapies such as biologics and gene therapy.</p><p><strong>Conclusion: </strong>Treg cells are central to maintaining immune tolerance across allergic, autoimmune, and immunodeficient states. Advances in understanding dysregulated immunity and barrier defects are driving personalized treatment strategies for patients with both food allergy and IEIs.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}