Annals of Allergy Asthma & Immunology最新文献

{"title":"Categorizing clinical response to mepolizumab for patients with chronic rhinosinusitis with nasal polyps: SYNAPSE trial","authors":"Claire Hopkins DM , Larry Borish MD , Jared Silver MD , Peter Howarth DM , Robert Chan MD , Priya Dsilva MSc , Joseph K. Han MD","doi":"10.1016/j.anai.2025.06.018","DOIUrl":"10.1016/j.anai.2025.06.018","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 336-338"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of asthma in US adults with COVID-19 in real-world settings","authors":"Yi-Sheng Jhang BSc , Hui-Chin Chang MLS , Shuo-Yan Gau MD","doi":"10.1016/j.anai.2025.04.009","DOIUrl":"10.1016/j.anai.2025.04.009","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 347-348"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of language barriers on pulmonary function and asthma control","authors":"Maria Paula Henao MD ,&nbsp;Joshua Malerich MD ,&nbsp;Daniel R. George PhD, MSc","doi":"10.1016/j.anai.2025.06.003","DOIUrl":"10.1016/j.anai.2025.06.003","url":null,"abstract":"<div><h3>Background</h3><div>Asthma disproportionately affects non–English-speaking populations, with language barriers contributing to worse health outcomes, including increased emergency department (ED) visits and hospitalizations. Addressing these disparities requires culturally and linguistically appropriate care.</div></div><div><h3>Objective</h3><div>To evaluate the impact of language barriers on asthma control and pulmonary function testing.</div></div><div><h3>Methods</h3><div><span>A retrospective cohort study<span> analyzed data from 28,346 patients aged 12 years and older with asthma. Patients were categorized as English- or non–English-speaking on the basis of language preference in electronic health records. Asthma outcomes were measured using the </span></span>asthma control test<span><span><span> (ACT), pulmonary function tests, and </span>health care utilization patterns (outpatient visits, ED visits, and hospitalizations). </span>Atopy was assessed using skin prick tests or specific IgE when available.</span></div></div><div><h3>Results</h3><div><span>English-speaking patients were more likely to have ACT scores (odds ratio [OR] 1.43, 95% CI 1.11-1.83) and pulmonary function tests (OR 1.75, 95% CI 1.31-2.31) recorded in their health records. Non–English-speaking patients were more likely to have uncontrolled asthma (ACT ≤ 20, OR 4.3, 95% CI 2.61-7.09) and lower forced expiratory volume in 1 second percent predicted (mean = 70.7 vs 78.4, </span><em>P</em> = .007). Non-English speakers were less likely to have ambulatory visits (OR 2.00, 95% CI 1.56-2.57) but more likely to seek care in EDs (OR 1.36, 95% CI 1.17-1.58). Hospitalization rates were similar between groups. Atopy prevalence was similar.</div></div><div><h3>Conclusion</h3><div>Language barriers significantly impact asthma management, leading to worse outcomes in patients with limited English proficiency. Health systems should prioritize professional interpreters, bilingual education, and technological solutions (eg, artificial intelligence–based translation models) to reduce disparities. Future research should assess the long-term effects of language-concordant interventions.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 287-290"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of eosinophilic granulomatosis with polyangiitis–associated sinusitis with dual biologics","authors":"S. Shahzad Mustafa MD ,&nbsp;Anthony Ocon MD, PhD ,&nbsp;Karthik Vadamalai MD ,&nbsp;Allison Ramsey MD","doi":"10.1016/j.anai.2025.06.010","DOIUrl":"10.1016/j.anai.2025.06.010","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 332-334"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of aspirin allergy evaluation in cardiac patients presenting with non–ST-elevation myocardial infarction","authors":"Sarah S. Han MD ,&nbsp;Ryan Wilson BS ,&nbsp;Ellen Liu MD ,&nbsp;Lauren Hassen MD ,&nbsp;Monica T. Kraft MD","doi":"10.1016/j.anai.2025.06.023","DOIUrl":"10.1016/j.anai.2025.06.023","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 334-335"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors’ response","authors":"David I. Bernstein MD ,&nbsp;Thomas B. Casale MD ,&nbsp;Sarina Tanimoto MD, PhD","doi":"10.1016/j.anai.2025.06.028","DOIUrl":"10.1016/j.anai.2025.06.028","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Page 350"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective study of the level of education on early peanut introduction and parental implementation","authors":"Heema Shah DO ,&nbsp;Margo Saharovici MD ,&nbsp;Emily McCulley BS ,&nbsp;Jason Yaun MD ,&nbsp;Jay A. Lieberman MD","doi":"10.1016/j.anai.2025.06.016","DOIUrl":"10.1016/j.anai.2025.06.016","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 341-343"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous immunotherapy administration on college campuses","authors":"Michael W. Tsoulis MD, MSc ,&nbsp;Marcus S. Shaker MD, MS ,&nbsp;Marylee Verdi APRN, MSN ,&nbsp;Samuel Gubernick DO ,&nbsp;Jean Ly MD ,&nbsp;Dana V. Wallace MD","doi":"10.1016/j.anai.2025.05.006","DOIUrl":"10.1016/j.anai.2025.05.006","url":null,"abstract":"<div><h3>Background</h3><div>Student health center or clinic (SHC) administration of subcutaneous immunotherapy (SCIT) while at college/university is not well studied.</div></div><div><h3>Objective</h3><div>To clarify SCIT administration on campus both from the Allergist’s and SHC’s perspectives using Florida as an example.</div></div><div><h3>Methods</h3><div>The Florida Allergy, Asthma &amp; Immunology Society (FAAIS) Practice Standards Committee surveyed all FAAIS members in the fall of 2023 regarding SCIT administration at SHCs. All Florida colleges and universities offering 4-year bachelor's degrees were surveyed in the spring of 2024 to assess the following 3 variables: presence of a SHC on campus, whether SCIT is offered at said SHC, and whether there were protocols or policies available regarding SCIT administration. Available polices and protocols were analyzed.</div></div><div><h3>Results</h3><div>Among FAAIS members responding (23% response rate) to the 29-question survey, almost all would provide important specific information (ie, allergic diagnoses, buildup/maintenance schedules, medications, recording sheet, instructions for local/systemic reactions, pre-SCIT antihistamine<span> use, and student epinephrine autoinjector carriage) either upfront or if requested by SHCs, but vial label components provided varied between FAAIS members. Among the 37 Florida colleges and universities with SHCs (29%), 21 (57%) offered SCIT, and of these, 11 (52%) had available policies or protocols outlining how SCIT is administered. Available protocol details varied, but Allergist protocols were required by all.</span></div></div><div><h3>Conclusion</h3><div>Florida Allergists varied in terms of information provided to SHCs regarding SCIT administration at SHCs, and among the 57% of SHCs administering SCIT in Florida, there was a similar variability.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 291-296.e1"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing a hereditary angioedema prevalence for the United States using a large administrative claims database","authors":"Anthony J. Castaldo MPA ,&nbsp;Karen E. Wells MPH ,&nbsp;Subhan Khalid MS ,&nbsp;Emaan Rashidi MHS ,&nbsp;Christine N. Selva BA ,&nbsp;Deborah Corcoran MSci ,&nbsp;Sandra C. Christiansen MD ,&nbsp;Marc A. Riedl MD ,&nbsp;Bruce L. Zuraw MD ,&nbsp;Nilsa Loyo-Berrios PhD, MS","doi":"10.1016/j.anai.2025.05.018","DOIUrl":"10.1016/j.anai.2025.05.018","url":null,"abstract":"<div><h3>Background</h3><div>Hereditary angioedema (HAE) is a rare, potentially life-threatening genetic disorder. No US prevalence for all types of HAE has been estimated. Approval of 8 effective HAE therapies in the United States significantly expanded treated patient numbers and data collected in claims databases.</div></div><div><h3>Objective</h3><div>To provide the first US prevalence estimate of HAE (all types) using claims-based insurance data.</div></div><div><h3>Methods</h3><div>This retrospective study estimated the US prevalence of HAE using IQVIA’s PharMetrics Plus MedTech claims database. Patients with 24 months of continuous database enrollment were divided into the following 3 cohorts: 2018, 2019, and 2020. Owing to the absence of International Classification of Diseases, Ninth Revision, Clinical Modification or International Classification of Diseases, 10th Revision, Clinical Modification diagnostic codes specific to HAE, we developed a proxy algorithm using International Classification of Diseases, 10th Revision, Clinical Modification codes for “angioneurotic edema” or “defects in the complement system” with more than or equal to 1 pharmacy claim for an HAE-indicated medication. An expert panel reviewed anonymized patient-level aggregate claims data to determine HAE status. A sensitivity analysis generated adjustment factors to address underrepresentation of Medicare patients in PharMetrics Plus MedTech database.</div></div><div><h3>Results</h3><div>For 2018, 2019, and 2020, the claims-based algorithm yielded overall annual unadjusted HAE prevalence estimates per 100,000 and number of people diagnosed with HAE of 2.67, 9559; 2.61, 9341; and 2.43, 8694, respectively. The corresponding estimates based on expert physician analysis were 2.13, 7602; 2.03, 7275; and 1.84, 6595, respectively.</div></div><div><h3>Conclusion</h3><div>Our study provides the first claims-based comprehensive estimate of the US prevalence for all types of HAE across age groups, sexes, and geographic regions. Our calculations (which exceed the frequently cited 2:100,000 prevalence for HAE with C1 inhibitor deficiency) afford a real-world projected prevalence encompassing all types of HAE.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 303-310"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social media utilization within allergy and immunology fellowship programs","authors":"Ashna Jain MD ,&nbsp;Sahil A. Patel MD ,&nbsp;Marc S. McMorris MD","doi":"10.1016/j.anai.2025.04.015","DOIUrl":"10.1016/j.anai.2025.04.015","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 345-346"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}