Annals of Diagnostic Pathology最新文献_第9页

How reliable is pre-sleeve endoscopy to characterize pathological features? 套管前内镜检查在确定病理特征方面的可靠性如何？

IF 2 4区医学

Annals of Diagnostic Pathology Pub Date : 2024-04-20 DOI: 10.1016/j.anndiagpath.2024.152319

Mohammad Heiat , Mohammad Javanbakht , Mohammad Ali Abyazi , Farrokh Modarresi , Hamed Gholizadeh

{"title":"How reliable is pre-sleeve endoscopy to characterize pathological features?","authors":"Mohammad Heiat , Mohammad Javanbakht , Mohammad Ali Abyazi , Farrokh Modarresi , Hamed Gholizadeh","doi":"10.1016/j.anndiagpath.2024.152319","DOIUrl":"https://doi.org/10.1016/j.anndiagpath.2024.152319","url":null,"abstract":"<div><h3>Background</h3><p>Vertical sleeve gastrectomy is a relatively new bariatric procedure with lower morbidity and mortality than other weight loss surgeries. The predictive values of preoperative esophagogastroduodenoscopy for detecting histopathological abnormalities prior to sleeve gastrectomy have not been clearly described. This study aimed to determine the negative predictive value of preoperative endoscopic biopsies for detecting <em>Helicobacter pylori</em> (<em>H. pylori</em>) infection and other pathological findings.</p></div><div><h3>Methods</h3><p>This cross-sectional study examined 102 patients who underwent vertical sleeve gastrectomy from January 2023 to November 2023. Preoperative histopathology of esophagogastroduodenoscopy specimens was compared to postoperative ones for <em>H. pylori</em> infection, gastritis, atrophy, and metaplasia. Moreover, gastroesophageal reflux disease symptoms were postoperatively followed for 6 months.</p></div><div><h3>Results</h3><p>The negative predictive value of preoperative esophagogastroduodenoscopy for detecting <em>H. pylori</em> infection, gastritis, metaplasia and atrophy were 95 %, 79 %, 93 %, and 98 %, respectively. In an overall view, for all pathologies, the negative predictive value was 53.4 %. Moderate gastritis and focal metaplasia were significantly underdiagnosed preoperatively (<em>p</em> < 0.001). <em>H. pylori</em> infection and focal metaplasia were significantly more prevalent in females after surgery (<em>p</em> < 0.001). <em>H. pylori</em> infection and gastritis were positively correlated with increased postoperative gastroesophageal reflux disease symptoms (<em>p</em> < 0.001).</p></div><div><h3>Conclusion</h3><p>Preoperative endoscopy has a high negative predictive value for detecting <em>H. pylori</em> infection, atrophy, and metaplasia but has suboptimal values for gastritis.</p></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"72 ","pages":"Article 152319"},"PeriodicalIF":2.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140633264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of CSF3R mutations in atypical chronic myeloid leukemia and other myeloid malignancies 非典型慢性髓性白血病和其他髓性恶性肿瘤中的 CSF3R 突变分析

IF 2 4区医学

Annals of Diagnostic Pathology Pub Date : 2024-04-18 DOI: 10.1016/j.anndiagpath.2024.152317

Seon Young Kim , Ik-Chan Song , Jimyung Kim , Gye Cheol Kwon

{"title":"Analysis of CSF3R mutations in atypical chronic myeloid leukemia and other myeloid malignancies","authors":"Seon Young Kim , Ik-Chan Song , Jimyung Kim , Gye Cheol Kwon","doi":"10.1016/j.anndiagpath.2024.152317","DOIUrl":"https://doi.org/10.1016/j.anndiagpath.2024.152317","url":null,"abstract":"<div><p>We report a series of patients with <em>CSF3R</em>-mutant (<em>CSF3R</em><sup>mut</sup>) atypical chronic myeloid leukemia (aCML), chronic neutrophilic leukemia (CNL) or other hematologic malignancies. We included 25 patients: 5 aCML and 4 CNL <em>CSF3R</em><sup>mut</sup> patients; 1 aCML, 2 CNL, and 2 myelodysplastic/myeloproliferative neoplasm, not otherwise specified patients without <em>CSF3R</em> mutation; and 11 <em>CSF3R</em><sup>mut</sup> patients with other diseases [8 acute myeloid leukemia (AML), 1 chronic myelomonocytic leukemia (CMML), 1 myelodysplastic syndrome (MDS), and 1 acute lymphoblastic leukemia (ALL)]. Patients with aCML or CNL were tested by Sanger sequencing and pyrosequencing to identify <em>CSF3R</em> T618I. Twenty-two patients underwent gene panel analysis. <em>CSF3R</em> mutations, mostly T618I (8/9), were found at high frequencies in both aCML and CNL patients [5/6 aCML and 4/6 CNL]. Two aCML patients in early adulthood with <em>CSF3R</em> T618I and biallelic or homozygous <em>CEBPA</em> mutations without other mutations presented with increased blasts and exhibited remission for >6 years after transplantation. The other 7 <em>CSF3R</em><sup>mut</sup> aCML or CNL patients were elderly adults who all had <em>ASXL1</em> mutations and frequently presented with <em>SEBP1</em> and <em>SRSF2</em> mutations. Five AML patients had <em>CSF3R</em> exon 14 or 15 point mutations, and 6 other patients (3 AML, 1 CMML, 1 MDS, and 1 ALL) had truncating mutations, demonstrating differences in leukocyte counts and mutation status. In conclusion, <em>CSF3R</em> mutations were found at a higher frequency in aCML patients than in previous studies, which might reflect ethnic differences. Additional studies are needed to confirm these findings and the relationship between <em>CSF3R</em> and <em>CEBPA</em> mutations.</p></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"71 ","pages":"Article 152317"},"PeriodicalIF":2.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140619180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-analysis of SATB2 immunohistochemical expression in colorectal cancer versus primary ovarian mucinous neoplasms 结直肠癌与原发性卵巢黏液瘤中 SATB2 免疫组化表达的 Meta 分析

IF 2 4区医学

Annals of Diagnostic Pathology Pub Date : 2024-04-16 DOI: 10.1016/j.anndiagpath.2024.152302

Barry Maguire , William P. Duggan , Jochen H.M. Prehn , John P. Burke

{"title":"Meta-analysis of SATB2 immunohistochemical expression in colorectal cancer versus primary ovarian mucinous neoplasms","authors":"Barry Maguire , William P. Duggan , Jochen H.M. Prehn , John P. Burke","doi":"10.1016/j.anndiagpath.2024.152302","DOIUrl":"https://doi.org/10.1016/j.anndiagpath.2024.152302","url":null,"abstract":"<div><h3>Background</h3><p>Reliably distinguishing primary ovarian mucinous neoplasms (POMNs) from metastatic colorectal cancers (CRCs) is both challenging to the histopathologist and of great clinical importance. Special AT-rich sequence binding protein-2 (SATB2) has emerged as a useful diagnostic immunohistochemical marker of colorectal cancer. This meta-analysis compares SATB2 expression in POMNs and CRC.</p></div><div><h3>Methods</h3><p>A systematic literature search for relevant studies was conducted. Meta-analysis of SATB2 positivity was undertaken using a random effects model.</p></div><div><h3>Results</h3><p>Seven studies including 711 CRCs and 528 POMNs were included. SATB2 positivity was seen in 81 % (95 % CI: 72–88 %) of CRCs and 4 % (95 % CI: 1–11 %) of POMNs. Variation was seen in immunohistochemical methods used for SATB2 detection and threshold for positivity.</p></div><div><h3>Conclusion</h3><p>SATB2 staining remains high in CRC and low in POMNs, supporting its use in differentiating these two pathologies with vastly differing prognosis and treatment.</p></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"71 ","pages":"Article 152302"},"PeriodicalIF":2.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140619181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amendments in surgical pathology reports: An 8-year institutional experience 手术病理报告的修订：8 年的机构经验

IF 2 4区医学

Annals of Diagnostic Pathology Pub Date : 2024-04-16 DOI: 10.1016/j.anndiagpath.2024.152308

Anila Sharma, Gurudutt Gupta, Vikas Nishadham, Akanksha Malik, Ankur Kumar, Sunil Pasricha, Meenakshi Kamboj, Garima Durga, Anurag Mehta

{"title":"Amendments in surgical pathology reports: An 8-year institutional experience","authors":"Anila Sharma, Gurudutt Gupta, Vikas Nishadham, Akanksha Malik, Ankur Kumar, Sunil Pasricha, Meenakshi Kamboj, Garima Durga, Anurag Mehta","doi":"10.1016/j.anndiagpath.2024.152308","DOIUrl":"https://doi.org/10.1016/j.anndiagpath.2024.152308","url":null,"abstract":"<div><p>Surgical pathology reports may undergo revisions broadly categorized as addenda (supplementary information) or amendments (changes to finalized reports). Amendments indicate potential flaws in the diagnostic process and serve as important indicators of vulnerabilities in the histopathology workflow. This study analyzed the frequency and distribution of amendments in surgical pathology reports over 8 years to identify patterns highlighting opportunities for improvement. Surgical biopsies, excisions, and resections were included; cytology and molecular tests were excluded. Amended reports were categorized using previously used taxonomy documented in literature. Defects were classified as misinterpretations, misidentifications, defective specimens, or defective reports. Of 101,355 reports, 155 (0.15 %) were signed out with amendments. The amendment rate was approximately 1–2 cases per 1000 reports annually. Misinterpretations accounted for the majority (52 %) of amended reports, with undercalls (62 %) and overcalls (27 %) being predominant subtypes. Tumor staging was amended in 57 (37 %) cases, with 30 being upstaged and 11 downstaged clinically. The highest number of misinterpretation defects occurred in head and neck (36 %) and breast (21 %) specimens. Misinterpretation defects were present in 53 % of malignant cases versus 42 % of benign cases. In 18 cases, there were significant changes in pathological diagnosis (14 major and 4 minor). A standard taxonomy categorizing report defects is crucial for measuring and improving quality control. Accurate pathology reporting impacts patient care and guides workflow improvements. This taxonomy enables us to track variations and deficiencies in our pathology reporting processes in a reproducible way across the department.</p></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"71 ","pages":"Article 152308"},"PeriodicalIF":2.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140619178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depth of invasion analysis to predict acral melanoma outcomes 预测尖锐湿疣预后的浸润深度分析

IF 2 4区医学

Annals of Diagnostic Pathology Pub Date : 2024-04-16 DOI: 10.1016/j.anndiagpath.2024.152305

Marcel Arakaki Asato , Francisco Alves Moares-Neto , Marcelo Padovani de Toledo Moraes , Juliana Polizel Ocanha-Xavier , Luiz Carlos Takita , Mariangela Esther Alencar Marques , José Cândido Caldeira Xavier-Júnior

{"title":"Depth of invasion analysis to predict acral melanoma outcomes","authors":"Marcel Arakaki Asato , Francisco Alves Moares-Neto , Marcelo Padovani de Toledo Moraes , Juliana Polizel Ocanha-Xavier , Luiz Carlos Takita , Mariangela Esther Alencar Marques , José Cândido Caldeira Xavier-Júnior","doi":"10.1016/j.anndiagpath.2024.152305","DOIUrl":"https://doi.org/10.1016/j.anndiagpath.2024.152305","url":null,"abstract":"<div><h3>Background</h3><p>Acral melanoma is a subtype with worse outcomes. The Breslow micrometric measurement is the most critical parameter in planning treatment and predicting outcomes. However, for acral lentiginous melanoma, the value of the Breslow thickness is a matter of debate. Depth of Invasion (DOI) is a well-established measure for staging oral squamous cell carcinoma.</p></div><div><h3>Objective</h3><p>This study compared DOI and Breslow thickness for predicting acral melanoma outcomes.</p></div><div><h3>Methods</h3><p>We performed a retrospective cross-sectional study of 71 acral melanoma lesions subjected to sentinel lymph node biopsy at one Brazilian referral center.</p></div><div><h3>Results</h3><p>Cox model univariate analysis showed that both DOI and Breslow thickness predicted melanoma specific survival (HR 1.12; <em>p</em> = 0.0255 and HR 1.144; <em>p</em> = 0.0006, respectively), although Kaplan Meier curve was only significant for Breslow (χ<sup>2</sup> = 5.792; <em>p</em> = 0.0161) and not for DOI (χ<sup>2</sup> = 0.2556; <em>p</em> = 0.6132). Sentinel lymph node status and presence or absence of ulceration also predicted specific survival in patients with acral melanoma (χ<sup>2</sup> = 6.3514; <em>p</em> = 0.0117 and χ<sup>2</sup> = 4.2793; <em>p</em> = 0.0386, respectively). Multivariate analysis, however, demonstrated that Breslow depth was the only independent parameter for predicting acral melanoma specific survival (HR 1.144; <em>p</em> = 0.0006).</p></div><div><h3>Conclusion</h3><p>Even though Breslow thickness remains the main predictor for survival in acral melanoma, it is not a perfect parameter. The introduction of DOI in this context opens new perspectives for predicting acral melanoma outcomes.</p></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"71 ","pages":"Article 152305"},"PeriodicalIF":2.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140619179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

P16 and HPV status in head and neck sarcomas and sarcomatoid carcinomas 头颈部肉瘤和肉瘤样癌中的 P16 和 HPV 状态

IF 2 4区医学

Annals of Diagnostic Pathology Pub Date : 2024-04-10 DOI: 10.1016/j.anndiagpath.2024.152307

Nuha Shaker , Parisa Mansoori , Yasmin H. Fattah , Monika Ellis , Tammy Sexton , Stacey O'Neill , Shadi A. Qasem

引用次数: 0

Does presence of complex translocations involving BCR::ABL1 in chronic myeloid leukemia affect the response rate to tyrosine kinase inhibitors? A systematic review of the literature 慢性髓性白血病患者存在涉及BCR::ABL1的复杂易位会影响对酪氨酸激酶抑制剂的反应率吗？文献系统回顾

IF 2 4区医学

Annals of Diagnostic Pathology Pub Date : 2024-04-09 DOI: 10.1016/j.anndiagpath.2024.152303

Diwakar Sharma , Christine Wilson , Sachin Kumar, Sampa Ghose, Ranjit Sahoo, Surender K. Sharawat

{"title":"Does presence of complex translocations involving BCR::ABL1 in chronic myeloid leukemia affect the response rate to tyrosine kinase inhibitors? A systematic review of the literature","authors":"Diwakar Sharma , Christine Wilson , Sachin Kumar, Sampa Ghose, Ranjit Sahoo, Surender K. Sharawat","doi":"10.1016/j.anndiagpath.2024.152303","DOIUrl":"https://doi.org/10.1016/j.anndiagpath.2024.152303","url":null,"abstract":"<div><p>Philadelphia (Ph) chromosome (9;22)(q34;q11) comprises 90–95 % of chronic myeloid leukemia (CML), while 5–10 % of CML have translocations involving three or more chromosomes. The outcome of treating patients harbouring complex Ph-positive cytogenetics with tyrosine kinase inhibitors (TKI) is unclear. In the present systematic review, we aim to summarise the response of patients with complex Ph-positive cytogenetics to treatment with TKI therapy. We collated all available literature from databases such as PubMed, Google Scholar, Web of Science database, Cochrane library, Scopus and Embase (up until January 31st, 2024), which describe cases of patients with CML, harbouring complex Ph-positive variations (three and four-way translocations), and summarised their response to TKI therapy. The studies were screened for the following criteria: documented TKI intervention and outcome (whether CR was achieved). Studies that did not report the same, were excluded. Additionally, we report a case from our center of a 55-year-old patient with CML, positive for the Ph-chromosome, harbouring a three-way translocation involving chromosome 15 i.e. 46XX, t(9;15;22) (q34;p11;q11). Identification of BCR::ABL and involvement of chromosome 15 was carried out using conventional cytogenetics, fluorescence in situ hybridization (FISH), and quantitative PCR (qPCR). Based on the inclusion criteria, a total of 15 studies were included from which a total of 87 cases were covered. Overall, we identified 38 unique complex three- and four-way translocations across 87 Ph-positive cases and found that 85 patients with complex Ph-positive cytogenetics achieved complete remission upon treatment and did not appear to have a lesser response to TKI therapy.</p></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"71 ","pages":"Article 152303"},"PeriodicalIF":2.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140558622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

INSM1 is a useful neuroendocrine marker to differentiate pancreatic serous cystadenoma from pancreatic well-differentiated neuroendocrine tumors in cytology and surgical specimens INSM1 是一种有用的神经内分泌标记物，可用于区分细胞学和手术标本中的胰腺浆液性囊腺瘤和胰腺分化良好的神经内分泌肿瘤

IF 2 4区医学

Annals of Diagnostic Pathology Pub Date : 2024-04-09 DOI: 10.1016/j.anndiagpath.2024.152304

Zhikai Chi, Jing Xu, Dipti M. Karamchandani, Lan Peng

{"title":"INSM1 is a useful neuroendocrine marker to differentiate pancreatic serous cystadenoma from pancreatic well-differentiated neuroendocrine tumors in cytology and surgical specimens","authors":"Zhikai Chi, Jing Xu, Dipti M. Karamchandani, Lan Peng","doi":"10.1016/j.anndiagpath.2024.152304","DOIUrl":"https://doi.org/10.1016/j.anndiagpath.2024.152304","url":null,"abstract":"<div><h3>Introduction</h3><p>Differentiating pancreatic serous cystadenoma (SCA) from well-differentiated neuroendocrine tumors (WDNETs) based on histomorphology is critical yet challenging, particularly in small biopsy samples. Our study aimed to examine the expression profile of INSM1 in cytologic and surgical resection specimens from pancreatic SCA to evaluate its potential as a discriminative marker against pancreatic WDNET.</p></div><div><h3>Methods</h3><p>We characterized INSM1 immunohistochemistry in 34 patients with pancreatic SCA, comprising 23 surgical resections and 11 cytology specimens. As a control, we used 28 cytology specimens from pancreatic WDNET. Clinical information was retrieved through a review of electronic medical records.</p></div><div><h3>Results</h3><p>All 11 pancreatic SCA cytology specimens and 15 of 23 pancreatic SCA surgical resections exhibited absent INSM1 immunostaining. Each of the remaining eight surgical resection specimens demonstrated 1 % immunoreactivity. In contrast, 27 out of 28 (96 %) pancreatic WDNET cytology specimens were positive for INSM1 immunostaining, with a median immunoreactivity of 90 % and a range of 30–90 %. Overall, INSM1 immunostains perform similarly to chromogranin and synaptophysin in pancreatic SCA.</p></div><div><h3>Conclusions</h3><p>The results indicate that INSM1 immunohistochemistry staining may serve as a useful neuroendocrine marker to differentiate pancreatic SCA from pancreatic WDNET in clinical practice. To our knowledge, this represents the first large-scale study to evaluate INSM1 immunostaining in surgical and cytology specimens from pancreatic SCA.</p></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"71 ","pages":"Article 152304"},"PeriodicalIF":2.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140550334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral cavity salivary gland pleomorphic adenoma: a histomorphological case series 口腔唾液腺多形性腺瘤：组织形态学病例系列

IF 2 4区医学

Annals of Diagnostic Pathology Pub Date : 2024-04-09 DOI: 10.1016/j.anndiagpath.2024.152306

Rahul Rajbhar, Sangita Margam, Gwendolyn Fernandes

{"title":"Oral cavity salivary gland pleomorphic adenoma: a histomorphological case series","authors":"Rahul Rajbhar, Sangita Margam, Gwendolyn Fernandes","doi":"10.1016/j.anndiagpath.2024.152306","DOIUrl":"https://doi.org/10.1016/j.anndiagpath.2024.152306","url":null,"abstract":"<div><h3>Background</h3><p>Pleomorphic adenoma (PA), the most common benign salivary gland epithelial lesion, has a biphasic epithelial-mesenchymal pattern and great histopathological diversity.</p></div><div><h3>Methods</h3><p>This study's objective was to conduct a retrospective clinicopathological analysis, focusing on the histopathology characteristics of salivary gland PA.</p></div><div><h3>Results</h3><p>There were ten cases of pleomorphic adenoma. The mean age was 33.5 years and no gender predilection was observed. All the patients presented with an asymptomatic mass and the duration of presentation was 31.2 ± 19.4 months. The cellular subtype (50 %) of PA was the most common. Capsular infiltration and incomplete capsules occurred in 20 % of cases. All the cases had round (100 %) and myxoid stroma.</p><p>The cellular subtype was more common in the major salivary glands; showed capsular abnormalities (incomplete capsule, absent capsule, and tumor infiltration); and had more plasmacytoid, angular, spindled non-luminal cells as well as inflammation and cystic degeneration. The classic subtype had more clear and oncocytic cells along with sebaceous and squamous differentiation. The stroma-rich subtype had the shortest duration of complaints (three months) and showed giant cell reaction.</p></div><div><h3>Conclusions</h3><p>These findings confirm previous studies on the clinicopathological features of pleomorphic adenomas and highlight important morphologic characteristics like capsular invasion and squamous metaplasia, which can otherwise indicate malignancy.</p></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"71 ","pages":"Article 152306"},"PeriodicalIF":2.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140546082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of tumor-infiltrating immune cells (mast cells, neutrophils and lymphocytes) on neoadjuvant chemotherapy response in breast carcinomas 肿瘤浸润免疫细胞（肥大细胞、中性粒细胞和淋巴细胞）对乳腺癌新辅助化疗反应的影响

IF 2 4区医学

Annals of Diagnostic Pathology Pub Date : 2024-04-02 DOI: 10.1016/j.anndiagpath.2024.152301

Oğuzhan Okcu , Çiğdem Öztürk , Nazlıcan Yalçın , Anıl Can Yalçın , Bayram Şen , Esra Aydın , Ahmet Emin Öztürk

{"title":"Effect of tumor-infiltrating immune cells (mast cells, neutrophils and lymphocytes) on neoadjuvant chemotherapy response in breast carcinomas","authors":"Oğuzhan Okcu , Çiğdem Öztürk , Nazlıcan Yalçın , Anıl Can Yalçın , Bayram Şen , Esra Aydın , Ahmet Emin Öztürk","doi":"10.1016/j.anndiagpath.2024.152301","DOIUrl":"https://doi.org/10.1016/j.anndiagpath.2024.152301","url":null,"abstract":"<div><h3>Introduction</h3><p>Despite screening, the incidence of breast cancer is increasing worldwide. Neoadjuvant chemotherapy (NAC) response is one of the most important parameters taken into consideration in surgery, optimal adjuvant chemotherapy planning and prognosis prediction. Research on predictive markers for the response to NAC is still ongoing. In our study, we investigated the relationship between tumor-infiltrating neutrophils/mast cells/lymphocytes and NAC response in breast carcinomas.</p></div><div><h3>Material and method</h3><p>Study included 117 patients who were diagnosed with invasive breast carcinoma using core needle biopsy. In these biopsies tumor-infiltrating neutrophils/mast cells/lymphocytes were evaluated and Miller Payne Score was used for NAC response.</p></div><div><h3>Result</h3><p>53 patients exhibited high TILs, 36 had high TINs, and 46 showed high TIMs. While pathological complete response was 27 % in all patients, it was 38 % in high TINs patients, 35 % in high TILs patients, and 28 % in high TIMs patients. High TIMs were observed to be statistically associated with survival.</p><p>TILs, TINs, nuclear grade, ER, PR and HER2 expression, Ki-67 proliferation index were found to be associated with the Miller - Payne score. In multivariate analysis, TINs, nuclear grade, pathological stage, and molecular subtype were found to be independent risk factors for treatment response.</p></div><div><h3>Conclusion</h3><p>TINs have better prognostic value to predict neoadjuvant treatment than TILs. High TIMs are associated with increased overall survival. The inclusion of TINs in NAC response and TIMs in overall survival in pathology reports and treatment planning is promising in breast carcinomas as they are simple to use and reproducible markers.</p></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"70 ","pages":"Article 152301"},"PeriodicalIF":2.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140351406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0