Annals of Allergy Asthma & Immunology最新文献

{"title":"Increased likelihood of COVID-19-related asthma exacerbation with higher eosinophil count","authors":"Mirna Ayache MD, MPH , Faiza Khalid MD","doi":"10.1016/j.anai.2025.06.026","DOIUrl":"10.1016/j.anai.2025.06.026","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 328-329"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Asthma Control Program","authors":"Waleed Omar DO , Paige Hardy MPH , Andrea A. Pappalardo MD","doi":"10.1016/j.anai.2025.06.027","DOIUrl":"10.1016/j.anai.2025.06.027","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 247-248"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple therapy vs dual inhaler therapy for moderate-to-severe asthma","authors":"Daniel G. Rayner MSc ,&nbsp;Layla Bakaa BSc ,&nbsp;Flavia Hoyte MD ,&nbsp;Tamara T. Perry MD ,&nbsp;Katherine Rivera-Spoljaric MD, MSci ,&nbsp;Kaharu Sumino MD ,&nbsp;Bradley Chipps MD ,&nbsp;John Oppenheimer MD ,&nbsp;Sharmilee M. Nyenhuis MD ,&nbsp;Elliot Israel MD ,&nbsp;Ellen McCabe PhD ,&nbsp;Paul M. O’Byrne MBChB ,&nbsp;Lindsay E. Shade MHS, PA-C ,&nbsp;Valerie G. Press MD, MPH ,&nbsp;Gordon H. Guyatt MD ,&nbsp;Susana Rangel MSN, FNP-C ,&nbsp;Dia Sue-Wah-Sing MS ,&nbsp;Lisa Hall ,&nbsp;Hilarry Orr BSE ,&nbsp;Angel Melendez MHL, MSRC ,&nbsp;Derek K. Chu MD, PhD","doi":"10.1016/j.anai.2025.06.011","DOIUrl":"10.1016/j.anai.2025.06.011","url":null,"abstract":"<div><h3>Background</h3><div>Long-acting muscarinic antagonists are typically added to inhaled corticosteroids (ICS) and long-acting β-agonists (LABA) for asthma management.</div></div><div><h3>Objective</h3><div>To systematically synthesize the benefits and harms of triple therapy (ICS/LABA/long-acting muscarinic antagonists) compared with dual therapy (ICS/LABA) for asthma management across key subpopulations as part of developing linked American Academy of Allergy, Asthma, and Immunology/American College of Allergy, Asthma, and Immunology guidelines.</div></div><div><h3>Methods</h3><div>We searched MEDLINE, EMBASE, the Cochrane Controlled Register of Trials, and the International Clinical Trials Registry Platform from January 1, 2020 to February 1, 2025, for randomized trials comparing inhaled triple therapy to dual therapy for asthma to update our previous systematic review. Paired reviewers independently screened citations, extracted data, and assessed the risk of bias. Random effects meta-analyses assessed asthma control (asthma control questionnaire-7; 0-6), asthma-related quality of life (asthma quality of life questionnaire; 1-7), prebronchodilator forced expiratory volume in 1 second, severe exacerbations, and serious adverse events. The Grading of Recommendations, Assessment, Development, and Evaluation approach informed the certainty of evidence. Open Science Framework Registration (<span><span>https://osf.io/u8t4q/</span><svg><path></path></svg></span>).</div></div><div><h3>Results</h3><div>A total of 26 trials randomized 12,431 participants. Compared with dual therapy, triple therapy reduces severe exacerbations in patients at high risk for future exacerbation (relative risk 0.83, 95% CI 0.76-0.90; risk difference 5.3% fewer; high certainty), with trivial improvement in asthma control (mean difference [MD] −0.04, 95% CI −0.07 to 0.00, moderate certainty; lower better), quality of life (MD 0.05, 95% CI −0.03 to 0.14, moderate certainty; higher better), and prebronchodilator forced expiratory volume in 1 second (MD 0.07, 95% CI 0.05-0.09; high certainty), without increase in serious adverse events (moderate certainty). The effects were consistent across age, body mass index, and exacerbation history.</div></div><div><h3>Conclusion</h3><div>In patients with moderate-to-severe asthma, triple therapy, compared with dual therapy, reduces severe exacerbations in patients at high risk for future exacerbation with minimal harm.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 278-286.e11"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the pages of AllergyWatch.","authors":"Stanley M Fineman, Timothy Chow, Shyam R Joshi, Iris Otani","doi":"10.1016/j.anai.2025.05.025","DOIUrl":"https://doi.org/10.1016/j.anai.2025.05.025","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"352-353"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors’ response","authors":"Hongxuan Fan PhD ,&nbsp;Zhaoyu Ren MM ,&nbsp;Ping Zhang MD ,&nbsp;Boda Zhou MD","doi":"10.1016/j.anai.2025.06.002","DOIUrl":"10.1016/j.anai.2025.06.002","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 348-349"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The usual suspects","authors":"Victoria T. Nguyen DO ,&nbsp;Kristina Roth MD ,&nbsp;Emily Engelhardt MD ,&nbsp;Adam Pearlstein DO ,&nbsp;Theresia R. Davita MD ,&nbsp;Mitchell H. Grayson MD","doi":"10.1016/j.anai.2025.04.013","DOIUrl":"10.1016/j.anai.2025.04.013","url":null,"abstract":"<div><div>Recurrent wheeze and asthma are major health problems, especially in children. Respiratory viral infections are known to induce recurrent wheeze and asthma. Two respiratory viruses associated with most recurrent wheeze and asthma development are respiratory syncytial virus (RSV) and rhinovirus (RV). This review evaluates the roles these 2 viruses play in the development of wheeze and asthma. RSV tends to drive recurrent wheeze in those infants who have a severe infection in the first 2 to 6 months of life and do not have preexisting atopy. This is in contrast with RV, which tends to drive wheeze and asthma in those with preexisting atopy. In the review, the mechanisms that have been proposed to drive the development of asthma and wheeze are explored. Finally, newer developments, such as vaccines, are discussed. In particular, vaccines and treatment for RSV have the potential to alter the development of recurrent wheezing, although vaccines and treatment for RV remain elusive. Both RSV and RV remain a major source of recurrent wheezing in young children.</div></div>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":"135 3","pages":"Pages 261-267"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total IgE as a biomarker of response to omalizumab in chronic urticaria: A prospective study.","authors":"Levi Keller, Jenny M Stitt, Stephen C Dreskin","doi":"10.1016/j.anai.2025.08.017","DOIUrl":"10.1016/j.anai.2025.08.017","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-life evaluation of novel forced expiratory ratios with asthma exacerbations and symptoms.","authors":"Fraser Paterson, Jing Yuan On, Dania Ahmed, Remo Poto, Atanu Bhattacharjee, Robert Greig, Jake Brown, Frans de Jongh, Zuzana Diamant, Tom Fardon, Brian Lipworth, Rory Chan","doi":"10.1016/j.anai.2025.08.015","DOIUrl":"https://doi.org/10.1016/j.anai.2025.08.015","url":null,"abstract":"<p><strong>Background: </strong>Small airways dysfunction (SAD) is an important treatable trait in persistent asthma but remains poorly captured by conventional spirometry. The (FEV3-FEV1)/FVC and FEV3/FEV6 ratios have been proposed as novel markers of peripheral airflow limitation.</p><p><strong>Objective: </strong>We investigated the relationship between (FEV3-FEV1)/FVC and FEV3/FEV6 with symptom control and severe exacerbation frequency in patients with moderate-to-severe asthma.</p><p><strong>Methods: </strong>Clinical, physiological and biomarker data were collected from adults with GINA-defined moderate-to-severe asthma visiting a specialist severe asthma centre in Scotland, UK. Associations between spirometric and oscillometric parameters with clinically relevant outcomes were retrospectively analysed using multivariate models.</p><p><strong>Results: </strong>294 patients were included in the analysis. The (FEV3-FEV1)/FVC and FEV3/FEV6 ratios were not significantly associated with asthma symptoms or severe exacerbation rates. Conversely, traditional measures such as FEV1/FVC [adjusted odds ratio (95%CI) 2.11 (1.27,3.50); p<0.01], FEF25-75/FVC [2.11 (1.27,3.50); p<0.01], and oscillometric Rrs5-20 [OR 1.90 (1.14,3.16); p<0.05] were significantly associated with ≥2 exacerbations in the previous year. High coefficient of determination (r2) values were observed between FEV1/FVC with (a) (FEV3-FEV1)/FVC r2=0.61 and (b) FEV3/FEV6r2=0.83, suggesting overlapping aspects of lung function being measured. There was a weak correlation between FEV1/FVC and Rrs5-20 values (r2=0.08) indicating that these parameters assess unique aspects of lung function and mechanics.</p><p><strong>Conclusion: </strong>In moderate-to-severe asthma, the (FEV3-FEV1)/FVC and FEV3/FEV6 ratios were not independently associated with exacerbation risk or symptom control and did not provide additional clinical value compared to conventional lung function measures.</p>","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High prevalence of eosinophilic esophagitis and hypogammaglobulinemia in patients with Pitt-Hopkins syndrome.","authors":"Rebecca Revell, Samantha Nguyen, Barrett H Barnes, Monica G Lawrence, Emily C McGowan","doi":"10.1016/j.anai.2025.08.016","DOIUrl":"10.1016/j.anai.2025.08.016","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the quality and readability of online food protein-induced enterocolitis syndrome patient education materials.","authors":"Benjamin S Daines, Christopher K Wong, Asif Hossain, Caleb Lin, Sara Anvari","doi":"10.1016/j.anai.2025.08.010","DOIUrl":"10.1016/j.anai.2025.08.010","url":null,"abstract":"","PeriodicalId":50773,"journal":{"name":"Annals of Allergy Asthma & Immunology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}