Biophysical Modeling of Synaptic Plasticity

IF 10.4 1区生物学 Q1 BIOPHYSICS

Annual Review of Biophysics Pub Date : 2024-02-21 DOI:10.1146/annurev-biophys-072123-124954

Christopher T. Lee, Miriam Bell, Mayte Bonilla-Quintana, Padmini Rangamani

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引用次数: 0

Abstract

Dendritic spines are small, bulbous compartments that function as postsynaptic sites and undergo intense biochemical and biophysical activity. The role of the myriad signaling pathways that are implicated in synaptic plasticity is well studied. A recent abundance of quantitative experimental data has made the events associated with synaptic plasticity amenable to quantitative biophysical modeling. Spines are also fascinating biophysical computational units because spine geometry, signal transduction, and mechanics work in a complex feedback loop to tune synaptic plasticity. In this sense, ideas from modeling cell motility can inspire us to develop multiscale approaches for predictive modeling of synaptic plasticity. In this article, we review the key steps in postsynaptic plasticity with a specific focus on the impact of spine geometry on signaling, cytoskeleton rearrangement, and membrane mechanics. We summarize the main experimental observations and highlight how theory and computation can aid our understanding of these complex processes.Expected final online publication date for the Annual Review of Biophysics, Volume 53 is May 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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突触可塑性的生物物理建模

树突棘是一个小的球状区室，具有突触后部位的功能，并经历着激烈的生物化学和生物物理活动。人们对突触可塑性所涉及的无数信号通路的作用进行了深入研究。最近大量的定量实验数据使得与突触可塑性相关的事件可以进行定量生物物理建模。脊柱也是引人入胜的生物物理计算单元，因为脊柱的几何形状、信号转导和力学在一个复杂的反馈回路中共同作用，以调整突触可塑性。从这个意义上说，细胞运动建模的思路可以启发我们开发多尺度方法来预测突触可塑性建模。在这篇文章中，我们回顾了突触后可塑性的关键步骤，特别关注脊柱几何形状对信号传导、细胞骨架重排和膜力学的影响。我们总结了主要的实验观察结果，并强调了理论和计算如何帮助我们理解这些复杂的过程。《生物物理学年刊》（Annual Review of Biophysics）第 53 卷的最终在线出版日期预计为 2024 年 5 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。

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来源期刊

Annual Review of Biophysics 生物-生物物理

CiteScore

21.00

自引率

0.00%

发文量

期刊介绍： The Annual Review of Biophysics, in publication since 1972, covers significant developments in the field of biophysics, including macromolecular structure, function and dynamics, theoretical and computational biophysics, molecular biophysics of the cell, physical systems biology, membrane biophysics, biotechnology, nanotechnology, and emerging techniques.