Annual Review of Biophysics最新文献_第3页

Single-Cell Mechanics: Structural Determinants and Functional Relevance 单细胞力学：结构决定因素和功能相关性

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2024-02-21 DOI: 10.1146/annurev-biophys-030822-030629

Marta Urbanska, Jochen Guck

引用次数: 0

Cholesterol and Lipid Rafts in the Biogenesis of Amyloid-β Protein and Alzheimer's Disease 胆固醇和脂质筏在淀粉样蛋白-β和阿尔茨海默病的生物生成过程中的作用

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2024-02-21 DOI: 10.1146/annurev-biophys-062823-023436

George A. Pantelopulos, Conor B. Abraham, John E. Straub

{"title":"Cholesterol and Lipid Rafts in the Biogenesis of Amyloid-β Protein and Alzheimer's Disease","authors":"George A. Pantelopulos, Conor B. Abraham, John E. Straub","doi":"10.1146/annurev-biophys-062823-023436","DOIUrl":"https://doi.org/10.1146/annurev-biophys-062823-023436","url":null,"abstract":"Cholesterol has been conjectured to be a modulator of the amyloid cascade, the mechanism that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease. We propose that cholesterol impacts the genesis of Aβ not through direct interaction with proteins in the bilayer, but indirectly by inducing the liquid-ordered phase and accompanying liquid–liquid phase separations, which partition proteins in the amyloid cascade to different lipid domains and ultimately to different endocytotic pathways. We explore the full process of Aβ genesis in the context of liquid-ordered phases induced by cholesterol, including protein partitioning into lipid domains, mechanisms of endocytosis experienced by lipid domains and secretases, and pH-controlled activation of amyloid precursor protein secretases in specific endocytotic environments. Outstanding questions on the essential role of cholesterol in the amyloid cascade are identified for future studies.Expected final online publication date for the Annual Review of Biophysics, Volume 53 is May 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":50756,"journal":{"name":"Annual Review of Biophysics","volume":"32 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139923379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomics and Microbial Metabolism: Toward a Systematic Understanding 代谢组学与微生物代谢：实现系统性理解

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-12-18 DOI: 10.1146/annurev-biophys-030722-021957

Duncan Holbrook-Smith, Julian Trouillon, Uwe Sauer

{"title":"Metabolomics and Microbial Metabolism: Toward a Systematic Understanding","authors":"Duncan Holbrook-Smith, Julian Trouillon, Uwe Sauer","doi":"10.1146/annurev-biophys-030722-021957","DOIUrl":"https://doi.org/10.1146/annurev-biophys-030722-021957","url":null,"abstract":"Over the past decades, our understanding of microbial metabolism has increased dramatically. Metabolomics, a family of techniques that are used to measure the quantities of small molecules in biological samples, has been central to these efforts. Advances in analytical chemistry have made it possible to measure the relative and absolute concentrations of more and more compounds with increasing levels of certainty. In this review, we highlight how metabolomics has contributed to understanding microbial metabolism and in what ways it can still be deployed to expand our systematic understanding of metabolism. To that end, we explain how metabolomics was used to ( a) characterize network topologies of metabolism and its regulation networks, ( b) elucidate the control of metabolic function, and ( c) understand the molecular basis of higher-order phenomena. We also discuss areas of inquiry where technological advances should continue to increase the impact of metabolomics, as well as areas where our understanding is bottlenecked by other factors such as the availability of statistical and modeling frameworks that can extract biological meaning from metabolomics data.Expected final online publication date for the Annual Review of Biophysics, Volume 53 is May 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":50756,"journal":{"name":"Annual Review of Biophysics","volume":"306 2 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138744442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Speed Atomic Force Microscopy for Filming Protein Molecules in Dynamic Action 高速原子力显微镜拍摄蛋白质分子的动态动作

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-12-07 DOI: 10.1146/annurev-biophys-030722-113353

Toshio Ando, Shingo Fukuda, Kien X. Ngo, Holger Flechsig

引用次数: 0

Structure and Mechanism of Human ABC Transporters. 人类ABC转运蛋白的结构和机制。

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 Epub Date: 2023-02-03 DOI: 10.1146/annurev-biophys-111622-091232

Amer Alam, Kaspar P Locher

{"title":"Structure and Mechanism of Human ABC Transporters.","authors":"Amer Alam, Kaspar P Locher","doi":"10.1146/annurev-biophys-111622-091232","DOIUrl":"10.1146/annurev-biophys-111622-091232","url":null,"abstract":"<p><p>ABC transporters are essential for cellular physiology. Humans have 48 ABC genes organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for membrane transporters, of which several are involved in drug resistance and disease pathways resulting from transporter dysfunction. Over the last decade, advances in structural biology have vastly expanded our mechanistic understanding of human ABC transporter function, revealing details of their molecular arrangement, regulation, and interactions, facilitated in large part by advances in cryo-EM that have rendered hitherto inaccessible targets amenable to high-resolution structural analysis. As a result, experimentally determined structures of multiple members of each of the five families of ABC transporters in humans are now available. Here we review this recent progress, highlighting the physiological relevance of human ABC transporters and mechanistic insights gleaned from their direct structure determination. We also discuss the impact and limitations of model systems and structure prediction methods in understanding human ABC transporters and discuss current challenges and future research directions.</p>","PeriodicalId":50756,"journal":{"name":"Annual Review of Biophysics","volume":"52 ","pages":"275-300"},"PeriodicalIF":12.4,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9437904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Hybrid Quantum Mechanical/Molecular Mechanical Methods For Studying Energy Transduction in Biomolecular Machines. 研究生物分子机械中能量转换的量子力学/分子机械混合方法。

IF 10.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 Epub Date: 2023-02-15 DOI: 10.1146/annurev-biophys-111622-091140

T Kubař, M Elstner, Q Cui

引用次数: 0

Assembly and Architecture of NLR Resistosomes and Inflammasomes. NLR抵抗体和炎性小体的组装和结构。

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 DOI: 10.1146/annurev-biophys-092922-073050

Zehan Hu, Jijie Chai

引用次数: 4

Ball-and-Chain Inactivation in Potassium Channels. 钾离子通道的球链失活。

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 DOI: 10.1146/annurev-biophys-100322-072921

Nattakan Sukomon, Chen Fan, Crina M Nimigean

{"title":"Ball-and-Chain Inactivation in Potassium Channels.","authors":"Nattakan Sukomon, Chen Fan, Crina M Nimigean","doi":"10.1146/annurev-biophys-100322-072921","DOIUrl":"https://doi.org/10.1146/annurev-biophys-100322-072921","url":null,"abstract":"Carefully orchestrated opening and closing of ion channels controls the diffusion of ions across cell membranes, generating the electrical signals required for fast transmission of information throughout the nervous system. Inactivation is a parsimonious means for channels to restrict ion conduction without the need to remove the activating stimulus. Voltage-gated channel inactivation plays crucial physiological roles, such as controlling action potential duration and firing frequency in neurons. The ball-and-chain moniker applies to a type of inactivation proposed first for sodium channels and later shown to be a universal mechanism. Still, structural evidence for this mechanism remained elusive until recently. We review the ball-and-chain inactivation research starting from its introduction as a crucial component of sodium conductance during electrical signaling in the classical Hodgkin and Huxley studies, through the discovery of its simple intuitive mechanism in potassium channels during the molecular cloning era, to the eventual elucidation of a potassium channel structure in a ball-and-chain inactivated state. Expected final online publication date for the Annual Review of Biophysics, Volume 52 is May 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":50756,"journal":{"name":"Annual Review of Biophysics","volume":"52 ","pages":"91-111"},"PeriodicalIF":12.4,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9814900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Expanded Central Dogma: Genome Resynthesis, Orthogonal Biosystems, Synthetic Genetics. 扩展的中心法则:基因组再合成，正交生物系统，合成遗传学。

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 DOI: 10.1146/annurev-biophys-111622-091203

Karola Gerecht, Niklas Freund, Wei Liu, Yang Liu, Maximilian J L J Fürst, Philipp Holliger

引用次数: 1

Next-Gen Biophysics: Look to the Forest, Beyond the Trees. 新一代生物物理学：透过树木看森林。

IF 12.4 1区生物学

Annual Review of Biophysics Pub Date : 2023-05-09 DOI: 10.1146/annurev-bb-52-030923-100001

Jeremy Schmit, Ken A Dill

引用次数: 0