Annual Review of Biophysics最新文献_第4页

Mechanisms of Protein Quality Control in the Endoplasmic Reticulum by a Coordinated Hsp40-Hsp70-Hsp90 System. Hsp40-Hsp70-Hsp90协同系统在内质网中蛋白质质量控制的机制

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 DOI: 10.1146/annurev-biophys-111622-091309

Judy L M Kotler, Timothy O Street

引用次数: 1

Emerging Time-Resolved X-Ray Diffraction Approaches for Protein Dynamics. 蛋白质动力学的新兴时间分辨X射线衍射方法。

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 DOI: 10.1146/annurev-biophys-111622-091155

Doeke R Hekstra

{"title":"Emerging Time-Resolved X-Ray Diffraction Approaches for Protein Dynamics.","authors":"Doeke R Hekstra","doi":"10.1146/annurev-biophys-111622-091155","DOIUrl":"10.1146/annurev-biophys-111622-091155","url":null,"abstract":"Proteins guide the flows of information, energy, and matter that make life possible by accelerating transport and chemical reactions, by allosterically modulating these reactions, and by forming dynamic supramolecular assemblies. In these roles, conformational change underlies functional transitions. Time-resolved X-ray diffraction methods characterize these transitions either by directly triggering sequences of functionally important motions or, more broadly, by capturing the motions of which proteins are capable. To date, most successful have been experiments in which conformational change is triggered in light-dependent proteins. In this review, I emphasize emerging techniques that probe the dynamic basis of function in proteins lacking natively light-dependent transitions and speculate about extensions and further possibilities. In addition, I review how the weaker and more distributed signals in these data push the limits of the capabilities of analytical methods. Taken together, these new methods are beginning to establish a powerful paradigm for the study of the physics of protein function.","PeriodicalId":50756,"journal":{"name":"Annual Review of Biophysics","volume":null,"pages":null},"PeriodicalIF":12.4,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9642991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Simulation of Complex Biomolecular Systems: The Ribosome Challenge. 复杂生物分子系统的模拟:核糖体挑战。

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 DOI: 10.1146/annurev-biophys-111622-091147

Lars V Bock, Sara Gabrielli, Michal H Kolář, Helmut Grubmüller

引用次数: 2

HX and Me: Understanding Allostery, Folding, and Protein Machines. HX和我:理解变构、折叠和蛋白质机器。

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 DOI: 10.1146/annurev-biophys-062122-093517

S Walter Englander

引用次数: 1

Protein Diffusion Along Protein and DNA Lattices: Role of Electrostatics and Disordered Regions. 蛋白质沿蛋白质和DNA晶格扩散:静电和无序区域的作用。

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 DOI: 10.1146/annurev-biophys-111622-091220

Lavi S Bigman, Yaakov Levy

{"title":"Protein Diffusion Along Protein and DNA Lattices: Role of Electrostatics and Disordered Regions.","authors":"Lavi S Bigman, Yaakov Levy","doi":"10.1146/annurev-biophys-111622-091220","DOIUrl":"https://doi.org/10.1146/annurev-biophys-111622-091220","url":null,"abstract":"Diffusion is a pervasive process present in a broad spectrum of cellular reactions. Its mathematical description has existed for nearly two centuries and permits the construction of simple rules for evaluating the characteristic timescales of diffusive processes and some of their determinants. Although the term diffusion originally referred to random motions in three-dimensional (3D) media, several biological diffusion processes in lower dimensions have been reported. One-dimensional (1D) diffusions have been reported, for example, for translocations of various proteins along DNA or protein (e.g., microtubule) lattices and translation of helical peptides along the coiled-coil interface. Two-dimensional (2D) diffusion has been shown for dynamics of proteins along membranes. The microscopic mechanisms of these 1-3D diffusions may vary significantly depending on the nature of the diffusing molecules, the substrate, and the interactions between them. In this review, we highlight some key examples of 1-3D biomolecular diffusion processes and illustrate the roles that electrostatic interactions and intrinsic disorder may play in modulating these processes.","PeriodicalId":50756,"journal":{"name":"Annual Review of Biophysics","volume":null,"pages":null},"PeriodicalIF":12.4,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9499388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Prospects and Limitations of High-Resolution Single-Particle Cryo-Electron Microscopy. 高分辨率单粒子冷冻电子显微镜的前景与局限性。

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 DOI: 10.1146/annurev-biophys-111622-091300

Ashwin Chari, Holger Stark

引用次数: 2

Decoding and Recoding of mRNA Sequences by the Ribosome. 核糖体对mRNA序列的解码和再编码。

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 DOI: 10.1146/annurev-biophys-101922-072452

Marina V Rodnina

引用次数: 6

On the Rational Design of Cooperative Receptors. 论合作受体的合理设计。

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 DOI: 10.1146/annurev-biophys-091222-082247

Gabriel Ortega, Alejandro Chamorro-Garcia, Francesco Ricci, Kevin W Plaxco

引用次数: 4

Free Energy Methods for the Description of Molecular Processes. 描述分子过程的自由能方法。

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 DOI: 10.1146/annurev-biophys-062722-093258

Christophe Chipot

{"title":"Free Energy Methods for the Description of Molecular Processes.","authors":"Christophe Chipot","doi":"10.1146/annurev-biophys-062722-093258","DOIUrl":"https://doi.org/10.1146/annurev-biophys-062722-093258","url":null,"abstract":"Efforts to combine theory and experiment to advance our knowledge of molecular processes relevant to biophysics have been considerably enhanced by the contribution of statistical-mechanics simulations. Key to the understanding of such molecular processes is the underlying free-energy change. Being able to accurately predict this change from first principles represents an appealing prospect. Over the past decades, the synergy between steadily growing computational resources and unrelenting methodological developments has brought free-energy calculations into the arsenal of tools commonly utilized to tackle important questions that experiment alone has left unresolved. The continued emergence of new options to determine free energies has also bred confusion amid the community of users, who may find it difficult to choose the best-suited algorithm to address the problem at hand. In an attempt to clarify the current landscape, this review recounts how the field has been shaped and how the broad gamut of methods available today is rooted in a few foundational principles laid down many years ago.Three examples of molecular processes central to biophysics illustrate where free-energy calculations stand and what are the conceptual and practical obstacles that we must overcome to increase their predictive power.","PeriodicalId":50756,"journal":{"name":"Annual Review of Biophysics","volume":null,"pages":null},"PeriodicalIF":12.4,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9444040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Graphene and Two-Dimensional Materials for Biomolecule Sensing. 用于生物分子传感的石墨烯和二维材料。

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 DOI: 10.1146/annurev-biophys-111622-091121

Deependra Kumar Ban, Prabhakar R Bandaru

引用次数: 2