Annals of Diagnostic Pathology最新文献

筛选
英文 中文
Papillary renal neoplasm with reverse polarity: A distinct entity ready for the World Health Organization classification 具有反极性的肾乳头状肿瘤:一个为世界卫生组织分类准备好的独特实体
IF 1.5 4区 医学
Annals of Diagnostic Pathology Pub Date : 2025-07-19 DOI: 10.1016/j.anndiagpath.2025.152530
Sean R. Williamson , Khaleel I. Al-Obaidy
{"title":"Papillary renal neoplasm with reverse polarity: A distinct entity ready for the World Health Organization classification","authors":"Sean R. Williamson , Khaleel I. Al-Obaidy","doi":"10.1016/j.anndiagpath.2025.152530","DOIUrl":"10.1016/j.anndiagpath.2025.152530","url":null,"abstract":"","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"80 ","pages":"Article 152530"},"PeriodicalIF":1.5,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From the archives of MD Anderson Cancer Center: Small lymphocytic lymphoma/chronic lymphocytic leukemia diagnosed in Warthin tumor 来自MD安德森癌症中心的档案:Warthin肿瘤诊断为小淋巴细胞淋巴瘤/慢性淋巴细胞白血病
IF 1.5 4区 医学
Annals of Diagnostic Pathology Pub Date : 2025-07-19 DOI: 10.1016/j.anndiagpath.2025.152533
Jing Zhou, L. Jeffrey Medeiros
{"title":"From the archives of MD Anderson Cancer Center: Small lymphocytic lymphoma/chronic lymphocytic leukemia diagnosed in Warthin tumor","authors":"Jing Zhou,&nbsp;L. Jeffrey Medeiros","doi":"10.1016/j.anndiagpath.2025.152533","DOIUrl":"10.1016/j.anndiagpath.2025.152533","url":null,"abstract":"<div><div>Warthin tumor is uncommonly associated with lymphoma. We describe a case of a 73-year-old man with persistent left neck swelling in the submandibular region. Core needle biopsy with aspiration showed Warthin tumor and small lymphocytic lymphoma (SLL)/chronic lymphocytic leukemia (CLL). Histologic sections showed fragments of a Warthin tumor composed of oncocytic ductal epithelium in a background of a diffuse infiltration of small lymphocytes with small proliferation centers. The lymphocytes were predominantly CD5-positive monotypic B-cells by immunophenotypic analysis. This is the first report in the literature describing a concurrent Warthin tumor and SLL/CLL diagnosed by needle biopsy with aspiration. Based on our review of the literature and including the current case, 45 cases of lymphoma involving Warthin tumor have been reported previously. Forty-four of these lymphomas were lymph node-based neoplasms, with follicular lymphoma most common (<em>n</em> = 15; 34 %). Five (11 %) cases of SLL/CLL associated with Warthin tumor including the current case have been reported. Notably, extranodal marginal zone lymphoma is rarely associated with Warthin tumor, reported in a single case. These findings support the hypothesis that Warthin tumor arises from heterotopic salivary gland ducts within lymph nodes. We review the pathogenesis of this uncommon phenomenon and discuss the differential diagnosis.</div></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"79 ","pages":"Article 152533"},"PeriodicalIF":1.5,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous expression of CD5 and INSM1 may distinguish parotid CASTLE from other primary tumors with a squamous phenotype CD5和INSM1的同时表达可以将腮腺CASTLE与其他具有鳞状表型的原发性肿瘤区分开来
IF 1.5 4区 医学
Annals of Diagnostic Pathology Pub Date : 2025-07-14 DOI: 10.1016/j.anndiagpath.2025.152531
Dan Zhang , Chaoshan Wang , Haorui Zhang , Wenmin Yang , Ling Nie
{"title":"Simultaneous expression of CD5 and INSM1 may distinguish parotid CASTLE from other primary tumors with a squamous phenotype","authors":"Dan Zhang ,&nbsp;Chaoshan Wang ,&nbsp;Haorui Zhang ,&nbsp;Wenmin Yang ,&nbsp;Ling Nie","doi":"10.1016/j.anndiagpath.2025.152531","DOIUrl":"10.1016/j.anndiagpath.2025.152531","url":null,"abstract":"<div><div>Parotid carcinoma showing thymus-like element (CASTLE) is positive for the immunohistochemical markers CD5 and CD117. However, the specificity of the markers has not been evaluated in parotid tumors with a squamous phenotype. This study aims to validate the efficiency of CD5, CD117, and INSM1 in distinguishing CASTLE from other parotid tumors with a squamous phenotype, including squamous cell carcinoma (SCC, <em>n</em> = 4), lymphoepithelial carcinoma (LEC, <em>n</em> = 5), and pleomorphic adenoma with squamous differentiation (PA-SD, <em>n</em> = 3). The parotid CASTLE exhibited diffusely CD5 membranous positivity (Immunoreactive Score, IRS = 12) and moderate INSM1 nuclear expression (IRS = 6), while SCC, PA-SD, and LEC showed negligible CD5 (IRS ≤ 2) and weak/focal INSM1 (IRS ≤ 3) expression. Although CD117 was diffusely positive in CASTLE, it was moderately to strongly expressed in the LECs (IRS = 9), limiting its diagnostic utility in differential diagnosis. EBER <em>in situ</em> hybridization (ISH) confirmed EBV association in all LECs but not in the CASTLE. In summary, simultaneous CD5 and INSM1 expression may serve as a distinct feature for parotid CASTLE, facilitating differential diagnosis in salivary gland pathology. In addition, EBER ISH remains essential to exclude LEC.</div></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"79 ","pages":"Article 152531"},"PeriodicalIF":1.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Appendix-like morphology in primary ovarian mucinous tumors lacking a concurrent mature teratoma: A series of 4 cases illustrating the utility of STR analysis 未并发成熟畸胎瘤的原发性卵巢粘液瘤的阑尾样形态:一系列4例病例说明STR分析的实用性
IF 1.5 4区 医学
Annals of Diagnostic Pathology Pub Date : 2025-07-13 DOI: 10.1016/j.anndiagpath.2025.152532
Xiaoyan Yang , William M. Rehrauer , Paul S. Weisman , Jin Xu
{"title":"Appendix-like morphology in primary ovarian mucinous tumors lacking a concurrent mature teratoma: A series of 4 cases illustrating the utility of STR analysis","authors":"Xiaoyan Yang ,&nbsp;William M. Rehrauer ,&nbsp;Paul S. Weisman ,&nbsp;Jin Xu","doi":"10.1016/j.anndiagpath.2025.152532","DOIUrl":"10.1016/j.anndiagpath.2025.152532","url":null,"abstract":"<div><div>Recently in this journal, Ramalingam et al described the clinicopathological features of mucinous ovarian tumors arising in association with mature cystic teratomas (MT). Of particular interest to us are the appendix-like histological features including prominent subepithelial stromal clefts and pseudomyxoma ovarii described by Ramalingam et al and others.</div><div>In our own practice, we have encountered a handful of mucinous ovarian tumors with the above-noted histological features for which no MT and no appendiceal tumor could be found, leaving the tumors' origin in question.</div><div>Here we share our experience using short tandem repeat (STR) analysis in order to address this very scenario using 4 illustrative cases. Using STR analysis, we show that the above-noted histological features may indeed suggest a teratomatous origin even in the absence of a histologically apparent MT. We also show that these same histological features may be seen in bona fide primary ovarian mucinous tumors that have a purely somatic origin.</div></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"79 ","pages":"Article 152532"},"PeriodicalIF":1.5,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of tumor budding with prognostic factors and lymph node metastasis in penile cancer: A prospective cohort of 218 cases 218例阴茎癌肿瘤出芽与预后因素及淋巴结转移的关系
IF 1.5 4区 医学
Annals of Diagnostic Pathology Pub Date : 2025-07-12 DOI: 10.1016/j.anndiagpath.2025.152526
Camila Souto Aguiar , Marcos Adriano Garcia Campos , Antonio Augusto Lima Teixeira Júnior , Syomara Pereira da Costa Melo , Liseana de Oliveira Barbosa , Denner Rodrigo Diniz Duarte , Lucas Vieira de Lima , Pedro Manuel Barros de Sousa , Jaqueline Diniz Pinho , Joyce Santos Lages , Isabela Werneck da Cunha , Gyl Eanes Barros Silva
{"title":"Association of tumor budding with prognostic factors and lymph node metastasis in penile cancer: A prospective cohort of 218 cases","authors":"Camila Souto Aguiar ,&nbsp;Marcos Adriano Garcia Campos ,&nbsp;Antonio Augusto Lima Teixeira Júnior ,&nbsp;Syomara Pereira da Costa Melo ,&nbsp;Liseana de Oliveira Barbosa ,&nbsp;Denner Rodrigo Diniz Duarte ,&nbsp;Lucas Vieira de Lima ,&nbsp;Pedro Manuel Barros de Sousa ,&nbsp;Jaqueline Diniz Pinho ,&nbsp;Joyce Santos Lages ,&nbsp;Isabela Werneck da Cunha ,&nbsp;Gyl Eanes Barros Silva","doi":"10.1016/j.anndiagpath.2025.152526","DOIUrl":"10.1016/j.anndiagpath.2025.152526","url":null,"abstract":"<div><div>Histopathological evaluation of lymph nodes in penile cancer remains the gold standard for identifying lymph node metastases; however, it is an invasive procedure that can lead to postoperative complications. Several studies have reported that tumor budding is an independent prognostic factor for locoregional disease recurrence in many solid cancers. We evaluated the relationship between tumor budding categories and other histological parameters of aggressiveness in 218 patients diagnosed with penile squamous cell carcinoma. We performed a prospective cohort study with a 6-month follow-up period. Clinical data were extracted from the medical records and patient interviews, and pathologists evaluated histopathological data. Tumor budding was associated with histopathological characteristics and the appearance of nodal metastasis within 6 months of diagnosis. The chi-square test was applied at a significance level of 5 %. Our study demonstrated a statistically significant association between tumor budding scores of 2 and 3 and the following variables: high histological grade (G2 and G3), presence of angiolymphatic invasion, presence of perineural invasion, higher pathological stage (pT3 and pT4), and presence of nodal metastasis. This may indicate that moderate/high-grade tumor growth (scores of 2 and 3) is related to a more aggressive behavior of penile squamous cell carcinoma. Tumor budding shows promise as a prognostic tool in histopathological evaluations, particularly for predicting lymph node metastases. Its simplicity makes it an accessible method, especially in underdeveloped countries and regions with high incidence rates of this neoplasm.</div></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"79 ","pages":"Article 152526"},"PeriodicalIF":1.5,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myxoid adrenocortical adenoma with pseudoglandular pattern: A clinicopathological study of a rare histologic variant and its diagnostic challenges 具有假腺型的黏液样肾上腺皮质腺瘤:一种罕见的组织学变异及其诊断挑战的临床病理研究
IF 1.5 4区 医学
Annals of Diagnostic Pathology Pub Date : 2025-07-08 DOI: 10.1016/j.anndiagpath.2025.152527
Runlin Feng , Tao Zhang , Changxing Ke , Yanping Tao
{"title":"Myxoid adrenocortical adenoma with pseudoglandular pattern: A clinicopathological study of a rare histologic variant and its diagnostic challenges","authors":"Runlin Feng ,&nbsp;Tao Zhang ,&nbsp;Changxing Ke ,&nbsp;Yanping Tao","doi":"10.1016/j.anndiagpath.2025.152527","DOIUrl":"10.1016/j.anndiagpath.2025.152527","url":null,"abstract":"<div><h3>Objective</h3><div>Myxoid adrenocortical adenoma (MAA) with a pseudoglandular pattern is a rare variant of adrenal cortical tumors, characterized by a prominent myxoid matrix and diverse architectural patterns. Due to its overlapping features with malignant and metastatic myxoid tumors, it poses significant diagnostic challenges. This study aimed to delineate the clinicopathologic, immunohistochemical, and differential diagnostic features of MAA based on a case series.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed nine cases of MAA diagnosed between 2015 and 2023. Comprehensive clinicoradiologic, histopathologic, and immunophenotypic data were collected. Histologic evaluation included Weiss scoring, mitotic activity, and reticulin framework analysis. Immunohistochemistry was performed using a panel of markers including α-inhibin, Melan-A, Synaptophysin, CD56, CK, Vimentin, S100, and HMB45. Alcian blue and AB-PAS staining were applied to assess mucin content. All cases were followed for postoperative outcomes.</div></div><div><h3>Results</h3><div>The cohort included 5 females and 4 males, with a median age of 40 years (range 27–53). Tumor sizes ranged from 2.2 to 7.4 cm (mean 4.1 cm). Grossly, all tumors were well-demarcated, solid, and mucin-rich without evidence of necrosis or vascular invasion. Histologically, all cases exhibited abundant extracellular myxoid stroma (mean proportion: 78.3 %) and diverse pseudoglandular, cord-like, and sieve-like architectures. Tumor cells were polygonal with eosinophilic or hyaline cytoplasm and minimal atypia. No mitotic figures &gt;2/20 HPF were observed. Immunohistochemistry showed diffuse positivity for α-inhibin (100 %), Melan-A (88.9 %), CD56 (77.8 %), Synaptophysin (66.7 %), and Vimentin (100 %), while S100, HMB45, and Chromogranin A were consistently negative. Ki-67 index was &lt;3 % in all cases. Alcian blue was strongly positive in 77.8 % of tumors, supporting the myxoid component. During a median follow-up of 14 months, no recurrence or metastasis occurred.</div></div><div><h3>Conclusions</h3><div>MAA with a pseudoglandular pattern is a benign but diagnostically challenging adrenal neoplasm due to its histologic overlap with myxoid adrenal cortical carcinoma and metastatic mucinous tumors. Recognition of its characteristic morphology, immunoprofile, and benign clinical course is critical to prevent overtreatment. Incorporating Weiss criteria, reticulin staining, and a myxoid tumor differential panel enhances diagnostic accuracy in clinical practice.</div></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"79 ","pages":"Article 152527"},"PeriodicalIF":1.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of clinicopathological and immunohistochemical features of pheochromocytoma/paraganglioma 嗜铬细胞瘤/副神经节瘤的临床病理及免疫组织化学特征分析
IF 1.5 4区 医学
Annals of Diagnostic Pathology Pub Date : 2025-07-08 DOI: 10.1016/j.anndiagpath.2025.152525
Ling-Ling Wang , Xue-Jing Wei , Qiao-Chu Zhang , Feng Li , Guang-Yong Chen
{"title":"Analysis of clinicopathological and immunohistochemical features of pheochromocytoma/paraganglioma","authors":"Ling-Ling Wang ,&nbsp;Xue-Jing Wei ,&nbsp;Qiao-Chu Zhang ,&nbsp;Feng Li ,&nbsp;Guang-Yong Chen","doi":"10.1016/j.anndiagpath.2025.152525","DOIUrl":"10.1016/j.anndiagpath.2025.152525","url":null,"abstract":"<div><div>This study aimed to analyze the expression of three immune markers, succinate dehydrogenase (SDHB), S-100, and alpha thalassemia retardation syndrome X-linked (ATRX), in pheochromocytoma and paraganglioma (PPGL) tumor tissues and to evaluate their correlation with histopathological parameters to predict the recurrence risk in PPGLs. A retrospective analysis was conducted using a cohort of 173 patients with PPGLs with definite pathological diagnoses and complete follow-up data. The expression of SDHB, S-100, and ATRX in the tumor tissues was detected using the EnVision immunohistochemical method. Histological grading of PPGLs was performed using the Compound Adrenal Pheochromocytoma and Paraganglioma Grading System (COPPS), and the correlation between the expression of the three immune markers and metastasis or recurrence of PPGLs was analyzed. Among 173 patients with PPGLs, 57 (32.9 %) had metastasis or recurrence. Of these 57 patients, 57.9 % (33/57) had tumors in the retroperitoneum. In 83 % (53/57) of the cases, the maximum diameter of the tumors was ≥5 cm. Vascular invasion was observed in 46 patients (80.7 %). SDHB, ATRX, and S-100 were negatively stained in 33 (57.9 %), 40(70.2 %), and 43(75.4 %) PPGL patients with metastasis or recurrence, respectively, which was significantly higher than that in those without metastasis or recurrence. These differences were statistically significant (<em>P</em> &lt; 0.001). Multivariate analysis showed that tumor diameter ≥ 5 cm, negative ATRX and SDHB expressions, and vascular invasion were independent risk factors for tumor metastasis and recurrence. SDHB, ATRX and S-100 can be used as immunohistochemical indicators to predict the metastatic risk of PPGLs.</div></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"79 ","pages":"Article 152525"},"PeriodicalIF":1.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic tumors to the pancreas: An institutional experience 转移到胰腺的肿瘤:一个机构的经验
IF 1.5 4区 医学
Annals of Diagnostic Pathology Pub Date : 2025-07-08 DOI: 10.1016/j.anndiagpath.2025.152528
Matthew Romanish, Rana Naous
{"title":"Metastatic tumors to the pancreas: An institutional experience","authors":"Matthew Romanish,&nbsp;Rana Naous","doi":"10.1016/j.anndiagpath.2025.152528","DOIUrl":"10.1016/j.anndiagpath.2025.152528","url":null,"abstract":"<div><div>Metastatic malignancies to pancreas are extremely rare with most common origins being kidney and melanoma. This study aims to evaluate types of solid malignant metastasis in pancreatic FNAs at our institution along with comprehensive review of reported literature. Our laboratory information system was queried over years 2000–2024 to identify all pancreatic FNAs with metastasis. “Positive for Malignant Cells” diagnosis was included in our review. “Atypical” or “Suspicious for malignancy” were excluded. Type of metastatic malignancy, location and presence of synchronous metastasis were documented. Our results show that out of 4051 pancreatic FNAs with “Positive for Malignant Cells”, 83 (2 %) cases were metastatic, while remaining 127 cases represented primary pancreatic adenocarcinomas or neuroendocrine tumors. 43 (52 %) renal cell carcinomas, 15 lung carcinomas (17.6 %), 7 skin melanoma (8.2 %),4 breast ductal adenocarcinoma (4.7 %), 3 urothelial carcinomas (3.5 %), 2 leiomyosarcoma (2.4 %), 2 ovarian serous carcinoma (2.4 %),1 uterine adenocarcinoma (1.2 %),1 prostatic carcinoma (1.2 %), 1 skin Merkel-cell carcinoma (1.2 %),1 gastric adenocarcinoma (1.2 %),1 colorectal adenocarcinoma (1.2 %), and 1 vulvar Squamous-cell carcinoma (1.2 %) were identified. Majority (~59 %) of tumors had synchronous presentation. Most common synchronous organs were lungs, liver, and mesenteric lymph nodes. In conclusion, our study demonstrated further support for lung being the second most common primary site of pancreatic metastasis. Renal origin is the most common secondary tumor in our institutional review, followed by combination of lung, breast, and melanoma. Sarcomas can rarely present as pancreatic metastasis, and thorough clinical and histomorphology correlation is warranted. Origin-specific immunostains and molecular testing may help in challenging secondary pancreatic tumors.</div></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"79 ","pages":"Article 152528"},"PeriodicalIF":1.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sebaceous gland ectopia of the esophagus: A clinical, endoscopic, and pathologic study of a rare condition with literature review 食道皮脂腺异位:一种罕见疾病的临床、内窥镜及病理研究,并附文献回顾
IF 1.5 4区 医学
Annals of Diagnostic Pathology Pub Date : 2025-07-08 DOI: 10.1016/j.anndiagpath.2025.152529
Pierre Tran , Khalid Shittu , Ehsan Aliniagerdroudbari , Sumit Singla , Momal Tara Chand , Beena U. Ahsan
{"title":"Sebaceous gland ectopia of the esophagus: A clinical, endoscopic, and pathologic study of a rare condition with literature review","authors":"Pierre Tran ,&nbsp;Khalid Shittu ,&nbsp;Ehsan Aliniagerdroudbari ,&nbsp;Sumit Singla ,&nbsp;Momal Tara Chand ,&nbsp;Beena U. Ahsan","doi":"10.1016/j.anndiagpath.2025.152529","DOIUrl":"10.1016/j.anndiagpath.2025.152529","url":null,"abstract":"<div><div>Sebaceous gland ectopia (SGE) is a disorder in which sebaceous gland lobules appear in atypical anatomical locations. Sebaceous glands are normally found in the skin, particularly abundant on the face, scalp and other areas with hair follicles. SGE in the esophagus is an extremely rare, benign condition that morphologically may mimic epidermoid metaplasia due to the presence of excretory duct, lined by keratinized squamous epithelium. We present a retrospective case series of patients with evidence of SGE per endoscopic biopsy tissue analysis between 2000 and 2025. A total of 12 biopsy analyses from 10 patients were included: 7 women (70 %) and 3 men (30 %). The mean age at diagnosis was 63 years. There were 7 patients who reported previous or current alcohol use (70 %); one patient reported previous tobacco use (10 %). Gastrointestinal reflux disease, the most common clinical indication, was seen in six patients (60 %). The lesions, when visible on endoscopy, were located in the proximal and/or mid esophagus (100 %); three endoscopies noted no lesions (25 %). Two repeat biopsies in one patient showed persistent SGE. No biopsies showed dysplasia (0 %). Additionally, we performed a literature review of articles in the PubMed database, identifying 65 other reported patients. The clinicopathologic findings in this study add additional evidence on this rare entity.</div></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"79 ","pages":"Article 152529"},"PeriodicalIF":1.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MTAP and p16 as immunohistochemical surrogates of CDKN2A/B homozygous deletion in central nervous system tumors: A multicentre Italian experience MTAP和p16在中枢神经系统肿瘤中作为CDKN2A/B纯合缺失的免疫组化替代物:一项多中心的意大利经验
IF 1.5 4区 医学
Annals of Diagnostic Pathology Pub Date : 2025-07-07 DOI: 10.1016/j.anndiagpath.2025.152524
Serena Salzano , Rosario Caltabiano , Gaetano Magro , Antonio D'Amati , Cristina Pizzimenti , Andrea Maugeri , Antonella Agodi , Giuseppe Barbagallo , Francesco Certo , Francesco Fiorentino , Giovanni Tuccari , Maurizio Martini , Antonio Ieni , Valeria Barresi , Giuseppe Broggi
{"title":"MTAP and p16 as immunohistochemical surrogates of CDKN2A/B homozygous deletion in central nervous system tumors: A multicentre Italian experience","authors":"Serena Salzano ,&nbsp;Rosario Caltabiano ,&nbsp;Gaetano Magro ,&nbsp;Antonio D'Amati ,&nbsp;Cristina Pizzimenti ,&nbsp;Andrea Maugeri ,&nbsp;Antonella Agodi ,&nbsp;Giuseppe Barbagallo ,&nbsp;Francesco Certo ,&nbsp;Francesco Fiorentino ,&nbsp;Giovanni Tuccari ,&nbsp;Maurizio Martini ,&nbsp;Antonio Ieni ,&nbsp;Valeria Barresi ,&nbsp;Giuseppe Broggi","doi":"10.1016/j.anndiagpath.2025.152524","DOIUrl":"10.1016/j.anndiagpath.2025.152524","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the diagnostic performance of MTAP and p16 immunohistochemistry (IHC) as surrogate markers for CDKN2A/B homozygous deletion (HD) in central nervous system (CNS) tumors, and to assess their prognostic significance.</div></div><div><h3>Methods</h3><div>Molecular tests including gene sequencing or fluorescence in situ hybridization (FISH) have traditionally been used to assess CDKN2A/B HD. However, due to lower costs and wider availability, IHC surrogates such as MTAP and p16 are gaining interest. We investigated the concordance between MTAP and p16 IHC expression and CDKN2A/B status as determined by FISH.</div></div><div><h3>Results</h3><div>Our cohort consisted of 227 patients with various CNS tumor types: glioblastoma IDH-wild type (n = 64; 28.2 %), meningioma (n = 61; 26.9 %), IDH-mutant astrocytoma (n = 52; 22.9 %), IDH-mutant and 1p/19q-codeleted oligodendroglioma (n = 35; 15.4 %), and pleomorphic xanthoastrocytoma (n = 15; 6.6 %). In all tumor types, most cases with CDKN2A/B HD showed MTAP loss and p16 negativity (<em>p</em>-values &lt; 0.05). The combination of MTAP and p16 IHC yielded a sensitivity of 92 %, specificity of 80 %, positive predictive value of 86 %, and negative predictive value of 88 % in detecting CDKN2A/B HD. Survival analysis demonstrated significantly reduced disease-free and overall survival among patients with MTAP loss, p16 negativity, and CDKN2A/B HD.</div></div><div><h3>Conclusions</h3><div>MTAP immunohistochemistry, alone or combined with p16, represents a cost-effective and feasible surrogate for detecting CDKN2A/B homozygous deletion in CNS tumors and provides relevant prognostic information.</div></div>","PeriodicalId":50768,"journal":{"name":"Annals of Diagnostic Pathology","volume":"79 ","pages":"Article 152524"},"PeriodicalIF":1.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信