{"title":"Future of therapy and monitoring for eosinophilic esophagitis and eosinophilic gastrointestinal diseases.","authors":"Andrew Dickerson, Evan S Dellon, Seema S Aceves","doi":"10.1016/j.anai.2025.05.016","DOIUrl":null,"url":null,"abstract":"<p><p>Eosinophilic gastrointestinal disorders, including eosinophilic esophagitis, are chronic T<sub>H</sub>2-mediated diseases. Establishing a diagnosis and initiating treatment are crucial to limit disease progression that may lead to tissue remodeling and the development of strictures that significantly affect patients' quality of life. Expert consensus guidelines provide a framework for treating eosinophilic esophagitis with diet elimination, proton pump inhibitors, swallowed topical steroids, or dupilumab, and for monitoring with sedated endoscopy for gross and histologic evaluation. Although this provides an established algorithm for treating and monitoring eosinophilic esophagitis, there is less established research for the rarer eosinophilic gastrointestinal disorders (eosinophilic gastritis, enteritis, and colitis). Research advancements continue rapidly to emerge, identifying potential biomarkers, therapeutic targets, and monitoring strategies. In this article, we review the currently accepted methods for treating and monitoring eosinophilic gastrointestinal disorders with a focus on eosinophilic esophagitis, assess methods currently under investigation, and provide an aspirational vision for future disease management with a streamlined algorithm of personalized medicine and less invasive monitoring.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":5.8000,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Allergy Asthma & Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.anai.2025.05.016","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
Abstract
Eosinophilic gastrointestinal disorders, including eosinophilic esophagitis, are chronic TH2-mediated diseases. Establishing a diagnosis and initiating treatment are crucial to limit disease progression that may lead to tissue remodeling and the development of strictures that significantly affect patients' quality of life. Expert consensus guidelines provide a framework for treating eosinophilic esophagitis with diet elimination, proton pump inhibitors, swallowed topical steroids, or dupilumab, and for monitoring with sedated endoscopy for gross and histologic evaluation. Although this provides an established algorithm for treating and monitoring eosinophilic esophagitis, there is less established research for the rarer eosinophilic gastrointestinal disorders (eosinophilic gastritis, enteritis, and colitis). Research advancements continue rapidly to emerge, identifying potential biomarkers, therapeutic targets, and monitoring strategies. In this article, we review the currently accepted methods for treating and monitoring eosinophilic gastrointestinal disorders with a focus on eosinophilic esophagitis, assess methods currently under investigation, and provide an aspirational vision for future disease management with a streamlined algorithm of personalized medicine and less invasive monitoring.
期刊介绍:
Annals of Allergy, Asthma & Immunology is a scholarly medical journal published monthly by the American College of Allergy, Asthma & Immunology. The purpose of Annals is to serve as an objective evidence-based forum for the allergy/immunology specialist to keep up to date on current clinical science (both research and practice-based) in the fields of allergy, asthma, and immunology. The emphasis of the journal will be to provide clinical and research information that is readily applicable to both the clinician and the researcher. Each issue of the Annals shall also provide opportunities to participate in accredited continuing medical education activities to enhance overall clinical proficiency.