Biosystems最新文献_第10页

2022 IEEE conference on computational intelligence in bioinformatics and computational biology (IEEE CIBCB, 2022) 2022 年电气和电子工程师学会生物信息学和计算生物学计算智能会议（IEEE CIBCB 2022）

IF 1.6 4区生物学

Biosystems Pub Date : 2024-03-01 DOI: 10.1016/j.biosystems.2024.105129

Joseph Alexander Brown, Sheridan Houghten, Gary B. Fogel

引用次数: 0

Early detection of glaucoma integrated with deep learning models over medical devices 在医疗设备上集成深度学习模型的青光眼早期检测。

IF 1.6 4区生物学

Biosystems Pub Date : 2024-02-28 DOI: 10.1016/j.biosystems.2024.105156

DilipKumar Jang Bahadur Saini , Siddhartha Choubey , Abha Choubey , Mariyam Kidwai , Monica Mehrotra , Sagar Kolekar , Yudhishthir Raut

{"title":"Early detection of glaucoma integrated with deep learning models over medical devices","authors":"DilipKumar Jang Bahadur Saini , Siddhartha Choubey , Abha Choubey , Mariyam Kidwai , Monica Mehrotra , Sagar Kolekar , Yudhishthir Raut","doi":"10.1016/j.biosystems.2024.105156","DOIUrl":"10.1016/j.biosystems.2024.105156","url":null,"abstract":"<div><p>The early detection of some diseases can be a decisive factor in postponing or stabilizing their most adverse effects on the people who suffer from them. In the case of glaucoma, which is an ocular pathology that is the second leading cause of blindness in the world, early detection can make the difference between a patient’s complete losses of vision, or preserve their sight, as well as improve their subsequent treatment. It is for this reason that there are currently medical campaigns for the early detection of pathologies with these characteristics in a certain study population, called screening, which have shown very good results. In addition, the application of telemedicine to these processes has allowed remote evaluation of cases by clinical experts and numerous initiatives have emerged for its use in new screening strategies. On the other hand, biomedical image processing techniques based on deep learning have undergone great development in recent years, and there are several works that have demonstrated their possible application in the automatic detection of glaucoma with fundus images. The article has consisted of the development of a web platform that integrates both scenarios: on the one hand, the remote evaluation of fundus images by medical specialists, and on the other, the application of a tool based on Deep Learning for the automatic detection of glaucoma in the case studies.</p></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic biological neural networks: From current implementations to future perspectives 合成生物神经网络：从当前实施到未来展望

IF 1.6 4区生物学

Biosystems Pub Date : 2024-02-23 DOI: 10.1016/j.biosystems.2024.105164

Ana Halužan Vasle, Miha Moškon

{"title":"Synthetic biological neural networks: From current implementations to future perspectives","authors":"Ana Halužan Vasle, Miha Moškon","doi":"10.1016/j.biosystems.2024.105164","DOIUrl":"10.1016/j.biosystems.2024.105164","url":null,"abstract":"<div><p>Artificial neural networks, inspired by the biological networks of the human brain, have become game-changing computing models in modern computer science. Inspired by their wide scope of applications, synthetic biology strives to create their biological counterparts, which we denote synthetic biological neural networks (SYNBIONNs). Their use in the fields of medicine, biosensors, biotechnology, and many more shows great potential and presents exciting possibilities. So far, many different synthetic biological networks have been successfully constructed, however, SYNBIONN implementations have been sparse. The latter are mostly based on neural networks pretrained <em>in silico</em> and being heavily dependent on extensive human input. In this paper, we review current implementations and models of SYNBIONNs. We briefly present the biological platforms that show potential for designing and constructing perceptrons and/or multilayer SYNBIONNs. We explore their future possibilities along with the challenges that must be overcome to successfully implement a scalable <em>in vivo</em> biological neural network capable of <em>online</em> learning.</p></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0303264724000492/pdfft?md5=e79e739aeda5f5a871e0774e83598ea8&pid=1-s2.0-S0303264724000492-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139948064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterisation of the fig-fig wasp holobiont 无花果叶蜂全缘体的特征。

IF 1.6 4区生物学

Biosystems Pub Date : 2024-02-22 DOI: 10.1016/j.biosystems.2024.105162

Praveen Prathapan

引用次数: 0

An efficient approach for identifying important biomarkers for biomedical diagnosis 识别生物医学诊断重要生物标志物的高效方法

IF 1.6 4区生物学

Biosystems Pub Date : 2024-02-22 DOI: 10.1016/j.biosystems.2024.105163

Jing-Wen Huang , Yan-Hong Chen , Frederick Kin Hing Phoa , Yan-Han Lin , Shau-Ping Lin

引用次数: 0

Intrinsic growth rate and evolution of the Premnotrypes Vorax population using fuzzy information 使用模糊信息研究Premnotrypes Vorax种群的内在增长率和进化。

IF 1.6 4区生物学

Biosystems Pub Date : 2024-02-21 DOI: 10.1016/j.biosystems.2024.105161

Élder J. Villamizar-Roa, Leidy V. Espitia-Cruz, Gilberto Arenas-Díaz

{"title":"Intrinsic growth rate and evolution of the Premnotrypes Vorax population using fuzzy information","authors":"Élder J. Villamizar-Roa, Leidy V. Espitia-Cruz, Gilberto Arenas-Díaz","doi":"10.1016/j.biosystems.2024.105161","DOIUrl":"10.1016/j.biosystems.2024.105161","url":null,"abstract":"<div><p>The white potato worm (Premnotrypes Vorax (Hustache)) is one of the pests that causes the greatest damage to the potato crop and the greatest economic losses to the grower; therefore, knowing its life cycle and estimating its intrinsic growth rate is crucial for selecting an appropriate chemical control method, in order to reduce the environmental impact and ensure a profitable production suitable for consumption. In this article, we present a fuzzy Malthusian model describing the evolution of the white potato worm in the crop, considering that the intrinsic growth rate and the reported initial data on the problem are of fuzzy nature. The main contributions and novelty of this paper are summarized in the following two aspects: first, the estimation of the intrinsic growth rate of the white potato worm, in function of the temperature, by using a Takagi–Sugeno–Kang type fuzzy rule-based model; and second, since in practice the initial white potato worm population in a crop is subjective, imprecise and vague, knowing the intrinsic growth rate, we propose and solve a fuzzy initial value problem to determine the evolution in time of the white potato worm population. In conclusion, given a weekly average temperature, it is possible to know the white potato worm population per unit area oscillating in an interval whose length depends on the degree of inaccuracy of the initial population and the intrinsic growth rate. This study can be relevant for grower decision making in terms of the type and frequency of pest control on his crop.</p></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139934032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A global solution to a hyperbolic problem for blood flow modelling 血流建模双曲线问题的全局解决方案

IF 1.6 4区生物学

Biosystems Pub Date : 2024-02-20 DOI: 10.1016/j.biosystems.2024.105160

Nie Dayong

{"title":"A global solution to a hyperbolic problem for blood flow modelling","authors":"Nie Dayong","doi":"10.1016/j.biosystems.2024.105160","DOIUrl":"10.1016/j.biosystems.2024.105160","url":null,"abstract":"<div><p>The paper aims to examine the hyperbolic system of equations governing one-dimensional haemodynamics and its relevance in analysing blood flow under mechanical influences, with particular emphasis on the impact of altering the angle of the leg axis. Methods and approaches for solving hyperbolic equations have been developed in light of their properties and characteristics. The primary objective of this study was to investigate the interplay between vein pressure, pulse wave velocity, and vascular distension. The study revealed an inverse relationship between vein pressure and pulse wave velocity. A decrease in pulse wave velocity occurs when vein pressure rises, and vice versa. Both real measurements and modelling results confirmed this dependence. The pressure in the veins is between 10.8 and 13.6 kPa, and the speed of the pulse wave is between 0.061 and 0.27 kPa. The agreement between real and model data was high. The modelled venous pressure and pulse wave velocity values are close to the actual values. However, it is essential to acknowledge the limitations of this paper. These limitations include the utilisation of one-dimensional haemodynamic models, which fail to consider the three-dimensional structure of the circulatory system. Additionally, the analysis is restricted to examining changes solely in the leg axis angle. The research helps to clarify the relationship between mechanical actions and haemodynamic parameters. The findings may help research and develop new methods for identifying and treating conditions associated with the cardiovascular system.</p></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139920870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The time of appearance of the genetic code 遗传密码出现的时间。

IF 1.6 4区生物学

Biosystems Pub Date : 2024-02-17 DOI: 10.1016/j.biosystems.2024.105159

Massimo Di Giulio

{"title":"The time of appearance of the genetic code","authors":"Massimo Di Giulio","doi":"10.1016/j.biosystems.2024.105159","DOIUrl":"10.1016/j.biosystems.2024.105159","url":null,"abstract":"<div><p>I support the hypothesis that the origin of the genetic code occurred simultaneously with the evolution of cellularity. That is to say, I favour the hypothesis that the origin of the genetic code is a very, very late event in the history of life on Earth. I corroborate this hypothesis with observations favouring the progenote's stage for the Last Universal Common Ancestor (LUCA), for the ancestor of bacteria and that of archaea. Indeed, these progenotic stages would imply that - at that time - the origin of the genetic code was still ongoing simply because this origin would fall within the very definition of progenote. Therefore, if the evolution of cellularity had truly been coeval with the origin of the genetic code - at least in its terminal part - then this would favour theories such as the coevolution theory of the origin of the genetic code because this theory would postulate that this origin must have occurred in extremely complex protocellular conditions and not concerning stereochemical or physicochemical interactions having to do with other stages of the origin of life. In this sense, the coevolution theory would be corroborated while the stereochemical and physicochemical theories would be damaged. Therefore, the origin of the genetic code would be linked to the origin of the cell and not to the origin of life as sometimes asserted. Therefore, I will discuss the late hypothesis of the origin of the genetic code in the context of the theories proposed to explain this origin and more generally of its implications for the early evolution of life.</p></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissipative scaling of development and aging in multicellular organisms 多细胞生物体发育和衰老的耗散缩放效应

IF 1.6 4区生物学

Biosystems Pub Date : 2024-02-15 DOI: 10.1016/j.biosystems.2024.105157

Andres Kriete

{"title":"Dissipative scaling of development and aging in multicellular organisms","authors":"Andres Kriete","doi":"10.1016/j.biosystems.2024.105157","DOIUrl":"10.1016/j.biosystems.2024.105157","url":null,"abstract":"<div><p>Evolution, self-replication and ontogenesis are highly dynamic, irreversible and self-organizing processes dissipating energy. While progress has been made to decipher the role of thermodynamics in cellular fission, it is not yet clear how entropic balances shape organism growth and aging. This paper derives a general dissipation theory for the life history of organisms. It implies a self-regulated energy dissipation facilitating exponential growth within a hierarchical and entropy lowering self-organization. The theory predicts ceilings in energy expenditures imposed by geometric constrains, which promote thermal optimality during development, and a dissipative scaling across organisms consistent with ecological scaling laws combining isometric and allometric terms. The theory also illustrates how growing organisms can tolerate damage through continuous extension and production of new dissipative structures low in entropy. However, when organisms reduce their rate of cell division and reach a steady adult state, they become thermodynamically unstable, increase internal entropy by accumulating damage, and age.</p></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S030326472400042X/pdfft?md5=1347876619e7839f9179203aadbab908&pid=1-s2.0-S030326472400042X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139812163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collective durotaxis along a self-generated mobile stiffness gradient in vivo 体内沿自生移动刚度梯度的集体杜罗塔斯运动

IF 1.6 4区生物学

Biosystems Pub Date : 2024-02-15 DOI: 10.1016/j.biosystems.2024.105155

Ivana Pajic-Lijakovic, Milan Milivojevic

{"title":"Collective durotaxis along a self-generated mobile stiffness gradient in vivo","authors":"Ivana Pajic-Lijakovic, Milan Milivojevic","doi":"10.1016/j.biosystems.2024.105155","DOIUrl":"https://doi.org/10.1016/j.biosystems.2024.105155","url":null,"abstract":"<div><p>A crucial aspect of tissue self-organization during morphogenesis, wound healing, and cancer invasion is directed migration of cell collectives. The majority of in vivo directed migration has been guided by chemotaxis, whereby cells follow a chemical gradient. In certain situations, migrating cell collectives can also self-generate the stiffness gradient in the surrounding tissue, which can have a feedback effect on the directionality of the migration. The phenomenon has been observed during collective durotaxis in vivo. Along the biointerface between neighbouring tissues, heterotypic cell-cell interactions are the main cause of this self-generated stiffness gradient. The physical processes in charge of tissue self-organization along the biointerface, which are related to the interplay between cell signalling and the formation of heterotypic cell-cell adhesion contacts, are less well-developed than the biological mechanisms of the cellular interactions.</p><p>This complex phenomenon is discussed here in the model system, such as collective migration of neural crest cells between ectodermal placode and mesoderm subpopulations within Xenopus embryos by pointing to the role of the dynamics along the biointerface between adjacent cell subpopulations on the subpopulation stiffness.</p></div>","PeriodicalId":50730,"journal":{"name":"Biosystems","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139748862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0