Annals of Allergy Asthma & Immunology最新文献

{"title":"Randomized, placebo-controlled, phase 1 safety study of oral mucosal immunotherapy in adults with peanut allergy","authors":"William E. Berger MD, MBA ,&nbsp;Nicole Faris MSc ,&nbsp;Mark Weinstein MD ,&nbsp;Gregory E. Wilding PhD ,&nbsp;Erick Berglund PhD","doi":"10.1016/j.anai.2025.01.013","DOIUrl":"10.1016/j.anai.2025.01.013","url":null,"abstract":"<div><h3>Background</h3><div>Oral mucosal immunotherapy (OMIT) involves the use of a specifically formulated toothpaste to deliver allergenic proteins to immunologically active areas of the oral cavity. This represents a novel delivery mechanism with several features designed to improve food allergy desensitization. OMIT has advantages over other approaches to allergy immunotherapy due to its targeted delivery and simplified administration.</div></div><div><h3>Objective</h3><div>To determine the safety, tolerability, and adherence to OMIT with INT301 in adults with peanut allergy.</div></div><div><h3>Methods</h3><div>The Oral Mucosal Escalation Goal Assessment study enrolled 32 adults, aged 18 to 55 years, with peanut allergy in a 3:1 ratio to receive either an escalating dose of INT301 or a placebo. Entry criteria included a positive skin prick test result with a wheal diameter greater than or equal to 3 mm than control and/or peanut-specific IgE level greater than or equal to 0.35 kU/L. Subjects were required to fail an oral food challenge less than or equal to 100 mg dose of peanut protein. Safety and tolerability were monitored in the 48-week trial period.</div></div><div><h3>Results</h3><div>All active subjects (100%) tolerated the prespecified protocol at the highest dose. No moderate or severe systemic reactions were observed in the active participants. Nonsystemic adverse reactions were mostly local (oral and nasal cavities), mild and transient. Active subjects adhered to the treatment for 97% of the days in the study, with no withdrawals due to study medication.</div></div><div><h3>Conclusion</h3><div>In the Oral Mucosal Escalation Goal Assessment trial, INT301 met all primary and secondary end points of safety, tolerability, and adherence. Thus, OMIT seems to be a safe and convenient option for individuals with food allergies. These results support the need for further evaluation in the pediatric population.</div></div><div><h3>Trial Registration</h3><div>ClinicalTrials.gov Identifier: NCT04603300.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 4","pages":"Pages 448-456"},"PeriodicalIF":5.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in ciliary beat frequency based on chronic rhinosinusitis endotype and phenotype","authors":"Asher C. Park BS ,&nbsp;Theodore V. Nguyen BS ,&nbsp;Lidek Chou BS ,&nbsp;Katelyn K. Dilley BS ,&nbsp;Zhikai Zhu MS ,&nbsp;Akarsh Lal BS ,&nbsp;Pranav Nair BS ,&nbsp;Zhongping Chen PhD ,&nbsp;Edward C. Kuan MD, MBA ,&nbsp;Brian J.F. Wong MD, PhD","doi":"10.1016/j.anai.2025.01.009","DOIUrl":"10.1016/j.anai.2025.01.009","url":null,"abstract":"<div><h3>Background</h3><div>Chronic rhinosinusitis (CRS) is traditionally classified into CRS with or without nasal polyps and, more recently, into eosinophilic and noneosinophilic endotypes. Limited research exists on the relationship between CRS subtypes and mucociliary function. This study compares ciliary beat frequency (CBF) across CRS subtypes.</div></div><div><h3>Objective</h3><div>To investigate CBF across different CRS subtypes and validate spectrally encoded interferometric microscopy (SEIM) against phase-contrast microscopy (PCM) for measuring CBF.</div></div><div><h3>Methods</h3><div>Sinonasal mucosa from endoscopic endonasal surgery cases were imaged ex vivo at physiological temperatures using PCM and SEIM. CBF measurements were compared between disease states (control vs CRS with nasal polyps [CRSwNPs] vs CRS without nasal polyps [CRSsNPs] and control vs eosinophilic CRS vs noneosinophilic CRS) and between PCM and SEIM.</div></div><div><h3>Results</h3><div>CRSwNP mucosa (5.77 ± 0.12 Hz) had significantly lower CBF compared with control (6.23 ± 0.11 Hz) (<em>P</em> = .001). Both eosinophilic rhinosinusitis (5.74 ± 0.16 Hz; <em>P</em> = .005) and noneosinophilic CRS mucosa (6.00 ± 0.08 Hz; <em>P</em> = .03) had significantly lower CBF compared with control (6.28 ± 0.11 Hz). There was no significant difference between PCM (7.65 ± 0.60 Hz) and SEIM (7.64 ± 0.51 Hz) as a means of evaluating CBF (<em>P</em> = .36).</div></div><div><h3>Conclusion</h3><div>Among the CRS subtypes, eosinophilic, noneosinophilic, and CRSwNP are associated with lower CBF compared with healthy controls. SEIM may have value in measuring CBF.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 4","pages":"Pages 442-447"},"PeriodicalIF":5.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can daily teeth brushing help treat your peanut allergy?","authors":"Aikaterini Anagnostou MD, MSc, PhD ,&nbsp;David R. Stukus MD","doi":"10.1016/j.anai.2025.01.027","DOIUrl":"10.1016/j.anai.2025.01.027","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 4","pages":"Pages 372-373"},"PeriodicalIF":5.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of asthma across the ages","authors":"Michael Miligkos MD, PhD ,&nbsp;Jiyeon Oh MD ,&nbsp;Rosie Kwon BS ,&nbsp;George Ν. Konstantinou MD, PhD, MSc, MC ,&nbsp;Soeun Kim BS ,&nbsp;Dong Keon Yon MD, PhD ,&nbsp;Nikolaos G. Papadopoulos MD, PhD","doi":"10.1016/j.anai.2024.12.004","DOIUrl":"10.1016/j.anai.2024.12.004","url":null,"abstract":"<div><div>In the past 3 decades, the overall prevalence of asthma appears to be plateauing, although large geographic and socioeconomic variation is evident. Overall, asthma prevalence slightly decreased in most age groups, except for school-aged children. Of note, asthma mortality steadily decreased, potentially highlighting improved asthma management strategies. Several epidemiologic studies indicate that a complex interplay between genetic, environmental, and immunologic factors predisposes individuals to asthma inception and persistence across different life stages. Established risk factors for preschool wheezing to asthma persistence comprise a combination of pre- and post-natal parameters including the maternal history of asthma, prematurity, caesarian section, early-life respiratory infections, exposure to air pollution or tobacco smoke, and allergic polysensitization. On the other hand, persistence into adulthood is mainly driven by disease severity, allergic multimorbidity, relevant comorbidities, severe respiratory infections, and tobacco smoke exposure. It is evident that asthma prevention strategies do not fit a “one size fits all” concept and key environmental interventions should be tailored to different regions of the world. Undoubtedly, the heterogeneity of asthma as a disease is at least partly reflected in the reported epidemiologic measures, and continuing, methodologically rigorous studies will allow us to unravel some of the observed discrepancies.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 4","pages":"Pages 376-384.e13"},"PeriodicalIF":5.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to seeing a health care provider among rural adolescents with poorly controlled asthma","authors":"Jean-Marie Bruzzese PhD ,&nbsp;Amarilis Céspedes PhD ,&nbsp;Visesha Ainapudi MPH ,&nbsp;Sharon Kingston PhD ,&nbsp;Joseph Santana MPH ,&nbsp;Yihong Zhao PhD","doi":"10.1016/j.anai.2025.01.018","DOIUrl":"10.1016/j.anai.2025.01.018","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 4","pages":"Pages 486-488"},"PeriodicalIF":5.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the prevalence and impact of silent rhinovirus infection in chronic rhinosinusitis with nasal polyps","authors":"Xinyi Ma MBBS ,&nbsp;Shu Guo MBBS ,&nbsp;Fangying Liu MBBS ,&nbsp;Changqing Li MBBS ,&nbsp;Xueyun Shi MBBS ,&nbsp;Weiyuan Liu MBBS ,&nbsp;Lijie Qi MD ,&nbsp;Ye Yuan MBBS ,&nbsp;Xinyu Xie MBBS ,&nbsp;Pin Wang PhD ,&nbsp;Larry Borish MD ,&nbsp;Xin Feng MD","doi":"10.1016/j.anai.2025.01.026","DOIUrl":"10.1016/j.anai.2025.01.026","url":null,"abstract":"<div><h3>Background</h3><div>Chronic rhinosinusitis with nasal polyps (CRSwNPs) involves persistent sinus inflammation, with emerging evidence suggesting a potential role of rhinovirus (RV) in its pathophysiology. However, whether RV exists in nasal tissues and affects the nasal mucosa after the resolution of infection symptoms remains unknown.</div></div><div><h3>Objective</h3><div>To investigate the prevalence and impact of silent RV infection in nasal tissues.</div></div><div><h3>Methods</h3><div>RV loads were detected in the nasal tissues of 47 controls and 101 patients with CRSwNP without respiratory infection. Participants were categorized into RV-positive (+), RV-negative (−), and the “gray zone” groups. Quantitative polymerase chain reaction, Western blotting, and immunofluorescence assays were used to analyze the impact of silent RV infection on the immune status of nasal tissues.</div></div><div><h3>Results</h3><div>Silent RV infection was prevalent in both control (34%) and CRSwNP (30.7%) tissues, with higher viral loads observed in the nasal polyps. In controls, it was associated with high expression of types 1 and 2 interferon (IFN), type 2 inflammation, interleukin (IL)-17A, and IL-10. In patients with CRSwNP, silent RV infection was associated with lower levels of type 1 IFN, IL-17A, type 2 inflammation, and IL-10 but higher levels of type 2 IFN compared with those without RV infection. Meanwhile, RV (+) nasal polyps exhibited fewer tissue eosinophils and neutrophils than RV (−) nasal polyps.</div></div><div><h3>Conclusion</h3><div>Silent RV infection was prevalent in the nasal tissues, with a higher viral load detected in the nasal polyps. This silent RV infection is associated with distinct immune responses in healthy controls and patients with CRSwNP, involving differential modulation of IFNs, T_H2 cytokines, IL-17A, IL-10, and eosinophil and neutrophil levels.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 4","pages":"Pages 420-430.e1"},"PeriodicalIF":5.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world effects of tezepelumab on small airway dysfunction in severe refractory asthma","authors":"Robert Greig MbChB,&nbsp;Rory Chan PhD,&nbsp;Tom C. Fardon MD,&nbsp;Brian J. Lipworth MD","doi":"10.1016/j.anai.2025.01.024","DOIUrl":"10.1016/j.anai.2025.01.024","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 4","pages":"Pages 484-485"},"PeriodicalIF":5.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Long-term prevention of hereditary angioedema attacks with lanadelumab in adolescents”","authors":"Ayesha Khan MBBS ,&nbsp;Saad Khan MBBS ,&nbsp;Rizwan Ahmad MBBS ,&nbsp;Fatima Naveed MBBS ,&nbsp;Faraz Arshad MBBS","doi":"10.1016/j.anai.2024.12.017","DOIUrl":"10.1016/j.anai.2024.12.017","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 4","pages":"Pages 492-493"},"PeriodicalIF":5.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinguished Authors class of 2025!","authors":"Mitchell H. Grayson MD","doi":"10.1016/j.anai.2024.12.010","DOIUrl":"10.1016/j.anai.2024.12.010","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 4","pages":"Page 370"},"PeriodicalIF":5.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signaling lymphocytic activation molecule family 8 disrupts epithelial barrier in chronic rhinosinusitis with nasal polyps through M1 macrophage polarization","authors":"Danyang Li MD,&nbsp;Longgang Yu MD,&nbsp;Jiajia Zi MM,&nbsp;Xiaoyun Du MD,&nbsp;Xudong Yan MD,&nbsp;Han Chen MD,&nbsp;Lin Wang MM,&nbsp;Chunge Zheng MD,&nbsp;Guangyi Wang MM,&nbsp;Jisheng Zhang MD,&nbsp;Yan Jiang MD","doi":"10.1016/j.anai.2025.01.020","DOIUrl":"10.1016/j.anai.2025.01.020","url":null,"abstract":"<div><h3>Background</h3><div>Recent studies reveal that M1 macrophages accumulate predominantly in noneosinophilic chronic rhinosinusitis with nasal polyps (neCRSwNP). However, the precise mechanisms regulating M1 macrophages and their impact on the epithelial barrier remain unclear.</div></div><div><h3>Objective</h3><div>To investigate the expression and regulatory role of signaling lymphocytic activation molecule family (SLAMF)8, a molecule exclusively expressed in myeloid cells, in M1 macrophage polarization and its potential contribution to neCRSwNP development.</div></div><div><h3>Methods</h3><div>We evaluated SLAMF8 expression and its correlation with clinical variables using real-time quantitative polymerase chain reaction and Western blot in sinonasal mucosa samples from CRSwNP and control subjects. Immunofluorescence staining confirmed the co-expression of SLAMF8 with macrophages. After SLAMF8 knockdown, we explored the influence on macrophage M1 polarization and the effect on epithelial-mesenchymal transition (EMT) process and tight junction integrity in epithelial cells through an indirect co-culture system of M1 macrophages with human nasal epithelial cells.</div></div><div><h3>Results</h3><div>SLAMF8 was highly expressed on M1 macrophages in polyp tissues, notably in neCRSwNP, and correlated with disease severity indices only in neCRSwNP. SLAMF8 knockdown in THP-1 cells reduced M1 macrophage markers (CD86, iNOS, and NLRP3) and decreased secretion of inflammatory cytokines (interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha). Co-culture with M1 macrophage supernatant after SLAMF8 knockdown enhanced epithelial viability, reduced EMT and apoptosis, and up-regulated tight junction markers, occludin and claudin-4, in nasal epithelial cells.</div></div><div><h3>Conclusion</h3><div>SLAMF8 elevation correlates with the EMT, epithelial tight junction, and disease severity in neCRSwNP. SLAMF8 up-regulation promotes M1 macrophage polarization, which facilitates EMT and impairs nasal epithelial barrier function. SLAMF8 may represent a novel therapeutic target for neCRSwNP.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"134 4","pages":"Pages 431-441.e4"},"PeriodicalIF":5.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}