Chromosome Research最新文献_第4页

Exploiting a living biobank to delineate mechanisms underlying disease-specific chromosome instability. 利用活体生物库来描述疾病特异性染色体不稳定的潜在机制。

IF 2.4 4区生物学

Chromosome Research Pub Date : 2023-08-17 DOI: 10.1007/s10577-023-09731-x

Louisa Nelson, Bethany M Barnes, Anthony Tighe, Samantha Littler, Camilla Coulson-Gilmer, Anya Golder, Sudha Desai, Robert D Morgan, Joanne C McGrail, Stephen S Taylor

{"title":"Exploiting a living biobank to delineate mechanisms underlying disease-specific chromosome instability.","authors":"Louisa Nelson, Bethany M Barnes, Anthony Tighe, Samantha Littler, Camilla Coulson-Gilmer, Anya Golder, Sudha Desai, Robert D Morgan, Joanne C McGrail, Stephen S Taylor","doi":"10.1007/s10577-023-09731-x","DOIUrl":"10.1007/s10577-023-09731-x","url":null,"abstract":"Chromosome instability (CIN) is a cancer hallmark that drives tumour heterogeneity, phenotypic adaptation, drug resistance and poor prognosis. High-grade serous ovarian cancer (HGSOC), one of the most chromosomally unstable tumour types, has a 5-year survival rate of only ~30% - largely due to late diagnosis and rapid development of drug resistance, e.g., via CIN-driven ABCB1 translocations. However, CIN is also a cell cycle vulnerability that can be exploited to specifically target tumour cells, illustrated by the success of PARP inhibitors to target homologous recombination deficiency (HRD). However, a lack of appropriate models with ongoing CIN has been a barrier to fully exploiting disease-specific CIN mechanisms. This barrier is now being overcome with the development of patient-derived cell cultures and organoids. In this review, we describe our progress building a Living Biobank of over 120 patient-derived ovarian cancer models (OCMs), predominantly from HGSOC. OCMs are highly purified tumour fractions with extensive proliferative potential that can be analysed at early passage. OCMs have diverse karyotypes, display intra- and inter-patient heterogeneity and mitotic abnormality rates far higher than established cell lines. OCMs encompass a broad-spectrum of HGSOC hallmarks, including a range of p53 alterations and BRCA1/2 mutations, and display drug resistance mechanisms seen in the clinic, e.g., ABCB1 translocations and BRCA2 reversion. OCMs are amenable to functional analysis, drug-sensitivity profiling, and multi-omics, including single-cell next-generation sequencing, and thus represent a platform for delineating HGSOC-specific CIN mechanisms. In turn, our vision is that this understanding will inform the design of new therapeutic strategies.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"31 3","pages":"21"},"PeriodicalIF":2.4,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10503487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromosomal instability and inflammation: a catch-22 for cancer cells. 染色体不稳定和炎症：癌症细胞的第二十二条军规。

IF 2.6 4区生物学

Chromosome Research Pub Date : 2023-08-10 DOI: 10.1007/s10577-023-09730-y

Anouk van den Brink, Maria F Suárez Peredo Rodríguez, Floris Foijer

{"title":"Chromosomal instability and inflammation: a catch-22 for cancer cells.","authors":"Anouk van den Brink, Maria F Suárez Peredo Rodríguez, Floris Foijer","doi":"10.1007/s10577-023-09730-y","DOIUrl":"10.1007/s10577-023-09730-y","url":null,"abstract":"Chromosomal instability (CIN), an increased rate of chromosomal segregation abnormalities, drives intratumor heterogeneity and affects most human cancers. In addition to chromosome copy number alterations, CIN results in chromosome(s) (fragments) being mislocalized into the cytoplasm in the form of micronuclei. Micronuclei can be detected by cGAS, a double-strand nucleic acid sensor, which will lead to the production of the second messenger 2'3'-cGAMP, activation of an inflammatory response, and downstream immune cell activation. However, the molecular network underlying the CIN-induced inflammatory response is still poorly understood. Furthermore, there is emerging evidence that cancers that display CIN circumvent this CIN-induced inflammatory response, and thus immune surveillance. The STAT1, STAT3, and NF-κB signaling cascades appear to play an important role in the CIN-induced inflammatory response. In this review, we discuss how these pathways are involved in signaling CIN in cells and how they are intertwined. A better understanding of how CIN is being signaled in cells and how cancer cells circumvent this is of the utmost importance for better and more selective cancer treatment.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"31 3","pages":"19"},"PeriodicalIF":2.6,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10152605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Twenty years of merotelic kinetochore attachments: a historical perspective. 二十年的裂殖子动粒附着：一个历史的视角。

IF 2.4 4区生物学

Chromosome Research Pub Date : 2023-07-19 DOI: 10.1007/s10577-023-09727-7

Daniela Cimini

引用次数: 0

Human artificial chromosome carrying 3p21.3-p22.2 region suppresses hTERT transcription in oral cancer cells. 携带 3p21.3-p22.2 区域的人类人工染色体可抑制口腔癌细胞中 hTERT 的转录。

IF 2.6 4区生物学

Chromosome Research Pub Date : 2023-06-24 DOI: 10.1007/s10577-023-09726-8

Takahito Ohira, Kaho Yoshimura, Hiroyuki Kugoh

{"title":"Human artificial chromosome carrying 3p21.3-p22.2 region suppresses hTERT transcription in oral cancer cells.","authors":"Takahito Ohira, Kaho Yoshimura, Hiroyuki Kugoh","doi":"10.1007/s10577-023-09726-8","DOIUrl":"10.1007/s10577-023-09726-8","url":null,"abstract":"Telomerase is a ribonucleoprotein ribonucleic enzyme that elongates telomere repeat sequences at the ends of chromosomes and contributes to cellular immortalization. The catalytic component of telomerase, human telomerase reverse transcriptase (hTERT), has been observed to be reactivated in immortalized cells. Notably, most cancer cells have been found to have active hTERT mRNA transcription, resulting in continuous cell division, which is crucial for malignant transformation. Therefore, discovering mechanisms underlying the regulation of hTERT transcription is an attractive target for cancer-specific treatments.Loss of heterozygosity (LOH) of chromosome 3p21.3 has been frequently observed in human oral squamous cell carcinoma (OSCC). Moreover, we previously reported that HSC3 OSCC microcell hybrid clones with an introduced human chromosome 3 (HSC3#3) showed inhibition of hTERT transcription compared with the parental HSC3 cells. This study examined whether hTERT transcription regulators are present in the 3p21.3 region. We constructed a human artificial chromosome (HAC) vector (3p21.3-HAC) with only the 3p21.3-p22.2 region and performed functional analysis using the 3p21.3-HAC. HSC3 microcell hybrid clones with an introduced 3p21.3-HAC exhibited significant suppression of hTERT transcription, similar to the microcell hybrid clones with an intact chromosome 3. In contrast, HSC3 clones with truncated chromosome 3 with deletion of the 3p21.3 region (3delp21.3) showed no effect on hTERT expression levels. These results provide direct evidence that hTERT suppressor gene(s) were retained in the 3p21.3 region, suggesting that the presence of regulatory factors that control telomerase enzyme activity may be involved in the development of OSCC.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"31 3","pages":"17"},"PeriodicalIF":2.6,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10010038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromosomal conservatism vs chromosomal megaevolution: enigma of karyotypic evolution in Lepidoptera. 染色体保守主义与染色体大进化：鳞翅目核型进化之谜。

IF 2.6 4区生物学

Chromosome Research Pub Date : 2023-06-10 DOI: 10.1007/s10577-023-09725-9

Elena A Pazhenkova, Vladimir A Lukhtanov

{"title":"Chromosomal conservatism vs chromosomal megaevolution: enigma of karyotypic evolution in Lepidoptera.","authors":"Elena A Pazhenkova, Vladimir A Lukhtanov","doi":"10.1007/s10577-023-09725-9","DOIUrl":"10.1007/s10577-023-09725-9","url":null,"abstract":"In the evolution of many organisms, periods of slow genome reorganization (= chromosomal conservatism) are interrupted by bursts of numerous chromosomal changes (= chromosomal megaevolution). Using comparative analysis of chromosome-level genome assemblies, we investigated these processes in blue butterflies (Lycaenidae). We demonstrate that the phase of chromosome number conservatism is characterized by the stability of most autosomes and dynamic evolution of the sex chromosome Z, resulting in multiple variants of NeoZ chromosomes due to autosome-sex chromosome fusions. In contrast during the phase of rapid chromosomal evolution, the explosive increase in chromosome number occurs mainly through simple chromosomal fissions. We show that chromosomal megaevolution is a highly non-random canalized process, and in two phylogenetically independent Lysandra lineages, the drastic parallel increase in number of fragmented chromosomes was achieved, at least partially, through reuse of the same ancestral chromosomal breakpoints. In species showing chromosome number doubling, we found no blocks of duplicated sequences or duplicated chromosomes, thus refuting the hypothesis of polyploidy. In the studied taxa, long blocks of interstitial telomere sequences (ITSs) consist of (TTAGG)n arrays interspersed with telomere-specific retrotransposons. ITSs are sporadically present in rapidly evolving Lysandra karyotypes, but not in the species with ancestral chromosome number. Therefore, we hypothesize that the transposition of telomeric sequences may be triggers of the rapid chromosome number increase. Finally, we discuss the hypothetical genomic and population mechanisms of chromosomal megaevolution and argue that the disproportionally high evolutionary role of the Z sex chromosome can be additionally reinforced by sex chromosome-autosome fusions and Z-chromosome inversions.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"31 2","pages":"16"},"PeriodicalIF":2.6,"publicationDate":"2023-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10041801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of chromosomal instability (CIN) tolerance in aggressive tumors: surviving the genomic chaos. 侵袭性肿瘤的染色体不稳定性（CIN）耐受机制：在基因组混乱中生存。

IF 2.4 4区生物学

Chromosome Research Pub Date : 2023-04-14 DOI: 10.1007/s10577-023-09724-w

Brittiny Dhital, Veronica Rodriguez-Bravo

{"title":"Mechanisms of chromosomal instability (CIN) tolerance in aggressive tumors: surviving the genomic chaos.","authors":"Brittiny Dhital, Veronica Rodriguez-Bravo","doi":"10.1007/s10577-023-09724-w","DOIUrl":"10.1007/s10577-023-09724-w","url":null,"abstract":"Chromosomal instability (CIN) is a pervasive feature of human cancers involved in tumor initiation and progression and which is found elevated in metastatic stages. CIN can provide survival and adaptation advantages to human cancers. However, too much of a good thing may come at a high cost for tumor cells as excessive degree of CIN-induced chromosomal aberrations can be detrimental for cancer cell survival and proliferation. Thus, aggressive tumors adapt to cope with ongoing CIN and most likely develop unique susceptibilities that can be their Achilles' heel. Determining the differences between the tumor-promoting and tumor-suppressing effects of CIN at the molecular level has become one of the most exciting and challenging aspects in cancer biology. In this review, we summarized the state of knowledge regarding the mechanisms reported to contribute to the adaptation and perpetuation of aggressive tumor cells carrying CIN. The use of genomics, molecular biology, and imaging techniques is significantly enhancing the understanding of the intricate mechanisms involved in the generation of and adaptation to CIN in experimental models and patients, which were not possible to observe decades ago. The current and future research opportunities provided by these advanced techniques will facilitate the repositioning of CIN exploitation as a feasible therapeutic opportunity and valuable biomarker for several types of human cancers.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"31 2","pages":"15"},"PeriodicalIF":2.4,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9939787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromosome-length genome assemblies and cytogenomic analyses of pangolins reveal remarkable chromosome counts and plasticity. 穿山甲的染色体长度基因组组装和细胞基因组分析揭示了显著的染色体数量和可塑性。

IF 2.6 4区生物学

Chromosome Research Pub Date : 2023-04-12 DOI: 10.1007/s10577-023-09722-y

Marlys L Houck, Klaus-Peter Koepfli, Taylor Hains, Ruqayya Khan, Suellen J Charter, Julie A Fronczek, Ann C Misuraca, Sergei Kliver, Polina L Perelman, Violetta Beklemisheva, Alexander Graphodatsky, Shu-Jin Luo, Stephen J O'Brien, Norman T-L Lim, Jason S C Chin, Vanessa Guerra, Gaik Tamazian, Arina Omer, David Weisz, Kenneth Kaemmerer, Ginger Sturgeon, Joseph Gaspard, Alicia Hahn, Mark McDonough, Isabel Garcia-Treviño, Jordan Gentry, Rob L Coke, Jan E Janecka, Ryan J Harrigan, Jen Tinsman, Thomas B Smith, Erez Lieberman Aiden, Olga Dudchenko

{"title":"Chromosome-length genome assemblies and cytogenomic analyses of pangolins reveal remarkable chromosome counts and plasticity.","authors":"Marlys L Houck, Klaus-Peter Koepfli, Taylor Hains, Ruqayya Khan, Suellen J Charter, Julie A Fronczek, Ann C Misuraca, Sergei Kliver, Polina L Perelman, Violetta Beklemisheva, Alexander Graphodatsky, Shu-Jin Luo, Stephen J O'Brien, Norman T-L Lim, Jason S C Chin, Vanessa Guerra, Gaik Tamazian, Arina Omer, David Weisz, Kenneth Kaemmerer, Ginger Sturgeon, Joseph Gaspard, Alicia Hahn, Mark McDonough, Isabel Garcia-Treviño, Jordan Gentry, Rob L Coke, Jan E Janecka, Ryan J Harrigan, Jen Tinsman, Thomas B Smith, Erez Lieberman Aiden, Olga Dudchenko","doi":"10.1007/s10577-023-09722-y","DOIUrl":"https://doi.org/10.1007/s10577-023-09722-y","url":null,"abstract":"We report the first chromosome-length genome assemblies for three species in the mammalian order Pholidota: the white-bellied, Chinese, and Sunda pangolins. Surprisingly, we observe extraordinary karyotypic plasticity within this order and, in female white-bellied pangolins, the largest number of chromosomes reported in a Laurasiatherian mammal: 2n = 114. We perform the first karyotype analysis of an African pangolin and report a Y-autosome fusion in white-bellied pangolins, resulting in 2n = 113 for males. We employ a novel strategy to confirm the fusion and identify the autosome involved by finding the pseudoautosomal region (PAR) in the female genome assembly and analyzing the 3D contact frequency between PAR sequences and the rest of the genome in male and female white-bellied pangolins. Analyses of genetic variability show that white-bellied pangolins have intermediate levels of genome-wide heterozygosity relative to Chinese and Sunda pangolins, consistent with two moderate declines of historical effective population size. Our results reveal a remarkable feature of pangolin genome biology and highlight the need for further studies of these unique and endangered mammals.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"31 2","pages":"13"},"PeriodicalIF":2.6,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9706353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An essential role for the Ino80 chromatin remodeling complex in regulation of gene expression during cellular quiescence. 在细胞静止期间，Ino80染色质重塑复合体在基因表达调控中的重要作用。

IF 2.6 4区生物学

Chromosome Research Pub Date : 2023-04-12 DOI: 10.1007/s10577-023-09723-x

Yasaman Zahedi, Shengyuan Zeng, Karl Ekwall

{"title":"An essential role for the Ino80 chromatin remodeling complex in regulation of gene expression during cellular quiescence.","authors":"Yasaman Zahedi, Shengyuan Zeng, Karl Ekwall","doi":"10.1007/s10577-023-09723-x","DOIUrl":"https://doi.org/10.1007/s10577-023-09723-x","url":null,"abstract":"Cellular quiescence is an important physiological state both in unicellular and multicellular eukaryotes. Quiescent cells are halted for proliferation and stop the cell cycle at the G0 stage. Using fission yeast as a model organism, we have previously found that several subunits of a conserved chromatin remodeling complex, Ino80C (INOsitol requiring nucleosome remodeling factor), are required for survival in quiescence. Here, we demonstrate that Ino80C has a key function in the regulation of gene expression in G0 cells. We show that null mutants for two Ino80C subunits, Iec1 and Ies2, a putative subunit Arp42, a null mutant for the histone variant H2A.Z, and a null mutant for the Inositol kinase Asp1 have very similar phenotypes in quiescence. These mutants show reduced transcription genome-wide and specifically fail to activate 149 quiescence genes, of which many are localized to the subtelomeric regions. Using spike in normalized ChIP-seq experiments, we show that there is a global reduction of H2A.Z levels in quiescent wild-type cells but not in iec1∆ cells and that a subtelomeric chromosome boundary element is strongly affected by Ino80C. Based on these observations, we propose a model in which Ino80C is evicting H2A.Z from chromatin in quiescent cells, thereby inactivating the subtelomeric boundary element, leading to a reorganization of the chromosome structure and activation of genes required to survive in quiescence.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"31 2","pages":"14"},"PeriodicalIF":2.6,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9664634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Characterization of centromeric DNA of Gossypium anomalum reveals sequence-independent enrichment dynamics of centromeric repeats. 反常棉着丝粒DNA的特征揭示了着丝粒重复序列的非序列富集动力学。

IF 2.6 4区生物学

Chromosome Research Pub Date : 2023-03-27 DOI: 10.1007/s10577-023-09721-z

Wenjie Ding, Yuanbin Zhu, Jinlei Han, Hui Zhang, Zhenzhen Xu, Haris Khurshid, Fang Liu, Robert Hasterok, Xinlian Shen, Kai Wang

{"title":"Characterization of centromeric DNA of Gossypium anomalum reveals sequence-independent enrichment dynamics of centromeric repeats.","authors":"Wenjie Ding, Yuanbin Zhu, Jinlei Han, Hui Zhang, Zhenzhen Xu, Haris Khurshid, Fang Liu, Robert Hasterok, Xinlian Shen, Kai Wang","doi":"10.1007/s10577-023-09721-z","DOIUrl":"https://doi.org/10.1007/s10577-023-09721-z","url":null,"abstract":"Centromeres in eukaryotes are composed of highly repetitive DNAs, which evolve rapidly and are thought to achieve a favorable structure in mature centromeres. However, how the centromeric repeat evolves into an adaptive structure is largely unknown. We characterized the centromeric sequences of Gossypium anomalum through chromatin immunoprecipitation against CENH3 antibodies. We revealed that the G. anomalum centromeres contained only retrotransposon-like repeats but were depleted in long arrays of satellites. These retrotransposon-like centromeric repeats were present in the African-Asian and Australian lineage species, suggesting that they might have arisen in the common ancestor of these diploid species. Intriguingly, we observed a substantial increase and decrease in copy numbers among African-Asian and Australian lineages, respectively, for the retrotransposon-derived centromeric repeats without apparent structure or sequence variation in cotton. This result indicates that the sequence content is not a decisive aspect of the adaptive evolution of centromeric repeats or at least retrotransposon-like centromeric repeats. In addition, two active genes with potential roles in gametogenesis or flowering were identified in CENH3 nucleosome-binding regions. Our results provide new insights into the constitution of centromeric repetitive DNA and the adaptive evolution of centromeric repeats in plants.","PeriodicalId":50698,"journal":{"name":"Chromosome Research","volume":"31 2","pages":"12"},"PeriodicalIF":2.6,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9666851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Cre-LoxP-based approach for combinatorial chromosome rearrangements in human HAP1 cells. 基于cre - loxp的人类HAP1细胞组合染色体重排方法

IF 2.6 4区生物学

Chromosome Research Pub Date : 2023-02-26 DOI: 10.1007/s10577-023-09719-7

Anna Khabarova, Galina Koksharova, Pavel Salnikov, Polina Belokopytova, Roman Mungalov, Inna Pristyazhnuk, Artem Nurislamov, Maria Gridina, Veniamin Fishman

引用次数: 0