GPNMB表达可将室管膜下巨细胞星形细胞瘤与其他类似物区分开来。

IF 1.5 4区医学 Q3 PATHOLOGY

Annals of Diagnostic Pathology Pub Date : 2025-01-17 DOI:10.1016/j.anndiagpath.2025.152442

Rui Pan, Xiaotong Wang, Ru Fang, Qiuyuan Xia, Xuan Wang, Rusong Zhang, Xue Wei, Nan Wu, Qiu Rao

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引用次数: 0

摘要

室管膜下巨细胞星形细胞瘤（SEGAs）是一种生长缓慢的肿瘤，与结节性硬化症（TSC）密切相关。最近的研究表明，TFE3/ tfeb靶向的生物标志物糖蛋白非转移性B （GPNMB）是上调的intsc1 /2相关肿瘤。在本研究中，我们对SEGA进行了分子分析，并通过免疫组化分析了GPNMB在6例SEGA、10例PXAs、9例GBMs、8例egbm、8例弥漫性星形细胞瘤、8例少突胶质细胞瘤和7例胶质神经元肿瘤中的表达，100%（6/6）的SEGA病例显示GPNMB阳性表达，而在其他所有中枢神经系统肿瘤中均为阴性表达。结果表明GPNMB在所有SEGAs中特异性表达，将其与其他形态相似的肿瘤区分开来。研究结果证实了GPNMB在SEGA中的特异性表达，强调了其作为诊断性生物标志物的前景。

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GPNMB expression differentiates subependymal giant cell astrocytoma from other mimickers.

Subependymal giant cell astrocytomas (SEGAs) are neoplasms that exhibit slow growth patterns and are closely associated with tuberous sclerosis complex (TSC). Recent research indicates that TFE3/TFEB-targeted biomarker glycoprotein nonmetastatic B (GPNMB) is upregulated inTSC1/2-related tumours. In this study, we performed molecular analysis on SEGAs and analyzed GPNMB expression in 6 SEGAs, 10 PXAs, 9 GBMs, 8 eGBMs, 8 diffuse astrocytomas, 8 oligodendrogliomas and 7 glioneuronal tumours through immunohistochemistry, 100 % (6/6) of the SEGA cases exhibited positive GPNMB expression, whereas it was negative in all other CNS tumours. The results indicated that GPNMB is specifically expressed in all SEGAs, distinguishing it from other morphologically similar tumours. The findings demonstrate specific GPNMB expression in SEGA, underscoring its promise as a diagnostic biomarker.

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来源期刊

Annals of Diagnostic Pathology 医学-病理学

CiteScore

3.90

自引率

5.00%

发文量

149

审稿时长

26 days

期刊介绍： A peer-reviewed journal devoted to the publication of articles dealing with traditional morphologic studies using standard diagnostic techniques and stressing clinicopathological correlations and scientific observation of relevance to the daily practice of pathology. Special features include pathologic-radiologic correlations and pathologic-cytologic correlations.